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1Clinical characteristics of 24 asymptomatic infections with COVID-19 screened among close contacts in Nanjing,China显示文摘Previous studies have showed clinical characteristics of patients with the 2019 novel coronavirus disease(COVID-19)and the evidence of person-to-person transmission.Limited data are available for asymptomatic infections.This study aims to present the clinical characteristics of 24 cases with asymptomatic infection screened from close contacts and to show the transmission potential of asymptomatic COVID-19 virus carriers.Epidemiological investigations were conducted among all close contacts of COVID-19 patients(or suspected patients)in Nanjing,Jiangsu Province,China,from Jan 28 to Feb 9,2020,both in clinic and in community.Asymptomatic carriers were laboratory-confirmed positive for the COVID-19 virus by testing the nucleic acid of the pharyngeal swab samples.Their clinical records,laboratory assessments,and chest CT scans were reviewed.As a result,none of the 24 asymptomatic cases presented any obvious symptoms while nucleic acid screening.Five cases(20.8%)developed symptoms(fever,cough,fatigue,etc.)during hospitalization.Twelve(50.0%)cases showed typical CT images of ground-glass chest and 5(20.8%)presented stripe shadowing in the lungs.The remaining 7(29.2%)cases showed normal CT image and had no symptoms during hospitalization.These 7 cases were younger(median age:14.0 years;P=0.012)than the rest.None of the 24 cases developed severe COVID-19 pneumonia or died.The median communicable period,defined as the interval from the first day of positive nucleic acid tests to the first day of continuous negative tests,was 9.5 days(up to 21 days among the 24 asymptomatic cases).Through epidemiological investigation,we observed a typical asymptomatic transmission to the cohabiting family members,which even caused severe COVID-19 pneumonia.Overall,the asymptomatic carriers identified from close contacts were prone to be mildly ill during hospitalization.However,the communicable period could be up to three weeks and the communicated patients could develop severe illness.These results highlighted the importance of close contact tracing and longitudinally surveillance via virus nucleic acid tests.Further isolation recommendation and continuous nucleic acid tests may also be recommended to the patients discharged.Zhiliang Hu Ci Song Chuanjun Xu Guangfu Jin Yaling Chen Xin Xu Hongxia Ma Wei Chen Yuan Lin Yishan Zheng Jianming Wang Zhibin Hu Yongxiang Yi Hongbing Shen 2020Science China(Life Sciences)2020,63,5:77
2Exploratory study on new pulse detonation engines显示文摘The worldwide progress in studies on pulse detonation engines (PDE) is briefly reviewed and some results of our exploratory study on PDE are presented. Analysis of thermodynamic cycle is made and the specific impulse formula is improved. A proof-of-principle experiment of a two-phase PDE is successfully carried out, using poor-detonable liquid C8H16/air mixture with a low-energy system (total spark energy of 50 mJ) and a newly developed one-step detonation initiation method. The measured detonation wave pressure ratio is very close to that of C-J detonation. The effects of length, diameter and detonation frequency on PDE performance are experimentally investigated. For liquid hydrocarbon fuel/air mixture, the PDE operation is successfully realized with an engine length of 1000 mm and detonation frequency up to 36 Hz, which has made an important step toward practical PDE. The developed code can be used for simulating PDE operation processes including deflagration to detonation transition (DDT) phenomenon. The numerical results are in good agreement with the experimental ones.YAN Chuanjun, FAN Wei, HUANG Xiqiao, ZHANG Qun and ZHENG Longxi(Department of Aeroengines, Northwestern Polytechnical University, Xi’an 710072, China) 2003Progress in Natural Science:Materials International2003,13,2:12
3Fluid-solid Interaction Model for Hydraulic Reciprocating O-ring Seals显示文摘Elastohydrodynamic lubrication characteristics of hydraulic reciprocating seals have significant effects on sealing and tribology performances of hydraulic actuators,especially in high parameter hydraulic systems.Only elastic deformations of hydraulic reciprocating seals were discussed,and hydrodynamic effects were neglected in many studies.The physical process of the fluid-solid interaction effect did not be clearly presented in the existing fluid-solid interaction models for hydraulic reciprocating O-ring seals,and few of these models had been simultaneously validated through experiments.By exploring the physical process of the fluid-solid interaction effect of the hydraulic reciprocating O-ring seal,a numerical fluid-solid interaction model consisting of fluid lubrication,contact mechanics,asperity contact and elastic deformation analyses is constructed with an iterative procedure.With the SRV friction and wear tester,the experiments are performed to investigate the elastohydrodynamic lubrication characteristics of the O-ring seal.The regularity of the friction coefficient varying with the speed of reciprocating motion is obtained in the mixed lubrication condition.The experimental result is used to validate the fluid-solid interaction model.Based on the model,The elastohydrodynamic lubrication characteristics of the hydraulic reciprocating O-ring seal are presented respectively in the dry friction,mixed lubrication and full film lubrication conditions,including of the contact pressure,film thickness,friction coefficient,liquid film pressure and viscous shear stress in the sealing zone.The proposed numerical fluid-solid interaction model can be effectively used to analyze the operation characteristics of the hydraulic reciprocating O-ring seal,and can also be widely used to study other hydraulic reciprocating seals.LIAO Chuanjun HUANG Weifeng WANG Yuming SUO Shuangfu LIU Ying 2013Chinese Journal of Mechanical Engineering2013,26,1:10
4Thermal Fluid-Solid Interaction Model and Experimental Validation for Hydrostatic Mechanical Face Seals显示文摘Hydrostatic mechanical face seals for reactor coolant pumps are very important for the safety and reliability of pressurized-water reactor power plants.More accurate models on the operating mechanism of the seals are needed to help improve their performance.The thermal fluid–solid interaction(TFSI)mechanism of the hydrostatic seal is investigated in this study.Numerical models of the flow field and seal assembly are developed.Based on the mechanism for the continuity condition of the physical quantities at the fluid–solid interface,an on-line numerical TFSI model for the hydrostatic mechanical seal is proposed using an iterative coupling method.Dynamic mesh technology is adopted to adapt to the changing boundary shape.Experiments were performed on a test rig using a full-size test seal to obtain the leakage rate as a function of the differential pressure.The effectiveness and accuracy of the TFSI model were verified by comparing the simulation results and experimental data.Using the TFSI model,the behavior of the seal is presented,including mechanical and thermal deformation,and the temperature field.The influences of the rotating speed and differential pressure of the sealing device on the temperature field,which occur widely in the actual use of the seal,are studied.This research proposes an on-line and assembly-based TFSI model for hydrostatic mechanical face seals,and the model is validated by full-sized experiments.HUANG Weifeng LIAO Chuanjun LIU Xiangfeng SUO Shuangfu LIU Ying WANG Yuming 2014Chinese Journal of Mechanical Engineering2014,27,5:10
5Operation of a Rotary-valved Pulse Detonation Rocket Engine Utilizing Liquid-kerosene and Oxygen显示文摘The pulse detonation rocket engine (PDRE) requires periodic supply of oxidizer, fuel and purge gas. A rotary-valve assembly is fabricated to control the periodic supply in this research. Oxygen and liquid aviation kerosene are used as oxidizer and fuel respectively. An ordinary automobile spark plug, with ignition energy as low as 50 mJ, is used to initiate combustion. Steady operation of the PDRE is achieved with operating frequency ranging from 1 Hz to 10 Hz. Experimentally measured pressure is lower than theoretical value by 13% at 1 Hz and 37% at 10 Hz, and there also exists a velocity deficit at different operating frequencies. Both of these two phenomena are believed mainly due to droplet size which depends on atomization and vaporiza-tion of liquid fuel.WANG Ke FAN Wei YAN Yu ZHU Xudong YAN Chuanjun 2011Chinese Journal of Aeronautics2011,24,6:9
6Fluid-solid strong-interaction model of mechanical seals in reactor coolant pumps显示文摘The studies on the mechanisms and performances of the mechanical seals in reactor coolant pumps are very important for the safe operations of the pressurized water reactor power plants.Based on the hydrostatic mechanical seal in reactor coolant pumps,an analytical fluid-solid strong-interaction model is proposed in this paper.According to the design features and operational principles of the seal,an analytical method to calculate the mechanical deformation of the seal assembly is developed based on the ring deformation theory.A strong-interaction algorithm combining the analysis of the mechanical deformation of the seal assembly and flow field between the seal faceplates is utilized,in which the three kinds of equations including the fluid domain,solid domain and coupling action are constituted in the same equations set and all the variables are solved simultaneously.So the analytical fluid-solid strong-interaction model used for the seal is built.Moreover,the model is verified by the experimental results.Based on the model,the design parameters of the seal are studied.Two different conditions of the general case and fixed seal leakage rate are discussed respectively,and the regularities that the seal behaviors are affected by the parameters of the holding screws on the clamp rings and seal faceplates are obtained.The research results can provide a theoretical basis for performance analysis,design and assemblage of the seal.Compared to the numerical methods,the proposed model has the unique advantages of high efficiency,convenience and easy application of constraints.LIAO ChuanJun HUANG WeiFeng SUO ShuangFu LIU XiangFeng WANG YuMing 2011Science China(Technological Sciences)2011,54,9:9
7Neurofilament proteins in axonal regeneration and neurodegenerative diseases显示文摘Neurofilament protein is a component of the mature neuronal cytoskeleton, and it interacts with the zygosome, which is mediated by neurofilament-related proteins. Neurofilament protein regulates enzyme function and the structure of linker proteins. In addition, neurofilament gene expression plays an important role in nervous system development. Previous studies have shown that neurofilament gene transcriptional regulation is crucial for neurofilament protein expression, especially in axonal regeneration and degenerative diseases. Post-transcriptional regulation increased neurofilament protein gene transcription during axonal regeneration, ultimately resulting in a pattern of neurofilament protein expression. An expression imbalance of post-transcriptional regulatory proteins and other disorders could lead to amyotrophic lateral sclerosis or other neurodegenerative diseases. These findings indicated that after transcription, neurofilament protein regulated expression of related proteins and promoted regeneration of damaged axons, suggesting that regulation disorders could lead to neurodegenerative diseases.Haitao Wang Minfei Wu Chuanjun Zhan Enyuan Ma Maoguang Yang Xiaoyu Yang Yingpu Li 2012Neural Regeneration Research2012,7,8:8
8The Mars rover subsurface penetrating radar onboard China's Mars 2020 mission显示文摘China's Mars probe,named Tianwen-1,including an orbiter and a landing rover,will be launched during the July-August 2020 Mars launch windows.Selected to be among the rover payloads is a Subsurface Penetrating Radar module(RoSPR).The main scientific objective of the RoSPR is to characterize the thickness and sub-layer distribution of the Martian soil.The RoSPR consists of two channels.The low frequency channel of the RoSPR will penetrate the Martian soil to depths of 10 to 100 m with a resolution of a few meters.The higher frequency channel will penetrate to a depth of 3 to 10 m with a resolution of a few centimeters.This paper describes the design of the instrument and some results of field experiments.Bin Zhou ShaoXiang Shen Wei Lu Qing Liu ChuanJun Tang ShiDong Li GuangYou Fang 2020Earth and Planetary Physics2020,4,4:6
9A Systematic Characterization of Structural Brain Changes in Schizophrenia显示文摘A systematic characterization of the similarities and differences among different methods for detecting structural brain abnormalities in schizophrenia,such as voxel-based morphometry(VBM),tensor-based morphometry(TBM),and projection-based thickness(PBT),is important for understanding the brain pathology in schizophrenia and for developing effective biomarkers for a diagnosis of schizophrenia.However,such studies are still lacking.Here,we performed VBM,TBM,and PBT analyses on T1-weighted brain MR images acquired from 116 patients with schizophrenia and 116 healthy controls.We found that,although all methods detected wide-spread structural changes,different methods captured different information-only 10.35%of the grey matter changes in cortex were detected by all three methods,and VBM only detected 11.36%of the white matter changes detected by TBM.Further,pattern classification between patients and controls revealed that combining different measures improved the classification accuracy(81.9%),indicating that fusion of different structural measures serves as a better neuroimaging marker for the objective diagnosis of schizophrenia.Wasana Ediri Arachchi Yanmin Peng Xi Zhang Wen Qin Chuanjun Zhuo Chunshui Yu Meng Liang 2020Neuroscience Bulletin2020,36,10:6
10Pantograph-catenary electrical contact system of high-speed railways:recent progress,challenges,and outlooks显示文摘As the unique power entrance,the pantograph-catenary electrical contact system maintains the efficiency and reliability of power transmission for the high-speed train.Along with the fast development of high-speed railways all over the world,some commercialized lines are built for covering the remote places under harsh environment,especially in China;these environmental elements including wind,sand,rain,thunder,ice and snow need to be considered during the design of the pantograph-catenary system.The pantograph-catenary system includes the pantograph,the contact wire and the interface—pantograph slide.As the key component,this pantograph slide plays a critical role in reliable power transmission under dynamic condition.The fundamental material characteristics of the pantograph slide and contact wire such as electrical conductivity,impact resistance,wear resistance,etc.,directly determine the sliding electrical contact performance of the pantograph-catenary system;meanwhile,different detection methods of the pantograph-catenary system are crucial for the reliability of service and maintenance.In addition,the challenges brought from extreme operational conditions are discussed,taking the Sichuan-Tibet Railway currently under construction as a special example with the high-altitude climate.The outlook for developing the ultra-high-speed train equipped with the novel pantograph-catenary system which can address the harsher operational environment is also involved.This paper has provided a comprehensive review of the high-speed railway pantograph-catenary systems,including its progress,challenges,outlooks in the history and future.Guangning Wu Keliang Dong Zhilei Xu Song Xiao Wenfu Wei Huan Chen Jie Li Zhanglin Huang Jingwei Li Guoqiang Gao Guozheng Kang Chuanjun Tu Xingyi Huang 2022Railway Engineering Science2022,30,4:5
11Magnetic confinement fusion: a brief review显示文摘Chuanjun HUANG Laifeng LI 2018Frontiers in Energy2018,12,2:5
12Diagnosis of CO2 dynamics and fluxes in global coastal oceans显示文摘Global coastal oceans as a whole represent an important carbon sink but,due to high spatial–temporal variability,a mechanistic conceptualization of the coastal carbon cycle is still under development,hindering the modelling and inclusion of coastal carbon in Earth SystemModels.Although temperature is considered an important control of sea surface pCO2,we show that the latitudinal distribution of global coastal surface pCO2 does not match that of temperature,and its inter-seasonal changes are substantially regulated by non-thermal factors such as watermassmixing and net primary production.These processes operate in both ocean-dominated and river-dominated margins,with carbon and nutrients sourced from the open ocean and land,respectively.These can be conceptualized by a semi-analytical framework that assesses the consumption of dissolved inorganic carbon relative to nutrients,to determine how a coastal system is a CO2 source or sink.The framework also finds utility in accounting for additional nutrients in organic forms and testing hypotheses such as using Redfield stoichiometry,and is therefore an essential step toward comprehensively understanding and modelling the role of the coastal ocean in the global carbon cycle.Zhimian Cao Wei Yang Yangyang Zhao Xianghui Guo Zhiqiang Yin Chuanjun Du Huade Zhao Minhan Dai 2020National Science Review2020,7,4:5
13Adjuvant hormone therapy after radical prostatectomy in highrisk localized and locally advanced prostate cancer: First multicenter, observational study in China显示文摘Objective: Potential of combined androgen blockade(CAB) has not been explored extensively in Chinese males with prostate cancer(PCa). Therefore, this study evaluated the 2-year prostate-specific antigen(PSA) recurrence rate and quality of life(Qo L) in patients with high-risk localized and locally advanced PCa receiving adjuvant hormone therapy(HT) after radical prostatectomy(RP).Methods: This prospective, multicenter, observational study conducted in 18 centers across China enrolled patients with high-risk factor(preoperative PSA>20 ng/m L or Gleason score >7) or locally advanced PCa. Different adjuvant HT were administered after RP according to investigator’s decision in routine clinical practice.Relationship of baseline and postoperative characteristics was assessed with recurrence rate. PSA recurrence rate and Functional Assessment of Cancer Therapy-Prostate(FACT-P) Qo L scores were recorded at 12 months and 24 months. Kaplan-Meier analysis was used to construct the PSA recurrence rate during follow-up.Results: A total of 189 patients(mean age: 66.9±6.5 years) were recruited, among which 112(59.3%) patients showed serum PSA>20 ng/m L preoperatively. The highest postoperative pathological advancement noticed was from clinical T2(c T2) to pathological T3(p T3)(43.9%) stage. The majority of the patients(66.1%) received CAB as adjuvant HT, for a median duration of 20.0 months. The least recurrence(15.2%) was noticed in patients treated with CAB, followed by those treated with luteinizing hormone-releasing hormone agonist(LHRHa)(16.1%), and antiandrogen(19.0%), with non-significant difference noted among the groups. None of the baseline or postoperative characteristics was related with PSA recurrence in our study. The 24-month FACT-P Qo L score of119 patients treated for >12 months showed significant improvement above baseline compared with those treated for ≤12 months.Conclusions: Adjuvant CAB therapy after RP showed reduction trend in 2-year PSA recurrence rate in highrisk Chinese patients with localized and locally advanced PCa, compared with adjuvant anti-androgens(AA) or LHRHa therapy. Further long-term therapy(>12 months) significantly improved Qo L compared to short-term HT therapy, suggesting the beneficial effect of long-term CAB therapy in improving Qo L.Dingwei Ye Wei Zhang Lulin Ma Chuanjun Du Liping Xie Yiran Huang Qiang Wei Zhangqun Ye Yanqun Na 2019Chinese Journal of Cancer Research2019,31,3:4
14Evolution of the microstructure and solute distribution of Sn-10wt% Bi alloys during electromagnetic field-assisted directional solidification显示文摘The effects of forced flows at different velocities on microstructure and solute distribution during the directional solidification of Sn-10 wt% Bi alloys under a simultaneous imposition of a transverse static magnetic field(TSMF) and an external direct current(DC) have been investigated experimentally and numerically. The experimental results show that the solid-liquid interface will gradually become sloping with the increase of the forced flow velocity when the thermoelectric magnetic convection(TEMC)dominates the forced flow at solidification front. However, the interface will gradually become planar as the flow velocity further increases when the electromagnetic convection(EMC) dominates the forced flow. Moreover, when the flow velocity gradually increases, the primary dendrite spacing decreases from384 to 105 μm accordingly. The simulation results show that the solute distribution at the two sides of the sample can be significantly changed by the forced flow at solidification front. The rejected solute will be unidirectionally transported to one side of the sample along the TEMC(a low-velocity forced flow),thereby causing the formation of a sloping interface. However, the rejected solute will be returned back along the EMC(a higher-velocity force flow), which results in a planar interface. Furthermore, the solute content at the two sides of the sample under the forced flows at different velocities was measured. The results are in good agreement with the simulation results, which shows that the solute content difference between the two sides of the sample reaches the maximum when a 0.5 T TSMF is applied, while the solute content difference decreases to zero with a simultaneous application of a 0.5 T TSMF and a 1.6 × 10~5 A/m^2 external DC.Zhe Shen Minghu Peng Dongsheng Zhu Tianxiang Zheng Yunbo Zhong Weili Ren Chuanjun Li Weidong Xuan Zhongming Ren 2019Journal of Materials Science & Technology2019,35,4:4
15HOMOCLINIC BIFURCATION IN SEMI-CONTINUOUS DYNAMIC SYSTEMS显示文摘CHUANJUN DAI MIN ZHAO LANSUN CHEN 2012International Journal of Biomathematics2012,5,6:3
16Experimental Investigation of Nozzle Effects on Thrust and Inlet Pressure of an Air-breathing Pulse Detonation Engine显示文摘Nozzle effects on thrust and inlet pressure of a multi-cycle air-breathing pulse detonation engine (APDE) are investigated experimentally. An APDE with 68 mm in diameter and 2 050 mm in length is operated using gasoline/air mixture. Straight nozzle, converging nozzle, converging-diverging nozzle and diverging nozzle are tested. The results show that thrust augmentation of converging-diverging nozzle, diverging nozzle or straight nozzle is better than that of converging nozzle on the whole. Thrust augmentation of straight nozzle is worse than those of converging-diverging nozzle and diverging nozzle. Thrust augmentations of diverging nozzle with larger expansion ratio and converging-diverging nozzle with larger throat area range from 20% to 40% on tested frequencies and are better than those of congeneric other nozzles respectively. Nozzle effects on inlet pressure are also researched. At each frequency it is indicated that filling pressures and average peak pressures of inlet with diverging nozzle and converging-diverging nozzle with large throat cross section area are higher than those with straight nozzle and converging nozzle. Pressures near thrust wall increase in an increase order from without nozzle, with diverging nozzle, straight nozzle and converging-diverging nozzle to converging nozzle.CHEN Wenjuan FAN Wei ZHANG Qun PENG Changxin YUAN Cheng YAN Chuanjun 2012Chinese Journal of Aeronautics2012,25,3:3
17Applications of Wigner high-order spectra in feature extraction of acoustic emission signals显示文摘The characteristics of typical AE signals initiated by mechanical component damages are analyzed. Based on the extracting principle of acoustic emission(AE) signals from damaged components,the paper introduces Wigner high-order spectra to the field of feature extraction and fault diagnosis of AE signals. Some main performances of Wigner binary spectra,Wigner triple spectra and Wigner-Ville distribution (WVD) are discussed,including of time-frequency resolution,energy accumulation,reduction of crossing items and noise elimination. Wigner triple spectra is employed to the fault diagnosis of rolling bearings with AE techniques. The fault features reading from experimental data analysis are clear,accurate and intuitionistic. The validity and accuracy of Wigner high-order spectra methods proposed agree quite well with simulation results. Simulation and research results indicate that wigner high-order spectra is quite useful for condition monitoring and fault diagnosis in conjunction with AE technique,and has very important research and application values in feature extraction and faults diagnosis based on AE signals due to mechanical component damages.Xiao Siwen Liao Chuanjun Li Xuejun 2009Engineering Sciences2009,7,3:2
18Experimental study of an air-breathing pulse detonation engine ejector显示文摘Peng Changxin Fan Wei Zhang Qun Yuan Cheng Chen Wenjuan Yan Chuanjun 2011Experimental Thermal and Fluid Science2011,,6:2
19The Effects of Polyphenol Oxidase and Cycloheximide on the Early Stage of Browning in Phalaenopsis Explants显示文摘Explant browning is one of the major problems in the tissue culture process, and polyphenol oxidase(PPO), is the major proteases involved in plant tissue browning. We investigated the effects of polyphenol oxidase on the early stage of browning in explants of the orchid Phalaenopsis. Our results show that PPO activity was significantly higher in explants cultured for 3 d than in the 0 h control. The levels of PPO transcripts and PPO protein were significantly higher in explants cultured for 6 h compared to the 0 h control; these high expression levels were maintained over increasing cultivation time. Cycloheximide(CHX) treatment reduced PPO transcript levels, PPO protein levels, and PPO enzyme activity. High levels of PPO m RNA and PPO protein were detected in the cytoplasm and vascular bundles of Phalaenopsis explants cultured for 6 h compared to explants cultured for 0 h, 24 h, and 3 d. CHX treatment did not significantly affect the distribution of PPO m RNA and PPO protein in explant tissues, but their levels were significantly lower than those of the untreated control.XU Chuanjun RU Zhiwei LI Ling ZENG Biyu HUANG Junmei HUANG Wen HU Ou 2015Horticultural Plant Journal2015,1,3:2
20Adjustable thermal expansion in La(Fe,Si)13-based conductive composites by high-pressure synthesis显示文摘Providing a suitable contact interface, where a high conductivity material with a desirable coefficient of thermal expansion(CTE) adjoins the target micro-electric devices, is very crucial to optimize the properties and service life of the relevant instruments. Regrettably, a high conductivity, low thermal expansion and relatively inexpensive material is very rare. Composites, fortunately, can offer a method to design materials with adjustable properties by mixing two or more diverse constituents. In this paper, high conductivity composites with adjustable thermal expansion were successfully prepared by a high-pressure synthesis. The composites are based on combining La(Fe,Si)13-based compounds, the materials showing a giant, isotropic negative thermal expansion(NTE) properties, within Cu matrix. The La(Fe,Si)13-based compounds were used to adjust the CTE of the composites, while the Cu phase is in charge of tuning the thermal conductivity properties. Thus, by changing the relative amount of the two components, the composites with high conductivities and adjustable CTE were achieved. Furthermore, the thermal expansion and magnetic properties of the composites were investigated by a physical property measurement system. The present results highlight the potential applications of the Cu-based high conductivity composites with room-temperature NTE properties in the thermal contacts to various semiconductor and microelectronic devices.Wei Wang Rongjin Huang Yi Shan Yuqiang Zhao Xinran Shan Shibin Guo Chuanjun Huang Laifeng Li 2019Progress in Natural Science:Materials International2019,29,1:2
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