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| 1 | Heparin resistance in severe thermal injury:a prospective cohort study显示文摘Background:Low molecular-weight heparin(LMWH)is routinely administered to burn patients for thromboprophylaxis.Some studies have reported heparin resistance,yet the mechanism(s)and prevalence have not been systematically studied.We hypothesized that nucleosomes,composed of histone structures with associated DNA released from injured tissue and activated immune cells in the form of neutrophil extracellular traps(NETs or NETosis),neutralize LMWH resulting in suboptimal anticoagulation,assessed by reduction in anti-factor Xa activity.Methods:Blood was sampled from>15%total body surface area(TBSA)burn patients receiving LMWH on days 5,10 and 14.Peak anti-factor Xa(AFXa)activity,anti-thrombin(ATIII)activity,cellfree DNA(cfDNA)levels and nucleosome levels were measured.Mixed effects regression was adjusted for multiple confounders,including injury severity and ATIII activity,and was used to test the association between nucleosomes and AFXa.Results:A total of 30 patients with severe burns were included.Mean TBSA 43%(SD 17).Twentythree(77%)patients were affected by heparin resistance(defined by AFXa activity<0.2 IU/mL).Mean peak AFXa activity across samples was 0.18 IU/mL(SD 0.11).Mean ATIII was 81.9%activity(SD 20.4).Samples taken at higher LWMH doses were found to have significantly increased AFXa activity,though the effect was not observed at all doses,at 8000 IU no samples were heparin resistant.Nucleosome levels were negatively correlated with AFXa(r=−0.29,p=0.050)consistent with the hypothesis.The final model,with peak AFXa as the response variable,was adjusted for nucleosome levels(p=0.0453),ATIII activity(p=0.0053),LMWH dose pre-sample(p=0.0049),drug given(enoxaparin or tinzaparin)(p=0.03),and other confounders including severity of injury,age,gender,time point of sample.Conclusions:Heparin resistance is a prevalent issue in severe burns.Nucleosome levels were increased post-burn,and showed an inverse association with AFXa consistent with the hypothesis that they may interfere with the anticoagulant effect of heparin in vivo and contribute to heparin resistance.Accurate monitoring of AFXa activity with appropriate therapy escalation plans are recommended with dose adjustment following severe burn injury. | Liam D Cato Benjamin Bailiff Joshua Price Christos Ermogeneous Jon Hazeldine William Lester Gillian Lowe Christopher Wearn Jonathan RB Bishop Janet M Lord Naiem Moiemen Paul Harrison | 2021 | Burns & Trauma2021，9，1： | 3 |
| 2 | Mechanistic and functional differentiation of tapentadol and tramadol显示文摘 | Raffa RB Buschmann H Christoph T | | 0，，： | 1 |
| 3 | Mechanistic and functional differentiation of tapentadol and tramadol显示文摘 | Raffa RB Buschmann H Christoph T | | 0，，： | 1 |
| 4 | From 3D to 2D : A review of the molecular imprinting of proteins 显示文摘 | Nicholas WT Christopher WJ Keith RB | 2006 | Biotechnol Prog2006，22，6： | 1 |
| 5 | New applications for noninvasive cardiac imaging: dual-source computed tomography显示文摘 | Carsten R Thorsten R J Christoph RB | 2007 | Eur Radiol2007，17，6： | 1 |
| 6 | Pneumomediastinum revisited显示文摘 | Christopher MZ James RS George RB | 2000 | Radiographics2000，20，4： | 1 |
| 7 | Mechanistic and functional differentiation of tapentadol and tramadol 显示文摘 | Raffa RB Buschmann H Christoph T Eichenbaum G | 2012 | Expert Opin Pharmacother2012，13，10： | 1 |
| 8 | Concentrations of selected carotenoids and vitamin A in human liver,kidney and lung tissue显示文摘 | Harold HS Christopher LP Wellman RB | | 0，，： | 1 |
| 9 | Electrocardiogram phically gated thin-section CT显示文摘 | Joseph US Christoph RB Roland DB | 1999 | Radiology1999，212，9： | 1 |
| 10 | CT of Coronary Artery Disease 显示文摘 | Joseph Schoepf U Christoph RB | 2004 | Radiolgy2004，232，1： | 1 |
| 11 | Aspirin inhibits surface glycoprotein Ⅱb/Ⅲa,P-selection,CD63,and CD107a receptor expression on human platelets显示文摘 | Marcus EM Alex IM Christopher RB | 2003 | Blood Coagulation and Fibrinolvsis2003，14，： | 1 |
| 12 | Coronary Artery Calcium Measurement: Agreement of Multirow Detector and Electron Beam CT显示文摘 | Christoph RB Kleffel T Knez A | 2001 | AJR2001，176，5： | 1 |
| 13 | The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV21 protease inhibitors显示文摘 | Kim RB Fromm MF Christoph W | 1998 | J Clin Invest1998，101，： | 1 |
| 14 | Mechanistic and functional differentiation of tapentadol and tramadol显示文摘 | Raffa RB Buschmann H Christoph T | 2012 | Expert Opinion on Pharmacotherapy2012，13，10： | 1 |
| 15 | Yucel CT of Coronary Artery Disease显示文摘 | Schoepf UJ Christoph RB Bernd MO | 2004 | Radiology2004，232，1： | 1 |
| 16 | Aspirin inhibits surface glycoprorein Ⅱb/Ⅲa, P-selection, CD63, and CD107 receptor expression on human platelet s显示文摘 | Moarcus EM Alex IM Christopher RB | 2003 | Blood Coagulation and Fibrinolysis2003，14，3： | 1 |
| 17 | 使用量化的MRI对代偿期肝硬化患者进行多器官评估显示文摘【据《J Hepatol》2018年5月报道】题:使用量化的MRI对代偿期肝硬化患者进行多器官评估(作者Christopher RB等)肝脏疾病的进展会导致一些关键器官的损害。在一次扫描中测量多个器官的结构、血流量和组织灌注量的能力,对于确定治疗的利和弊有着重要的意义。本研究目的是确定MRI评估代偿期肝硬化变化的可行性,并将其与疾病严重程度和未来肝脏相关结果(LROs)联系起来。 | 刘智勇 谢智钦 朱泽民 Christopher RB | 2018 | 临床肝胆病杂志2018，34，8： | 0 |
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