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| 1 | Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics显示文摘交往受体的蛋白质 kinase-3 (RIP3 或 RIPK3 ) 是执行 “ 的细胞的机械的必要部分; programmed”或 “ regulated”坏死。这里,我们证明那规划坏死响应许多化学疗法的代理人被激活并且贡献导致化疗的房间死亡。然而,我们证明那 RIP3 表情经常在化学疗法的死亡期间由于它的 transcriptional 开始地点, MLKL 的这样 RIP3 依赖的激活和下游地规划的坏死附近的 genomic methylation 是在癌症房间的 silenced 大部分被镇压。不过,有 hypomethylating 代理人的治疗恢复 RIP3 表示,并且从而以一种 RIP3 依赖的方式把敏感提升到 chemotherapeutics。RIP3 表示在 85% 乳癌病人与正常织物相比在肿瘤被减少,建议那 RIP3 缺乏断然在肿瘤生长 / 发展期间被选择。因为 hypomethylating 代理人在病人是相当容忍得好的,我们建议病人们可以从收到 hypomethylating 代理人与常规 chemotherapeutics 在治疗以前导致 RIP3 表示有益于的那 RIP3 缺乏的癌症。 | Gi-Bang Koo Michael J Morgan Da-Gyum Lee Woo-Jung Kim Jung-Ho Yoon Ja Seung Koo Seung I1 Kim Soo Jung Kim Mi Kwon Son Soon Still Hong Jean M Mulcahy Levy Daniel A Pollyea Craig T Jordan Pearlly Yan David Frankhouser Deedra Nicolet Kati Maharry Guido Marcucci Kyeong Sook Choi Hyeseong Cho ndrew Thorbum You-Sun Kim | 2015 | Cell Research2015，25，6： | 20 |
| 2 | 血压控制良好的老年高血压患者血压变异性与认知功能的关系显示文摘尽管已知较高血压和血压变异性与认知功能损害有关,但关于血压控制良好的老年患者血压变异性与认知功能之间的关系的数据仍旧很少。方法:本研究纳入伴有一种或多种心血管病危险因素的门诊老年高血压患者232例进行分析。所有患者进行动态血压监测和日本版的蒙特利尔认知功能评估(Montreal cognitiveassessment,MoCA-J )量表测试。 | Cho N Hoshide S Nishizawa M Fujiwara T Kario K 陈云 叶鹏 | 2019 | 中华高血压杂志2019，27，2： | 4 |
| 3 | Effects of Yttrium-90 selective internal radiation therapy on non-conventional liver tumors显示文摘The liver is a common site of metastasis, with essentially all metastatic malignancies having been known to spread to the liver. Nearly half of all patients with extrahepatic primary cancer have hepatic metastases. The severe prognostic implications of hepatic metastases have made surgical resection an important first line treatment in management. However, limitations such as the presence of extrahepatic spread or poor functional hepatic reserve exclude the majority of patients as surgical candidates, leaving chemotherapy and locoregional therapies as next best options. Selective internal radiation therapy(SIRT) is a form of catheter-based locoregional cancer treatment modality for unresectable tumors, involving trans-arterial injection of microspheres embedded with a radioisotope Yttrium-90. The therapeutic radiation dose is selectively delivered as the microspheres permanently embed themselves within the tumor vascular bed. Use of SIRT has been conventionally aimed at treating primary hepatic tumors(hepatocellular carcinoma) or colorectal and neuroendocrine metastases. Numerous reviews are available for these tumor types. However, little is known or reviewed on non-colorectal or nonneuroendocrine primaries. Therefore, the aim of this paper is to systematically review the current literature to evaluate the effects of Yttrium-90 radioembolization on non-conventional liver tumors including those secondary to breast cancer, cholangiocarcinoma, ocular and percutaneous melanoma, pancreatic cancer, renal cell carcinoma, and lung cancer. | Andrew Kuei Sammy Saab Sung-Ki Cho Stephen T Kee Edward Wolfgang Lee | 2015 | World Journal of Gastroenterology2015，21，27： | 2 |
| 4 | End-stage renal disease is associated with increased post endoscopic retrograde cholangiopancreatography adverse events in hospitalized patients显示文摘AIM To determine if end-stage renal disease (ESRD) is a risk factor for post endoscopic retrograde cholangio-pancreatography (ERCP) adverse events (AEs). METHODS We performed a retrospective cohort study using the Nationwide Inpatient Sample (NIS) 2011-2013. We identified adult patients who underwent ERCP using the International Classification of Diseases 9^(th) Revision (ICD-9-CM). Included patients were divided into three groups: ESRD, chronic kidney disease (CKD), and control. The primary outcome was post-ERCP AEs including pancreatitis, bleeding, and perforation determined based on specific ICD-9-CM codes. Secondary outcomes were length of hospital stay, in-hospital mortality, and admission cost. AEs and mortality were compared using multivariate logistic regression analysis.RESULTS There were 492175 discharges that underwent ERCP during the 3 years. The ESRD and CKD groups contained 7347 and 39403 hospitalizations respectively, whereas the control group had 445424 hospitalizations. Post-ERCP pancreatitis (PEP) was significantly higher in the ESRD group (8.3%) compared to the control group (4.6%) with adjusted odd ratio (aOR) = 1.7 (95% CI: 1.4-2.1, ~aP < 0.001). ESRD was associated with significantly higher ERCP-related bleeding (5.1%) compared to the control group 1.5% (aOR = 1.86, 95%CI: 1.4-2.4, ~aP < 0.001). ESRD had increased hospital mortality 7.1% vs 1.15% in the control OR = 6.6 (95%CI: 5.3-8.2, ~aP < 0.001), longer hospital stay with adjusted mean difference (aMD) = 5.9 d (95% CI: 5.0-6.7 d, ~aP < 0.001) and higher hospitalization charges aMD = $+82064 (95%CI: $68221-$95906, ~aP < 0.001). CONCLUSION ESRD is a risk factor for post-ERCP AEs and is associated with higher hospital mortality. Careful selection and close monitoring is warranted to improve outcomes. | Tarek Sawas Fateh Bazerbachi Samir Haffar Won K Cho Michael J Levy John A Martin Bret T Petersen Mark D Topazian Vinay Chandrasekhara Barham K Abu Dayyeh | 2018 | World Journal of Gastroenterology2018，24，41： | 2 |
| 5 | Damage identification in beam-type structures: frequency-based method vs mode-shape-based method 显示文摘 | Kim J T Ryu Y S Cho H M | 2003 | Engineering Structures2003，25，1： | 2 |
| 6 | Ginsenoside-Rd attenuates oxidative damage related to aging in senescence-accelerated mice显示文摘 | Satoh A Cho EJ | 2004 | J Pharm Pharmacol2004，56，： | 1 |
| 7 | Multivariate statistical modeling for image denoising using wavelet transforms显示文摘 | Cho D Bui T D | 2005 | Signal Processing:Image Communication2005，20，： | 1 |
| 8 | Postischemic infusion of sivelestat sodium hydrate, a selective neutrophiI elastase inhibitor,protects against myocardial stunning in swine显示文摘 | Akiyama D Hara T Yoshitomi O Maekawa T Cho S Sumika wa K | 2010 | J Anesth2010，24，： | 1 |
| 9 | Lifetime expression of stem cell markers in the uterine endometrium显示文摘 | Cho N H Park Y K Kim Y T | 2004 | Fertil Steril2004，81，2： | 1 |
| 10 | Effects of lactate dehydrogenase suppression and glycerol-3-phosphate dehydrogenase overexpression on cellular metabolism显示文摘 | Jeong D W Cho I T Kim T S | 2006 | Mol Cell Biochem2006，2，14： | 1 |
| 11 | Long term effects of zonisamide in the treatment of epilepsy in children with intellectual disability显示文摘 | Iinuma K Minami T Cho K | 1998 | J Intellect Disabil Res1998，42，1： | 1 |
| 12 | Proteomic analysis of differentially expressed proteins induced by rice blast fungus and elicitor in suspension-cultured rice cells 显示文摘 | Kim S T Cho K S Yu S | 2003 | Proteomics2003，3，12： | 1 |
| 13 | Lattice parameter as a measure of electrochemical properties of LiMn2O4 显示文摘 | CHUNG H T MYUNG S T CHO T H | 2001 | J Power Sources2001，9798，： | 1 |
| 14 | Polyvinyl alcohol embolization of the inferior epigastric artery as treatment for abdominal wall hemorrhage from multiple sites complicating enoxaparin therapy显示文摘 | Semiz-Oysu A Moustafa T Cho K J | 2007 | European Journal of Radiology Extra2007，64，： | 1 |
| 15 | Gambogic acid inhibits angiogenesis and prostate tumor growth by suppressing vascular endothelial growth factor receptor 2 signaling显示文摘 | Yi T Yi Z Cho SG | 2008 | Cancer Res2008，68，6： | 1 |
| 16 | Fulminant type 1 diabetes in Korea: high prevalence among patients with adult - onset type 1 di- abetes显示文摘 | CHO Y M KIM J T KO K S | 2007 | Diabetologia2007，50，： | 1 |
| 17 | On an elementary operator with w-hyponormal operator entries 显示文摘 | Cho M Djordjevic S V Duggal B P Yamazaki T | 2010 | Linear Algebra Appl2010，433，： | 1 |
| 18 | Attention as the mediator be- tween top management team characteristics and strategic change : The case of airline deregulation 显示文摘 | Cho T S Hambrick D C | 2006 | Organiza- tion Science2006，17，4： | 1 |
| 19 | Static and dynamic removal of aquatic natural organic matter by carbon nanotubes显示文摘 | AJMANI G S CHO H H ABBOTT-CHALEW T E | 2014 | Water Research2014，59，： | 1 |
| 20 | A rnicro-LC-resonator fabricated by MEMS techenique for high-frequency sensor applications 显示文摘 | LEA T CHO W S KIM Y S | 2007 | Sens Act A2007，135，： | 1 |
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