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| 1 | Therapy of gallstone disease:What it was,what it is,what it will be显示文摘Cholesterol gallstone disease is a common clinical condition influenced by genetic factors,increasing age,female gender,and metabolic factors.Although laparoscopic cholecystectomy is currently considered the gold standard in treating patients with symptomatic gallstones,new perspectives regarding medical therapy of cholelithiasis are currently under discussion,also taking into account the pathogenesis of gallstones,the natural history of the disease and the analysis of the overall costs of therapy.A careful selection of patients may lead to successful nonsurgical therapy in symptomatic subjects with a functioning gallbladder harboring small radiolucent stones.The classical oral litholysis by ursodeoxycholic acid has been recently paralleled by new experimental observations,suggesting that cholesterol-lowering agents which inhibit cholesterol synthesis (statins) or intestinal cholesterol absorption (ezetimibe),or drugs acting on specific nuclear receptors involved in cholesterol and bile acid homeostasis,might be proposed as additional approaches for treating cholesterol gallstones.In this review we discuss old,recent and future perspectives on medical treatment of cholesterol cholelithiasis. | Piero Portincasa Agostino Di Ciaula Leonilde Bonfrate David QH Wang | 2012 | World Journal of Gastrointestinal Pharmacology and Therapeutics2012，3，2： | 21 |
| 2 | Ultrasonographic study of postcibal gastro-esophageal reflux and gastric emptying in infants with recurrent respiratory disease显示文摘AIM: To check the utility of postcibal ultrasonography for the evaluation of reflux in relation to gastric emptying in infants with recurrent respiratory symptoms and to link imaging with clinical data.METHODS: Esophageal reflux (hyperechoic retrograde filling) and gastric emptying (antral areas) were quantified before and after ingestion of a standard formula in 35 untreated infants (13 with chronic cough,22 with recurrent bronchitis) and in 31 controls.RESULTS: The prevalence of abnormal (≥8 episodes)postcibal refluxes was 74% in patients and 3% in controls. Number, duration of the longest episode and extent of refluxes were significantly higher in patients compared to controls. Number of refluxes was higher in patients with symptomatic refluxes than in those without.Infants with recurrent bronchitis had more refluxes than those with chronic cough and controls. Extent and timing of gastric emptying were similar in patients and controls.CONCLUSION: Esophageal ultrasonography is a useful and physiological test in infants with recurrent respiratory diseases, which have a high prevalence of abnormal postcibal esophageal reflux and a gastric emptying similar to that of normal controls. Esophageal reflux is more severe in subjects with recurrent bronchitis than in those with chronic cough. | Agostino Di Ciaula Piero Portincasa Leonardo Di Terlizzi Domenico Paternostro Giuseppe Palasciano | 2005 | World Journal of Gastroenterology2005，11，46： | 3 |
| 3 | Current Views on Genetics and Epigenetics of Cholesterol Gallstone Disease显示文摘 | Agostino Di Ciaula David Q.-H. Wang Leonilde Bonfrate Piero Portincasa Gloria L. Vega | 2013 | Cholesterol2013，，： | 2 |
| 4 | Gall- bladder motor function in gallstone patients: sonographic and in vitro studies on the role of gallstones, smooth muscle function and gallbladder wall inflammation显示文摘 | Portincasa P Di Ciaula A Baldassarre G | 1994 | J Hepatol1994，21，3： | 1 |
| 5 | Smooth muscle function and dysfunction in gallbladder disoase显示文摘 | Portincasa P Di Ciaula A vanBerge-Henegouwen GP | 2004 | CUlT Gastroenterol Rep2004，6，2： | 1 |
| 6 | Gall- bladder motility and cholesterol crystallization in bile from patients with pigment and cholesterol gallstones 显示文摘 | Portincasa P Di Ciaula A Vendemiale G | 2000 | Eur J Clin Invest2000，30，4： | 1 |
| 7 | Targets for Current Pharmacologic Therapy in Cholesterol Gallstone Disease显示文摘 | Agostino Di Ciaula David Q.H. Wang Helen H. Wang Leonilde Bonfrate Piero Portincasa | 2010 | Gastroenterology Clinics of North America2010，，2： | 1 |
| 8 | Impaired gallbladder and gastric motility and pathological gastroesophageal reflux in gallstone patients 显示文摘 | Di Ciaula A Palmieri V Velardi A Vanberge-Henegouwen GP Palasciano G | 1997 | Eur J Clin Invest1997，27，8： | 1 |
| 9 | Therapeutic reflections in cholesterol homeostasis and gallstone disease: a review显示文摘 | Di Ciaula A Wang DQ Garruti G | 2014 | Curt Med Chem2014，21，12： | 1 |
| 10 | Gallbladder motility and cholesterol crystallization in bile from patients with pigment and cholesterol gallstones显示文摘 | Di Ciaula A Vendemiale G | 2000 | Eur J Clin Invest2000，30，4： | 1 |
| 11 | Coordinateregulation of gallbladder motor function in the gut-liver axis显示文摘 | PORTINCASA P DI CIAULA A WANG HH | 2008 | Hepatology2008，47，： | 1 |
| 12 | Gastroin- testinal symptoms and motility disorders in patients with sys- temic scleroderma显示文摘 | DI CIAULA A COVELLI M BERARDINO M | 2008 | BMC Gastroenterol2008，27，8： | 1 |
| 13 | Smooth muscle function and dysfunction in gallbladder disease显示文摘 | Portincasa P Di Ciaula A VanBerge-Henegouwen GP | | 0，，02： | 1 |
| 14 | Gallbladder motor function in gallstone patients:sonographic and in vitro studies on the role of gallstones,smooth muscle function and gallbladder wall inflammation显示文摘 | Portincasa P Di Ciaula A Baldassarre G | | 0，，03： | 1 |
| 15 | Therapy of gall- stone disease: what it was ,what it is,what it will be 显示文摘 | Portincasa P Ciaula AD Bonfrate L | 2012 | World J Gastrointest Pharamacol Ther2012，3，2： | 1 |
| 16 | Relationships between emissions of toxic airborne molecules and type 1 diabetes incidence in children:An ecologic study显示文摘BACKGROUND Type 1 diabetes originates from gene-environment interactions,with increasing incidence over time.AIM To identify correlates of childhood type 1 diabetes in European countries using an ecological approach.Several environmental variables potentially influencing the onset of type 1 diabetes have been previously evaluated.However,the relationships between epidemiologic data and exposure to toxic airborne molecules are scarcely studied.METHODS We employed an ecological model to explore,in a wide time period(1990-2018),associations between type 1 diabetes incidence in 19 European countries(systematic literature review)and the nationwide production of five widely diffused air pollutants:particulate matter<10μm(PM10),nitrogen oxides(NO),non-methane volatile organic compounds(VOCs),sulphur oxide(SO2),and ammonia.RESULTS Data confirm a raising incidence of type 1 diabetes in 18 out of 19 explored countries.The average difference(last vs first report,all countries)was+6.9×100000/year,with values ranging from-1.4(Germany)to+16.6(Sweden)per 100000/year.Although the overall production of pollutants decreased progressively from 1990 to 2018,type 1 diabetes incidence was positively associated with the nationwide emissions of PM10,VOCs,and NO but not with those of SO2 and ammonia.Type 1 diabetes incidence was significantly higher in countries with high emissions than in those with low emissions of PM10(27.5±2.4 vs 14.6±2.4×100000 residents,respectively),VOCs(24.5±4.4 vs 13.2±1.7×100000 residents,respectively),and NO(26.6±3 vs 13.4±2.4×100000 residents,respectively),but not of SO2 or ammonia.CONCLUSION Evidence justify further studies to explore better links between long-term air quality and type 1 diabetes onset at the individual level,which should include exposures during pregnancy.In this respect,type 1 diabetes could be,at least in part,a preventable condition.Thus,primary prevention policies acting through a marked abatement of pollutant emissions might attenuate future type 1 diabetes incidence throughout Europe. | Agostino Di Ciaula Piero Portincasa | 2021 | World Journal of Diabetes2021，12，5： | 1 |
| 17 | Smooth muscle function and dysfunction in gallbladder disease显示文摘 | Portincasa P Ciaula AD van Berge-Henegouwen GP | 2004 | Curr Gastroenterol Rep2004，6，2： | 1 |
| 18 | Coordinate regulation of gallbladder motor function in the gut-liver axis显示文摘 | Portincasa P Ciaula AD Wang HH | 2008 | Hepatology2008，47，6： | 1 |
| 19 | Coordinate regulation ofgallbladder motor function in the gut-liver axis 显示文摘 | Portincasa P Di Ciaula A Wang HH | 2008 | Hepatology2008，47，6： | 1 |
| 20 | Medicinal treatments of cholesterol gallstones:old,current and new perspectives显示文摘 | Portincas P DI Ciaula A Wang HH | 2009 | Curr Med Chem2009，16，12： | 1 |
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