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| 1 | HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity显示文摘 | Clement V Sanchez P de Tribolet N Radovanovic I Ruiz i Altaba A | 2007 | 中国神经肿瘤杂志2007，5，2： | 96 |
| 2 | Intestinal microbiota in health and disease: Role of bifidobacteria in gut homeostasis显示文摘The pool of microbes inhabiting our body is known as 'microbiota' and their collective genomes as 'microbiome'. The colon is the most densely populated organ in the human body, although other parts, such as the skin, vaginal mucosa, or respiratory tract, also harbour specific microbiota. This microbial community regulates some important metabolic and physiological functions of the host, and drives the maturation of the immune system in early life, contributing to its homeostasis during life. Alterations of the intestinal microbiota can occur by changes in composition(dysbiosis), function, or microbiota-host interactions and they can be directly correlated with several diseases. The only disease in which a clear causal role of a dysbiotic microbiota has been demonstrated is the case of Clostridium difficile infections. Nonetheless, alterations in composition and function of the microbiota have been associated with several gastrointestinal diseases(inflammatory bowel disease, colorectal cancer, or irritable bowel syndrome), as well as extra-intestinal pathologies, such as those affecting the liver, or the respiratory tract(e.g., allergy, bronchial asthma, and cystic fibrosis), among others. Species of Bifidobacterium genus are the normal inhabitants of a healthy human gut and alterations in number and composition of their populations is one of the most frequent features present in these diseases. The use of probiotics, including bifidobacteria strains, in preventive medicine to maintain a healthy intestinal function is well documented. Probiotics are also proposed as therapeutic agents for gastrointestinal disorders and other pathologies. The World Gastroenterology Organization recently published potential clinical applications for several probiotic formulations, in which species of lactobacilli are predominant. This review is focused on probiotic preparations containing Bifidobacterium strains, alone or in combination with other bacteria, which have been tested in human clinical studies. In spite of extensive literature on and research into this topic, the degree of scientific evidence of the effectiveness of probiotics is still insufficient in most cases. More effort need to be made to design and conduct accurate human studies demonstrating the efficacy of probiotics in the prevention, alleviation, or treatment of different pathologies. | Rafael Tojo Adolfo Suárez Marta G Clemente Clara G de los Reyes-Gavilán Abelardo Margolles Miguel Gueimonde Patricia Ruas-Madiedo | 2014 | World Journal of Gastroenterology2014，20，41： | 33 |
| 3 | Comparison between endoscopic sphincterotomy vs endoscopic sphincterotomy associated with balloon dilation for removal of bile duct stones:A systematic review and meta-analysis based on randomized controlled trials显示文摘AIM To compare gallstones removal rate and incidence of bleeding, pancreatitis, use of mechanical lithotripsy, cholangitis and perforation between isolated sphincterotomy vs sphincterotomy associated with balloon dilation of papilla in choledocholithiasis through the meta-analysis of randomized clinical trials. METHODS We conducted a systematic review according to the PRISMA guidelines. Literature search was restricted to randomized controlled trials(RCTs) on Med Line, Cochrane Library, LILACS, and EMBASE database platforms in July 2017. The manual search included references of retrieved articles. We extracted data focusing on outcomes: The primary endpoint was the stones removal rate; Secondary endpoints were rates of pancreatitis, bleeding, use of mechanical lithotripsy(ML), perforation and cholangitis. RESULTS Eleven RCTs with 1824 patients were included. EST was associated with more post-endoscopic retrograde cholangiopancreatography(ERCP) bleeding [FE RD-0.02, CI(-0.03,-0.00), I2 = 33%, P = 0.05] and more need of mechanical lithotripsy in general [RE RD-0.16, CI(-0.25,-0.06), I2 = 90%, P = 0.002] and in subgroup analysis of stones greater than 15 mm [RE RD-0.20, CI(-0.38,-0.02), I2 = 82%, P = 0.003]. Incidence of pancreatitis [FE RD-0.01, CI(-0.03, 0.01), I2 = 0, P = 0.36], cholangitis [FE RD-0.00, CI(-0.01, 0.01), I2 =0, P = 0.97] and perforation [FE RD-0.01, CI(-0.01, 0.00), I2 = 0, P = 0.23] was similar between the groups as well as similar stone removal rates in general [FE RD-0.01, CI(-0.01, 0.04), I2 = 0, P = 0.23] and pooled analysis of stones greater than 15 mm [FE RD-0.02, CI(-0.02, 0.07), I2 = 11%, P = 0.31]. CONCLUSION Through meta-analysis of randomized clinical trials we found that isolated sphincterotomy was associated with more post-ERCP bleeding and more need for mechanical lithotripsy. However, there was no statistical difference in the stone removal rate between isolated sphincterotomy and sphincterotomy associated with balloon dilation in the approach to remove gallstones. | Cesar Capel de Clemente Junior Wanderley Marques Bernardo Tomazo Prince Franzini Gustavo Oliveira Luz Marcos Eduardo Lera dos Santos Jonah Maxwell Cohen Diogo Turiani Hourneaux de Moura Fábio Ramalho Tavares Marinho Martin Coronel Paulo Sakai Eduardo Guimaraes Hourneaux de Moura | 2018 | World Journal of Gastrointestinal Endoscopy2018，10，8： | 8 |
| 4 | The influence of chemical composition and microstructure of API linepipe steels on hydrogen induced cracking and sulfide stress corrosion cracking显示文摘 | Rogério Augusto Carneiro Rajindra Clement Ratnapuli Vanessa de Freitas Cunha Lins | 2003 | Materials Science & Engineering A2003，，1： | 2 |
| 5 | The world’s ten most feared fungi显示文摘An account is provided of the world’s ten most feared fungi.Within areas of interest,we have organized the entries in the order of concern.We put four human pathogens first as this is of concern to most people.This is followed by fungi producing mycotoxins that are highly harmful for humans;Aspergillus flavus,the main producer of aflatoxins,was used as an example.Problems due to indoor air fungi may also directly affect our health and we use Stachybotrys chartarum as an example.Not everyone collects and eats edible mushrooms.However,fatalities caused by mushroom intoxications often make news headlines and therefore we include one of the most poisonous of all mushrooms,Amanita phalloides,as an example.We then move on to the fungi that damage our dwellings causing serious anxiety by rotting our timber structures and flooring.Serpula lacrymans,which causes dry rot is an excellent example.The next example serves to represent all plant and forest pathogens.Here we chose Austropuccinia psidii as it is causing devastating effects in Australia and will probably do likewise in New Zealand.Finally,we chose an important amphibian pathogen which is causing serious declines in the numbers of frogs and other amphibians worldwide.Although we target the top ten most feared fungi,numerous others are causing serious concern to human health,plant production,forestry,other animals and our factories and dwellings.By highlighting ten feared fungi as an example,we aim to promote public awareness of the cost and importance of fungi. | Kevin D.Hyde Abdullah M.S.Al-Hatmi Birgitte Andersen Teun Boekhout Walter Buzina Thomas L.Dawson Jr. Dan C.Eastwood E.B.Gareth Jones Sybren de Hoog Yingqian Kang Joyce E.Longcore Eric H.C.McKenzie Jacques F.Meis Laetitia Pinson-Gadais Achala R.Rathnayaka Florence Richard-Forget Marc Stadler Bart Theelen Benjarong Thongbai Clement K.M.Tsui | 2018 | Fungal Diversity2018，，6： | 2 |
| 6 | Enhanced expression of MMP-7 and MMP-9 in demyelinating multiple sclerosis lesions显示文摘 | Judy A. Cossins John M. Clements Janice Ford Karen M. Miller Rod Pigott Wim Vos P. Van Der Valk C. J. A. De Groot | 1997 | Acta Neuropathologica1997，，6： | 1 |
| 7 | Sedation in PACU: the role of propofol 显示文摘 | De Cosmo G Congedo E Clemente A | 2005 | Curr Drug Targets2005，6，7： | 1 |
| 8 | Chemical strategies to design textured materials:from microporous and mesoporous oxides to nanonetwords and hierarchical structures 显示文摘 | Galo J de A A Soler L Clement | 2002 | Chemical Reviews2002，102，： | 1 |
| 9 | Antihypertensive effects of calcium antagonists: clinical facts and modulating factors显示文摘 | Clement DL De BM Duprez D | 1994 | Am J Hypertension1994，7，2： | 1 |
| 10 | Can warm climate-related structure of littoral predator assemblies weaken the clear water state in shallow lakes显示文摘 | Meerhoff M Clemente J M De Mello F T Iglesias C Pedersen A R Jeppesen E | 2007 | Global Change Biology2007，13，9： | 1 |
| 11 | HLA class II genes in chronic hepatitis C virus-infection and associated immunological disorders显示文摘 | M Congia MG Clemente C Dessi F Cucca AP Mazzoleni F Frau R Lampis A Cao ME Lai S De Virgiliis | 1996 | Hepatology1996，，6： | 1 |
| 12 | Brachial plexus blocks:a review of approaches and techniques显示文摘 | De Tran QH Clemente A Doan J | 2007 | Can J Anaesth2007，54，8： | 1 |
| 13 | Long-term effects of clinical outcome with low-and high dose in the Captopril in Heart Insufficient Pa-tients Study (CHIPS) 显示文摘 | De Buyzere M Tomas M | 2000 | Acta Cardiol2000，55，： | 1 |
| 14 | Long-term effects of clinical outcome with low and high dose in the captopril in heart insufficient patients study显示文摘 | Clement DL De Buyxere M Tomas M | 2000 | Acta Cardiol2000，55，1： | 1 |
| 15 | Prognostic value of ambulatmTb lood-pressure recordings in patients with treated hyperten- sion显示文摘 | Clement DL De Buyzere ML De Bacquer DA | 2003 | NEngl JM ed2003，34，： | 1 |
| 16 | Unexpected gallbladder cancer after laparoscopic cholecystectomy for acute cholecystitis : a worrisome picture显示文摘 | Clemente G Nuzzo G De Rose AM | 2012 | J Gastrointest Surg2012，16，8： | 1 |
| 17 | The photo-crys- tallization of amorphous selenium thin films显示文摘 | Clement R Carballes J C De Cremoux B | 1974 | J Non Cryst Sol- ids1974，15，3： | 1 |
| 18 | p38 MAPK activation by TGF-beta1 increases MLC phosphorylation and endothelial monolayer permeability显示文摘 | Goldberg PL MacNaughton DE Clements RT | 2002 | Am J Physiol Lung Cell Mol Physiol2002，282，1： | 1 |
| 19 | Prognostic value of ambulatory blood-pressure recordings in patients with treated hypertension显示文摘 | Clement DL De Buyzere ML De Bacquer DA | 2003 | N Engl J Med2003，348，24： | 1 |
| 20 | There is no direct relationship between N-status and frost hardiness in needles of NH3-exposed Scots pine seedlings显示文摘 | Clement J M A M de Boer M Venema J H | 2000 | Python2000，40，： | 1 |
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