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| 1 | Overexpression of Arabidopsis YUCCA6 in Potato Results in High-Auxin Developmental Phenotypes and Enhanced Resistance to Water Deficit显示文摘Indole-3-acetic 酸(IAA ) ,主要植物植物生长素,在色氨酸依赖者和色氨酸无关的小径被生产。在 Arabidopsis thaliana 的一条主要小径从色氨酸在二反应产生 IAA。步骤一由把国际语音学协会变换成丝兰属植物蛋白质催化的 IAA 的一个限制率的步骤跟随的色氨酸 aminotransferases 把色氨酸变换成 indole-3-pyruvic 酸(国际语音学协会) 。我们识别了推出了氨基酸序列的基因分享的八通常认为的 StYUC (茄属 tuberosum 丝兰属植物) Arabidopsis 丝兰属植物蛋白质的有那些的 50%70% 身份。都包括正规、保存丝兰属植物序列:FATGY 主题, FMO 签名顺序和 NADP 有约束力的序列。另外,五基因与 ~ 被发现 50% 氨基酸顺序身份到 Arabidopsis 色氨酸 aminotransferases。转基因的土豆(茄属 tuberosum cv。Jowon ) 组成地, overexpressing Arabidopsis AtYUC6 显示了象狭窄的向下卷的叶子,增加的高度,直立的身高,和长寿那样的高植物生长素的显型。转基因的土豆植物 overexpressing AtYUC6 基于减少的水损失显示出提高的干旱忍耐。显型在叶子与反应的氧种类的减少的层次被相关。结果在可以被利用改变植物回答到环境的土豆建议植物生长素生合成的一条功能的丝兰属植物小径。 | Jeong Im Kim Dongwon Baek Hyeong Cheol Park Hyun Jin Chun Dong-Ha Oh Min Kyung Lee Joon-Yung Cha Woe-Yeon Kim Min Chul Kim Woo Sik Chung Hans J. Bohner Sang Yeol Lee Ray A. Bressan Shin-Woo Lee Dae-Jin Yun | 2013 | Molecular Plant2013，6，2： | 15 |
| 2 | Increased end-stage renal disease risk in patients with inflammatory bowel disease:A nationwide populationbased study显示文摘AIM To estimate the risk of end-stage renal disease(ESRD)in patients with inflammatory bowel disease(IBD).METHODS From January 2010 to December 2013, patients with Crohn's disease(CD) and ulcerative colitis(UC) were identified, based on both the International Classification of Diseases, 10 th revision(ICD-10) and the rare,intractable disease registration program codes from the National Health Insurance(NHI) database in South Korea. We compared 38812 patients with IBD to ageand sex-matched non-IBD controls with a ratio of 1:3.Patients newly diagnosed with ESRD were identified with the ICD-10 code.RESULTS During a mean follow-up of 4.9 years, ESRD was detected in 79(0.2%) patients with IBD and 166(0.1%)controls. The incidence of ESRD in patients with IBD was0.42 per 1000 person-years. Patients with IBD had a significantly higher risk of ESRD than controls [adjusted hazard ratio(HR) = 3.03; 95% confidence interval(CI):1.77-5.20; P < 0.001]. The incidences(per 1000 personyears)of ESRD were 0.51 in patients with CD and 0.13 in controls, respectively(adjusted HR = 6.33; 95%CI:2.75-14.56; P < 0.001). In contrast, the incidence of ESRD was similar between the UC and control groups(0.37 vs 0.37 per 1000 person-years; adjusted HR = 2.01;95%CI: 0.90-4.51; P = 0.089).CONCLUSION The risk of ESRD was elevated in patients with CD, but not UC. Patients with CD should be monitored carefully for signs of renal insufficiency. | Seona Park Jaeyoung Chun Kyung-Do Han Hosim Soh Kookhwan Choi Ji Hye Kim Jooyoung Lee Changhyun Lee Jong Pil Im Joo Sung Kim | 2018 | World Journal of Gastroenterology2018，24，42： | 7 |
| 3 | Risk of inflammatory bowel disease in patients with chronic obstructive pulmonary disease: A nationwide, population-based study显示文摘BACKGROUND There is a growing evidence regarding an increased risk of inflammatory bowel disease(IBD)among patients with airway diseases.AIM To investigate the influence of chronic obstructive pulmonary disease(COPD)on the risk of IBD.METHODS A nationwide,population-based study was conducted using data from the National Health Insurance Service database.A total of 1303021 patients with COPD and 6515105 non-COPD controls were identified.The COPD group was divided into the severe and the mild COPD group according to diagnostic criteria.The risk of IBD in patients with COPD compared to controls was analyzed by Cox proportional hazard regression models.The cumulative incidences of IBD were compared between the groups.RESULTS The COPD group had higher incidences of IBD compared to non-COPD controls(incidence rate,9.98 vs 7.18 per 100000 person-years,P<0.001).The risk of IBD in the COPD group was increased by 1.38(adjusted hazard ratio(HR);95%CI:1.25-1.52).The incidence rate of IBD was higher in the severe COPD group than in the mild COPD group(12.39 vs 9.77 per 100000 person-year,P<0.001).The severity of COPD was associated with an increased risk of IBD(adjusted HR 1.70 in severe COPD,95%CI:1.27-2.21 and adjusted HR 1.35 in mild COPD,95%CI:1.22-1.49)CONCLUSION The incidences of IBD were significantly increased in COPD patients in South Korea and the risk of developing IBD also increased as the severity of COPD increased. | Jooyoung Lee Jong Pil Im Kyungdo Han Seona Park Hosim Soh Kukhwan Choi Jihye Kim Jaeyoung Chun Joo Sung Kim | 2019 | World Journal of Gastroenterology2019，25，42： | 7 |
| 4 | Periodontitis combined with smoking increases risk of the ulcerative colitis: A national cohort study显示文摘BACKGROUND Periodontitis is a chronic inflammation of periodontal tissues.The effect of periodontitis on the development of inflammatory bowel disease(IBD)remains unclear.AIM To assessed the risk of IBD among patients with periodontitis,and the risk factors for IBD related to periodontitis.METHODS A nationwide population-based cohort study was performed using claims data from the Korean National Healthcare Insurance Service.In total,9950548 individuals aged≥20 years who underwent national health screening in 2009 were included.Newly diagnosed IBD[Crohn’s disease(CD),ulcerative colitis(UC)]using the International Classification of Disease 10th revision and rare intractable disease codes,was compared between the periodontitis and nonperiodontitis groups until 2017.RESULTS A total of 1092825 individuals(11.0%)had periodontitis.Periodontitis was significantly associated with older age,male gender,higher body mass index,quitting smoking,not drinking alcohol,and regular exercise.The mean age was 51.4±12.9 years in the periodontitis group and 46.6±14.2 years in the nonperiodontitis group(P<0.01),respectively.The mean body mass index was 23.9±3.1 and 23.7±3.2 in the periodontitis and non-periodontitis groups,respectively(P<0.01).Men were 604307(55.3%)and 4844383(54.7%)in the periodontitis and non-periodontitis groups,respectively.The mean follow-up duration was 7.26 years.Individuals with periodontitis had a significantly higher risk of UC than those without periodontitis[adjusted hazard ratio:1.091;95%confidence interval(CI):1.008-1.182],but not CD(adjusted hazard ratio:0.879;95%confidence interval:0.731-1.057).The risks for UC were significant in the subgroups of age≥65 years,male gender,alcohol drinker,current smoker,and reduced physical activity.Current smokers aged≥65 years with periodontitis were at a 1.9-fold increased risk of UC than non-smokers aged≥65 years without periodontitis.CONCLUSION Periodontitis was significantly associated with the risk of developing UC,but not CD,particularly in current smokers aged≥65 years. | Eun Ae Kang Jaeyoung Chun Jee Hyun Kim Kyungdo Han Hosim Soh Seona Park Seung Wook Hong Jung Min Moon Jooyoung Lee Hyun Jung Lee Jun-Beom Park Jong Pil Im Joo Sung Kim | 2020 | World Journal of Gastroenterology2020，26，37： | 3 |
| 5 | Effect of gastric acid suppressants and prokinetics on peritoneal dialysis-related peritonitis显示文摘AIM: To investigate the effect of gastric acid suppressants and prokinetics on peritonitis development in peritoneal dialysis(PD) patients.METHODS: This was a single-center, retrospective study. The medical records of 398 PD patients were collected from January 2000 to September 2012 and analyzed to compare patients with at least one episode of peritonitis(peritonitis group, group A) to patients who never had peritonitis(no peritonitis group, group B). All peritonitis episodes were analyzed to compare peritonitis caused by enteric organisms and peritonitis caused by non-enteric organisms.RESULTS: Among the 120 patients who met the inclusion criteria, 61 patients had at least one episode ofperitonitis and 59 patients never experienced peritonitis. Twenty-four of 61 patients(39.3%) in group A and 15 of 59 patients(25.4%) in group B used gastric acid suppressants. Only the use of H2-blocker(H2B) was associated with an increased risk of PD-related peritonitis; the use of proton pump inhibitors, other antacids, and prokinetics was not found to be a significant risk factor for PD-related peritonitis. A total of 81 episodes of peritonitis were divided into enteric peritonitis(EP) or non-enteric peritonitis, depending on the causative organism, and gastric acid suppressants and prokinetics did not increase the risk of EP in PD patients.CONCLUSION: The use of H2B showed a trend for an increased risk of overall PD-related peritonitis, although further studies are required to clarify the effects of drugs on PD-related peritonitis. | Ji Eun Kwon Seong-Joon Koh Jaeyoung Chun Ji Won Kim Byeong Gwan Kim Kook Lae Lee Jong Pil Im Joo Sung Kim Hyun Chae Jung | 2014 | World Journal of Gastroenterology2014，20，25： | 2 |
| 6 | Novel Risk Stratification for Recurrence after Endoscopic Resection of Advanced Colorectal Adenoma显示文摘 | Ji Yeon Seo Jaeyoung Chun Changhyun Lee Kyoung Sup Hong Jong Pil Im Sang Gyun Kim Hyun Chae Jung Joo Sung Kim | 2014 | Gastrointestinal Endoscopy2014，，： | 2 |
| 7 | Use of 3′-deoxy-3′-[18F]fluorothymidine PET to monitor early responses to radiation therapy in murine SCCVII tumors显示文摘 | You-Jung Yang Jin-Sook Ryu Seog-Young Kim Seung Jun Oh Ki Chun Im Heuiran Lee Sang-wook Lee Kyung Ja Cho Gi-Jeong Cheon Dae Hyuk Moon | 2006 | European Journal of Nuclear Medicine and Molecular Imaging2006，，4： | 1 |
| 8 | Localization and propagation analysis of ictal source rhythm by electrocorticography显示文摘 | June Sic Kim Chang Hwan Im Young Jin Jung Eun Young Kim Sang Kun Lee Chun Kee Chung | 2010 | Neuroimage2010，，： | 1 |
| 9 | Neurologic injury and recovery in patients with burst fracture of the thoracolumbar spine 显示文摘 | Kim NH Lee HM Chun IM | 1999 | Spine1999，24，3： | 1 |
| 10 | Anti-inflammatory effect of Lycium Fruit water extract in lipopolysaccharide-stimulated RAW 264.7 macrophage cells显示文摘 | You-Chang Oh Won-Kyung Cho Ga Young Im Yun Hee Jeong Youn-Hwan Hwang Chun Liang Jin Yeul Ma | 2012 | International Immunopharmacology2012，，： | 1 |
| 11 | Massive hemoperitone- um with splenic infarction in Evans syndrome 显示文摘 | Ryu E M Im S A Chun H J | 2011 | J Pediatr Hematol Oncol2011，33，1： | 1 |
| 12 | Pulmonary oil embolism after tran-scatheter oily Chemoembolization of hepatocellar carcinoma 显示文摘 | Chun JW Park J-H Im JG | 1993 | Radioology1993，187，： | 1 |
| 13 | Determination of carbon source utilization of Bacillus and Pythium species by biolog(R) microplate assay显示文摘 | Chun SC Schneider RW Chung IM | 2003 | J Microbiol2003，41，3： | 1 |
| 14 | Leg edema with deep venous thrombosis-like symptoms as an unusual complication of occult bladder distensionand right May-Thumer syndrome in a stroke patient :a case report显示文摘 | Im S Lim SH Chun HJ | 2009 | Arch Phys Med Rehabil2009，9015，： | 1 |
| 15 | Resveratrol accumulationand resveratrol synthase gene expressionin response to abioticstresses and hormones in peanut plants显示文摘 | Chung IM Myoung RP Chun JC | 2003 | Plant Sci2003，164，： | 1 |
| 16 | Supratentorial ganglioglioma and epilepsy: postopera- tive seizure outcome显示文摘 | So--Hyang Im Chun Kee Chung Byung--Kyu Cho | 2002 | Journal of Neuro--Oncology2002，57，： | 1 |
| 17 | Correlation of breast cancer subtypes, based on estrogen receptor, progesterone receptor, and HER2, with functional imaging parameters from 68 Ga-RGD PET/CT and 18 F-FDG PET/CT显示文摘 | Hai-Jeon Yoon Keon Wook Kang In Kook Chun Nariya Cho Seock-Ah Im Sunjoo Jeong Song Lee Kyeong Cheon Jung Yun-Sang Lee Jae Min Jeong Dong Soo Lee June-Key Chung Woo Kyung Moon | 2014 | European Journal of Nuclear Medicine and Molecular Imaging2014，，8： | 1 |
| 18 | Neurologcal ingury and yecovery in patients with burst fracture of the thoracolumbar spine 显示文摘 | Kiminh Lee HM chun Im | 1999 | Spine1999，24，3： | 1 |
| 19 | Changes in CT appearance of intrathoracic gossypiboma over 10 years显示文摘 | Park HJ Im SA Chun H J | 2008 | Br J Radiol2008，81，962： | 1 |
| 20 | Intracranial Ganglioglioma: Preoperative Characteristics and Oncologic Outcome after Surgery显示文摘 | So-Hyang Im Chun Kee Chung Byung-Kyu Cho Kyu-Chang Wang In-Kyu Yu In Chan Song Gi Jeong Cheon Dong Soo Lee Na-Rae Kim Je G. Chi | 2002 | Journal of Neuro - Oncology2002，，2： | 1 |
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