|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Effects of porosity on seismic velocities, elastic moduli and Poisson's ratios of solid materials and rocks显示文摘The generalized mixture rule(GMR) is used to provide a unified framework for describing Young's(E),shear(G) and bulk(K) moduli, Lame parameter(l), and P- and S-wave velocities(V_p and V_s) as a function of porosity in various isotropic materials such as metals, ceramics and rocks. The characteristic J values of the GMR for E, G, K and l of each material are systematically different and display consistent correlations with the Poisson's ratio of the nonporous material(v_0). For the materials dominated by corner-shaped pores, the fixed point at which the effective Poisson's ratio(n) remains constant is at v_0=0.2, and J(G) > J(E) > J(K) > J(l) and J(G) < J(E) < J(K) < J(l) for materials with v_0> 0.2 and v_0< 0.2, respectively.J(V_s) > J(V_p) and J(V_s) < J(V_p) for the materials with v_0 > 0.2 and v_0< 0.2, respectively. The effective n increases, decreases and remains unchanged with increasing porosity for the materials with v_0 < 0.2,v_0 > 0.2 and v_0 =0.2, respectively. For natural rocks containing thin-disk-shaped pores parallel to mineral cleavages, grain boundaries and foliation, however, the n fixed point decreases nonlinearly with decreasing pore aspect ratio(a: width/length). With increasing depth or pressure, cracks with smaller a values are progressively closed, making the n fixed point rise and finally reach to the point at v_0=0.2. | Chengbo Yu Shaocheng Ji Qi Li | 2016 | Journal of Rock Mechanics and Geotechnical Engineering2016，8，1： | 15 |
| 2 | Bacillus licheniformis PF9 improves barrier function and alleviates inflammatory responses against enterotoxigenic Escherichia coli F4 infection in the porcine intestinal epithelial cells显示文摘Background:Enterotoxigenic Escherichia coli(ETEC)F4 commonly colonizes the small intestine and releases enterotoxins that impair the intestinal barrier function and trigger inflammatory responses.Although Bacillus licheniformis(B.licheniformis)has been reported to enhance intestinal health,it remains to be seen whether there is a functional role of B.licheniformis in intestinal inflammatory response in intestinal porcine epithelial cell line(IPEC-J2)when stimulated with ETEC F4.Methods:In the present study,the effects of B.licheniformis PF9 on the release of pro-inflammation cytokines,cell integrity and nuclear factor-κB(NF-κB)activation were evaluated in ETEC F4-induced IPEC-J2 cells.Results:B.licheniformis PF9 treatment was capable of remarkably attenuating the expression levels of inflammation cytokines tumor necrosis factor-α(TNF-α),interleukin(IL)-8,and IL-6 during ETEC F4 infection.Furthermore,the gene expression of Toll-like receptor 4(TLR4)-mediated upstream related genes of NF-κB signaling pathway has been significantly inhibited.These changes were accompanied by significantly decreased phosphorylation of p65 NF-κB during ETEC F4 infection with B.licheniformis PF9 treatment.The immunofluorescence and western blotting analysis revealed that B.licheniformis PF9 increased the expression levels of zona occludens 1(ZO-1)and occludin(OCLN)in ETEC F4-infected IPEC-J2 cells.Meanwhile,the B.licheniformis PF9 could alleviate the injury of epithelial barrier function assessed by the trans-epithelial electrical resistance(TEER)and cell permeability assay.Interestingly,B.licheniformis PF9 protect IPEC-J2 cells against ETEC F4 infection by decreasing the gene expressions of virulence-related factors(including luxS,estA,estB,and elt)in ETEC F4.Conclusions:Collectively,our results suggest that B.licheniformis PF9 might reduce inflammation-related cytokines through blocking the NF-κB signaling pathways.Besides,B.licheniformis PF9 displayed a significant role in the enhancement of IPEC-J2 cell integrity. | Qiao Li Linyan Li Yanhong Chen Changning Yu Paula Azevedo Joshua Gong Chengbo Yang | 2022 | Journal of Animal Science and Biotechnology2022，13，5： | 4 |
| 3 | Regulation of aerobic glycolysis to decelerate tumor proliferation by small molecule inhibitors targeting glucose transporters显示文摘Dear Editor,Different from normal differentiated cells,metabolic reprogramming was spotted in cancer cells,due to increased demand for energy and macromolecule synthesis during their rapid proliferation(Hanahan and Weinberg,2011;Pavlova and Thompson,2016).Most cancer cells prefer anaerobic glycolysis even with oxygen in the environment due to its higher speed to produce macromolecular materials required for biosynthesis(Vander Heiden et al.,2009;DeBerardinis and Chandel,2016).But to compensate for the lower efficiency of anaerobic glycolysis in producing ATP,these cancer cells demand much higher glucose supply(Warburg,1956;Vander Heiden et al.,2009).These metabolic characteristics point to the huge demand of cancer cells for carbohydrate substrates,which creates the possibility of treating tumors by exploiting this feature(Patra et al.,2013;DeBerardinis and Chandel,2016). | Meng Gao Jian Huang Xin Jiang Yafei Yuan Huanhuan Pang Shuchen Luo Nan Wang Chengbo Yao Zuwan Lin Debing Pu Shuo Zhang Pengcheng Sun Zhuoyi Liu Yu Xiao Qian Wang Zeping Hu Hang Yin | 2020 | Protein & Cell2020，11，6： | 2 |
| 4 | Establishment and characterization of immortalized human hepatocyte cell line for applications in bioartificial livers显示文摘 | XiaoPing Pan JianZhou Li WeiBo Du XiaoPeng Yu ChunXia Zhu ChengBo Yu HongCui Cao YiMin Zhang Yu Chen LanJuan Li | 2012 | Biotechnology Letters2012，，12： | 1 |
| 5 | Advanced glycation end products depress function of endothelial progenitor cells via p38 and ERK 1/2 mitogen-activated protein kinase pathways 显示文摘 | Chengbo?S Chun?L Yu SR | 2009 | Basic Research in Cardiology2009，104，1： | 1 |
| 6 | Differential FBG sensor for temperature-compensated high-pressure (or displacement) measurement显示文摘 | ZHAO Yong YU Chengbo LIAO Yanbiao | 2004 | Optics & Laser Technology2004，，36： | 1 |
| 7 | Jilun Li and his profound impact on theoretica and applied agricultural microbiology显示文摘 | Chengbo Rong Yu Liu Ying Wen | 2017 | Protein & Cell2017，8，3： | 1 |
| 8 | Differential FBG sensor for temperature-compensated high-pressure(or displacement)measurement显示文摘 | ZHAO Yong YU Chengbo LIAO Yanbiao | 2004 | Optics & Laser Technology2004，36，： | 1 |
| 9 | Region growth-based feature extraction method for finger-vein recognition显示文摘 | Huafeng Qin Lan Qin Chengbo Yu | 2011 | Opti- cal Engineering2011，50，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员