|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Treatment of functional dyspepsia with sertraline:A double-blind randomized placebo-controlled pilot study显示文摘AIM:To evaluate sertraline,a selective serotonin reuptake inhibitor in the treatment of patients with functional dyspepsia.METHODS:Consecutive tertiary hospital patients with a clinical diagnosis of functional dyspepsia(FD) according to the Rome Ⅱ criteria with a Hong Kong dyspepsia index(HKDI) of greater than 16 were recruited.Patients commenced enrolment prior to the inception of the Rome Ⅲ criteria for functional dyspepsia.All patients were ethnic Chinese,had a normal upper endoscopy and were Helicobacter pylori negative prior to enrolment.Study patients were randomized to receive sertraline 50 mg or placebo daily for 8 wk.HKDI symptom scores,quality of life,hospital anxiety and depression(HAD) scale and global symptom relief were evaluated before,during and after treatment.Adverse effects were monitored during and after treatment.RESULTS:A total of 193 patients were randomized in the intention to treat(ITT),and 150 patients were included in the per protocol(PP) analysis.In both the ITT and PP,there was no difference in the primary outcome of global dyspepsia symptoms between the sertraline and placebo groups at week 8.In the ITT analysis,98 and 95 patients were randomized to the sertraline and placebo groups respectively.A total of 43 patients withdrew from the study(22.3%) by week 8,with 23 of the 24 drop-outs in the sertraline group occurring prior to week 4(95.8%).In contrast,in the placebo arm,11 of 19 patients dropped out by week 4(57.9%).Utilizing the last response carried forward to account for the drop-outs,there were no differences between the sertraline and placebo groups at baseline in terms of the HKDI,HKDI 26.08 ± 6.19 vs 26.70 ± 5.89,P = 0.433;and at week 8,HKDI 22.41 ± 6.36 vs 23.25 ± 7.30,P = 0.352 respectively.In the PP analysis,74 and 76 patients were randomized to the sertraline and placebo groups respectively.At baseline,there were no statistically significant differences between the sertraline and placebo groups,HKDI 25.83 ± 6.313 vs 27.19 ± 5.929 respectively,P = 0.233;however by week 8,patients in the sertraline group demonstrated a statistically significant difference in their Hong Kong Dyspepsia Index compared to placebo,HKDI 20.53 ± 6.917 vs 23.34 ± 7.199,P = 0.02,respectively).There was also no statistically significant difference in overall quality of life measures or the HAD scale related to treatment in either the ITT or PP analysis at week 8.CONCLUSION:This pilot study,the first to examine sertraline,a selective serotonin reuptake inhibitor,for the management of FD,did not find that it was superior to placebo. | Victoria PY Tan Tin K Cheung Wai M Wong Roberta Pang Benjamin CY Wong | 2012 | World Journal of Gastroenterology2012，18，42： | 14 |
| 2 | 产房复苏时的胸外按压和正压通气显示文摘新生儿心肺复苏(cardiopulmonary resuscitation,CPR)重点在于纠正低氧血症和增加冠状动脉及体循环灌注压。如何优化胸外按压和正压通气的临床数据有限。动物模型及人体模型研究建议按压-通气(compression-to-ventilation ratio,C∶V)比例是3∶1,这一比例胸外按压可改善通气,纠正低氧血症。 | 岳丽琴 虞人杰 Solevag AL Cheung PY Schmolzer GM | 2015 | 中国新生儿科杂志2015，30，4： | 4 |
| 3 | Vessel extraction under non-uniform il umination:a level set approach显示文摘 | Sum KW Cheung PY | | 0，，01： | 1 |
| 4 | Early childhood neurodevelopment in very low birth weight infants with predischarge apnea显示文摘 | Cheung PY Barrington KJ Finer NN | 1999 | Pediatr Pulmonol1999，27，1： | 1 |
| 5 | Long-term cognitive impairment and myelination deficiency in a rat model of perinatal hypoxicischemic brain injury显示文摘 | Huang Z Liu J Cheung PY | | 0，，： | 1 |
| 6 | Long-term cognitive impairment and myelination deficiency in rat model of perinatal hypoxic-ischemic brain injury显示文摘 | Huang Z Liu J Cheung PY | 2009 | Brain Res2009，1301，： | 1 |
| 7 | Online social net-works:why do students use Facebook?显示文摘 | CHRISTY M K CHEUNG CHIU PY | 2011 | Computers in HumanBehavior2011，，： | 1 |
| 8 | Matrix metalloproteinase--2 contributes to ischemia-reperfusion injury in the heart 显示文摘 | Cheung PY Sawicki G Wozniak M | 2000 | Circulation2000，101，15： | 1 |
| 9 | Matrix metalloproteinase-2 contributes to ischemia-reperfusion injury in the heart显示文摘 | Cheung PY Sawicki G Wozniak M ct al | 2000 | Circulation2000，101，15： | 1 |
| 10 | The mechanisms of platelet dysfunction during extracorporeal membrane oxygenation in critically ill neonates显示文摘 | Cheung PY Sawicki G Salas E | 2000 | Pediatric Crit Care Med2000，28，7： | 1 |
| 11 | Matrix metallopro- teinase-2contributes to ischemia reperfusion injury in heart'显示文摘 | Cheung PY Sawicki G Wozniak M | 2000 | Circulation2000，101，15： | 1 |
| 12 | Matrix metalloproteinase-2 contributes to ischemia-reperfusion injury in the heart显示文摘 | Cheung PY Sawicki G Wozniak M | 2000 | Circulation2000，101，： | 1 |
| 13 | Id-1 activation of PI3K/Akt/NFnB signaling pathway and its significance in promoting survival of esophageal cancer cells显示文摘 | Li B Cheung PY Wang X | 2007 | Carcinogenesis2007，28，： | 1 |
| 14 | Matrix metalloproteinase-2 contributes to ischemia-reperfusion injury in the heart显示文摘 | Cheung PY Sawicki G Wozniak M | 2000 | Circulation2000，101，： | 1 |
| 15 | Long - term cognitive impairment andmyelination deficiency in a rat model of perinatal hypoxic - ischemicbrain injury显示文摘 | Huang ZH Cheung PY Chen C | 2009 | Brain Res2009，1301，： | 1 |
| 16 | Using 100% oxygen for the re- suscitation of term neonates until evidence of spontaneous circula- tion : more investigations needed 显示文摘 | Liu JQ Saugstad OD Cheung PY | 2010 | Resuscitation2010，81，2： | 1 |
| 17 | Matrix metalloproteinase 2 contributes to ischemic reperfusion injury in the heart显示文摘 | Cheung PY Sawicki G Wozniak M | | 0，，15： | 1 |
| 18 | Matrix metalloproteinase-2 contributes to is chemia-reperfusion injury in the heart显示文摘 | Cheung PY Sawicki G Wozniak M | 2000 | Circulation2000，101，15： | 1 |
| 19 | Idl activation of PI3K/Akt/ NFkappaB signaling pathway and its significance in promoting survival of esophageal cancer cells显示文摘 | Li B Cheung PY Wang X | 2007 | Carcinogenesis2007，28，11： | 1 |
| 20 | Serum levels of matrix metalloproteinase-2 and-9 and conventional tumor markers (CEA and CA 19-9) in patients with colorectal and gastric cancers显示文摘 | Emara M Cheung PY Grabowski K | 2009 | Clin Chem Lab Med2009，47，8： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员