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| 1 | Randomised controlled trial comparing modified Sano's and narrow band imaging international colorectal endoscopic classifications for colorectal lesions显示文摘AIM To assess the utility of modified Sano′s(MS) vs thenarrow band imaging international colorectal endoscopic(NICE) classification in differentiating colorectal polyps.METHODS Patients undergoing colonoscopy between 2013 and 2015 were enrolled in this trial.Based on the MS or the NICE classifications,patients were randomised for real-time endoscopic diagnosis.This was followed by biopsies,endoscopic or surgical resection.The endoscopic diagnosis was then compared to the final(blinded) histopathology.The primary endpoint was the sensitivity(Sn),specificity(Sp),positive predictive value(PPV) and negative predictive value(NPV) of differentiating neoplastic and non-neoplastic polyps(MSⅡ/Ⅱo/Ⅲa/Ⅲb vs I or NICE 1 vs 2/3).The secondary endpoints were 'endoscopic resectability'(MSⅡ/Ⅱo/Ⅲa vs Ⅰ/Ⅲb or NICE 2 vs 1/3),NPV for diminutive distal adenomas and prediction of post-polypectomy surveillance intervals.RESULTS A total of 348 patients were evaluated.The Sn,Sp,PPV and NPV in differentiating neoplastic polyps from non-neoplastic polyps were,98.9%,85.7%,98.2% and 90.9% for MS;and 99.1%,57.7%,95.4% and 88.2% for NICE,respectively.The area under the receiver operating characteristic curve(AUC) for MS was 0.92(95%CI:0.86-0.98);and AUC for NICE was 0.78(95%CI:0.69,0.88).The Sn,Sp,PPV and NPV in predicting 'endoscopic resectability' were 98.9%,86.1%,97.8% and 92.5% for MS;and 98.6%,66.7%,94.7% and 88.9% for NICE,respectively.The AUC for MS was 0.92(95%CI:0.87-0.98);and the AUC for NICE was 0.83(95%CI:0.75-0.90).The AUC values were statistically different for both comparisons(P = 0.0165 and P = 0.0420,respectively).The accuracy for diagnosis of sessile serrated adenoma/polyp(SSA/P) with high confidence utilizing MS classification was 93.2%.The differentiation of SSA/P from other lesions achieved Sp,Sn,PPV and NPV of 87.2%,91.5%,89.6% and 98.6%,respectively.The NPV for predicting adenomas in diminutive rectosigmoid polyps(n = 150) was 96.6% and 95% with MS and NICE respectively.The calculated accuracy of post-polypectomy surveillance for MS group was 98.2%(167 out of 170) and for NICE group was 92.1%(139 out of 151).CONCLUSION The MS classification outperformed the NICE classification in differentiating neoplastic polyps and predicting endoscopic resectability.Both classifications met ASGE PIVI thresholds. | Leonardo Zorrón Cheng Tao Pu Kuan Loong Cheong Doreen Siew Ching Koay Sze Pheh Yeap Amanda Ovenden Mahima Raju Andrew Ruszkiewicz Philip W Chiu James Y Lau Rajvinder Singh | 2018 | World Journal of Gastrointestinal Endoscopy2018，10，9： | 4 |
| 2 | Nitric oxide counteracts the senescence of detached rice leaves induced by dehydration and polyethylene glycol but not by sorbitol 显示文摘 | Fang Y C Shih Y H Ching H K | 2002 | Plant Growth Regulation2002，38，： | 1 |
| 3 | Interesting physical properties of the new spinel phase of Si《,3》N《,4》 and C《,3》N《,4》显示文摘 | Ouyang L Z and Ching W Y | 1999 | Physical Review Letters1999，83，： | 1 |
| 4 | Demonstration of receptor binding properties of VP2 of very virulent strain infectious bursal disease virus on Veto cells显示文摘 | Chi W Y Yin S Y Ching M M | 2007 | Virus Res2007，123，1： | 1 |
| 5 | Theoretical prediction of the structure and properties of cubic spinel nitrides显示文摘 | Mo S D Ouyang L Z | 2002 | Journal of the American Ceramic Society2002，85，： | 1 |
| 6 | Synthesis of continuous MOF-5 membranes on porous a- alumina substrates 显示文摘 | Liu Y Ng Z Khan E Jeong H K Ching C Lai Z | 2009 | Microporous Mesoporous Materials2009，118，123： | 1 |
| 7 | Theoretical Construction of the Magnetic Hamiltonian and Zero-temperature Anisotropie Energy in Nd2FetaB 显示文摘 | ZHONG Xuefu CHING W Y | 1989 | Phys Rev B1989，40，： | 1 |
| 8 | Electronic and optrcal properties of three phases of titanium dioxide: futile anatase and brookite 显示文摘 | MO SHANG DI CHING W Y | 1995 | Phys Rev B1995，51，13： | 1 |
| 9 | Solar photocatalytic degradation of gaseous formaldehyde by sol-gel TiO2 thin fihn for enhancement of indoor air quality显示文摘 | Ching W H Leung Michael Leung Dennis Y C | 2004 | Solar Energy2004，77，2： | 1 |
| 10 | Imerphase precipltadon of nanometer-sized carbides in a titanium molybdenum bearing low carbon steel显示文摘 | Hung W Y Po Y C Ching Y H e* al | 2011 | Acta Materialia2011，59，： | 1 |
| 11 | Interesting physical properties of the new spinel phase of Si3 N4 and C3N4显示文摘 | MO S D OUYANG L CHING W Y | 1999 | Phys Rev Lett1999，83，24： | 1 |
| 12 | Detection of machine failure:hidden Markov model approach显示文摘 | TAI A H CHING W K CHAN L Y | 2009 | Computers and Industrial Engineering2009，57，2： | 1 |
| 13 | Temperature-insensitive linear strain measurement using two fiber Bragg gratings in a power detection scheme显示文摘 | CHING Y L WANG L K LIU W F | 2001 | Opt Com2001，197，4： | 1 |
| 14 | Antioxidant inhibition of oxygen radicals for measurement of total antioxidant capacity in biological samples显示文摘 | Simon Y L Ching Jon Hall Kevin Croft | 2006 | Analytical Biochemistry2006，353，2： | 1 |
| 15 | Suggesting a di-omega dibaryon search in heavy ion collision experiments显示文摘 | ZHANG Z Y YU Y W CHING C R | 2000 | Phys Rev2000，61，06： | 1 |
| 16 | Intrinsic mechanical properties of 20 MAX-phase compounds 显示文摘 | Ching W Y Mo Y Aryal S | 2013 | J Am Ceram Soc2013，96，7： | 1 |
| 17 | Efficient evaluation ofreliability for slopes with circular slip surfaces usingimportance sampling 显示文摘 | Ching J Phoon K K Hu Y G | 2009 | Journal of Geotechnical andGeoenvironmental Engineering2009，135，6： | 1 |
| 18 | Calculation of Crystal Field Parameters in NdzFeI4B Using Realistic Energy-band Results 显示文摘 | ZHONG Xuefu CHING W Y | 1988 | J Appl Phys1988，64，10： | 1 |
| 19 | Binaural benefits for adults who use hearing aids and cochlear implants in opposite ears显示文摘 | CHING T Y INCERTI P HILL M | 2004 | Ear Hear2004，25，： | 1 |
| 20 | Identification and characterization of the hypoxia-responsive element in human stanniocalcin-l gene 显示文摘 | Law A YS Ching L Y Lai KP | 2010 | Mol Cell Endocrinol2010，314，1： | 1 |
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