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| 1 | Time-course pattern of neuronal loss and gliosis in gerbil hippocampi following mild, severe, or lethal transient global cerebral ischemia显示文摘Transient ischemia in the whole brain leads to neuronal loss/death in vulnerable brain regions. The striatum, neocortex and hippocampus selectively loose specific neurons after transient ischemia. Just 5 minutes of transient ischemia can cause pyramidal neuronal death in the hippocampal cornu ammonis (CA) 1 field at 4 days after transient ischemia. In this study, we investigated the effects of 5-minute (mild), 15-minute (severe), and 20-minute (lethal) transient ischemia by bilateral common carotid artery occlusion (BCCAO) on behavioral change and neuronal death and gliosis (astrocytosis and microgliosis) in gerbil hippocampal subregions (CA1-3 region and dentate gyrus). We performed spontaneous motor activity test to evaluate gerbil locomotor activity, cresyl violet staining to detect cellular distribution, neuronal nuclei immunohistochemistry to detect neuronal distribution, and Fluoro-Jade B histofluorescence to evaluate neuronal death. We also conducted immunohistochemical staining for glial fibrillary acidic protein and ionized calcium-binding adapter molecule 1 (Ibal) to evaluate astrocytosis and microgliosis, respectively. Animals subjected to 20-minute BCCAO died in at least 2 days. BCCAO for 15 minutes led to pyramidal cell death in hippocampal CA1-3 region 2 days later and granule cell death in hippocampal de匚tate gyrus 5 days later. Similar results were not found in animals subjected to 5-minute BCCAO. Gliosis was much more rapidly and severely progressed in animals subjected to 15-minute BCCAO than in those subjected to 5- minute BCCAO. Our results indicate that neuronal loss in the hippocampal formation following transient ischemia is significantly different according to regions and severity of transient ischemia. The experimental protocol was approved by Institutional Animal Care and Use Committee (AICUC) of Kangwon National University (approval No. KW-180124-1) on May 22, 2018. | Tae-Kyeong Lee Hyunjung Kim Minah Song Jae-Chul Lee Joon Ha Park Ji Hyeon Ahn Go Eun Yang Hyeyoung Kim Taek Geun Ohk Myoung Cheol Shin Jun Hwi Cho Moo-Ho Won | 2019 | Neural Regeneration Research2019，14，8： | 3 |
| 2 | A phase II study of S-1 and oxaliplatin (SOx) combination chemotherapy as a first-line therapy for patients with advanced gastric cancer显示文摘 | Sung Yong Oh Hyuk-Chan Kwon Sang-Ho Jeong Young-Tae Joo Young-Joon Lee Su Cho Myoung Hee Kang Se-il Go Gyeong-won Lee Hoon Kim Jung Hun Kang | 2012 | Investigational New Drugs2012，，1： | 1 |
| 3 | Total laparoscopic nervesparing radical trachelectomy显示文摘 | Park NY Chong GO Cho YL | 2009 | J Laparoendosc Adv Surg Tech A2009，19，1： | 1 |
| 4 | Snapping Microswitches with Adjustable Acceleration Threshold显示文摘 | Go J S Cho Y H Kwak B M | 1996 | Sensors and Actuators1996，54，1： | 1 |
| 5 | Quercetin exerts multiple inhibitory effects on vascular smooth muscle cells: role of ERK1/2, cell-cycle regulation, and matrix metalloproteinase-9显示文摘 | Moon SK Cho GO Jung SY | 2003 | Biochem Biophys Res Commun2003，301，： | 1 |
| 6 | A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits显示文摘 | Cho YS Go MJ Kim YJ | 2009 | Nat Genet2009，41，5： | 1 |
| 7 | A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits显示文摘 | Cho YS Go MJ Kim YJ | 2009 | Nat Genet2009，41，5： | 1 |
| 8 | A Study on Time-Dependent Low Temperature Power Performance of a Lithium-Ion Battery 显示文摘 | L Cho H M Choi W S Go J Y | 2012 | Journal of Power Sources2012，198，： | 1 |
| 9 | Phytogenic feed additives alleviate pathogenic Escherichia coli-induced intestinal damage through improving barrier integrity and inhibiting inflammation in weaned pigs显示文摘Background:This study was conducted to investigate the effects of each phytogenic feed additive(PFA;PFA1,bitter citrus extract;PFA2,a microencapsulated blend of thymol and carvacrol;PFA3,a mixture of bitter citrus extract,thymol,and carvacrol;PFA4,a premixture of grape seed,grape marc extract,green tea,and hops;PFA5,fenugreek seed powder)on the growth performance,nutrient digestibility,intestinal morphology,and immune response in weaned pigs infected with Escherichia coli(E.coli).Results:A total of 634-week-old weaned pigs were placed in individual metabolic cages and assigned to seven treatment groups.The seven treatments were as follows:1)NC;basal diet without E.coli challenge,2)PC;basal diet with E.coli challenge,3)T1;PC+0.04%PFA1,4)T2;PC+0.01%PFA2,5)T3;PC+0.10%PFA3,6)T4;PC+0.04%PFA4,7)T5;PC+0.10%PFA5.The experiments lasted in 21 d,including 7 d before and 14 d after the first E.coli challenge.In the E.coli challenge treatments,all pigs were orally inoculated by dividing a total of 10 mL of E.coli F18 for 3 consecutive days.The PFA-added groups significantly increased(P<0.05)average daily gain and feed efficiency and decreased(P<0.05)the fecal score at d 0 to 14 post-inoculation(PI).Tumor necrosis factorαwas significantly lower(P<0.05)in the PFA-added groups except for T1 in d 14 PI compared to the PC treatment.The T3 had a higher(P<0.05)immunoglobulin G and immunoglobulin A concentration compared to the PC treatment at d 7 PI.Also,T3 showed significantly higher(P<0.05)villus height:crypt depth and claudin 1 expression in ileal mucosa,and significantly downregulated(P<0.05)the expression of calprotectin compared to the PC treatment.Conclusions:Supplementation of PFA in weaned pigs challenged with E.coli alleviated the negative effects of E.coli and improved growth performance.Among them,the mixed additive of bitter citrus extract,thymol,and carvacrol showed the most effective results,improving immune response,intestinal morphology,and expression of tight junctions. | Se Yeon Chang Min Ho Song Ji Hwan Lee Han Jin Oh Yong Ju Kim Jae Woo An Young Bin Go Dong Cheol Song Hyun AhCho Seung Yeol Cho Dong Jun Kim Mi Suk Kim Hyeun Bum Kim Jin Ho Cho | 2023 | Journal of Animal Science and Biotechnology2023，14，1： | 1 |
| 10 | A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits显示文摘 | Cho YS Go MJ Kim YJ | 2009 | Nat Genet2009，41，5： | 1 |
| 11 | A Study on Time-dependent Low Temperature Power Performance of a Lithium Ion Battery显示文摘 | Cho H M Choi W S Go J Y | 2012 | Journal of Power Sources2012，198，15： | 1 |
| 12 | Inverted Y incision and trans-sacral approach in retroperitoneal aggressive angiomyxoma:a case report显示文摘 | Hong DG Chong GO Cho YL | 2013 | J Med Case Rep2013，7，： | 1 |
| 13 | A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits 显示文摘 | Cho YS Go MJ Kim YJ | 2009 | Nat Genet2009，41，： | 1 |
| 14 | A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits 显示文摘 | Cho YS Go MJ Kim YJ | 2009 | Nat Genet2009，41，5： | 1 |
| 15 | A phase II study of S-1 and oxaliplatin (SOx) combination chemotherapy as a first-line therapy for patients with advanced gastric cancer显示文摘 | Sung Yong Oh Hyuk-Chan Kwon Sang-Ho Jeong Young-Tae Joo Young-Joon Lee Su Cho Myoung Hee Kang Se-il Go Gyeong-won Lee Hoon Kim Jung Hun Kang | 2012 | Investigational New Drugs2012，，1： | 1 |
| 16 | Correlation between proliferatingindex and prognostic factors in papillary cystic tumors of the pancreas显示文摘 | Cho NH Go JH Jung SH | 1995 | J Korean Med Sci1995，10，5： | 1 |
| 17 | Experimental evaluation of anodic bonding process based on the Taguchi analysis of interfacial fracture toughness显示文摘 | Go J S Cho Y H | 1999 | Sensors & Actuators A1999，73，： | 1 |
| 18 | Snapping microswitches with adjustable acceleration threshold显示文摘 | Go J S Cho Y H Kwak B M | 1996 | Sensors and Actuaors:A1996，54，： | 1 |
| 19 | An experimental study on cell- impedance-controlled lithium transport though Li1-δ Mn2O4 film electrode with partially inactive fractal surface by analysis of potentiostatie current transient and linear sweep voltammogram 显示文摘 | GO J Y PYUN S I CHO S I | 2005 | Electroehimiea Aeta2005，50，27： | 1 |
| 20 | Massive congenital intracranial teratoma-an autopsy case显示文摘 | Go JH Kim TS Cho SH | 1995 | Yonsei Med J1995，36，3： | 1 |
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