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您的检索式：作者名="Chuangang Fu"
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| 1 | p53 deficiency-induced Smad1 upregulation suppresses tumorigenesis and causes chemoresistance in colorectal cancers显示文摘The DNA damage response helps to maintain genome integrity,suppress tumorigenesis,and mediate the effects of radiotherapy and chemotherapy.Our previous studies have shown that Smad1 is upregulated and activated by Atm in DNA damage response,which can further bind to p53 and promote p53 stabilization.Herewe report another aspect of the interplay between p53 and Smad1.Comparison of rectal tumor against paired paraneoplastic specimens and analysis of>500 colorectal tumors revealed that Smad1 was upregulated in tumor samples,which was attributable to p53 defects.Using MEFs as a model,we found that knockdown of the elevated Smad1 in p532/2 MEFs promoted cell proliferation,E1A/Ras-induced cell transformation,and tumorigenesis.Mechanistic studies suggest that elevated Smad1 and momentary activation inhibit cell proliferation by upregulating p57Kip2 and enhancing Atm–Chk2 activation.Surprisingly,elevated Smad1 appears to have a negative effect on chemotherapy,as colorectal tumors,primary cancer cells,and cell lines with Smad1 knockdown all showed an increase in chemosensitivity,which could be attributable to elevated p57Kip2.These findings underscore the significance of Smad1–p53 interaction in tumor suppression and reveal an unexpected role for Smad1 in chemoresistance of colorectal cancers. | Xinsen Ruan Qiao Zuo Hao Jia Jenny Chau Jinlin Lin Junping Ao Xuechun Xia Huijuan Liu Samy LHabib Chuangang Fu Baojie Li | 2015 | Journal of Molecular Cell Biology2015，7，2： | 2 |
| 2 | Influencing fac-tors of symptomatic anastomotic leakage after anterior resection ofthe rectum for cancer显示文摘 | Zhijie Cong Chuangang Fu Hantao Wang pt al | 2009 | World J Surg2009，33，6： | 1 |
| 3 | miR-128 and its target genes in tumorigenesis and metastasis显示文摘 | Molin Li Weiming Fu Lulu Wo Xiaohong Shu Fang Liu Chuangang Li | 2013 | Experimental Cell Research2013，，20： | 1 |
| 4 | Influencing factors of symptomatic anastomotic leakage after anterior resection of the rectum for cancer 显示文摘 | Zhijie Cong Chuangang Fu Hantao Wang | 2009 | World J Surg2009，33，6： | 1 |
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