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| 1 | Mechanisms of drug resistance in colon cancer and its therapeutic strategies显示文摘Drug resistance develops in nearly all patients with colon cancer, leading to a decrease in the therapeutic efficacies of anticancer agents. This review provides an up-to-date summary on over-expression of ATPbinding cassette(ABC) transporters and evasion of apoptosis, two representatives of transport-based and non-transport-based mechanisms of drug resistance, as well as their therapeutic strategies. Different ABC transporters were found to be up-regulated in colon cancer, which can facilitate the efflux of anticancer drugs out of cancer cells and decrease their therapeutic effects. Inhibition of ABC transporters by suppressing their protein expressions or co-administration of modulators has been proven as an effective approach to sensitize drug-resistant cancer cells to anticancer drugs in vitro. On the other hand, evasion of apoptosis observed in drug-resistant cancers also results in drug resistance to anticancer agents, especially to apoptosis inducers. Restoration of apoptotic signals by BH3 mimetics or epidermal growth factor receptor inhibitors and inhibition of cancer cell growth by alternative cell death pathways, such as autophagy, are effective means to treat such resistant cancer types. Given that the drug resistance mechanisms are different among colon cancer patients and may change even in a single patient at different stages, personalized and specific combination therapy is proposed to be more effective and safer for the reversal of drug resistance in clinics. | Tao Hu Zhen Li Chun-Ying Gao Chi Hin Cho | 2016 | World Journal of Gastroenterology2016，22，30： | 29 |
| 2 | Repurposing vitamin D for treatment of human malignancies via targeting tumor microenvironment显示文摘Tumor cells along with a small proportion of cancer stem cells exist in a stromal microenvironment consisting of vasculature, cancer-associated fibroblasts, immune cells and extracellular components.Recent epidemiological and clinical studies strongly support that vitamin D supplementation is associated with reduced cancer risk and favorable prognosis. Experimental results suggest that vitamin D not only suppresses cancer cells, but also regulates tumor microenvironment to facilitate tumor repression. In this review, we have outlined the current knowledge on epidemiological studies and clinical trials of vitamin D. Notably, wesummarized and discussed the anticancer action of vitamin D in cancer cells, cancer stem cells and stroma cells in tumor microenvironment, providing a better understanding of the role of vitamin D in cancer. We presently re-propose vitamin D to be a novel and economical anticancer agent. | Xu Wu Wei Hu Lan Lu Yueshui Zhao Yejiang Zhou Zhangang Xiao Lin Zhang Hanyu Zhang Xiaobing Li Wanping Li Shengpeng Wang Chi Hin Cho Jing Shen Mingxing Li | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 20 |
| 3 | Platelets generated from human embryonic stem cells are functional in vitro and in the microcirculation of living mice显示文摘 | Shi-Jiang Lu Feng Li Hong Yin Qiang Feng Erin A Kimbrel Eunsil Hahm Jonathan N Thon Wei Wang Joseph E ltaliano Jaehyung Cho Robert Lanza | 2011 | Cell Research2011，21，3： | 14 |
| 4 | Fluoride evaporation and crystallization behavior of CaF_2–CaO–Al_2O_3–(TiO_2) slag for electroslag remelting of Ti-containing steels显示文摘To elucidate the behavior of slag films in an electroslag remelting process, the fluoride evaporation and crystallization of CaF_2–CaO–Al_2O_3–(TiO_2) slags were studied using the single hot thermocouple technique. The crystallization mechanism of TiO_2-bearing slag was identified based on kinetic analysis. The fluoride evaporation and incubation time of crystallization in TiO_2-free slag are found to considerably decrease with decreasing isothermal temperature down to 1503 K. Fish-bone and flower-like CaO crystals precipitate in TiO_2-free slag melt, which is accompanied by CaF_2 evaporation from slag melt above 1503 K. Below 1503 K, only near-spherical CaF_2 crystals form with an incubation time of less than 1 s, and the crystallization is completed within 1 s. The addition of 8.1wt% TiO_2 largely prevents the fluoride evaporation from slag melt and promotes the slag crystallization. TiO_2 addition leads to the precipitation of needle-like perovskite(CaTiO_3) crystals instead of CaO crystals in the slag. The crystallization of perovskite(CaTiO_3) occurs by bulk nucleation and diffusion-controlled one-dimensional growth. | Cheng-bin Shi Jung-wook Cho Ding-li Zheng Jing Li | 2016 | International Journal of Minerals,Metallurgy and Materials2016，23，6： | 6 |
| 5 | Evaluation and SAR analysis of the cytotoxicity of tanshinones in colon cancer cells显示文摘AIM:This study was designed to evaluate the anti-cancer actions of tanshinone I and tanshinone IIA,and six derivatives of tanshinone IIA on normal and cancerous colon cells.Structure activity relationship(SAR) analysis was conducted to delineate the significance of the structural modifications of tanshinones for improved anti-cancer action.METHOD:Tanshinone derivatives were designed and synthesized according to the literature.The cytotoxicity of different compounds on colon cancer cells was determined by the MTT assay.Apoptotic activity of the tanshinones was measured by flow cytometry(FCM).RESULTS:Tanshinone I and tanshinone IIA both exhibited significant cytotoxicity on colon cancer cells.They are more effective in p53+/+ colon cancer cell line.It was also noted that the anti-cancer activity of tanshinone I was more potent and selective.Two of the derivatives of tanshinone IIA(N1 and N2) also exhibited cytotoxicity on colon cancer cells.CONCLUSIONS:The anti-colon cancer activity of tanshinone I was more potent and selective than tanshinone IIA,and is p53 dependent.The derivatives obtained by structural modifications of tanshinone IIA exhibited lower cytotoxicity on both normal and colon cancer cells.From steric and electronic characteristics point of view,it was concluded that structural modifications of ring A and furan or dihydrofuran ring D on the basic structure of tanshinones influences the activity.An increase of the delocalization of the A and B rings could enhance the cytotoxicity of such compounds,while a non-planar and small sized D ring region would provide improved anti-cancer activity. | WANG Lin LIU An ZHANG Fei-Long Yeung John H.K. LI Xu-Qin CHO Chi-Hin | 2014 | Chinese Journal of Natural Medicines2014，12，3： | 6 |
| 6 | Effect of TiO_2 on the viscosity and structure of low-fluoride slag used for electroslag remelting of Ti-containing steels显示文摘The viscosity of CaF_2–CaO–Al_2O_3–MgO–(TiO_2) slag was measured using a rotating crucible viscometer. Raman spectroscopy analysis was performed to correlate the viscosity to slag structure. The viscosity of the slag was found to decrease with increasing TiO_2 content in the slag from 0 to 9.73wt%. The activation energy decreased from 95.16 kJ /mol to 79.40 kJ /mol with increasing TiO_2 content in the slag. The introduction of TiO_2 into the slag played a destructive role in Al–O–Al structural units and Q^4 units by forming simpler structural units of Q^2 and Ti_2O_6^(4-) chain. The amount of Al–O–Al significantly decreased with increasing TiO_2 content. The relative fraction of Q^4 units in the [AlO_4]^(5-)-tetrahedral units shows a decreasing trend, whereas the relative fraction of Q^2 units and Ti_2O_6^(4-) chain increases with increasing TiO_2 content accordingly. Consequently, the polymerization degree of the slag decreases with increasing TiO_2 content. The variation in slag structure is consistent with the change in measured viscosity. | Cheng-bin Shi Ding-li Zheng Seung-ho Shin Jing Li Jung-wook Cho | 2017 | International Journal of Minerals,Metallurgy and Materials2017，24，1： | 5 |
| 7 | The Level of Expression of Thioredoxin is Linked to Fundamental Properties and Applications of Wheat Seeds显示文摘有谷物(大麦和小麦) 和荚(Medicago truncatula ) 的工作作为种子的中央规章的蛋白质建立了 thioredoxin h (Trx h ) 。Trx h 由减少二硫化物(SS ) 扮演一些多样的种子蛋白质(存储蛋白质,酶,和酶禁止者) ,从而便于萌芽。早,在 vitro,蛋白质研究与有在内乳的 Trx h overexpressed 的大麦种子在显示出加速的萌芽和联系的酶(淀粉酶和 pullulanase ) 的早或提高的表示的实验被补充。当前的学习扩大转基因的工作到小麦。二条途径被跟随在内乳改变 Trx h 基因的表示:(1 ) 一个大麦蛋白倡导者和它指向顺序的蛋白质身体导致了 Trx h5 的 overexpression,并且(2 ) Trx h9 的 antisense 构造导致了那基因(Arabidopsis 指明) 的 cytosolic underexpression。Trx h9 的 Underexpression 导致了对在萌芽的 barleyretardation 为 overexpression Trx h5 观察并且推迟了或减少联系的酶的表示的那些相反的效果。类似的酶变化在开发种子被观察。有 underexpressed Trx 的小麦线看了发芽的推迟的 preharvest 没有减少,什么时候在最后的产量在温室或领域成长。有 overexpressed Trx h5 的小麦显示出与同量的变化在 vitro 工作更早:二硫化物蛋白质的增加的溶解度和麦胶蛋白质部分的更低的 allergenicity。结果是在谷物内乳的 Trx h 的水平决定基本性质以及种子的潜在的应用程序的进一步的证据。 | Yong-Chun Li Jiang-Ping Ren Myeong-Je Cho Su-Mei Zhou Yong-Bum Kim Hong-Xiang Guo Joshua H. Wong Hong-Bin Niu Hyun-Kyung Kim Susumu Morigasaki Peggy G. Lemaux Oscar L. Frick Jun Yin Bob B. Buchanan | 2009 | Molecular Plant2009，2，3： | 5 |
| 8 | Discovery and validation of prognostic markers in gastric cancer by genome-wide expression profiling显示文摘AIM: To develop a prognostic gene set that can predict patient overall survival status based on the whole genome expression analysis. METHODS: Using Illumina HumanWG-6 BeadChip followed by semi-supervised analysis, we analyzed the expression of 47 296 transcripts in two batches of gastric cancer patients who underwent surgical resection. Thirty-nine samples in the first batch were used as the training set to discover candidate markers correlated to overall survival, and thirty-three samples in the second batch were used for validation. RESULTS: A panel of ten genes were identified as prognostic marker in the first batch samples and classified patients into a lowand a high-risk group with significantly different survival times (P = 0.000047). This prognostic marker was then verified in an independent validation sample batch (P = 0.0009). By comparing with the traditional Tumor-node-metastasis (TNM) staging system, this ten-gene prognostic marker showed consistent prognosis results. It was the only independent prognostic value by multivariate Cox regression analysis (P = 0.007). Interestingly, six of these ten genes are ribosomal proteins, suggesting a possible association between the deregulation of ribosome related gene expression and the poor prognosis. CONCLUSION: A ten-gene marker correlated with overall prognosis, including 6 ribosomal proteins, was identified and verified, which may complement the predictive value of TNM staging system. | Yue-Zheng Zhang Lian-Hai Zhang Yang Gao Chao-Hua Li Shu-Qinjia Ni Liu Feng Cheng De-Yun Niu William CS Cho Jia-Fu Ji Chang-Qing Zeng | 2011 | World Journal of Gastroenterology2011，17，13： | 5 |
| 9 | Neuroprotection of Chrysanthemum indicum Linne against cerebral ischemia/reperfusion injury by anti-inflammatory effect in gerbils显示文摘In this study, we tried to verify the neuroprotective effect of Chrysanthemum indicum Linne(CIL) extract, which has been used as a botanical drug in East Asia, against ischemic damage and to explore the underlying mechanism involving the anti-inflammatory approach. A gerbil was given CIL extract for 7 consecutive days followed by bilateral carotid artery occlusion to make a cerebral ischemia/reperfusion model. Then, we found that CIL extracts protected pyramidal neurons in the hippocampal CA1 region(CA1) from ischemic damage using neuronal nucleus immunohistochemistry and Fluoro-Jade B histofluorescence. Accordingly, interleukin-13 immunoreactivities in the CA1 pyramidal neurons of CIL-pretreated animals were maintained or increased after cerebral ischemia/reperfusion. These findings indicate that the pre-treatment of CIL can attenuate neuronal damage/death in the brain after cerebral ischemia/reperfusion via an anti-inflammatory approach. | Ki-YeonYoo In Hye Kim Jeong-Hwi Cho li Hyeon Ahn Joon Ha Park Jae-Chul Lee Hyun-Jin Tae Dae Won Kim Jong-Dai Kim Seongkweon Hong Moo-Ho Won il Jun Kang | 2016 | Neural Regeneration Research2016，11，2： | 4 |
| 10 | Efects of heparin on hepatic regeneration and function after partial hepatectomy in rats显示文摘INTRODUCTIONItisknownthatliverregeneratesquicklyinresponsetotisuedamage.Hepatocytegrowthfactor(HGF)hasbeenimplicatedintheregu... | Li Y, Wang HY and Chi Hin Cho | 1999 | World Journal of Gastroenterology1999，5，4： | 4 |
| 11 | The Impacts of Simulated Microgravity on Rat Brain Depended on Durations and Regions显示文摘Objective To explore the dynamic impacts of simulated microgravity(SM) on different vital brain regions of rats. Methods Microgravity was simulated for 7 and 21 days, respectively, using the tail-suspension rat model. Histomorphology, oxidative stress, inflammatory cytokines and the expression of some key proteins were determined in hippocampus, cerebral cortex and striatum. Results 21-day SM decreased brain derived neurotrophic factor and induced neuron atrophy in the cerebral cortex. Strong oxidative stress was triggered at day 7 and the oxidative status returned to physiological level at day 21. Inflammatory cytokines were gradually suppressed and in striatum, the suppression was regulated partially through c-Jun/c-Fos. Conclusion The results revealed that the significant impacts of SM on rat brain tissue depended on durations and regions, which might help to understand the health risk and to prevent brain damage for astronauts in space travel. | CHEN Bo ZHANG Yu Shi LI George CHO Jun-Lae DENG Yu Lin LI Yu Juan | 2019 | Biomedical and Environmental Sciences2019，32，7： | 4 |
| 12 | Development of RP-HPLC method for simultaneous determination of docetaxel and curcumin in rat plasma: Validation and stability显示文摘The purpose of the present research was to develop a suitable, simple, precise, accurate,robust, and reproducible RP-HPLC method for a reliable simultaneous quantification of docetaxel(DTX) and curcumin(CCM) in rat plasma samples using paclitaxel(PTX) as an internal standard. The samples were assayed by the Agilent 1260 Infinity HPLC instrument using a Capcell Pak C8 column(4.6 mm × 150 mm, 5 μm) under isocratic conditions. The mobile phase consisted of acetonitrile and triple distilled water(40/60, v/v) with a flow rate of 1.0 ml/min. The eluent was monitored at 230 nm for simultaneous measurement of curcumin and docetaxel. The method was validated by determining system suitability, selectivity, sensitivity, linearity, inter-day and intra-day precision, accuracy, robustness, and stability in accordance with the guidelines of the United States Food and Drug Administration(FDA).The developed chromatographic method proved to be simple, precise, accurate, robust and reproducible. Moreover, the samples showed stability at room temperature over a period of 48 h. Thus, this method would be employed for routine simultaneous quantification of docetaxel and curcumin in rat plasma samples. | Dong Wuk Kim Abid Mehmood Yousaf Dong Xun Li Jong Oh Kim Chul Soon Yong Kwan Hyung Cho Han-Gon Choi | 2017 | Asian Journal of Pharmaceutical Sciences2017，12，1： | 3 |
| 13 | Cyanidin suppresses amyloid beta-induced neurotoxicity by inhibiting reactive oxygen speciesmediated DNA damage and apoptosis in PC12 cells显示文摘Amyloid beta(Aβ)-induced oxidative stress is a major pathologic hallmark of Alzheimer's disease. Cyanidin, a natural flavonoid compound, is neuroprotective against oxidative damage-mediated degeneration. However, its molecular mechanism remains unclear. Here, we investigated the effects of cyanidin pretreatment against Aβ-induced neurotoxicity in PC12 cells, and explored the underlying mechanisms. Cyanidin pretreatment significantly attenuated Aβ-induced cell mortality and morphological changes in PC12 cells. Mechanistically, cyanidin effectively blocked apoptosis induced by Aβ, by restoring the mitochondrial membrane potential via upregulation of Bcl-2 protein expression. Moreover, cyanidin markedly protected PC12 cells from Aβ-induced DNA damage by blocking reactive oxide species and superoxide accumulation. These results provide evidence that cyanidin suppresses Aβ-induced cytotoxicity, by preventing oxidative damage mediated by reactive oxide species, which in turn inhibits mitochondrial apoptosis. Our study demonstrates the therapeutic potential of cyanidin in the prevention of oxidative stress-mediated Aβ neurotoxicity. | Yi Wang Xiao-ting Fu Da-wei Li Kun Wang Xin-zhi Wang Yuan Li Bao-liang Sun Xiao-yi Yang Zun-cheng Zheng Nam Chun Cho | 2016 | Neural Regeneration Research2016，11，5： | 3 |
| 14 | 石墨表面改性对MgO-C耐火材料抗氧化性能的改善(英文)显示文摘石墨常作为传统MgO-C耐火材料的碳源。石墨在经酸化剂改性后,可在表面产生负电荷,从而增强铝相的涂覆率。从弥散度和氧化性能方面对改性后的石墨与天然石墨进行了比较。首先,将经过和未经过表面改性的石墨颗粒分别添加至酸化剂Al(NO3)3悬浮液中,并在室温下过滤,得到改性后的石墨。试验表明:改性后的石墨较天然石墨具有更好的弥散性,其Al相涂覆率得到了增强。在氧化性能方面,优化后的石墨没有Al涂层时,在900°C热处理时与空气充分氧化;而有Al涂层时,则在900°C时开始氧化,在1000°C时充分氧化,并分别变为灰色和白色。可见,由于Al涂层在石墨表面均匀覆盖,Al相涂覆率的提高增强了石墨的抗氧化性能。 | Geun-Ho CHO Eun-Hee KIM Jing LI Je-Hyun LEE Yeon-Gil JUNG Yun-Ki BYEUN Chang-Yong JO | 2014 | Transactions of Nonferrous Metals Society of China2014，24，S1： | 2 |
| 15 | Fucoidan-Based Theranostic Nanogel for Enhancing Imaging and Photodynamic Therapy of Cancer显示文摘In this study, a fucoidan-based theranostic nanogel(CFN-gel) consisting of a fucoidan backbone, redox-responsive cleavable linker and photosensitizer is developed to achieve acti-vatable near-infrared fluorescence imaging of tumor sites and an enhanced photodynamic therapy(PDT) to induce the com-plete death of cancer cells. A CFN-gel has nanomolar a nity for P-selectin, which is overexpressed on the surface of tumor neovascular endothelial cells as well as many other cancer cells. Therefore, a CFN-gel can enhance tumor accumulation through P-selectin targeting and the enhanced permeation and retention e ect. Moreover, a CFN-gel is non-fluorescent and non-phototoxic upon its systemic administration due to the aggregation-induced self-quenching in its fluorescence and singlet oxygen generation. After internalization into cancer cells and tumor neovascular endothelial cells, its photoactivity is recovered in response to the intracellular redox potential, thereby enabling selective near-infrared fluorescence imaging and an enhanced PDT of tumors. Since a CFN-gel also shows nanomolar a nity for the vascular endothelial growth factor, it also provides a significant anti-tumor e ect in the absence of light treatment in vivo. Our study indicates that a fucoidan-based theranostic nanogel is a new theranostic material for imaging and treating cancer with high e cacy and specificity. | Mi Hyeon Cho Yan Li Pui‑Chi Lo Hyeri Lee Yongdoo Choi | 2020 | Nano-Micro Letters2020，12，4： | 2 |
| 16 | Cathelicidins in inflammation and tissue repair: Potential therapeutic applications for gastrointestinal disorders显示文摘Cathelicidins,主人防卫肽的一个家庭,高度在感染,发炎并且创伤愈合期间被表示。这些肽不仅举办用途广泛的抗菌剂活动,而且由在 diseased 纸巾改变 cytokine 反应和煽动性的房间的 chemoattraction 调制发炎。在这个连接,老鼠 cathelicidin 被表明了通过提高粘液生产并且减少支持 inflammatory cytokines 的生产在冒号阻止发炎。另外, cathelicidins 支持创伤在受伤纸巾通过 re-epithelialization 和 angiogenesis 的刺激愈合。在胃的溃疡的一个动物模型,老鼠 cathelicidin 支持溃疡由在 vitro 并且在 vivo 导致胃的上皮的房间的增长愈合。在结论, cathelicidins 在在胃肠的 mucosa 和另外的机关操作发炎和组织修理的复杂集成的天生的免疫系统代表受动器分子的一个重要的组。 | William Ka Kei WU Clover Ching Man WONG Zhi Jie LI Lin ZHANG Shun Xiang REN Chi Hin CHO | 2010 | Acta Pharmacologica Sinica2010，31，9： | 2 |
| 17 | Healing effects of heparin on acetic acid-induced gastric ulcers in rats显示文摘HealingefectsofheparinonaceticacidinducedgastriculcersinratsYangLi,QiBingMeiandChiHinChoDepartmentofPharmacology,FacultyofMe... | Yang Li, Qi Bing Mei and Chi Hin Cho Department of Pharmacology, Faculty of Medicine, The University of Hong Kong, 5 Sassoon Road, Hong Kong (Li Y, Mei QB and Cho CH) | 1998 | Chinese Medical Journal1998，，1： | 2 |
| 18 | Icariin Augments Bone Formation and Reverses the Phenotypes of Osteoprotegerin-Deficient Mice through the Activation of Wnt/ β -Catenin-BMP Signaling显示文摘 | Xiao-Feng Li Hao Xu Yong-Jian Zhao De-Zhi Tang Guo-Hua Xu Jonathan Holz Jing Wang Shao-Dan Cheng Qi Shi Yong-Jun Wang Stephen Cho Wing Sze | 2013 | Evidence-Based Complementary and Alternative Medicine2013，，： | 2 |
| 19 | Enhanced plasticity of twin-roll cast ZK60 magnesium alloy through differential speed rolling显示文摘 | Xibing Gong Suk Bong Kang Saiyi Li Jae Hyung Cho | 2009 | Materials and Design2009，，9： | 2 |
| 20 | Stability of Iterative Procedures with Errors Approximating Common Fixed Points for Qui-Contractive Mapping in q-Uniformly Smooth Banach Spaces 显示文摘 | Agaral R P Cho Y J Li J Huang Nan-jing | 2002 | Math Anal Appl2002，22，： | 1 |
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