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| 1 | HNF-4α determines hepatic differentiation of human mesenchymal stem cells from bone marrow显示文摘AIM: To investigate the differentiation status and key factors to facilitate hepatic differentiation of human bone-marrow-derived mesenchymal stem cells (MSCs). METHODS: Human MSCs derived from bone marrow were induced into hepatocyte-like cells following a previously published protocol. The differentiation status of the hepatocyte-like cells was compared with various human hepatoma cell lines. Overexpression of hepatocyte nuclear factor (HNF)-4α was mediated by adenovirus infection of these hepatocyte-like cells. The expression of interesting genes was then examined by either re-verse transcription-polymerase chain reaction (RT-PCR) or real-time RT-PCR methods. RESULTS: Our results demonstrated that the differentiation status of hepatocyte-like cells induced from human MSCs was relatively similar to poorly differentiated human hepatoma cell lines. Interestingly, the HNF-4 isoform in induced MSCs and poorly differentiated human hepatoma cell lines was identified as HNF4γ instead of HNF-4α. Overexpression of HNF-4α in induced MSCs significantly enhanced the expression level of hepatic-specific genes, liver-enriched transcription factors, and cytochrome P450 (P450) genes. CONCLUSION: Overexpression of HNF-4α improves the hepatic differentiation of human MSCs from bone marrow and is a simple way of providing better cell sources for clinical applications. | Mong-Liang Chen Kuan-Der Lee Huei-Chun Huang Yue-Lin Tsai Yi-Chieh Wu Tzer-Min Kuo Cheng-Po Hu Chungming Chang | 2010 | World Journal of Gastroenterology2010，16，40： | 9 |
| 2 | Analyses of spring mean circulations for major andminor dust storm years in China-Mongolia area显示文摘To better understand the dust storm (hereafter DS) inducing circulation in the China-Mongolia (CM) DS activity area,the spring mean circulation features and differences on lower levels in three subregions of the CM DS area for the majorandminor-DS years have,as a whole (not partly),been analyzed,utilizing the National Centers for Environmental Prediction and the National Center for Atmospheric Research (NCEP/NCAR) reanalyzed gridded data,the observed DS frequency data in the CM area,and the composite analysis method.The main conclusions are as follows:(1) Judging from the differences in the DS-inducing systems,dust origins,paths of invading cold air,and main DS-strike areas,the whole CM DS area is roughly divided into the three subre-gions:the East-,Middleand West-CM subregions (in this paper,referred to as E-,M-,and W-CM).(2) In major DSs during spring over the E-CM,the middleand lower-level troughs or cyclones over the Japan Sea and northeastern China (NEC) domi-nate.The invading cold air along the northeastern (NE) or north by east (NE) path often causes the DS in the E-CM region.But nearly the opposite is true inminor DS during spring in E-CM.(3) In the major DS during spring over the M-CM region,the Mongolian troughs or cyclones are the main DS-inducing systems.The strong invading cold air along the northwestern (NW)or north by west (Nw) path causes the DSs in the M-CM region.(4) In the major DSs during spring over the W-CM region,the South Xinjiang heat lows prevail,the intruding cold air has a western path,and creates the DSs in South Xinjiang.(5) In the past 50 years,the DSs over the M-CM region have had the most severe impact on the preceding three subregions of the CM DS area.Overall,DS activities over all of three regions of the CM area decreased in the past (particularly,over Mand W-CM regions since the mid-1980s.But there existed a short and sudden increasing in E-CM in the years 2000-2002.(6) It is circulation changes and desertification evolutions that cause the yearly and decadal changes of DS in CM area,especially the former.With the backdrop of global warming in the future,perhaps the decreased DS activities over Mand W-CM will persist for some time again,and special attention should be paid to ones over E-CM or to the individual DS events over Mand W-CM. | MinHong Song 1,ZhengAn Qian 1,Ying Cai 1,ChungMing Liu 2 1.Cold and Arid Regions Environmental and Engineering Research Institute,Chinese Academy of Sciences,Lanzhou Gansu 730000,China.2.Department of Atmospheric Sciences,Taiwan University,Taipei 106,China. | 2009 | Research in Cold and Arid Regions2009，1，4： | 3 |
| 3 | UIOE : A protocol test sequence generation method using the transition exeeutability analysis (TEA)显示文摘 | Huang Chungming Chiang Mengshu Jang Mingyuhe | 1998 | Computer Communication1998，21，16： | 1 |
| 4 | Setup error andef-fectiveness of weekly image-guided radiation therapy of to- modirect for early breast cancer 显示文摘 | ChungM J LeeGJ SuhY J etal | 2015 | Cancer Res Treat2015，47，4： | 1 |
| 5 | Executable EFSM--based data flow and control flow protocol test sequence generation using reaehability analysis 显示文摘 | Huang Chungming Jang Mingyuhe Yuan Chuenlin | 1999 | Journal of the Chinese Instituted of Engineers1999，22，5： | 1 |
| 6 | Layered P2P Video Streaming Using Asym- metric P2P Topology and Membership Management显示文摘 | HUANG CHUNGMING CHIA-CHING YANG CHENG CHUNGHENG | 2014 | Journal of the Chinese Institute of Engineers2014，37，6： | 1 |
| 7 | Effect ofresistant starch from corn or rice on glucose control, colonic events, and blood lipid concentrations in streptozotocin-induced diabetic rats 显示文摘 | Kim W K ChungM K Kang N E Kim M H Park Q J | 2003 | Journal of Nutritional Biochemistry2003，14，3： | 1 |
| 8 | The design of HEPS global timing system显示文摘Purpose The high energy photon source(HEPS)is a 4th generation synchrotron light source under construction by the institute of high energy physics.The accelerator complex consists of a 500-MeV Linac,a full-energy synchrotron booster,a 6-GeV synchrotron storage ring(SR),and three e-beam transport lines for injection and extraction among accelerators.A global timing system(GTS)covers the timing needs for all accelerator,beamline,and experiment systems.The GTS is designed to coordinate the injection processes and various measurements and protections.Most systems require that the RMS jitter of the GTS signal is less than 30 ps,while the trigger jitters for the electron gun and SR injection and extraction kickers are less than 10 ps.Method The HEPS GTS is an event-based timing system based on MicroTCA.4 hardware architecture.The MicroTCA.4300 series products from the micro-research Finland Oy are implemented in the HEPS GTS system.Results and conclusions The RMS jitter,integrated from 1 Hz to 10 MHz,of the 166.6 MHz event clock is 5.489 ps.The RMS jitter of TTL outputs is less than 30 ps.This paper reports the design of the HEPS GTS,which satisfies all of the HEPS physics requirements for timing with preliminary test results shown. | Fang Liu Ge Lei Zhe Duan Cai Meng Chenyan Lu Yanhua Shao Xinpeng Ma Nan Gan Yuemei Peng Jianshe Cao Chungming Chu Yanfeng Sui Jingyi Li IHEP | 2021 | Radiation Detection Technology and Methods2021，5，3： | 1 |
| 9 | Text features for classification of ultrasonie liver images显示文摘 | Wu Chungming ChenYungchang | | 0，，02： | 1 |
| 10 | Phenolics from Hypericum gem iniflorum 显示文摘 | CHUNGM H LAIM H YENM H | 1997 | Phytochemistry1997，44，5： | 1 |
| 11 | Expansion of an unstable trinucleotide CAG repeat in spinocerebellar ataxia type 1显示文摘 | Orr HT ChungM Y Banfi S | 1993 | Nat Genet1993，4，： | 1 |
| 12 | Preliminary feasibility assessment of green electricity in Taiwan 显示文摘 | Chifeng Chen Minglone Liou Chungming Liu | 2008 | Global change and sustainable development2008，2，1： | 1 |
| 13 | New ZVT-PWM DC/DC converters using active snubber显示文摘 | Wu Chaocheng Young Chungming | 2003 | IEEE Transactions on Aerospace and Electronic Systems2003，39，1： | 1 |
| 14 | UIOE: a protocol test sequence generation method using the transition executability analysis (TEA)显示文摘 | Huang Chungming Chiang Mengshu Jang Mingyu | 1998 | Computer Communication1998，21，16： | 1 |
| 15 | UIOE:a protocol test sequence generation method using the transition executability analysis (TEA)显示文摘 | Huang Chungming Chiang Mengshu Jang Mingyuhe | 1998 | Compu-ter Communication1998，21，16： | 1 |
| 16 | Clinical pharmacokinetics of doxazosin in a controlled-release gastrointestinal therapeutic system (GITS) formulation显示文摘 | ChungM Vashi V Puente J etal | 1999 | Br J hlin Pharmacol1999，48，： | 1 |
| 17 | Growth intention on entrepreneurs in a transitional eeonomy:the people's republie of China显示文摘 | Lau Chungming Lowell W Busenitz | 2001 | Entrepreneurship theory and praetiee2001，，： | 1 |
| 18 | Generating weighted fuzzy rules from relational database systems for estimating null values using genetic algorithms显示文摘 | CHEN Shyiming HUANG Chungming | 2003 | IEEE Trans on Fuzzy Systems2003，11，4： | 1 |
| 19 | A Novel Color Transfer Algorithm for Image Sequences 显示文摘 | Wang Chungming Huang Yaohsien | 2004 | Journal of hfformation Science and Engineering2004，20，6： | 1 |
| 20 | Proc Natl Acad Sci USA显示文摘 | Tse chungming Functional characteristics of a cloned epithelia Na+/H+ exchanger (NHE3): resistance to amiloride and inhibition by protein kinase c | 1993 | 90:9110-91141993，90，： | 1 |
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