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| 1 | Role of nitric oxide in the impairment of circular muscle contractility of distended, uninflamed mid-colon in TNBS-induced acute distal colitis in rats显示文摘AIM: To evaluate the role of nitric oxide (NO) in the motor disorders of the dilated uninflamed mid-colon (DUMC)from trinitrobenzene sulfonic acid (TNBS)-induced acute distal colitis in rats.METHODS: Colitis was induced in male Sprague-Dawley rats by a single intracolonic administration of TNBS.Control rats received an enema of 0.9% saline. The rats were killed 48 h after TNBS or saline administration.Macroscopic and histologic lesions of the colon were evaluated. Myeloperoxidase (MPO) and nitric oxide synthase (NOS) activity were measured on the colonic tissue. In TNBS rats, we evaluated spontaneous and evoked contractile activity in circular muscle strips derived from DUMC in comparison to the same colonic segment of control rats, both in the presence and in the absence of a non-selective NOS isoforms inhibitor N-nitro-Larginine (L-NNA). Pharmacological characterization of electric field stimulation (EFS)-evoked contractile responses was also performed.RESULTS: In TNBS rats, the distal colon showed severe histological lesions and a high MPO activity, while the DUMC exhibited normal histology and MPO activity.Constitutive NOS activity was similar in TNBS and control rats, whereas inducible NOS activity was significantly increased only in the injured distal colon of TNBS rats.Isometrically recorded mechanical activity of circular muscle strips from DUMC of TNBS rats showed a marked reduction of the force and frequency of spontaneous contractions compared to controls, as well as of the contractile responses to a contracting stimulus. In the presence of L-NNA, the contractile activity and responses displayed a significantly greater enhancement compared to controls. The pharmacological characterization of EFS contractile responses showed that a cooperative-like interaction between cholinergic muscarinic and tachykinergic neurokinin 1 and 2 receptors mediated transmission in DUMC of TNBS rats vs a simple additive interaction in controls.CONCLUSION: The results of this study show that, during TNBS-induced acute distal colitis, circular muscle intrinsic contractile mechanisms and possible enteric neural excitatory activity are inhibited in the distended uninflamed mid-colon. Suppression of NO synthesis markedly improves spontaneous and evokes muscle contractions, in spite of any evident change in local NO activity. | Luciano Onori Annalisa Aggio Simona D'Alo' Paola Muzi Maria Grazia Cifone Gabriella Mellillo Rachele Ciccocioppo Gennaro Taddei Giuseppe Frieri Giovanni Latella | 2005 | World Journal of Gastroenterology2005，11，36： | 7 |
| 2 | The emerging role of probiotics in neurodegenerative diseases:new hope for Parkinson’s disease?显示文摘Neurodegenerative disease etiology is still unclear,but different contributing factors,such as lifestyle and genetic factors are involved.Altered components of the gut could play a key role in the gut-brain axis,which is a bidirectional system between the central nervous system and the enteric nervous system.Variations in the composition of the gut microbiota and its function between healthy people and patients have been reported for a variety of human disorders comprising metabolic,autoimmune,cancer,and,notably,neurodegenerative disorders.Diet can alter the microbiota composition,affecting the gutbrain axis function.Different nutraceutical interventions have been devoted to normalizing gut microbiome dysbiosis and to improving biological outcomes in neurological conditions,including the use of probiotics.Preclinical and clinical investigations discussed in this review strengthen the correlation between intestinal microbiota and brain and the concept that modifying the microbiome composition may improve brain neurochemistry,modulating different pathways.This review will discuss the potential use of probiotics for Parkinson’s disease prevention or treatment or as adjuvant therapy,confirming that gut microbiota modulation influences different pro-survival pathways.Future investigations in Parkinson’s disease should consider the role of the gut-brain axis and additional comprehension of the underlying mechanisms is extremely necessary. | Vanessa Castelli Michele d’Angelo Massimiliano Quintiliani Elisabetta Benedetti Maria Grazia Cifone Annamaria Cimini | 2021 | Neural Regeneration Research2021，16，4： | 2 |
| 3 | Mammalian genotoxicity assessment of methylene blue in plasma: implications for virus inactivation 显示文摘 | Wagner SJ Cifone MA Murli H | 1995 | Transfusion1995，35，4： | 1 |
| 4 | In vitro growth characteristics associated with benign and metastatic variants of tumor cells显示文摘 | Cifone M A | 1982 | Cancer Metastasis Rev1982，1，： | 1 |
| 5 | Dexamethasone-induced apoptosis of thymocytes: role of glucocorticoid receptor-associated Src kinase and caspase-8 activation 显示文摘 | Marchetti MC Di Marco B Cifone G | 2003 | Blood2003，101，2： | 1 |
| 6 | In vitro growth characteristics associated with benign and metastatic variants of tumor cells显示文摘 | Cifone MA | | 0，，： | 1 |
| 7 | Dexamethasone-induced thymocyte apoptosis : apoptotic signal involves the sequential activation of phosphoinositide-specific phospholipase C, acidic sphingomyelinase, and caspases显示文摘 | Cifone M G Migliorati G Parroni R | 1999 | Blood1999，93，7： | 1 |
| 8 | Carnitine stands on its own in HIV infection treatment显示文摘 | Famularo G De Simone C Cifone G | 1999 | Archives of Internal Medicine1999，159，10： | 1 |
| 9 | Triggering of human monocyte activation through CD69, a member of the natural killer cell gene complex family of signal transducing receptors显示文摘 | De Maria R Cifone MG Trotta R | 1994 | J Exp Med1994，180，5： | 1 |
| 10 | Applicatioofsimplified in vitro screening tests to detect genotoxicityof aristolochic acid显示文摘 | Zhang H Cifone MA Murli H | 2004 | Food Chem Toxicol2004，42，12： | 1 |
| 11 | Sphingolipids and the immune system显示文摘 | Cinque B Di Marzio L Centi C Di Rocco C Riccardi C Grazia Cifone M | 2003 | Pharmacol Res2003，47，5： | 1 |
| 12 | Effects of cadmium on lymphocyte activation显示文摘 | Cifone MG | 1989 | Bichim-Biophys-Acta1989，1011，1： | 1 |
| 13 | Genotoxicity assessment of hexahydro-1,3,5-trinitro-1,3,5-triazine(RDX)显示文摘 | Reddy G Erexson GL Cifone MA | | 0，，06： | 1 |
| 14 | TNF - a downregulates PPAR3 expression in oligodendrocyte progenitor cells: Implica tions for demyelilmting diseases显示文摘 | Cimini A Bernardo A Cifone MG | 2003 | Glia2003，41，1： | 1 |
| 15 | In-ability of heterologous growth hormone (GH) to regulate GH binding protein in GH-transgenic swine显示文摘 | Cifone D Dominici F.P Pursel V.G Turyn D | | 0，，07： | 1 |
| 16 | Dexamethasone-induced thymocyte apoptosis:apoptotic signal involves the sequential activation of phosphoinositide-specific phospholipase C,acidic sphingomyelinase,and caspases显示文摘 | CIFONE M G MIGLIORATI G PARRONI R | 1999 | Blood1999，93，7： | 1 |
| 17 | Glucocorticoid hor- mone-induced modulation of gene expression and regulation of T-cell death: role of GITR and GILZ, two dexamethasone-in- duced genes显示文摘 | Riccardi C Cifone M G Migliorati G | 1999 | Cell Death Differ1999，6，12： | 1 |
| 18 | Glucocorticoid hormone-induced modulation of gene expression and regulation of T-cell death: role of GITR and GILZ, two dexamethasone-induced genes 显示文摘 | Riccardi C Cifone M G Migliorati G | 1999 | Cell Death Differ1999，6，12： | 1 |
| 19 | Application of simplied in vitro screening tests to detect genotoxicity of aristolochic acid显示文摘 | ZHANG H CIFONE MA MURLI H | 2004 | Food Chem Toxicol2004，42，12： | 1 |
| 20 | Glucocorticoid hormoneinduced modulation of gene expression and regulation of T cell death:role of GITR and GILZ,two dexamethasone induced genes显示文摘 | Riccardi C Cifone M G Migliorati G | 1999 | Cell Death Differ1999，6，12： | 1 |
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