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| 1 | Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25显示文摘堵住抗体 ipilimumab 的细胞毒素的 T 淋巴细胞 antigen-4 (CTLA-4 ) 在很少的病人导致变形黑瘤的调停免疫者的长期的控制。尽管 ipilimumab 无疑经由 immunostimulation 施加它的治疗学的效果,这样远的临床上有用的、 immunologically 相关的 biomarkers 预言治疗效率是逃犯的。这里,我们显示出 IL-2 的那中立化或堵住 α并且 βIL-2 受体的子单元(CD25 和 CD122,分别地) 否则在现出症状之前的潜的老鼠模型由 CTLA-4 封锁导致了,废除了 antitumor 效果和 intratumoral T 受动器对规章的房间(Tregs ) 的比率的伴随的改进,它是。CTLA-4 封锁导致了在失去了 FoxP3 表示并且在 regressing 肿瘤积累了的 IL-2-producing 受动器房间与伴随物上升表示 Lag3, ICOS, IL-10 和 Egr2 的一个镇压 CD4 + T 房间子集的减小。当 recombinant IL-2 改进了 CTLA-4 封锁的治疗学的功效时,圈套 IL-2 受体 α(IL-2Rα, sCD25 ) 禁止了 CTLA-4 的 anticancer 效果封锁。在收到 ipilimumab 的 262 个变形黑瘤病人, sCD25 的基线浆液集中代表了全面幸存的独立指示物,与预言到治疗的抵抗的高水平。总的来说,这些结果解开为在 CTLA-4 的 anticancer 活动的 IL-2 和 IL-2 受体的一个角色封锁。重要地,我们的学习提供第一 immunologically 相关的 biomarker,也就是提高的浆液 sCD25,那与黑瘤在病人预言抵抗到 CTLA-4 封锁。 | Dalil Hannani Marie Vetizou David Enot Sylvie Rusakiewicz Nathalie Chaput David Klatzmann Melanie Desbois Nicolas Jacquelot Nadege Vimond Salem Chouaib Christine Mateus James P Allison Antoni Ribas Jedd D Wolchok Jianda Yuan Philip Wong Michael Postow Andrzej Mackiewicz Jacek Mackiewicz Dirk Schadendorff Dirk Jaeger Alan J Korman Keith Bahjat Michele Maio Luana Calabro Michele WL Teng Mark J Smyth Alexander Eggennont Caroline Robert Guido Kroemer Laurence Zitvogel | 2015 | Cell Research2015，25，2： | 14 |
| 2 | TNF复杂生理学的新资料显示文摘本文综述了有关TNF 生物学活性的新资料。包括TNF 活性分子基础,如:TNF 受体和TNF 结合蛋白;TNF 和其它细胞因子,如IL-8,IL-6等的关系;TNF 基因表达的调节等。介绍了TNF 和疾病(如HIV 感染、自身免疫性疾病)的关系,评估了TNF 的临床应用效果。 | Salem Chouaib 沈佳禾 于清华 | 1992 | 国外医学(免疫学分册)1992，15，1： | 2 |
| 3 | Move imsights imto the complex physiology of TNF -α显示文摘 | Chouaib S | 2000 | Immunol Today2000，12，： | 1 |
| 4 | Tumor necrosis factor receptors显示文摘 | Chouaib S | 2000 | Immunol Chem2000，256，3： | 1 |
| 5 | Endothelial cells as key determinants of the tumor microenvironment:interaction with tumor cells,extracellular matrix and immune killer cells显示文摘 | Chouaib S Kieda C Benlalam H | 2010 | Crit Rev Immunol2010，30，6： | 1 |
| 6 | Horseshoe kidney stones: benefit of flexible ureterorenoscopy with holmium laser 显示文摘 | CHOUAIB A AL-QAHTANI S THOMA A | 2011 | Prog Urol2011，21，： | 1 |
| 7 | Differentialregulation of interleukin-12- and interleukin-15-inducednatural killer cell activation by interleukin-4 显示文摘 | Salvucci 0 Mami Chouaib F Moreau JL | 1996 | Eur JImmunol1996，26，11： | 1 |
| 8 | Horseshoe kidney stones: benefit of flexible ureterorenoscopy with holmium laser 显示文摘 | CHOUAIB A AL-QAHTANI S THOMA A | 2011 | Prog Urol2011，21，2： | 1 |
| 9 | Hypoxia promotes tumor growth in linking angiogenesis to immune escapte 显示文摘 | Chouaib S Messai Y Couve S | 2012 | Front Imr munol2012，3，： | 1 |
| 10 | Antitumor cytotoxic T - lymphocyte response in human lung carcinoma: indentification of a tumor - associated antigen 显示文摘 | Mami- Chouaib F Echchakir H Dorothee G | 2002 | Immunol Rev2002，1，1： | 1 |
| 11 | Tumor escape from killing: role of killer inhibitor receptors and acquisition of tumor resistance to cell death 显示文摘 | Chouaib S Thiery J Gati A | 2002 | Tissue Antigen2002，60，4： | 1 |
| 12 | Move imsights imto the complex physiology of TNF-α显示文摘 | Chouaib S | 2000 | Immunol Today2000，12，： | 1 |
| 13 | Endothelial cells as key determinants of the tumor microenvironment:interaction with tumor cells,extracellular matrix and immune killer cells显示文摘 | Chouaib S Kieda C Benlalam H | | 0，，06： | 1 |
| 14 | Differential effect of anti-beta2-microglobulin on IL-2 production and IL-2 receptor expression in the primary mixed lymphocyte culture reaction显示文摘 | Chouaib S Welte K Dupont B | 1985 | J lmmunol1985，134，： | 1 |
| 15 | Dental stem cell-conditioned medium for tissue regeneration: Optimization of production and storage显示文摘BACKGROUND Mesenchymal stem cells(MSC)effects on tissue regeneration are mainly mediated by their secreted substances(secretome),inducing their paracrine activity.This Conditioned medium(CM),including soluble factors(proteins,nucleic acids,lipids)and extracellular vesicles is emerging as a potential alternative to cell therapy.However,the manufacturing of CM suffers from variable procedures and protocols leading to varying results between studies.Besides,there is no welldefined optimized procedure targeting specific applications in regenerative medicine.AIM To focus on conditioned medium produced from dental MSC(DMSC-CM),we reviewed the current parameters and manufacturing protocols,in order to propose a standardization and optimization of these manufacturing procedures.METHODS We have selected all publications investigating the effects of dental MSC secretome in in vitro and in vivo models of tissue regeneration,in accordance with the PRISMA guidelines.RESULTS A total of 351 results were identified.And based on the inclusion criteria described above,118 unique articles were included in the systematic review.DMSC-CM production was considered at three stages:before CM recovery(cell sources for CM),during CM production(culture conditions)and after production(CM treatment).CONCLUSION No clear consensus could be recovered as evidence-based methods,but we were able to describe the most commonly used protocols:donors under 30 years of age,dental pulp stem cells and exfoliated deciduous tooth stem cells with cell passage between 1 and 5,at a confluence of 70%to 80%.CM were often collected during 48 h,and stored at-80°C.It is important to point out that the preconditioning environment had a significant impact on DMSCCM content and efficiency. | Batoul Chouaib Frédéric Cuisinier Pierre-Yves Collart-Dutilleul | 2022 | World Journal of Stem Cells2022，14，4： | 1 |
| 16 | Horseshoe kidney stones:benefit of flexible ureterorenoscopy with holmium laser显示文摘 | Chouaib A A1-Qahtani S Thoma A | 2011 | Prog Urol2011，21，2： | 1 |
| 17 | Horseshoe kidney stones: benefit of flexible ureterorenoscopy with holmium laser显示文摘 | Chouaib A A1-Qahtani S Thoma A | | Prog Urol0，21，2： | 1 |
| 18 | Early weight loss and high serum tumor necrosis factor-alpha levels in polyneuropathy,organomegaly,endocrinopathy,M protein,skin changes syndrome显示文摘 | Gherardi RK Chouaib S Malapert D | 1994 | Ann Neurol1994，35，： | 1 |
| 19 | Horseshoe kidney stones:benefit of flexible uretetorenoscopy with holmium laser显示文摘 | Chouaib A AI-Qahtani S Thoma A et aI | 2011 | Prog Urol2011，21，： | 1 |
| 20 | Antitumor cytotoxic T - lymphocyte response in human lung carcinoma : Identification of a tumor - associated antigen 显示文摘 | Mami - Chouaib F Echchakir H Dorothee G et at | 2002 | Immunol Rev2002，188，： | 1 |
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