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| 1 | High-intensity focused ultrasound ablation:An effective bridging therapy for hepatocellular carcinoma patients显示文摘AIM:To analyze whether high-intensity focused ultrasound(HIFU) ablation is an effective bridging therapy for patients with hepatocellular carcinoma(HCC).METHODS:From January 2007 to December 2010,49 consecutive HCC patients were listed for liver transplantation(UCSF criteria).The median waiting time for transplantation was 9.5 mo.Twenty-nine patients received transarterial chemoembolization(TACE) as a bringing therapy and 16 patients received no treatment before transplantation.Five patients received HIFU ablation as a bridging therapy.Another five patients with the same tumor staging(within the UCSF criteria) who received HIFU ablation but not on the transplant list were included for comparison.Patients were comparable in terms of Child-Pugh and model for end-stage liver disease scores,tumor size and number,and cause of cirrhosis.RESULTS:The HIFU group and TACE group showed no difference in terms of tumor size and tumor number.One patient in the HIFU group and no patient in the TACE group had gross ascites.The median hospital stay was 1 d(range,1-21 d) in the TACE group and two days(range,1-9 d) in the HIFU group(P < 0.000).No HIFU-related complication occurred.In the HIFU group,nine patients(90%) had complete response and one patient(10%) had partial response to the treatment.In the TACE group,only one patient(3%) had response to the treatment while 14 patients(48%) had stable disease and 14 patients(48%) had progressive disease(P = 0.00).Seven patients in the TACE group and no patient in the HIFU group dropped out from the transplant waiting list(P = 0.559).CONCLUSION:HIFU ablation is safe and effective in the treatment of HCC for patients with advanced cirrhosis.It may reduce the drop-out rate of liver transplant candidate. | Tan To Cheung Sheung Tat Fan See Ching Chan Kenneth SH Chok Ferdinand SK Chu Caroline R Jenkins Regina CL Lo James YY Fung Albert CY Chan William W Sharr Simon HY Tsang Wing Chiu Dai Ronnie TP Poon Chung Mau Lo | 2013 | World Journal of Gastroenterology2013，19，20： | 23 |
| 2 | Prevention of recurrent hepatitis B infection after liver transplantation显示文摘BACKGROUND:Recurrence of hepatitis B virus(HBV) infection after liver transplantation can lead to graft loss and a reduction in long-term survival.The purpose of this review is to summarize the current therapeutic options for preventing HBV recurrence in liver transplant recipients.DATA SOURCES:Up to January 2013,studies that were published in MEDLINE and EMBASE on prevention of HBV recurrence after liver transplantation were reviewed.RESULTS:There have been remarkable advancements in the past two decades on the prevention of HBV recurrence after liver transplantation,from the discovery of hepatitis B immune globulin(HBIG) and lamivudine monotherapy to the combination therapy using HBIG and lamivudine.With the development of newer and stronger antiviral agents,the need for life-long HBIG is doubtful.With their low resistance profile,oral antiviral prophylaxis using these new agents alone is sufficient and is associated with excellent outcome.CONCLUSIONS:Restoration of host HBV immunity with adoptive immunity transfer and vaccination may represent the ultimate strategy to withdraw prophylactic treatment and to achieve a drug free regimen against HBV recurrence after liver transplantation. | Tiffany CL Wong James YY Fung Chung Mau Lo | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，5： | 5 |
| 3 | High-intensity focused ultrasound ablation as a bridging therapy for hepatocellular carcinoma patients awaiting liver transplantation显示文摘The scarcity of liver grafts in Asia leads to a significant dropout of patients from liver transplant waiting lists, particularly patients with hepatocellular carcinoma and a low model for end-stage liver disease score. In order to reduce dropping out, different bridging therapies are employed. We report the use of high-intensity focused ultrasound ablation as a bridging therapy for a patient with hepatocellular carcinoma of stage two and an extremely low platelet count (20×10 9 /L). The ablation was successful. Blood tests showed that his liver function was similar before and after the treatment. No adhesion was encountered in the liver transplantation performed six months later. | Tan To Cheung Kenneth SH Chok Regina CL Lo William W Sharr See Ching Chan Ronnie TP Poon Sheung Tat Fan Chung Mau Lo | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，5： | 3 |
| 4 | Effect of repeated thoracenteses on fluid characteristics, cytokines, and fibrinolytic activity in malignant pleural effusion显示文摘 | Chung CL Chen YC Chang SC | 2003 | Chest2003，123，4： | 1 |
| 5 | Establishment of human prostate carcinoma skeletal metastasis models显示文摘 | Zhau HE Li CL Chung LW | 2000 | Cancer2000，88，12： | 1 |
| 6 | Effect of repeatedthoracente-ses on fluid characteristics,cytokines,andfibrinolytic activity in malignant pleural effusion 显示文摘 | Chung CL Chen YC Chang SC | 2003 | Chest2003，123，4： | 1 |
| 7 | Increased risk of deep vein thrombosis and pulmonary thromboembelism in patients with spinal cord injury: a nationwide cohort prospective study显示文摘 | Chung WS Lin CL Chang SN | 2014 | Thromb Res2014，133，4： | 1 |
| 8 | Establishment of human prostate carcinoma skeletal metastasis models显示文摘 | Zhau HE Li CL Chung LW | 2000 | Cancer2000，88，12： | 1 |
| 9 | Tuberculosis increases the subsequent risk of acute coronary syndrome: a nationwide population-based cohort study 显示文摘 | Chung WS Lin CL Hung CT | 2014 | Int J Tuberc Lung Dis2014，18，1： | 1 |
| 10 | Early effective drainage in the treatment of loculated tuberculous pleurisy显示文摘 | Chung CL Chen CH Yeh CY | 2008 | Eur Respir J2008，31，6： | 1 |
| 11 | Establishment of human prostate carcinoma skeletal metastasis models显示文摘 | Zhau HE Li CL Chung LW | 2000 | Cancer2000，88，12： | 1 |
| 12 | Comparison of acute respiratory e- vents between asthma-COPD overlap syndrome and COPD pa- tients: a population-based cohort study 显示文摘 | Chung WS Lin CL Kao CH | 2015 | Medicine (Balti- more)2015，94，17： | 1 |
| 13 | Increased risk of venous thromboembolism in patients with dermatomyositis/ polymyositis: a nationwide cohort study 显示文摘 | Chung WS Lin CL Sung FC | 2014 | Thromb Res2014，134，3： | 1 |
| 14 | Does chronic obstructive pulmonary disease with or without type 2 diabetes mellitus influence the risk of lung cancer? Result from a population-based cohort study显示文摘 | Shen TC Chung WS Lin CL | 2014 | PLoS One2014，9，98： | 1 |
| 15 | Novel neurotoxins from Tai- wan banded krait ( Bungarus muhieinetus ) venom : purification, characterization and gene organization 显示文摘 | Chang LS Chung CL Liou JC | 2003 | Toxicon2003，42，3： | 1 |
| 16 | Impaired odontogenic differentiation of senescent dental mesenchymal stem cells is associated with loss of Bmi-1 expression显示文摘 | Mehrazarin S Oh JE Chung CL | | 0，，05： | 1 |
| 17 | Statistical analysis of rice SAGEdata 显示文摘 | Su CL Chung Cl Lin YC | 2005 | J Genet Mol Biol2005，16，： | 1 |
| 18 | Effect of repeated thoracenteses on fluid characteristics, cytokines, and fibrinolytic activity in malignant pleural effusion显示文摘 | Chung CL Chen YC Chang SC | 2003 | Chest2003，123，4： | 1 |
| 19 | Second trimester maternal serum screening using alpha fetoprotein, free beta human chorionic gonadotropin and maternal age specific risk: result of chromosomal abnormalities detected in screen positive for Down syndrome in an Asian population显示文摘 | Chao AS Chung CL Wu CD | 1999 | Acta Obstet Gynecol Scand1999，78，5： | 1 |
| 20 | Female children respond torecombinant hepatitisB vaccine with a higher titre than male显示文摘 | Fang JW Lai CL Chung HT | 1994 | JTrop Pediatr1994，40，2： | 1 |
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