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| 1 | Hydromagnetic flow over a surface stretching with a power-law velocity显示文摘 | Chiam T C | 1995 | Int J of Eng Sci1995，33，3： | 1 |
| 2 | Curry consumption and cognitive function in the elderly显示文摘 | Ng T P Chiam P C Lee T | 2006 | Am J Epidemiol2006，164，9： | 1 |
| 3 | Vacuum membrane distillation processes for aqueous solution treatment-A review显示文摘 | Chiam C K Sarbatly R | 2013 | Chem Eng Processing: Process Intensification2013，74，8： | 1 |
| 4 | Serum outperforms plasma in small extracellular vesicle microRNA biomarker studies of adenocarcinoma of the esophagus显示文摘BACKGROUND Circulating microRNAs(miRNAs)are potential biomarkers for many diseases.However,they can originate from non-disease specific sources,such as blood cells,and compromise the investigations for miRNA biomarkers.While small extracellular vesicles(sEVs)have been suggested to provide a purer source of circulating miRNAs for biomarkers discovery,the most suitable blood sample for sEV miRNA biomarker studies has not been defined.AIM To compare the mi RNA profiles between matched serum and plasma s EV preparations to determine their suitability for biomarker studies.METHODS Matched serum and plasma samples were obtained from 10 healthy controls and10 patients with esophageal adenocarcinoma.s EV isolates were prepared from serum and plasma using Exo Quick TM and quantified using Nano Sight.RNA was extracted from s EV preparations with the mi RNeasy Serum/Plasma kit and profiled using the Taqman Openarray q PCR.The overall mi RNA content and theexpression of specific mi RNAs of reported vesicular and non-vesicular origins were compared between serum and plasma s EV preparations.The diagnostic performance of a previously identified multi-mi RNA biomarker panel for esophageal adenocarcinoma was also compared.RESULTS The overall mi RNA content was higher in plasma s EV preparations(480 mi RNAs)and contained 97.5%of the mi RNAs found in the serum s EV preparations(412 mi RNAs).The expression of commonly expressed mi RNAs was highly correlated(Spearman’s R=0.87,P<0.0001)between the plasma and serum s EV preparations,but was consistently higher in the plasma s EV preparations.Specific blood-cell mi RNAs(hsa-mi R-223-3 p,hsa-mi R-451 a,mi R-19 b-3 p,hsa-mi R-17-5 p,hsa-mi R-30 b-5 p,hsa-mi R-106 a-5 p,hsa-mi R-150-5 p and hsa-mi R-92 a-3 p)were expressed at 2.7 to 9.6 fold higher levels in the plasma s EV preparations compared to serum s EV preparations(P<0.05).In plasma s EV preparations,the percentage of protein-associated mi RNAs expressed at relatively higher levels(Ct 20-25)was greater than serum s EV preparations(50%vs 31%).While the percentage of vesicle-associated mi RNAs expressed at relatively higher levels was greater in the serum s EV preparations than plasma s EV preparations(70%vs 44%).A 5-mi RNA biomarker panel produced a higher cross validated accuracy for discriminating patients with esophageal adenocarcinoma from healthy controls using serum s EV preparations compared with plasma s EV preparations(AUROC 0.80 vs 0.54,P<0.05).CONCLUSION Although plasma s EV preparations contained more mi RNAs than serum s EV preparations,they also contained more mi RNAs from non-vesicle origins.Serum appears to be more suitable than plasma for s EV mi RNAs biomarkers studies. | Karen Chiam George C Mayne Tingting Wang David I Watson Tanya S Irvine Tim Bright Lorelle T Smith Imogen A Ball Joanne M Bowen Dorothy M Keefe Sarah K Thompson Damian J Hussey | 2020 | World Journal of Gastroenterology2020，26，20： | 1 |
| 5 | Balancing exploration and exploitation with adaptive variation for evolutionary multiobjective optimization显示文摘 | TAN K C CHIAM S C MAMWN A A | 2009 | European Journal of Operational Research2009，197，2： | 1 |
| 6 | Heat transfer with variable thermal conductivity in a stagnation point towards a stretching sheet显示文摘 | Chiam T C | 1996 | International Communications in Heat and Mass Transfer1996，23，2： | 1 |
| 7 | Curry consumption and cognitive function in the elderly显示文摘 | NG T P CHIAM P C LEE T | 2006 | Am J Epiderniol2006，164，： | 1 |
| 8 | A competitive and cooperative co-evolutionary approach to multi-objective particle swarm optimization algorithm design 显示文摘 | C K Goh K C Tan D S Liu S C Chiam | 2010 | European Jourllal of Operational Research2010，202，1： | 1 |
| 9 | Application of VUV irradiation to promote the wet etch resistance of PSZ-SOG film inside the gap显示文摘 | Chiaming C Minghsin Y Hungju C | 2010 | Microelectronic Engineering2010，87，： | 1 |
| 10 | Heat transfer with variable conductivity in stagnation-point flow towards a stretching sheet 显示文摘 | CHIAM T C | 1966 | Int Comm Heat Mass Transfer1966，23，： | 1 |
| 11 | Heat transfer in a fluid with variable thermal conductivity over a linearly stretching sheet 显示文摘 | CHIAM T C | 1998 | Acta Mech1998，129，： | 1 |
| 12 | Heat transfer in a fluid with variable thermal conductivity over a linearly stretching sheet显示文摘 | Chiam T C | 1998 | Acta Mechanica1998，129，12： | 1 |
| 13 | Heat transfer with variable thermal conductivity in a stagnation-point flow towards stretching sheet显示文摘 | Chiam T C | 1996 | Int Commun Heat Mass Transfer1996，23，2： | 1 |
| 14 | Oncogenic osteomalacia-hy-pophosphataemic spectrum from ' benignancy ' to ' malignancy'显示文摘 | Chiam P Tan H C Bee Y M | 2013 | Bone2013，53，1： | 1 |
| 15 | Vacuum membrane distillation processes for aqueous solution treatment A review 显示文摘 | CHIAM C K SARBATLY R | 2013 | Chemical Engineering and Processing2013，，74： | 1 |
| 16 | Characterization of Spiral Inductors with Patterned Floating Structures显示文摘 | CHIAMING A C | 2004 | IEEE Transactions on Microwave Theory and Techniques2004，52，5： | 1 |
| 17 | Heat transfer in a fluid with variable thermal conductivity over a linearly stretching sheet 显示文摘 | Chiam T C | 1998 | Acta Mechanica1998，129，12： | 1 |
| 18 | Intraoperative ultrasoundguided excision of nonpalpable breast lesions 显示文摘 | Bennett I C Greenslade J Chiam H | 2005 | World J Surg2005，29，3： | 1 |
| 19 | Percutaneous transcatheter left atrial appendage exclusion in atrial fibrillation显示文摘 | Chiam P T Ruiz C E | | 0，，04： | 1 |
| 20 | Stagnation-point flow towards a stretching plate显示文摘 | Chiam T C | 1994 | J Phy Soc Jap1994，63，7： | 1 |
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