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| 1 | Brood sex ratio in the Yellow-bellied Prinia(Prinia flaviventris)显示文摘Background:The adjustment of sex ratios in birds can occur at the egg and nestling stages. Previous studies showed that the sex ratio was affected by environmental factors and parental condition; it may result in seasonal and ecosystem differences.Methods:In this study, the brood sex ratio of the Yellow-bellied Prinia(Prinia flaviventris) in the Nonggang area, Guangxi, southwestern China, was investigated during the breeding season from May to June in 2013 using PCR amplification from whole-genome DNA extracted from blood samples. A total of 31 nests of Yellow-bellied Prinia, including 132 brood fledglings and 31 pairs, were sampled.Results:The results showed that the brood sex ratio of the Yellow-bellied Prinia was 1:1, and sex ratios of different nests were evenly distributed within the study area. No significant relationship was found between parental quality and nest characteristics with the brood sex ratio.Conclusions:The present study indicated that no brood sex ratio bias in the Yellow-bellied Prinia highlighted the complexity of sex ratio adjustment in birds. In spite of our negative results, the lack of an association between brood sex ratio and parental quality and environmental factors in the Yellow-bellied Prinia provides valuable information on the adjustment of sex ratios in birds. | Zhifeng Ding Fang Ji Qiuli Huang Longwu Wang Aiwu Jiang Chunlan Zhang Yongjun Feng Yuan Tian Huijian Hu Wei Liang | 2017 | Avian Research2017，8，2： | 2 |
| 2 | Acoustic characteristics of stop consonants in fluent reading Chinese Putonghua speech of adult stutterers显示文摘This study investigated whether adults who stutter and normal adult speakers differ in the production of stop consonants in fluent reading Chinese Putonghua speech.Voice onset time(VOT) was measured and the spectral moments at the stop burst were calculated for the stutterers(both before and after the speech therapy) and also for the nonstutterers. The statistical results showed that there were no significant differences in VOT between the nonstutterers and stutterers either prior to or after therapy,although the mean VOT of the stutterers was slightly greater than that of the nonstutterers.The results also indicated that both the obstruction place and the subsequent syllabic final exhibited an influence to a greater extent on VOT for the stutterers.In the spectral domain,the spectral mean of the stuttering participants before therapy was significantly different from that of the normal participants, whereas the group difference became insignificant after the therapy session.The smaller spectral mean for the stutterers might be interpreted as a more posterior occlusion in the oral cavity when producing alveolars and velars.In addition,productions of the stutterers scattered with a wider range in the space of spectral moments.Furthermore,the smaller main effect of syllabic finals on the mean spectral frequency of the burst suggested that the stutterers exhibited weaker anticipatory coarticulation than the nonstutterers. | FENG Yongqiang YAN Qian GAO Xinglong PAN Fuping XING Lili LIN Chunlan PAN Jielin | 2013 | Chinese Journal of Acoustics2013，32，3： | 1 |
| 3 | Bird diversity and the conservation value of a new Ramsar site:Guangdong Haifeng Wetlands, China显示文摘Wetlands are critical habitats for birds.However,wetlands are being degraded at an accelerating rate due to global human activity,and a disproportionate fraction of wetland-dependent bird species are in decline.We evaluated the conservation value of a new Ramsar site,Guangdong Haifeng Wetlands,China,for birds,by comparing bird communities(using line transect data)in 3 different districts:Gongping,Dongguan Lian’anwei and Dahu.We recorded 139 species of birds,including 26 species that are protected at a national level.Dahu had the highest species richness and diversity,whereas Dongguan Lian’anwei had the highest abundance of birds and the lowest species diversity.Finally,Gongping had both the lowest species richness and the lowest abundance.The ende-mism of constituent species differed among districts,and the bird communities were complementary.There were significant seasonal differences in the species richness and the number of individuals.Spring had the highest species richness and diversity.The present study identifies the high conservation value of Haifeng Wetlands for both waterbirds and terrestrial birds.Our findings suggest that conservation efforts in Haifeng Wetlands and other wetlands should focus not only on wintering migratory birds,but also on resident birds.To accomplish effective conservation,we should consider the reserve and surrounding wetlands as a whole,incorporating ecological research,education and local economic development. | Junhua HU Zhigang JIANG Chunlan ZHANG Feng XIAO Huijian HU | 2011 | Integrative Zoology2011，6，3： | 1 |
| 4 | A novel selective ERK1/2 inhibitor,Laxiflorin B,targets EGFR mutation subtypes in non-small-cell lung cancer显示文摘Extracellular regulated protein kinases 1/2(ERK1/2)are key members of multiple signaling pathways,including the ErbB axis.Ectopic ERK1/2 activation contributes to various types of cancer,especially drug resistance to inhibitors of RTK,RAF and MEK,and specific ERK1/2 inhibitors are scarce.In this study,we identified a potential novel covalent ERK inhibitor,Laxiflorin B,which is a herbal compound with anticancer activity.However,Laxiflorin B is present at low levels in herbs;therefore,we adopted a semi-synthetic process for the efficient production of Laxiflorin B to improve the yield.Laxiflorin B induced mitochondria-mediated apoptosis via BAD activation in non-small-cell lung cancer(NSCLC)cells,especially in EGFR mutant subtypes.Transcriptomic analysis suggested that Laxiflorin B inhibits amphiregulin(AREG)and epiregulin(EREG)expression through ERK inhibition,and suppressed the activation of their receptors,ErbBs,via a positive feedback loop.Moreover,mass spectrometry analysis combined with computer simulation revealed that Laxiflorin B binds covalently to Cys-183 in the ATP-binding pocket of ERK1 via the D-ring,and Cys-178 of ERK1 through non-inhibitory binding of the A-ring.In a NSCLC tumor xenograft model in nude mice,Laxiflorin B also exhibited strong tumor suppressive effects with low toxicity and AREG and EREG were identified as biomarkers of Laxiflorin B efficacy.Finally,Laxiflorin B-4,a C-6 analog of Laxiflorin B,exhibited higher binding affinity for ERK1/2 and stronger tumor suppression.These findings provide a new approach to tumor inhibition using natural anticancer compounds. | Cheng-Yao Chiang Min Zhang Junrong Huang Juan Zeng Chunlan Chen Dongmei Pan Heng Yang Tiantian Zhang Min Yang Qiangqiang Han Zou Wang Tian Xiao Yangchao Chen Yongdong Zou Feng Yin Zigang Li Lizhi Zhu Duo Zheng | 2024 | Acta Pharmacologica Sinica2024，45，2： | 0 |
| 5 | A forced alignment approach to detect Chinese repetitive stuttering显示文摘A forced alignment based algorithms to detect Chinese repetitive stuttering is studied. According to the features of repetitions in Chinese stuttered speech,improvement solutions are provided based on the previous research findings.First,a multi-span looping forced alignment decoding networks is designed to detect multi-syllable repetitions in Chinese stuttered speech.Second,branch penalty factor is added in the networks to adjust decoding trend using recursive search in order to reduce the error from the complexity of the decoding networks. Finally,we re-judge the detected stutters by calculating confidence to improve the reliability of the detection result.The experimental results show that compared to previous algorithm,the proposed algorithm can improve system performance significantly,about 18%average detection error rate relatively. | ZHANG Junbo YAN Qian GAO Xinglong PAN Fuping FENG Yongqiang XING Lili LIN Chunlan PAN Jielin | 2013 | Chinese Journal of Acoustics2013，32，3： | 0 |
| 6 | Current strategies for improving limitations of proteolysis targeting chimeras显示文摘Proteolysis targeting chimeras(PROTACs)are bifunctional degrader molecules via hijacking the ubiquitinproteasome system(UPS)to specifically eliminate targeted proteins.PROTACs have gained momentum as a new modality of attractive technologies in the drug discovery landscape,since it allows to degrade disease-related proteins effectively.Although some PROTACs drugs reached the clinical research,they are still facing some bottlenecks and challenges that should not be neglected,such as poor oral bioavailability and potential toxic side effects.To overcome these limitations,herein,we provide an overview of recent strategies for improving the durability of PROTACs by enhancing cell permeability and reducing toxic side effects.Meanwhile,the impact of these strategies on improving oral bioavailability as well as their advantages and drawbacks will also be discussed.This review will give a useful reference toolbox for PROTACs design and further promote its clinical application. | Chunlan Pu Shirui Wang Lei Liu Zhonghui Feng Hongjia Zhang Qianyuan Gong Yueshan Sun Yuanbiao Guo Rui Li | 2023 | Chinese Chemical Letters2023，34，6： | 0 |
| 7 | Targeting PDE4 as a promising therapeutic strategy in chronic ulcerative colitis through modulating mucosal homeostasis显示文摘Phosphodiesterase-4(PDE4) functions as a catalyzing enzyme targeting hydrolyzation of intracellular cyclic adenosine monophosphate(c AMP) and inhibition of PDE4 has been proven to be a competitive strategy for dermatological and pulmonary inflammation. However, the pathological role of PDE4 and the therapeutic feasibility of PDE4 inhibitors in chronic ulcerative colitis(UC) are less clearly understood. This study introduced apremilast, a breakthrough in discovery of PDE4 inhibitors,to explore the therapeutic capacity in dextran sulfate sodium(DSS)-induced experimental murine chronic UC. In the inflamed tissues, overexpression of PDE4 isoforms and defective c AMP-mediating pathway were firstly identified in chronic UC patients. Therapeutically, inhibition of PDE4 by apremilast modulated c AMP-predominant protein kinase A(PKA)-c AMP-response element binding protein(CREB)signaling and ameliorated the clinical symptoms of chronic UC, as evidenced by improvements on mucosal ulcerations, tissue fibrosis, and inflammatory infiltrations. Consequently, apremilast maintained a normal intestinal physical and chemical barrier function and rebuilt the mucosal homeostasis by interfering with the cross-talk between human epithelial cells and immune cells. Furthermore, we found that apremilast could remap the landscape of gut microbiota and exert regulatory effects on antimicrobial responses and the function of mucus in the gut microenvironment. Taken together, the present studyrevealed that intervene of PDE4 provided an infusive therapeutic strategy for patients with chronic and relapsing UC. | Heng Li Yao Zhang Moting Liu Chen Fan Chunlan Feng Qiukai Lu Caigui Xiang Huimin Lu Xiaoqian Yang Bing Wu Duowu Zou Wei Tang | 2022 | Acta Pharmaceutica Sinica B2022，12，1： | 0 |
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