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| 1 | Combination of corticosteroids and 5-aminosalicylates or corticosteroids alone for patients with moderate-severe active ulcerative colitis:A global survey of physicians'practice显示文摘AIM To examine treatment decisions of gastroenterologists regarding the choice of prescribing 5-aminosalycilates(5ASA) with corticosteroids(CS) versus corticosteroids alone for patients with active ulcerative colitis(UC). METHODS A cross-sectional questionnaire exploring physicians' attitude toward 5ASA + CS combination therapy vs CS alone was developed and validated. The questionnaire was distributed to gastroenterology experts in twelve countries in five continents. Respondents' agreement with stated treatment choices were assessed by standardized Likert scale. Background professional characteristics of respondents were analyzed for correlation with responses. RESULTS Six hundred and sixty-four questionnaires were distributed and 349 received(52.6% response rate). Of 340 eligible respondents, 221(65%) would continue 5ASA in a patient hospitalized for intravenous CS treatment due to a moderate-severe UC flare, while 108(32%) would stop the 5ASA(P < 0.001), and 11(3%) are undecided. Similarly, 62% would continue 5ASA in an out-patient starting oral CS. However, only 140/340(41%) would proactively start 5ASA in a hospitalized patient not receiving 5ASA before admission. Most(94%) physicians consider the safety profile of 5ASA as very good. Only 52% consider them inexpensive, 35% perceive them to be expensive and 12% are undecided. On multi-variable analysis, less years of practice and perception of a plausible additive mechanistic effect of 5ASA + CS were positively associated with the decision to continue 5ASA with CS. CONCLUSION Despite the absence of data supporting its benefit, most gastroenterologists endorse combination of 5ASA + CS for patients with active moderate-to-severe UC. Randomized controlled trials are needed to assess if 5ASA confer any benefit for these patients. | Shomron Ben-Horin Jane M Andrews Konstantinos H Katsanos Florian Rieder Flavio Steinwurz Konstantinos Karmiris Jae Hee Cheon Gordon William Moran Monica Cesarini Christian D Stone Doron Schwartz Marijana Protic Xavier Roblin Giulia Roda Min-Hu Chen Ofir Har-Noy Charles N Bernstein | 2017 | World Journal of Gastroenterology2017，23，16： | 3 |
| 2 | Controlled release of doxorubicin from thermosensitive poly (organophosphazene) hydrogels 显示文摘 | Kang G D Cheon S H Song S C | 2006 | Int J Pharm2006，319，12： | 1 |
| 3 | An experimental study of the brittle failure under true triaxial conditions显示文摘 | CHEON D S JEON S PARK C | 2006 | Tunnelling and Underground Space Technology2006，21，34： | 1 |
| 4 | Diagnostic utility of interleukin-6 (IL-6) for primary bile duct cancer and changes in serum IL-6 levels following photodynamic therapy 显示文摘 | Cheon Y K Cho Y D Moon J H | 2007 | Am J Gastroenterol2007，102，10： | 1 |
| 5 | Use of internal standard RNA molecules for the RT-PCR amplification of the faeces-borne RNA viruses显示文摘 | Kim K Park J Chung Y Cheon D Lee I B Lee S Yoon J Cho H Song C Lee K H | 2002 | J Virol Methods2002，104，2： | 1 |
| 6 | A practical synthesis oftrans-iodoolefin 显示文摘 | Cheon S H Christ W J Hawkins L D | 1986 | Tetrahedron Letters1986，27，： | 1 |
| 7 | Comparision of the pathogenicity of two strains (wild type and vaccine-like) of porcine reproductive and respiratory syndrome virus (PRRSV) in experimentally infected sows 显示文摘 | CHEON D S CHAE C | 2004 | J Comp Path2004，130，： | 1 |
| 8 | An Overview of JML Tools and Applications显示文摘 | Burdy L Cheon Y Cok D | 2005 | International Journal on Software Tools for Technology Transfer2005，7，3： | 1 |
| 9 | A study on thickness effect of HTS cable for insulation design显示文摘 | Cheon H G Kwag D S Choi J H | 2006 | 7th European Conference on Applied Superconductivi- ty2006，43，： | 1 |
| 10 | Antigenic variation and genotype of isolates of porcine reproductive and respiratory syndrome virus in Korea显示文摘 | Cheon D S Chae C | 2000 | Vet Rec2000，147，8： | 1 |
| 11 | Plasma ghrelin levels and theirrelationship with gastric emptying inpatients with dysmotility-like functionaldyspepsia显示文摘 | Lee K J Cha D Y Cheon S J el al | 2009 | Digestion2009，80，1： | 1 |
| 12 | Controlled release of doxorubicin from thermosensitive poly(organophosphazene) hydrogels显示文摘 | Kang G D Cheon S H Song S C | 2006 | Int J Pharm2006，319，12： | 1 |
| 13 | Seroprevalence of antibody to porcine reproductive and respiratory syndrome virus using enzyme-linked immunosorbent assay in selected herds in Korea显示文摘 | CHEON D S CHAE C LEE Y S | 1997 | J Vet Diagn Invest1997，9，4： | 1 |
| 14 | Distribution of porcine repro- ductive and respiratory syndrome virus in stillborn and liveborn piglets from experimentally infected sows 显示文摘 | CHEON D S CHAE C | 2001 | Journal of Comparative Pathology2001，124，： | 1 |
| 15 | Plasma ghrelin levels and their relationship with gastric emptying in patients with dysmotility-like functional dyspepsia 显示文摘 | Lee K J Cha D Y Cheon S J | 2009 | Digestion2009，80，1： | 1 |
| 16 | Comparison of virus isolation, reverse transcription polymerase chain reaction, immunohistochemistry, and in situ hybridization for the detection of porcine reproductive and respiratory syndrome virus from naturally aborted fetuses and stillborn piglets显示文摘 | Cheon D Chae C | 2000 | J Vet Diagn Invest2000，12，： | 1 |
| 17 | Comparison of virus isolation,revese transeription polymemse chain reaction,immunohistochemistry,and in situ hybridization for the detection of porcine reproductive and respiratory syndrome virus from naturally aborted fetuses and stillborn piglets显示文摘 | Cheon D Chae C | 2000 | J Vet Diagn Invest2000，12，： | 1 |
| 18 | Antigenic variation and genotype of isolates of Porcine reproductive and respiratory syndrome virus in Korea显示文摘 | CHEON D CHAE C | 2000 | Vet Rec2000，147，8： | 1 |
| 19 | Variable Inductance Multilayer Inductor with MOSFET Switch Control显示文摘 | Piljae P Cheon S K Mun Y P Sung D K | 2004 | IEEE Electron Device Letters2004，25，3： | 1 |
| 20 | Comparison of insulation test of mini-models with different winding for a HTS transformer显示文摘 | Cheon H G Baek S M Kwag D S | 2006 | IEEE Trans on Applied Superconductivity2006，16，2： | 1 |
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