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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Substance P up-regulates matrix metalloproteinase-1 and down-regulates collagen in human lung fibroblast显示文摘 | Ramos C Montano M Cisneros J | 2007 | Exp Lung Res2007，33，34： | 1 |
| 3 | Questionnaire development:face validity and item impact testing of the Child Oral Health Impact Profile显示文摘 | Broder HL McGrath C Cisneros GJ | 2007 | Community Dent Oral Epidemiol2007，35，1： | 1 |
| 4 | Efficacy of different irrigation and activation systems on the penetration of sodium hypochlorite into simulated lateral canals and up to working length:an in vitro study显示文摘 | de Gregorio C Estevez R Cisneros R | | 0，，07： | 1 |
| 5 | Efficacy of different irrigation and activation systems on the penetra- tion of sodium hypochlorite into simulated lateral canals and up to working length: An in vitro study显示文摘 | de Gregorio C Estevez R Cisneros R | 2010 | J Endod2010，36，7： | 1 |
| 6 | Multifractal Hurst analysis of crude oil prices显示文摘 | Alvarez - Ramirea J Cisneros M Ibarra - Valdez C Soriano Z | 2002 | Physica A2002，313，： | 1 |
| 7 | Internal jugular vein valve in- competence is highly prevalent in transient global amnesia 显示文摘 | Cejas C Cisneros LF Lagos R | 2010 | Strnke2010，41，1： | 1 |
| 8 | Hyperthermia inhibits recombi- nation repair of gemcitabine-stalled replication forks显示文摘 | Raoof M Zhu C Cisneros BT | 2014 | J Natl Cancer Inst2014，106，8： | 1 |
| 9 | Treatment of infections caused by carbapenemase-producing Enterobacteriaceae 显示文摘 | RODRIGUEZ-BAiO J CISNEROS JM GUDIOL C | 2014 | Enferm Infecc Microbiol Clin2014，32，4： | 1 |
| 10 | Osmoticall induced response in respreacntatives of halophilic:the bacterium Halomounos elongata and the archaeon Haloferax volcanii 显示文摘 | MOICA F J CISNEROS E FERRER C | 1997 | J Bacteriol1997，179，： | 1 |
| 11 | Mulitifractal Hurst analysis of crude oil prices显示文摘 | Alvarez-Ramirez J Cisneros M Ibarra-Valdez C | 2002 | Physica A2002，313，： | 1 |
| 12 | Pullout resistance of steel geogrids with weathered clay as backfill material 显示文摘 | Bergado D T Hardiyatimo H C Cisneros C B | 1992 | Geotechnical Testing Journal1992，15，1： | 1 |
| 13 | Multifractal Hurst Analysis of Crude Oil Prices 显示文摘 | Alvarez-Ramirez J Cisneros M Ibarra-Valdz C Soriano A | 2002 | Physica A2002，313，： | 1 |
| 14 | Effect of EDTA,sonic,and ultrasonic activation on the penetration of sodium hy-pochlorite into simulated lateral canals:an in vitro study显示文摘 | de Gregorio C Estevez R Cisneros R | 2009 | JEndod2009，35，6： | 1 |
| 15 | Efficacy of differ-ent irrigation and activation systems on the penetration of sodiumhypochlorite into simulated lateral canals and up to workinglength:an in vitro study显示文摘 | de Gregorio C Estevez R Cisneros R | 2010 | J Endod2010，36，7： | 1 |
| 16 | Influ- ence of rainfall spatial variability on flood prediction 显示文摘 | ARNAUD P BOUVIER C CISNEROS L | 2002 | Journal of Hydrology2002，260，1234： | 1 |
| 17 | Posterior chamber phakic intraocular lenses to correct high myopia:a comparative study between Staar and Adatomed models显示文摘 | Menezo JL Peris-Martinez C Cisneros A | 2001 | Refract Surg2001，17，： | 1 |
| 18 | Internal jugular vein valve incompetence is highly prevalent in transient global amnesia显示文摘 | Cejas C Cisneros LF Lagos R | | 0，，01： | 1 |
| 19 | Bentonites from Cabo de Gata, Almeria, Spain: A mineralog- ical and geochemical overview显示文摘 | Caballero E Jimenez De Cisneros C Huertas F J | 2005 | Clay Minerals2005，40，4： | 1 |
| 20 | Internal jugular vein valve incompetence is highly prevalent in transient global amnesia显示文摘 | Cejas C Cisneros LF Lagos R | 2010 | Stroke2010，41，： | 1 |
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