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| 1 | Lipid-dependent conformational dynamics underlie the functional versatility of T-cell receptor显示文摘T 房间 receptor-CD3 建筑群(TCR ) 是能基于 CD3 细胞质的领域的各种各样的生物化学的变化开始抗原特定的有免疫力的回答的一台万用的发信号机器,但是内在的结构的基础留下逃犯。这里,我们开发了生物物理的途径学习 CD3 细胞质的领域的 conformational 动力学(CD3 CD ) 。在单个分子的水平,我们发现那 CD3 CD 能与三个功能的主题的不同坦诚有多重 conformational 状态,即, ITAM, BRS 和 PRS。因为,这些符合构造被产生 CD3 CD 有异构的类脂化合物绑定性质因此有异构的动力学。实时房间的成像实验证明不同抗原刺激能稳定 CD3 在不同符合构造的 CD 。类脂化合物依赖者 conformational 动力学因此为 TCR 的万用的发信号性质提供结构的基础。 | Xingdong Guo Chengsong Yan Hua Li Wenmao Huan Xiaoshan Shi Min Huang Yingfang Wang Weiling Pan Mingjun Cai Lunyi Li Wei Wu Yibing Bai Chi Zhang Zhijun Liu Xinyan Wang Xiaohui F Zhang Chun Tang Hongda Wang Wanli Liu Bo Ouyang Catherine C Wong Yi Cao Chenqi Xu | 2017 | Cell Research2017，27，4： | 5 |
| 2 | The heterodimeric structure of heterogeneous nuclear ribonucleoprotein C1/C2 dictates 1,25-dihydroxyvitamin D-directed transcriptional events in osteoblasts显示文摘Heterogeneous nuclear ribonucleoprotein(hnRNP) C plays a key role in RNA processing but also exerts a dominant negative effect on responses to 1,25-dihydroxyvitamin D(1,25(OH)2D) by functioning as a vitamin D response element-binding protein(VDRE-BP). hnRNPC acts a tetramer of hnRNPC1(huC1) and hnRNPC2(huC2), and organization of these subunits is critical to in vivo nucleic acid-binding. Overexpression of either huC1 or huC2 in human osteoblasts is sufficient to confer VDRE-BP suppression of 1,25(OH)2D-mediated transcription. However, huC1 or huC2 alone did not suppress 1,25(OH)2D-induced transcription in mouse osteoblastic cells. By contrast, overexpression of huC1 and huC2 in combination or transfection with a bone-specific polycistronic vector using a ‘‘self-cleaving'' 2A peptide to co-express huC1/C2 suppressed1,25D-mediated induction of osteoblast target gene expression. Structural diversity of hnRNPC between human/NWPs and mouse/rat/rabbit/dog was investigated by analysis of sequence variations within the hnRNP CLZ domain. The predicted loss of distal helical function in hnRNPC from lower species provides an explanation for the altered interaction between huC1/C2 and their mouse counterparts. These data provide new evidence of a role for hnRNPC1/C2 in 1,25(OH)2D-driven gene expression, and further suggest that species-specific tetramerization is a crucial determinant of its actions as a regulator of VDR-directed transactivation. | Thomas S Lisse Kanagasabai Vadivel S Paul Bajaj Rui Zhou Rene F Chun Martin Hewison John S Adams | 2014 | Bone Research2014，2，2： | 2 |
| 3 | Cyto-chrome P450 1B1 :a target for inhibition in anticarci-nogenesis strategies 显示文摘 | GUENGERICH F CHUN Y J KIM D | 2003 | Mutation Research2003，，： | 1 |
| 4 | Mechanisms for inhibition of hepatitis B virus gene expression and replication by hepatitis C virus core protein显示文摘 | Shiow Y C Chih F K Chun M C | 2003 | J Biol Chem2003，278，： | 1 |
| 5 | HIV persistence and the prospect of long-term drug-free remissions for HIV-infected individuals显示文摘 | Trono D Van Lint C Rouzioux C Verdin E Barre-Sinoussi F Chun TW Chomont N | 2010 | Science2010，329，5988： | 1 |
| 6 | Electrophysiological findings during ablation of persistent atrial fibrillation with electroanatomic mapping and double Lasso catheter technique显示文摘 | Ouyang F Ernst S Chun J | 2005 | Circulation2005，112，20： | 1 |
| 7 | Complications and oth- er surgical outcomes associated with extended pelvic lymph- adenectomy in men with localized prostate cancer显示文摘 | Briganti A Chun F K Salonia A | 2006 | Europe- an Urology2006，50，5： | 1 |
| 8 | Polarimetric laser radar target classification 显示文摘 | C S L Chun F A Sadiadi | 2005 | Opt Lett2005，30，14： | 1 |
| 9 | Inequalities of Simpson type for functions whose third derivatives are extended s-convex functions and applications to means 显示文摘 | Chun L Qi F | 2015 | Journal of Computational Analysis & Applications2015，19，3： | 1 |
| 10 | 显示文摘 | CHUN R S QING F G AND LI C W | 2005 | J Phys Chem2005，109，22： | 1 |
| 11 | Role of caspases in murine limbbud cell death induced by 4-hydroperoxycy-clophosphamide, an activated analog of cyclophosphamide显示文摘 | CHUN W H BARBRA F H | 2002 | Teratology2002，66，4： | 1 |
| 12 | Electrophysiological findings during ablation of persistent atrial fibrillation with electroanatomic mapping and double Lasso catheter technique显示文摘 | Ouyang F Ernst S Chun J | 2005 | Circulation2005，112，： | 1 |
| 13 | Electrophysiological findings during ablation of persistent atrial fribrillation with electroanatomic mapping and double Lasso catheter technique显示文摘 | Ouyang F Ernst S Chun J | 2005 | Circulation2005，112，20： | 1 |
| 14 | Functional reproducibility of general multivariable non-linear systems显示文摘 | CHUN W L YUAN K F | 1987 | Int J Control1987，45，1： | 1 |
| 15 | Electrophysiological findings during ablation of persistent atrial fibrillation with electroanatomic mapping and double lasso catheter technique 显示文摘 | Ouyang F Ernst S Chun J | 2005 | Circulation2005，112，20： | 1 |
| 16 | Effects of light on nitrogen and car- bon uptakeduring a Prorocentrum minimum bloom 显示文摘 | CHUN L F GLIBERT P M | 2005 | Harmful Algae2005，4，3： | 1 |
| 17 | The relationship of mammographic density and age: implications for breast cancer screening显示文摘 | Checka C M Chun J E Schnabel F R et al | 2012 | AJR2012，198，3： | 1 |
| 18 | Role of caspases in murine limb bud cell death induced by 4-hydroperoxycy clophosphamide,an activated analog of cyclophosphamide显示文摘 | CHUN W H BARBRA F H | 2002 | Teratology2002，66，4： | 1 |
| 19 | Transcriptional expression profiles of oral squamous cell carcinomas显示文摘 | Eduardo M Chun CD Gregory F | 2002 | Cancer2002，95，： | 1 |
| 20 | Electrophysiological findings during ablation of persistent atrial fibrillation with electroanatomic mapping and double lasso catheter technique显示文摘 | Ernst S Chun J | 2005 | Circulation2005，112，20： | 1 |
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