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| 1 | The Genome Sequence Archive Family: Toward Explosive Data Growth and Diverse Data Types显示文摘The Genome Sequence Archive(GSA)is a data repository for archiving raw sequence data,which provides data storage and sharing services for worldwide scientific communities.Considering explosive data growth with diverse data types,here we present the GSA family by expanding into a set of resources for raw data archive with different purposes,namely,GSA(http://gffzz77e3413bc06540edsf56bv906qn0q6fxk.ffgz.tsg.suse.edu.cn/gsa/),GSA for Human(GSA-Human,http://gffzz77e3413bc06540edsf56bv906qn0q6fxk.ffgz.tsg.suse.edu.cn/gsa-human/),and Open Archive for Miscellaneous Data(OMIX,http://gffzz77e3413bc06540edsf56bv906qn0q6fxk.ffgz.tsg.suse.edu.cn/omix/).Compared with the 2017 version,GSA has been significantly updated in data model,online functionalities,and web interfaces.GSA-Human,as a new partner of GSA,is a data repository specialized in human genetics-related data with controlled access and security.OMIX,as a critical complement to the two resources mentioned above,is an open archive for miscellaneous data.Together,all these resources form a family of resources dedicated to archiving explosive data with diverse types,accepting data submissions from all over the world,and providing free open access to all publicly available data in support of worldwide research activities. | Tingting Chen Xu Chen Sisi Zhang Junwei Zhu Bixia Tang Anke Wang Lili Dong Zhewen Zhang Caixia Yu Yanling Sun Lianjiang Chi Huanxin Chen Shuang Zhai Yubin Sun Li Lan Xin Zhang Jingfa Xiao Yiming Bao Yanqing Wang Zhang Zhang Wenming Zhao | 2021 | Genomics, Proteomics & Bioinformatics2021，19，4： | 38 |
| 2 | Coal analysis using the pulsed neutron generator显示文摘A prototype of elemental analyzer for coal has been developed by using a PFTNA (pulse fast thermalneutron analysis) system. The PFTNA technology is based on the reactions such as (n, γ), (n, n'γ), (n, Pγ), etc. byexamining the characteristic gamma rays emitted. In our prototype a pulsed neutron generator provides 14 MeV pulseneutrons, which contribute to the separation of spectrum Ⅱ (the sum of capture and activation spectrum) fiom spec-trum Ⅰ (the sum of inelastic, capture and activation spectrum), and thus to the measurement of C and O contents incoal. Data management is completed by computer program using the least-square regression method. The experimentin Changshan Power Plant for 3 months showed that the precision of calorific value, whole water, volatile content andash content is 0.5 k J/kg, 1.0 wt%, 2.0 wt% and 1.5 wt%, respectively. | JING Shi-Wei, LIU Lin-Mao, GU De-Shan, QIAO Shuang, SANG Hai-Feng, ZHANG Yong-Xiang, ZHANG Zhong-Hua,CAO Xi-Zheng, TIAN Yu-Bing, CHI Yan-Tao, ZHAO Xin-Hui (The Radiation Technology Institute of the Northeast Normal University, Changchun 130024) | 2003 | Nuclear Science and Techniques2003，14，4： | 6 |
| 3 | Effect of HIV-1 Tat on Secretion of TNF-α and IL-1β by U87 Cells in AIDS Patients with or without AIDS Dementia Complex显示文摘Objective To explore the role of HIV-1 tat gene variations in AIDS dementia complex(ADC) pathogenesis.Methods HIV-1 tat genes derived from peripheral spleen and central basal ganglia of an AIDS patient with ADC and an AIDS patient without ADC were cloned for sequence analysis. HIV-1 tat gene sequence alignment was performed by using CLUSTAL W and the phylogentic analysis was conducted by using Neighbor-joining with MEGA4 software. All tat genes were used to construct recombinant retroviral expressing vector MSCV-IRES-GFP/tat. The MSCV-IRES-GFP/tat was cotransfected into 293T cells with pCMV-VSV-G and pUMVC vectors to assemble the recombinant retrovirus. After infection of gliomas U87 cells with equal amount of the recombinant retrovirus, TNF-α, and IL-1β concentrations in the supernatant of U87 cells were determined with ELISA. Results HIV-1 tat genes derived from peripheral spleen and central basal ganglia of the AIDS patient with ADC and the other one without ADC exhibited genetic variations. Tat variations and amino acid mutation sites existed mainly at Tat protein core functional area(38-47aa). All Tat proteins could induce U87 cells to produce TNF-α and IL-1β, but the level of IL-1β production was different among Tat proteins derived from the ADC patient's spleen, basal ganglia, and the non-ADC patient's spleen. The level of Tat proteins derived from the ADC patient's spleen, basal ganglia, and the non-ADC patient's spleen were obviously higher than that from the non-ADC patient's basal ganglia. Conclusion Tat protein core functional area(38-47aa) may serve as the key area of enhancing the secretion of IL-1β. This may be related with the neurotoxicity of HIV-1 Tat. | ZHAO Li PU Shuang Shuang GAO Wen Hua CHI Yuan Yuan WEN Hong Ling WANG Zhi Yu SONG Yan Yan YU Xue Jie | 2014 | Biomedical and Environmental Sciences2014，27，2： | 5 |
| 4 | Breeding for Parents of Hybrid Rice with Maize pepc Gene显示文摘The results of the investigation on transgenic rice with maize C4-specific phosphoenolpyruvate carboxylase (pepc) gene showed that the transgenic rice plants with the maize pepc gene expressed at high level and the maize PEPC expression was inherited in the progenies in a Mendelian manner. The transgenic plants had PEPC activity of more than 10-fold higher than untransformed plants. As compared with untransformed plants, the panicle per plant, spikelet per panicle, 1000-grain weight and grain-weight per plant for transgenic plants increased by 14.9 %, 5.7%, 1.3 % and 13.9 %, respectively. By crossing the maize pepc gene was incorporated into the parents of hybrid rice, which were the photo-sensitive genic male sterile (PGMS)lines of two-line hybrid rice such as Peiai64s, 7001s, 2302s, 2304s and 2306s-1, and the BT type of cytoplasmic male sterile (CMS) line of three-line hybrid rice such as Shuangjiu A, and restorer lines 5129, Wanjing97 in the spring of 1998. The following progresses were made: (1) The inheritance of the high-level expression of the maize PEPC was stable in different genetic background of rice; (2) PEPC activity of F1 hybrid was the mean of the two parents. Its saturated photosynthetic rate (Pn) rose to 50 % higher than that of the receptor parent. These results demonstrated that it is possible to increase the vigor of the rice plant by transgenic approach with maize pepc gene; (3) The activity of PEPC in leaf could be considered as the major physiological index because the correlation coefficient between PEPC activity and Pn was 0.6470 * *; (4) We have developed three rice lines with maize pepc gene; (5) The selection method of high photosynthetic efficiency rice has been established, which includes soaking seeds into solution of hygromycin phosphotransferase to germinate, tracing the pepc gene by PCR analysis, evaluating the performance of the rice plants in the field and examining PEPC activities and Pn of rice plants with maize pepc gene. | WANG De-zheng, JIAO De-mao, WU Shuang, LI Xia, LI Li, CHI Wei, WANG Shou-hai, LI Cheng-quan, LUO Yan-chang and WANG Xiu-feng(Rice Research Institute , Anhui Academy of Agricultural Sciences , Hefei 230031 , P. R . China Institute of Agrobiological Genetics and Physiology, Jiangsu Academy of Agricultural Sciences , Nanjing 210014 , P. R . China) | 2002 | Agricultural Sciences in China2002，1，10： | 2 |
| 5 | Optimization of medium and cultivation conditions for pullulan production by a new pullulan- producing yeast strain显示文摘 | CHI Zheng - ming ZHAO Shuang - zhi | 2003 | Enzyme and Microbial Technology2003，33，： | 1 |
| 6 | Anticancer Effects of Fusion Protein CAtin on DMBA-induced Carcinogenesis in Buccal Pouch of Chinese Hamster显示文摘Aberrant expression of carcinoembryonic antigen(CEA) is a common feature for multiple types of cancer,which makes it an attractive target for anticancer therapy.CAtin is a novel dual cancer-specific fusion protein,composed of an anti-CEA single-chain disulfide-stabilized Fv antibody(scdsFv) and Apoptin,a tumor-specific apoptosis-inducing protein.Oral squamous cell carcinoma(OSCC) is an important healthcare problem in the clinic.To evaluate the anticancer effects of CAtin on OSCC,7,12-dimethylbenz[a]anthracene(DMBA) was used to induce oral carcinogenesis and premalignant lesions in the buccal pouch of Chinese hamster,and the antitumor effects of CAtin were determined in pre-cancer,cancer and post-operatative cancer models,respectively.The results show that the administration of CAtin delayed the malignant transformation of early stage cancerous lesions,inhibited the growth of established solid oral tumors and reduced the post-operatative relapse of lesions,with no significant systemic toxicity.This study demonstrates that CAtin may have potential for the treatment of OSCC,and the development of preventive strategies based on CAtin may offer a practical approach for the treatment of human oral tumors. | BAI Jie-ying LI Xiao LI Chang ZHANG Xiao-fei LI Zhi-xin ZHAO Shuang LIU Xiao ZENG Lin CHI Bao-rong | 2012 | Chemical Research in Chinese Universities2012，28，2： | 1 |
| 7 | Prevalence and asso- ciated factors of depressive symptoms among Chinese doctors A cross - sectional survey 显示文摘 | Jia - NaWang Wei Sun Tie - Shuang Chi | 2010 | Int Arch Occup Environ Health2010，83，8： | 1 |
| 8 | Construction of Virtual Simulation Platform for Tourism显示文摘This paper introduced the application of the WebGIS and virtual reality technology in the tourism industry and analyzed the existing problems in the tourism information system.Taking Daqing Oil Field Scenic Sport as an example,it introduced a method of constructing the virtual simulation platform for tourism based on the combination of WebGIS and virtual reality technology.Through the virtual simulation platform of Daqing Tourism Scenic Spot,it verified the design idea,methods,and technical feasibility of the virtual tourism system,and built a specific,feasible,and practical virtual simulation platform for tourism.It showed the bright prospects of virtual tourism development based on WebGIS and virtual reality technology. | Shuang CHENG Qiuju XIE Jingfu ZHU Ya GAO Shuang WANG Ruichen CHI Ruijian LIU | 2017 | Asian Agricultural Research2017，9，2： | 1 |
| 9 | Optical Molecular Imaging Frontiers in Oncology: The Pursuit of Accuracy and Sensitivity显示文摘Cutting-edge technologies in optical molecular imaging have ushered in new frontiers in cancer research, clinical translation, and medical practice, as evidenced by recent advances in optical multimodality imaging, Cerenkov luminescence imaging(CLI), and optical imageguided surgeries. New abilities allow in vivo cancer imaging with sensitivity and accuracy that are unprecedented in conventional imaging approaches. The visualization of cellular and molecular behaviors and events within tumors in living subjects is improving our deeper understanding of tumors at a systems level. These advances are being rapidly used to acquire tumor-to-tumor molecular heterogeneity, both dynamically and quantitatively, as well as to achieve more effective therapeutic interventions with the assistance of real-time imaging. In the era of molecular imaging, optical technologies hold great promise to facilitate the development of highly sensitive cancer diagnoses as well as personalized patient treatment—one of the ultimate goals of precision medicine. | Kun Wang Chongwei Chi Zhenhua Hu Muhan Liu Hui Hui Wenting Shang Dong Peng Shuang Zhang Jiezuo Ye Haixiao Liu Jie Tian | 2015 | Engineering2015，1，3： | 1 |
| 10 | Overexpression of the dependence receptor UNC5H4 inhibits cell migration and invasion, and triggers apoptosis in neuroblastoma cell显示文摘 | Hong Wang Bin Zhang Min Gu Shuang Li Zuofei Chi Liangchun Hao | 2014 | Tumor Biology2014，，6： | 1 |
| 11 | Reduction of fatty acid flux results in enhancement of astaxanthin synthesis in a mutant strain of Phaffia rhodozyma 显示文摘 | Miao Lili Wang Yongxing Chi Shuang etal | 2010 | Journal of Industrial Microbiology & Biotechnology2010，37，6： | 1 |
| 12 | Host gut-derived Bacillus probiotics supplementation improves growth performance, serum and liver immunity, gut health, and resistive capacity against Vibrio harveyi infection in hybrid grouper(♀Epinephelus fuscoguttatus × ♂Epinephelus lanceolatus)显示文摘Several reports have revealed the vital role that probiotics play in fish growth and health.However,few works are available for host gut-derived probiotics on the growth,immunity,and gut microbiota of fish,especially in hybrid grouper (♀Epinephelus fuscoguttatus×♂Epinephelus lanceolatus) due to their isolation difficulty and functional verification.This study aimed at assessing 3 host gut-derived Bacillus species?effects on the growth,immune and antioxidant-biochemical responses,haematological parameters,intestinal morphology,immune-related gene expression,gut microbiota,and disease resistance against Vibrio harveyi in hybrid grouper.A total of 480 hybrid grouper (initial weight=9.03±0.02 g) were randomly allotted into 4 groups,namely,the group fed a basal diet without probiotic inclusion (control,B0),the group fed the basal diet with Bacillus velezensis GPSAK4 (BV),the group fed the basal diet with Bacillus subtilis GPSAK9 (BS),and the group fed the basal diet with Bacillus tequilensis GPSAK2 (BT) strains at 1.0×10^(9)CFU/g.After a 6-week feeding trial,the results revealed significant improvements (P<0.05) in the growth performance,whole fish-body proximate composition,blood haematological parameters,serum,liver,and intestinal biochemical indexes,intestinal morphology,and protection against V.harveyi pathogen in the probiotic-treated groups compared with the untreated.Additionally,the expressions of intestinal tight junction genes (occludin and ZO1),pro-and anti-inflammatory genes,including IL1β,IL6,IL8,TNFa,MyD88,IL10,and TGFβ,were upregulated (P<0.05) after Bacillus species administration.Host gut-derived Bacillus supplementation shaped the gut microbiota by significantly increasing (P<0.05) the relative abundance of Proteobacteria,Bacteroidetes,Actinobacteria (except the BS group),Acidobacteria(except the BT group),Cyanobacteria (except the BV and BT groups),and Verrucomicrobia phyla,as well as known beneficial genera (Romboutsia,Turicibacter,Epulopiscium,Clostridium_sensu_stricto 1 and 13,Lactobacillus,and Bacillus),but significantly decreased (P<0.05) the abundance of Firmicutes,Chloroflexi,and Fusobacteria phyla,and purported pathogenic genera (Staphylococcus and Photobacterium) compared with the control group.Collectively,the results suggest that B.velezensis GPSAK4,B.subtilis GPSAK9(especially this strain),B.tequilensis GPSAK2 dietary supplementation at 1.0×10^(9)CFU/g has positive effects on the intestinal health of hybrid grouper via microbial composition modulation,thus enhancing the assimilation and absorption of nutrients to boost fish growth,immunity,and disease resistance. | Kwaku Amoah Beiping Tan Shuang Zhang Shuyan Chi Qihui Yang Hongyu Liu Yuanzhi Yang Haitao Zhang Xiaohui Dong | 2023 | Animal Nutrition2023，，3： | 0 |
| 13 | Natural co-infection of fowl adenovirus type E-8b and avian hepatitis E virus in parental layer breeders in Hebei,China显示文摘Dear Editor,Fowl adenovirus(FAdV)and avian hepatitis E virus(aHEV)are the most important causative agents of hepatic injury,representing one of the greatest health concerns in layer chicken flocks(LCFs)in China and causes substantial economic losses.FAdVs are non-enveloped,double-stranded DNA viruses containing a genome of 43–45 kb in size and belong to the genus Aviadenovirus in the family of Adenoviridae(Hess,2000).Based on restriction enzyme digestion patterns and serum cross-neutralization tests,FAdV is currently clustered into five species(FAdV-A–FAdV-E)with 12 serotypes(FAdV-1 to-7,FAdV-8a,FAdV-8b,and FAdV-9 to-11).Different serotypes of FAdVs cause different clinical symptoms in poultry flocks.FAdV-1 can induce gizzard erosion in chickens,whereas inclusion body hepatitis(IBH)in chickens is often associated with FAdV-2,-8a,-8b,and-11.FAdV-4 causes hydropericardium hepatitis syndrome and IBH in chickens,and its infections have caused severe economic losses in the global poultry industry(Ye et al.,2016).Avian hepatitis E virus(aHEV)is a major causative agent of big liver and spleen disease(BLS),hepatitis splenomegaly syndrome,and hepatic rupture hemorrhage syndrome(HRHS)in chickens(Sun et al.,2019). | Lidan Hou Zengna Chi Yawen Zhang Qi Xue Tianshu Zhai Shuang Chang Jia Wang Peng Zhao | 2023 | Virologica Sinica2023，38，2： | 0 |
| 14 | Identification and Expression Profile of a Neuropeptide LFRFamide-Like Gene During Different Stages of Gonadal Development in the Cephalopod Sepia pharaonis显示文摘Neuropeptides are widely distributed in vertebrates and invertebrates,regulating a variety of physiological activities in the organisms,such as metabolism,feeding and reproduction.In this study,to explore the function of neuropeptide LFRFamide in Sepia pharaonis,the full-length cDNA of LFRFamide-like gene(named SpLFRFL,MG869822.1)was identified with rapid amplification of cDNA ends(RACE)method.The sequence of SpLFRFL was 860 bp in length and encoded 188 amino acids containing 4 different mature peptides:1 copy of PHTPFRFamide,NSLFRFamide,TIFRFamide,and 3 copies of GNLFRFamide.Multiple alignment and phylogenetic analysis results showed that SpLFRFL shared high identity with LFRFamides of Sepia officinalis and Sepiella japonica and had the closest relationship with them.Through quantitative Real-time PCR(qRT-PCR),it was found that the SpLFRFL gene was highly expressed in the optic lobe and brain at three different stages during gonad development in both genders.Moreover,the four mature peptides at a concentration of 0.01μmol L^(−1) could inhibit the protein synthesis in the Chinese hamster ovary cell strain-K1(CHOK1)induced by SpGnRH.These data suggest that SpLFRFL might be involved in the development and reproduction of S.pharaonis.The results can contribute to future studies on neuropeptide evolution and function and benefit the cuttlefish farming. | QIU Jiayin SUN Lianlian LI Shuang ZHOU Xu CHI Changfeng ZHENG Libing | 2024 | Journal of Ocean University of China2024，23，2： | 0 |
| 15 | Microwave-induced thermoacoustic imaging of joints显示文摘Due to the complexity of joint structures and the diversity of disorders in the joints,the diagnosis of joint diseases is challenging.Current clinical diagnostic techniques for evaluating joint diseases,such as arthritis,have strengths and weaknesses.New imaging techniques need to be developed for the diagnosis or auxiliary diagnosis of arthritis.As an emerging nonintrusive low-cost imaging method,microwave-induced thermoacoustic imaging(TAI)can present tissue morphology while providing the tissue microwave energy absorption density distribution related to dielectric properties.TAI is currently in development to potentially visualize joint anatomic structures and to detect arthritis.Here,we offer a mini review to summarize the status of research on TAI of joints and present an outlook to the future development of TAI in the detection of joint diseases. | Zi-Hui Chi Shuang Du Yang Wang Lin Huang Dan Wu Hua-Bei Jiang | 2023 | Journal of Electronic Science and Technology2023，21，2： | 0 |
| 16 | YAP调控巨噬细胞极化和肠道微生物稳态进而加重炎症性肠病显示文摘文章简介炎症性肠病(IBD)是一种慢性肠道炎症紊乱的疾病。YAP是Hippo通路中的转录共激活因子,但目前尚不清楚YAP如何调控巨噬细胞极化、炎症反应及肠道微生物稳态。本研究发现,与YAP在肠道上皮细胞发挥保护IBD的作用不同,巨噬细胞中缺失YAP才能有效减轻IBD。 | 周欣 Weiyun Li Shuang Wang Panli Zhang Qiong Wang Jun Xiao Chi Zhang Xin Zheng Xiaoyan Xu Shengjie Xue Lijian Hui Hongbin Ji 魏滨 王红艳 | 2020 | 科学新闻2020，，2： | 0 |
| 17 | Balanced Discriminative Transfer Feature Learning for Visual Domain Adaptation显示文摘Transfer learning aims to transfer source models to a target domain.Leveraging the feature matching can alleviate the domain shift effectively,but this process ignores the relationship of the marginal distribution matching and the conditional distribution matching.Simultaneously,the discriminative information of both domains is also neglected,which is important for improving the performance on the target domain.In this paper,we propose a novel method called Balanced Discriminative Transfer Feature Learning for Visual Domain Adaptation(BDTFL).The proposed method can adaptively balance the relationship of both distribution matchings and capture the category discriminative information of both domains.Therefore,balanced feature matching can achieve more accurate feature matching and adaptively adjust itself to different scenes.At the same time,discriminative information is exploited to alleviate category confusion during feature matching.And with assistance of the category discriminative information captured from both domains,the source classifier can be transferred to the target domain more accurately and boost the performance of target classification.Extensive experiments show the superiority of BDTFL on popular visual cross-domain benchmarks. | SU Limin ZHANG Qiang LI Shuang Chi Harold LIU | 2020 | ZTE Communications2020，18，4： | 0 |
| 18 | Observation of 1D Fermi arc states in Weyl semimetal TaAs显示文摘Fermi arcs on Weyl semimetals exhibit many exotic quantum phenomena.Usually found on atomically flat surfaces with approximate translation symmetry,Fermi arcs are rooted in the peculiar topology of bulk Bloch bands of 3D crystals.The fundamental question of whether a 1D Fermi arc can be probed remains unanswered.Such an answer could significantly broaden potential applications of Weyl semimetals.Here,we report a direct observation of robust edge states on atomic-scale ledges in TaAs using low-temperature scanning tunneling microscopy/spectroscopy.Spectroscopic signatures and theoretical calculations reveal that the 1D Fermi arcs arise from the chiral Weyl points of bulk crystals.The crossover from 2D Fermi arcs to eventual complete localization on 1D edges was arrested experimentally on a sequence of surfaces.Our results demonstrate extreme robustness of the bulk-boundary correspondence,which offers topological protection for Fermi arcs,even in cases in which the boundaries are at the atomic-scale.The persistent 1D Fermi arcs can be profitably exploited in miniaturized quantum devices. | Xiaohu Zheng Qiangqiang Gu Yiyuan Liu Bingbing Tong Jian-Feng Zhang Chi Zhang Shuang Jia Ji Feng Rui-Rui Du | 2022 | National Science Review2022，9，8： | 0 |
| 19 | Soybeanβ-conglycinin and glycinin reduced growth performance and the intestinal immune defense and altered microbiome in juvenile pearl gentian groupers Epinephelus fuscoguttatus♀×Epinephelus lanceolatus♂显示文摘The utilization efficiency of soy protein is affected by its 2 anti-nutritional substancesdthe antigens bconglycinin and glycinin.This study investigated their effects on the growth performance,intestinal immune defense,andmicrobiome in juvenile pearl gentian groupers(Epinephelus fuscoguttatus♀×Epinephelus lanceolatus♂).Three isonitrogenous and isolipidic diets were formulated containing fishmeal supplemented with 70 g/kgβ-conglycinin or 100 g/kg glycinin,or no supplementation(control).Each experimental diet was fed to quadruplicate groups with 30 fish in each tank for 8 weeks.Dietary inclusion of eitherβ-conglycinin or glycinin significantly reduced weight gain and specific growth rates,and cell proliferation of the distal intestine.Histological evaluation of the intestine tract revealed the inflammation signs,characterized by reducing of plica height and width as well as the number of the goblet cells,and widening of the lamina propria.The group fed theβ-conglycinin diet had reduced lysozyme activity,contents of immunoglobulin M and complements 3 and 4.Increased activities of caspase-3 and-9 were observed in the group fed the bconglycinin diet compared to the other 2 groups.In the intestinal microbiota,the relative abundances of the potentially pathogenic genera Photobacterium and Vibrio were significantly higher in the glycinin group than those in others.Therefore,the existence of soybean antigens(β-conglycinin or glycinin)could damage the structural integrity of the intestine,reduce immune defense,reshape the intestinal microbiome and,ultimately,impair growth in fish. | Yuanfa He Jinfang Liang Xiaohui Dong Hongyu Liu Qihui Yang Shuang Zhang Shuyan Chi Beiping Tan | 2022 | Animal Nutrition2022，，2： | 0 |
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