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您的检索式：作者名="Chengfeng Du"
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| 1 | Humoral immune response to circulating SARS-CoV-2 variants elicited by inactivated and RBD-subunit vaccines显示文摘SARS-CoV-2 variants could induce immune escape by mutations on the receptor-binding domain(RBD)and N-terminal domain(NTD).Here we report the humoral immune response to circulating SARS-CoV-2 variants,such as 501Y.V2(B.1.351),of the plasma and neutralizing antibodies(NAbs)elicited by CoronaVac(inactivated vaccine),ZF2001(RBD-subunit vaccine)and natural infection.Among 86 potent NAbs identified by high-throughput single-cell VDJ sequencing of peripheral blood mononuclear cells from vaccinees and convalescents,near half anti-RBD NAbs showed major neutralization reductions against the K417N/E484K/N501Y mutation combination,with E484K being the dominant cause.VH3-53/VH3-66 recurrent antibodies respond differently to RBD variants,and K417N compromises the majority of neutralizing activity through reduced polar contacts with complementarity determining regions.In contrast,the 242–244 deletion(242–244Δ)would abolish most neutralization activity of anti-NTD NAbs by interrupting the conformation of NTD antigenic supersite,indicating a much less diversity of anti-NTD NAbs than anti-RBD NAbs.Plasma of convalescents and CoronaVac vaccinees displayed comparable neutralization reductions against pseudo-and authentic 501Y.V2 variants,mainly caused by E484K/N501Y and 242–244Δ,with the effects being additive.Importantly,RBD-subunit vaccinees exhibit markedly higher tolerance to 501Y.V2 than convalescents,since the elicited anti-RBD NAbs display a high diversity and are unaffected by NTD mutations.Moreover,an extended gap between the third and second doses of ZF2001 leads to better neutralizing activity and tolerance to 501Y.V2 than the standard three-dose administration.Together,these results suggest that the deployment of RBD-vaccines,through a third-dose boost,may be ideal for combating SARS-CoV-2 variants when necessary,especially for those carrying mutations that disrupt the NTD supersite. | Yunlong Cao Ayijiang Yisimayi Yali Bai Weijin Huang Xiaofeng Li Zhiying Zhang Tianjiao Yuan Ran An Jing Wang Tianhe Xiao Shuo Du Wenping Ma Liyang Song Yongzheng Li Xiang Li Weiliang Song Jiajing Wu Shuo Liu Xuemei Li Yonghong Zhang Bin Su Xianghua Guo Yangyang Wei Chuanping Gao Nana Zhang Yifei Zhang Yang Dou Xiaoyu Xu Rui Shi Bai Lu Ronghua Jin Yingmin Ma Chengfeng Qin Youchun Wang Yingmei Feng Junyu Xiao Xiaoliang Sunney Xie | 2021 | Cell Research2021，31，7： | 12 |
| 2 | Hydrothermal synthesis of large-sized hydroxyapatite whiskers regulated by glutamic acid in solutions with low supersaturation of precipitation显示文摘 | Chengfeng Li Shuguang Liu Guochang Li Jiahai bai Weiwei Wang Qingyang Du | 2010 | Advanced Powder Technology2010，，4： | 1 |
| 3 | Pre-potassiated hydrated vanadium oxide as cathode for quasi-solid-state zinc-ion battery显示文摘Zinc-ion batteries(ZIBs),in particular quasi-solid-state ZIBs,occupy a crucial position in the field of energy storage devices owing to the superiorities of abundant zinc reserve,low cost,high safety and high theoretical capacity of zinc anode.However,as divalent Zn^(2+)ions experience strong electrostatic interactions when intercalating into the cathode materials,which poses challenges to the structural stability and higher demand in Zn^(2+)ions diffusion kinetics of the cathode materials.Here,a microwave-assisted hydrothermal method is adopted to prepare pre-potassiated hydrated vanadium pentoxide(K_(0.52)V_(2)O_(5)·0.29H_(2)O,abbreviated as KHVO)cathode material,in which the potassium ions preinserted into the interlayers can act as“pillars”to stabilize the lamellar structure,and crystal water can act as“lubricant”to improve the diffusion efficiency of Zn^(2+)ions.Consequently,the KHVO displays high electrochemical properties with high capacity(∼300 mAh/g),superior rate capability(69 mAh/g at 5 A/g)and ultralong cycling performance(>1500 cycles at 2 A/g)in quasi-solid-state ZIBs.These superior Zn storage properties result from the large diffusion coefficient and highly stable and reversible Zn^(2+)(de)intercalation reaction of KHVO. | Qifei Li Xiangxiang Ye Hong Yu Chengfeng Du Wenping Sun Weiling Liu Hongge Pan Xianhong Rui | 2022 | Chinese Chemical Letters2022，33，5： | 0 |
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