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| 1 | Enhanced phytoextraction of Pb and other metals from artificially contaminated soils through the combined application of EDTA and EDDS显示文摘 | Chunling LUO Zhenguo SHEN Xiangdong LI Alan J.M. Baker | 2006 | Chinese Journal Of Geochemistry2006，25，B08： | 31 |
| 2 | A review on phospholipids and their main applications in drug delivery systems显示文摘Phospholipids have the characteristics of excellent biocompatibility and a especial amphiphilicity.These unique properties make phospholipids most appropriate to be employed as important pharmaceutical excipients and they have a very wide range of applications in drug delivery systems.The aim of this review is to summarize phospholipids and some of their related applications in drug delivery systems,and highlight the relationship between the properties and applications,and the effect of the species of phospholipids on the efficiency of drug delivery.We refer to some relevant literatures,starting from the structures,main sources and properties of phospholipids to introduce their applications in drug delivery systems.The present article focuses on introducing five types of carriers based on phospholipids,including liposomes,intravenous lipid emulsions,micelles,drug-phospholipids complexes and cochleates. | Jing Li Xuling Wang Ting Zhang Chunling Wang Zhenjun Huang Xiang Luo Yihui Deng | 2015 | Asian Journal of Pharmaceutical Sciences2015，10，2： | 23 |
| 3 | Photodegradation of fluoroquinolone antibiotic gatifloxacin in aqueous solutions显示文摘Fluoroquinolone antibiotics (FQs) are frequently detected as emerging pollutants in aqueous environments.In this study,kinetics,influencing factors and mechanisms on the photodegradation of gatifloxacin,a representative FQ,were investigated.The photodegradation follows the pseudo-first-order kinetics.Gatifloxacin photodegrades with a quantum yield of (5.94 ± 0.95) × 10 3 in pure water and undergoes direct photolysis as well as self-sensitized photodegradation.The FQ photodegrades slower in freshwater and seawater than in pure water,which is attributed to the integrative effects of pH and the aqueous dissolved matter (e.g.,humic acids and NO 3-) on the photodegradation.A toxicity test using Vibrio fischeri revealed the formation of hazardous photoproducts. | GE LinKe CHEN JingWen ZHANG SiYu CAI XiYun WANG Zhuang WANG ChunLing | 2010 | Chinese Science Bulletin2010，55，15： | 17 |
| 4 | Marine Yeasts and Their Applications in Mariculture显示文摘The terrestrial yeasts have been receiving great attention in science and industry for over one hundred years because they can produce many kinds of bioactive substances. However, little is known about the bioactive substances of marine yeasts. In recent years, it has been found that marine yeasts have wide applications in mariculture and other fields. Therefore,marine yeasts, the bioactive substances from them and the applications of marine yeasts themselves and the bioactive substances they produced are reviewed in this paper. | CHI Zhenming LIU Zhiqiang GAO Lingmei GONG Fang MA Chunling WANG Xianghong LI Haifeng | 2006 | Journal of Ocean University of China2006，5，3： | 12 |
| 5 | Extraction of heavy metals from e-waste contaminated soils using EDDS显示文摘Environmental contamination due to uncontrolled e-waste recycling activities is drawing increasing attention in the world. Extraction of these metals with biodegradable chelant [S,S]-ethylenediaminedisuccinic acid (EDDS) and the factors influencing extraction efficacy were investigated in the present study. Results showed that the addition of EDDS at low pH (5.5) produced higher metal extraction than that at high pH (8.0) solution. Metal speciation analysis indicated that Cu was completely complexed with EDDS at different pH conditions with various amounts of EDDS applied. For Pb and Zn, at low EDDS dose of 0.304 mol/kg soil, they were present as Pb- and Zn-EDDS. However, at high EDDS dose of 1.26 mol/kg soil, most of Pb was bound with dissolved organic matter. Ca and Al were found to be strong competitors for trace metals to EDDS at low application dose and low pH condition. | Renxiu Yang Chunling Luo Gan Zhang Xiangdong Li Zhenguo Shen | 2012 | Journal of Environmental Sciences2012，24，11： | 12 |
| 6 | Naringenin reduces lung metastasis in a breast cancer resection model显示文摘Metastasis is the main cause of death in cancer patients. To improve the outcomes of patients undergoing a surgery, new adjuvant therapies that can effectively inhibit metastases have to be developed. Studies have shown that flavonoid naringenin, a natural product that is mainly present in grapes and citrus, may contribute to cancer prevention. It has many advantages compared to traditional chemotherapeutic drugs, such as low toxicity. To determine whether naringenin can also inhibit metastases, a breast cancer resection model that mimics clinical situations was established. We found that orally administered naringenin significantly decreased the number of metastatic tumor cells in the lung and extended the life span of tumor resected mice. Flow cytometry analysis revealed that T cells displayed enhanced antitumor activity in naringenin treated mice, with an increased proportion of IFN-γ and IL-2 expressing T cells. In vitro studies further demonstrated that relief of immunosuppression caused by regulatory T cells might be the fundamental mechanism of metastasis inhibition by naringenin. These results indicate that orally administered naringenin can inhibit the outgrowth of metastases after surgery via regulating host immunity. Thus, naringenin can be an ideal surgical adjuvant therapy for breast cancer patients. | Lei Qin Lingtao Jin Linlin Lu Xiaoyan Lu Chunling Zhang Fayun Zhang Wei Liang | 2011 | Protein & Cell2011，2，6： | 12 |
| 7 | Arab/c/opste N^(6)-methyladenosine reader CPSF30-L recognizes FUE signals to control polyadenylation site choice in liquid-like nuclear bodies显示文摘The biological functions of the epitranscriptomic modification N^(6)-methyladenosine(m^(6)A)in plants are not fully understood.CPSF30-L is a predominant isoform of the polyadenylation factor CPSF30 and consists of CPSF30-S and an m^(6)A-binding YTH domain.Little is known about the biological roles of CPSF30-L and the molecular mechanism underlying its m^(6)A-binding function in alternative polyadenylation.Here,we charac-terized CPSF30-L as an Arabidopsis m^(6)A reader whose m^(6)A-binding function is required for the floral tran-sition and abscisic acid(ABA)response.We found that the m^(6)A-binding activity of CPSF30-L enhances the formation of liquid-like nuclear bodies,where CPSF30-L mainly recognizes m*A-modified far-upstream elements to control polyadenylation site choice.Deficiency of CPSF30-L lengthens the 3'untranslated region of three phenotypes-related transcripts,thereby accelerating their mRNA degradation and leading to late flowering and ABA hypersensitivity.Collectively,this study uncovers a new molecular mechanism for m^(6)A-driven phase separation and polyadenylation in plants. | Peizhe Song Junbo Yang Chunling Wang Qiang Lu Linqing Shi Subiding Tayier Guifang Jia | 2021 | Molecular Plant2021，14，4： | 12 |
| 8 | An effective method for improving the accuracy of Argo objective analysis显示文摘基于南船座数据的最佳的插值目的分析,改进被做到广泛地在数据吸收和客观分析系统使用的一个背景错误协变性矩阵的实验公式。明确地,关联的一个评价可伸缩那能有效地改善南船座客观分析的精确性被开发了。这个方法能自动地适应一个变量的坡度变化并且被叫作坡度依赖者关联规模方法。它南船座客观分析上的效果与 Gaussian 脉搏和光谱分析理论上被验证。一个维的模拟实验的结果证明坡度依赖者关联规模能改进客观分析系统的适应性,为充分吸收在有更大的海洋学的坡度的区域的观察的短波信息的分析计划使它可能。新计划在太平洋被用于南船座数据目的分析系统。结果显然被改进。 | ZHANG Chunling XU Jianping BAO Xianwen WANG Zhenfeng | 2013 | Acta Oceanologica Sinica2013，32，7： | 11 |
| 9 | Comparative Immunization in BALB/c Mice with Recombinant Replication-Defective Adenovirus Vector and DNA Plasmid Expressing a SARS-CoV Nucleocapsid Protein Gene显示文摘In order to investigate immunogenicity in the induction of humoral and cellular immune responses, severe acute respiratory syndrome associated coronavirus (SARS-CoV)-N gene recombinant replication-defective adenoviral vector, rAd-N, was generated and immunized BALB/c mice in a pcDNA3.1-N prime-rAd-N boost regimen. After humoral and cellular immune response detection, different levels of SARS-CoV N protein specific antibodies and interferon-γ (IFN-γ) secretion are shown compared to controls. The humoral immune response was induced more effectively by the DNA priming and recombinant adenovirus boosting regimen. There is a significant difference between heterogeneous and homologous vaccinations. The heterogeneous combinations were all higher than those of the homologous combinations in the induction of anti-N antibody response. Among the three heterogeneous combinations, pcDNA3.1-N/pcDNA3.1-N/pcDNA3.1-N/rAd-N induced the strongest antibody response. In the induction of IFN-γ production, the homologous combination of rAd-N/rAd-N/rAd-N/rAd-N was significantly stronger than that of pcDNA3.1-N/pcDNA3.1-N/pcDNA3.1-N/pcDNA3.1-N, but was relatively weaker than the heterogeneous combination of pcDAN3.1-N/pcDAN3.1-N/pcDAN3.1-N/rAd-N. This combination was a most efficient immunization regimen in induction of SARS-CoV-N-specific (IFN-γ) secretion just as the antibody response. These results suggest that DNA immunization followed by recombinant adenovirus boosting could be used as a potential SARS-CoV vaccine. | Chunling Ma Kun Yao Feng Zhou Minsheng Zhu | 2006 | Cellular & Molecular Immunology2006，3，6： | 10 |
| 10 | Origin and accumulation of high-maturity oil and gas in deep parts of the Baxian Depression, Bohai Bay Basin, China显示文摘Great quantities of light oil and gas are produced from deep buried hill reservoirs at depths of 5,641 m to 6,027 m and 190 °C to 201 °C in the Niudong-1 Well, representing the deepest and hottest commercial hydrocarbons discovered in the Bohai Bay Basin in eastern China. This discovery suggests favorable exploration prospects for the deep parts of the basin. However, the discovery raises questions regarding the genesis and accumulation of hydrocarbons in deep reservoirs. Based on the geochemical features of the hydrocarbons and characteristics of the source rocks as well as thermal simulation experiments of hydrocarbon generation, we conclude that the oil and gas were generated from the highly mature Sha-4 Member (Es4 ) source rocks instead of thermal cracking of crude oils in earlier accumulations. The source kitchen with abnormal pressures and karsted carbonate reservoirs control the formation of high-maturity hydrocarbon accumulations in the buried hills (i.e., Niudong-1) in conjunction with several structural-lithologic traps in the Es4 reservoirs since the deposition of the upper Minghuazhen Formation. This means the oil and gas exploration potential in the deep parts of the Baxian Depression is probably high. | Zhao Xianzheng Jin Qiang Jin Fengming Ma Peng Wang Quan Wang Jing Ren Chunling Xi Qiuling | 2013 | Petroleum Science2013，10，3： | 10 |
| 11 | Dongbeititan dongi,the First Sauropod Dinosaur from the Lower Cretaceous Jehol Group of Western Liaoning Province,China显示文摘我们此处描述一条 sauropod 恐龙的头部的骨骼在西方的辽宁省的 Beipiao 区域从更低的白垩纪 Jehol 组恢复了的一根部分柱子,东北中国。它拥有的特征的一间套房,包括骆驼它的 presacral 元素,在背面的肋骨的近似结束的 pneumatocoels 的存在,和特别腿节的中间地偏斜的近似部分的晚内部的结构,决定性地建立标本的 titanosauriform 亲密关系。它在有不同于另外的 titanosauriforms 一 craniocaudally 伸长有摆平的 cranioventral 极端和一张长、光滑、稍微凸的王牌的鸟喙骨耻骨的平坦的边。它代表新税在上, Dongbeititan 盾 i 情报。et sp。nov。比较研究建议 Dongbeititan 是基础 titanosauriform,比 Euhelopus 导出,但是少些比 Gobititan 和 Jiutaisaurus 发源的更多, Fusuisaurus,和 Huanghetitan。Dongbeititan 表示第一条 sauropod 恐龙从西方的辽宁省的更低的白垩纪 Jehol 组报导了。 | WANG Xuri YOU Hailu MENG Qingjin GAO Chunling CHENG Xiaodong LIU Jinyuan | 2007 | Acta Geologica Sinica(English Edition)2007，81，6： | 9 |
| 12 | Olmutinib(HM61713) reversed multidrug resistance by inhibiting the activity of ATPbinding cassette subfamily G member 2 in vitro and in vivo显示文摘Overexpressing of ATP-binding cassette(ABC) transporters is the essential cause of multidrug resistance(MDR), which is a significant hurdle to the success of chemotherapy in many cancers.Therefore, inhibiting the activity of ABC transporters may be a logical approach to circumvent MDR.Olmutinib is an epidermal growth factor receptor(EGFR) tyrosine kinase inhibitor(TKI), which has been approved in South Korea for advanced EGFR T790 M-positive non-small cell lung cancer(NSCLC). Here,we found that olmutinib significantly increased the sensitivity of chemotherapy drug in ABCG2-overexpressing cells. Furthermore, olmutinib could also increase the retention of doxorubicin(DOX) and rhodamine 123(Rho 123) in ABC transporter subfamily G member 2(ABCG2)-overexpressing cells. In addition, olmutinib was found to stimulate ATPase activity and inhibit photolabeling of ABCG2 with [^(125) I]-iodoarylazidoprazosin(IAAP). However, olmutinib neither altered ABCG2 expression at protein and m RNA levels nor blocked EGFR, Her-2 downstream signaling of AKT and ERK. Importantly,olmutinib enhanced the efficacy of topotecan on the inhibition of S1-MI-80 cell xenograft growth. All the results suggest that olmutinib reverses ABCG2-mediated MDR by binding to ATP bind site of ABCG2 and increasing intracellular chemotherapeutic drug accumulation. Our findings encouraged to further clinical investigation on combination therapy of olmutinib with conventional chemotherapeutic drugs in ABCG2-overexpressing cancer patients. | Zhiqiang Zhang Xiaoran Guo Kenneth K.W.To Zhen Chen Xiaona Fang Min Luo Chunling Ma Jianhua Xu Shirong Yan Liwu Fu | 2018 | Acta Pharmaceutica Sinica B2018，8，4： | 9 |
| 13 | Vegetation Development and Water Level Changes in Shenjiadian Peatland in Sanjiang Plain,Northeast China显示文摘This paper documents a 7800-year proxy record from the Shenjiadian peatland on the Sanjiang Plain in Northeast China.High-resolution plant macrofossil and colorimetric humification methods were used to reconstruct the vegetation and hydrologic history from a 193 cm-long sedimentary profile.Detrended correspondence analysis(DCA) was applied to transform the raw plant macrofossil data into latent indices of peatland water level.The vegetation community transited from an Equisetum fluviatile community to a Carex lasiocarpa community at approximately 3800 cal yr BP and was followed by a Carex-shrub community at approximately 480 cal yr BP.Based on the plant macrofossil DCA axis 1 scores and humification values,we distinguished four hydrologic periods:a wet period from 7800 cal yr BP to 4500 cal yr BP,dry periods up to 1600 cal yr BP,drier periods until 300 cal yr BP,and the driest period from 300 cal yr BP until the present.Through a comparison with other climate records,we suggest that the East Asian summer monsoon(EAM) was the main driving force for vegetation and water level changes to the Shenjiadian peatland through its impacts on precipitation. | WANG Chunling ZHAO Hongyan WANG Guoping | 2015 | Chinese Geographical Science2015，25，4： | 8 |
| 14 | Radiative transfer models(RTMs)for field phenotyping inversion of rice based on UAV hyperspectral remote sensing显示文摘The nondestructive and rapid acquisition of rice field phenotyping information is very important for the precision management of the rice growth process.In this research,the phenotyping information LAI(leaf area index),leaf chlorophyll content(C_(ab)),canopy water content(C_(w)),and dry matter content(C_(dm))of rice was inversed based on the hyperspectral remote sensing technology of an unmanned aerial vehicle(UAV).The improved Sobol global sensitivity analysis(GSA)method was used to analyze the input parameters of the PROSAIL model in the spectral band range of 400-1100 nm,which was obtained by hyperspectral remote sensing by the UAV.The results show that C_(ab) mainly affects the spectrum on 400-780 nm band,C_(dm) on 760-1000 nm band,C_(w) on 900-1100 nm band,and LAI on the entire band.The hyperspectral data of the 400-1100 nm band of the rice canopy were acquired by using the M600 UAV remote sensing platform,and the radiance calibration was converted to the canopy emission rate.In combination with the PROSAIL model,the particle swarm optimization algorithm was used to retrieve rice phenotyping information by constructing the cost function.The results showed the following:(1)an accuracy of R^(2)=0.833 and RMSE=0.0969,where RMSE denotes root-mean-square error,was obtained for C_(ab) retrieval;R^(2)=0.816 and RMSE=0.1012 for LAI inversion;R^(2)=0.793 and RMSE=0.1084 for C_(dm);and R^(2)=0.665 and RMSE=0.1325 for C_(w).The C_(w) inversion accuracy was not particularly high.(2)The same band will be affected by multiple parameters at the same time.(3)This study adopted the rice phenotyping information inversion method to expand the rice hyperspectral information acquisition field of a UAV based on the phenotypic information retrieval accuracy using a high level of field spectral radiometric accuracy.The inversion method featured a good mechanism,high universality,and easy implementation,which can provide a reference for nondestructive and rapid inversion of rice biochemical parameters using UAV hyperspectral remote sensing. | Yu Fenghua Xu Tongyu Du Wen Ma Hang Zhang Guosheng Chen Chunling | 2017 | International Journal of Agricultural and Biological Engineering2017，10，4： | 8 |
| 15 | Chrysin promotes osteogenic differentiation via ERK/MAPK activation显示文摘T he effect of the anti-infl ammatory fl avonoid chrysin on osteogenesis was determined in preosteoblast MC3T3-E1 cells.Results demonstrated that chrysin could induce osteogenic differentiation in the absence of other osteo-genic agents.Chrysin treatment promoted the expres-sion of transcription factors(Runx2 and Osx)and bone formation marker genes(Col1A1,OCN,and OPN)as well as enhanced the formation of mineralized nodules.During osteogenic differentiation,chrysin preferentially activated ERK1/2,but not JNK nor the p38 MAPKs.Further experi-ments with inhibitors revealed the co-treatment of U0126,PD98059,or ICI182780(a general ER antagonist)with chrysin effectively abrogated the chrysin-induced osteo-genesis and ERK1/2 activation.Thus,the effect of chrysin on osteogenesis is ERK1/2-dependent and involves ER.Therefore,chrysin has the signifi cant potential to enhance osteogenesis for osteoporosis prevention and treatment. | Wenfeng Zeng Yan Yan Fayun Zhang Chunling Zhang Wei Liang | 2013 | Protein & Cell2013，4，7： | 8 |
| 16 | Guidance Control for Parallel Parking Tasks显示文摘Parking into small berths remains difficult for unskilled drivers. Researchers had proposed different automatic parking systems to solve this problem. The first kind of strategies(called parking trajectory planning) designs a detailed reference trajectory that links the start and ending points of a special parking task and let the vehicle track this reference trajectory so as to park into the berth. The second kind of strategies(called guidance control) just characterizes several regimes of driving actions as well as the important switching points in certain rule style and let the vehicle follows the pre-selected series of actions so as to park into the berth. Parking guidance control is simpler than parking trajectory planning. However, no studies thoroughly validated parking guidance control before. In this paper, a new automatic parking method is presented, which could characterize the desired control actions directly. Then the feasibility is examined carefully. Tests show that a simple parking guidance control strategy can work in most parallel parking tasks, if the available parking berth is not too small. This finding helps to build more concise automatic parking systems that can efficiently guide human drivers. | Jiyuan Tan Chunling Xu Li Li Fei-Yue Wang Dongpu Cao Lingxi Li | 2020 | IEEE/CAA Journal of Automatica Sinica2020，7，1： | 7 |
| 17 | Bioflocculant Produced by Klebsiella sp. MYC and Its Appli-cation in the Treatment of Oil-field Produced Water显示文摘Seventy-nine strains of bioflocculant-producing bacteria were isolated from 3 activated sludge samples. Among them, strain MYC was found to have the highest and stable flocculating rate for both kaolin clay suspension and oil-field produced water. The bacterial strain was identified as Klebsiella sp. MYC according to its morphological and biochemical characteristics and 16S rDNA sequence. The optimal medium for bioflocculant production by this bacterial strain was composed of cane sugar 20 g L -1, KH2PO4 2 g L -1, K2HPO4 5 g L -1, (NH4)2SO4 0.2 g [KG-*9]L -1, urea 0.5 g L -1 and yeast extract 0.5 g L -1, the initial pH being 5.5. When the suspension of kaolin clay was treated with 0.5% of Klebsiella sp. MYC culture broth, the flocculating rate reached more than 90.0% in the presence of 500 mg L -1 CaCl2, while the flocculating rate for oil-field produced water was near 80[KG-*3].0% in a pH range of 7.0-9.0 with the separation of oil and suspended particles from the oil-field produced water under similar conditions. The environment-friendly nature of the bioflocculant and high flocculating rate of the strain make the bioflocculant produced by Klebsiella sp. MYC an attractive bioflocculant in oil-field produced water treatment. | YUE Lixi MA Chunling CHI Zhenming | 2006 | Journal of Ocean University of China2006，5，4： | 7 |
| 18 | Using acupoint-to-acupoint penetrative needling to treat poststroke spastic paralysis:a clinical progress review显示文摘OBJECTIVE: To determine the characteristics and advantages of acupoint-to-acupoint penetrative needling(AAPN) treatment for post-stroke spastic paralysis(PSSP) to improve the clinical outcomes of this disease in the future.METHODS: Randomized, controlled trials of PSSP patients receiving AAPN treatment were searched from MEDLINE, EMBASE, and China National Knowledge Infrastructure Database between January 2006 and June 2013. Key words included: clinic or clinical, acupuncture, needling, acupoint-to-acupoint, penetrative or penetration or penetrating,stroke or apoplexy or cerebral infarction or cerebral hemorrhage, spastic paralysis or spasticity or palsy,and hypermyotonia. Language was limited to English and Chinese. Case series reports, review articles, and animal studies were excluded.RESULTS: AAPN showed better clinical results on PSSP than other acupuncture treatments, especially when combined with adjunct therapies such as electroacupuncture, bloodletting, and rehabilitation. The greatest benefit was achieved with rehabilitation combined with penetration from Yang-channel acupoints to Yin-channel acupoints in the upper limbs, and from Yin-channel acupoints to Yang-channel acupoints in the lower limbs with a reinforcing maneuver.CONCLUSION: AAPN is an effective treatment for PSSP, and it can accelerate and enhance functional repair of PSSP patients. | Xiafei Liu Chunling Bao Guirong Dong | 2014 | Journal of Traditional Chinese Medicine2014，34，5： | 7 |
| 19 | Autotuning algorithm of particle swarm PID parameter based on D-Tent chaotic model显示文摘An improved particle swarm algorithm based on the D-Tent chaotic model is put forward aiming at the standard particle swarm algorithm. The convergence rate of the late of proposed algorithm is improved by revising the inertia weight of global optimal particles and the introduction of D-Tent chaotic sequence. Through the test of typical function and the autotuning test of proportionalintegral-derivative(PID) parameter, finally a simulation is made to the servo control system of a permanent magnet synchronous motor(PMSM) under double-loop control of rotating speed and current by utilizing the chaotic particle swarm algorithm. Studies show that the proposed algorithm can reduce the iterative times and improve the convergence rate under the condition that the global optimal solution can be got. | Min Zhu Chunling Yang Weiliang Li | 2013 | Journal of Systems Engineering and Electronics2013，24，5： | 7 |
| 20 | Influence of polymers on the stability of Gudao crude oil emulsions显示文摘The influence of different types and concentrations of polymers on the stability of Gudao crude oil emulsion was investigated by measuring the volume of water separated from the emulsions and the interfacial shear viscosity of the oil/water interfacial film.Experimental results indicate that the simulated water-in-oil emulsion with 40 mg/L of partially hydrolyzed polyacrylamide(HPAM)3530S could be easily broken by adding demulsifier C and was readily separated into two layers.However, HPAM AX-74H and hydrophobically associating water-soluble polymer(HAP)could stabilize the crude oil emulsion.With increasing concentration of AX-74H and HAP,crude oil emulsions became more stable.Water droplets were loosely packed in the water-in model oil emulsion containing HPAM 3530S, but water droplets were smaller and more closely packed in the emulsion containing AX-74H or HAP.The polymers could be adsorbed on the oil/water interface,thereby increasing the strength of the interfacial film and enhancing the emulsion stability. | Lin Meiqin Zhang Chunling Zong Hua Li Mingyuan Fang Hongbo Guo Jixiang | 2008 | Petroleum Science2008，5，2： | 6 |
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