|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The relationship of Imp2 and DR3 genes with susceptibility to type Ⅰ diabetes mellitus in south China Han population显示文摘AIN To study the relationship of Imp2 and DR3genes with type Ⅰ diabetes mellitus.NETHODS Imp2 genotypes and DR3 wereidentified in 68 patients with type Ⅰ diabetesmellitus(Ⅰ-DM)and 71 healthy controls.Then,Ⅰ-DM patients and controls were respectivelyallocated into DR3-positive and DR3-negativegroups.The frequencies of Imp2 and DR3 genein random subjects,and Imp2 genotypes in DR3-matched subjects were compared between Ⅰ-DMpatients and controls.At the same time,Ⅰ-DMpatients were divided into 3 groups based on theonset age of diabetics:group A≤14 years,group B 15-30 years and group C≥31 years.RESULTS The frequency of DR3 in Ⅰ-DMpatients was significantly higher than that incontrols(47% vs 21%,P<0.005),and it wassignificantly higher in group A than that in groupB+C(70% vs 36%,x^2=7.07,P<0.01).Therewas a significant difference among groups withdifferent onset age of diabetics(x^2=8.19,rp=0.33,P<0.05).In random subjects,thefrequency of Imp2.R/R in Ⅰ-DM patients waslower(43% vs 61%,P<0.05)and Imp2.R/Hhigher(53% vs 28%,P<0.05)than that incontrols,and there was no significant differenceamong groups with different onset age ofdiabetics.In DR3-positive subjects,thefrequency of Imp2.R/R in Ⅰ-DM patients waslower(47% vs 87%,P<0.05)and Imp2-R/H higher(47% vs 13%,P<0.05)than that incontrols.In DR3-negative subjects,thefrequency of Imp2.R/H in Ⅰ-DM patients washigher than that in controls(58% vs 32%,P<0.01),but the frequency of Imp2-R/R and Imp2H/H was not significantly different betweenthese two groups.CONCLUSION DR3 gene may be one of thesusceptible genes of Ⅰ-DM,and significantlyrelated to the onset age of diabetics,and thepersons with DR3 may have an younger onsetage of diabeteS.The Imp2-R/R may be theprotective genotype of Ⅰ-DM,and Imp2-R/H thesusceptible genotype.These were not affectedby DR3 gene.Imp-2 genotypes were not relatedwith the onset age of diabetics. | Ding HL Cheng H Fu ZZ Deng QL Yan L Yan T | 2000 | World Journal of Gastroenterology2000，6，1： | 7 |
| 2 | Archaeological records of Dadiwan in the past 60 ka and the origin of millet agriculture显示文摘This paper reports the recent excavation of Unit Dadiwan06 at the Dadiwan site in Qin’an County, Gansu.A 65 ka chronological framework is established for Dadiwan06 on the basis of absolute dating (AMS 14C and OSL), stratigraphy, climate change events and archaeology.Artifact distributions reveal patterns of human behavioral variation and adaptation over the past 60 ka, from primitive hunting and gathering to advanced hunting and gathering, to primitive Neolithic agriculture, and finally to advanced Neolithic agriculture. | ZHANG DongJu CHEN FaHu BETTINGER R L BARTON L JI DuXue MORGAN C WANG Hui CHENG XiaoZhong DONG GuangHui GUILDERSON T P ZHAO Hui | 2010 | Chinese Science Bulletin2010，55，16： | 6 |
| 3 | Endoscopic ultrasound-guided vs endoscopic retrograde cholangiopancreatography biliary drainage for obstructed distal malignant biliary strictures: A systematic review and meta-analysis显示文摘BACKGROUND For palliation of malignant biliary obstruction(MBO), the gold-standard method of biliary drainage is endoscopic retrograde cholangiopancreatography(ERCP)with the placement of metallic stents. Endoscopic ultrasound(EUS)-guided drainage is an alternative that is typically reserved for cases of ERCP failure.Recently, however, there have been robust randomized clinical trials(RCTs)comparing EUS-guided drainage and ERCP as primary approaches to MBO.AIM To compare EUS guidance and ERCP in terms of their effectiveness and safety in palliative biliary drainage for MBO.METHODS This was a systematic review and meta-analysis, in which we searched the MEDLINE, Excerpta Medica, and Cochrane Central Register of Controlled Trials databases. Only RCTs comparing EUS and ERCP for primary drainage of MBO were eligible. All of the studies selected provided data regarding the rates of technical and clinical success, as well as the duration of the procedure, adverse events, and stent patency. We assessed the risk of biases using the Jadad score and the quality of evidence using the Grading of Recommendations Assessment,Development and Evaluation criteria.RESULTS The database searches yielded 5920 records, from which we selected 3 RCTs involving a total of 222 patients(112 submitted to EUS and 110 submitted to ERCP). In the EUS and ERCP groups, the rate of technical success was 91.96%n and 91.81%, respectively, with a risk difference(RD) of 0.00%(95%CI:-0.07, 0.07;P = 0.97; I^2 = 0%). The clinical success was 84.81% and 85.53% in the EUS and ERCP groups, respectively, with an RD of-0.01%(95%CI:-0.12, 0.10; P = 0.90; I^2 =0%). The mean difference(MD) for the duration of the procedure was-0.12%(95%CI:-8.20, 7.97; P = 0.98; I^2 = 84%). In the EUS and ERCP groups, there were14 and 25 adverse events, respectively, with an RD of-0.06%(95%CI:-0.23, 0.12; P= 0.54; I^2 = 77%). The MD for stent patency was 9.32%(95%CI:-4.53, 23.18; P =0.19; I^2 = 44%). The stent dysfunction rate was significantly lower in the EUS t group(MD =-0.22%; 95 CI:-0.35,-0.08; P = 0.001; I^2 = 0%).CONCLUSION EUS represents an interesting alternative to ERCP for MBO drainage,demonstrating lower stent dysfunction rates compared with ERCP. Technical and clinical success, duration, adverse events and patency rates were similar. | Fernanda P Logiudice Wanderlei M Bernardo Facundo Galetti Vitor M Sagae Carolina O Matsubayashi Antonio C Madruga Neto Vitor O Brunaldi Diogo T H de Moura Tomazo Franzini Spencer Cheng Sergio E Matuguma Eduardo G H de Moura | 2019 | World Journal of Gastrointestinal Endoscopy2019，11，4： | 6 |
| 4 | 工人脱离职业性噪声接触后的心电图分析显示文摘目的探讨工人脱离职业性噪声接触后的心电图变化。方法在进行《广州生物库队列研究》时,第一阶段收集10413名年龄在≥50岁居民的一般资料、体格检查和实验室检查结果。受检者70%为女性,50%以上年龄在60~69岁;受检者中有2120名(21.0%)曾经接触职业性噪声,但均已脱离接触且为退休或离岗者;用上海惠普有限公司制造的MAC-CS多导联心电图机进行12导联的心电图检查;噪声职业接触史通过问卷采集,心电图由2名中级以上具有诊断资格的医师进行独立诊断。结果(1)心电图异常检出率女性为82.4%,明显高于男性的79.1%;不论男性或女性,心电图异常检出率随年龄增加而上升(P=0.000),女性随文化程度增高而明显下降(P=0.000),但无论男女,脱离职业性噪声接触后,其心电图异常检出率与从未职业性噪声接触者比较,差异无统计学意义(P>0.05);(2)比较曾经有职业性噪声接触与非接触者心电图异常的分类,在校正年龄因素和文化程度后,心律失常、心电轴偏移、房或室肥厚、ST-T改变、心肌劳损、冠状动脉综合征等比较,差异无统计学意义(P>0.05)。结论脱离职业性噪声接触后的工人心电图异常检出率未见明显高于非职业性噪音接触者。 | 林洁明 江朝强 张维森 侯丽君 Cheng K K Lam T H | 2007 | 中华劳动卫生职业病杂志2007，25，10： | 3 |
| 5 | Feature-based process plan generation from 3 D DSG inputs显示文摘 | Perng D B Cheng C T | 1994 | Computers Industrial Engineering1994，26，3： | 3 |
| 6 | Extracellular histones stimulate collagen expression in vitro and promote liver fibrogenesis in a mouse model via the TLR4-MyD88 signaling pathway显示文摘BACKGROUND Liver fibrosis progressing to liver cirrhosis and hepatic carcinoma is very common and causes more than one million deaths annually.Fibrosis develops from recurrent liver injury but the molecular mechanisms are not fully understood.Recently,the TLR4-MyD88 signaling pathway has been reported to contribute to fibrosis.Extracellular histones are ligands of TLR4 but their roles in liver fibrosis have not been investigated.AIM To investigate the roles and potential mechanisms of extracellular histones in liver fibrosis.METHODS In vitro,LX2 human hepatic stellate cells(HSCs)were treated with histones in the presence or absence of non-anticoagulant heparin(NAHP)for neutralizing histones or TLR4-blocking antibody.The resultant cellular expression of collagen I was detected using western blotting and immunofluorescent staining.In vivo,the CCl4-induced liver fibrosis model was generated in male 6-week-old ICR mice and in TLR4 or MyD88 knockout and parental mice.Circulating histones were detected and the effect of NAHP was evaluated.RESULTS Extracellular histones strongly stimulated LX2 cells to produce collagen I.Histone-enhanced collagen expression was significantly reduced by NAHP and TLR4-blocking antibody.In CCl4-treated wild type mice,circulating histones were dramatically increased and maintained high levels during the duration of fibrosisinduction.Injection of NAHP not only reduced alanine aminotransferase and liver injury scores,but also significantly reduced fibrogenesis.Since the TLR4-blocking antibody reduced histone-enhanced collagen I production in HSC,the CCl4 model with TLR4 and MyD88 knockout mice was used to demonstrate the roles of the TLR4-MyD88 signaling pathway in CCl4-induced liver fibrosis.The levels of liver fibrosis were indeed significantly reduced in knockout mice compared to wild type parental mice.CONCLUSION Extracellular histones potentially enhance fibrogenesis via the TLR4–MyD88 signaling pathway and NAHP has therapeutic potential by detoxifying extracellular histones. | Zhi Wang Zhen-Xing Cheng Simon T Abrams Zi-Qi Lin ED Yates Qian Yu Wei-Ping Yu Ping-Sheng Chen Cheng-Hock Toh Guo-Zheng Wang | 2020 | World Journal of Gastroenterology2020，26，47： | 3 |
| 7 | 显示文摘 | Cheng H F Lin T F Hu C T | 1993 | J Am Ceram Soc1993，76，4： | 2 |
| 8 | Single machine scheduling with deadlines and increasing rates of processing times显示文摘 | Cheng T C E Ding Q | 2000 | Acta Informatica2000，36，910： | 2 |
| 9 | Laser transformation hardening of AISI440C martensitic stainless steel for higher cavitation erosion resistance显示文摘 | Lo K H Cheng F T Man H C | 2003 | Surface and Coating Technology2003，173，： | 2 |
| 10 | Genetic transformation of wheat mediated by Agrobacterium tumefaciens显示文摘 | Cheng M Fry J E Pang S Zhou H Hironaka C M Duncan D R Conner T W Wan Y | 1997 | Plant Physiol1997，，： | 2 |
| 11 | Modified ZehnerSchlunder models for stagnant thermal conductivity of porous media 显示文摘 | Hsu C T Cheng P Wong K W | 1994 | Int J Heat Mass Transfer1994，37，17： | 2 |
| 12 | A lumped-parameter model for stagnant thermal conductivity of spatially periodic porous media 显示文摘 | Hsu C T Cheng P Wong K W | 1995 | J Heat Transfer1995，177，： | 2 |
| 13 | Alpha 2-adrenergic agonists induce basic fibroblast growth factor expression in photoreceptors in vivo and ameliorate light damage显示文摘 | Wen R Cheng T Li Y | 1996 | J Neurosci1996，16，19： | 2 |
| 14 | The cutting stock problem-A survey 显示文摘 | Cheng C H Feiring B R Cheng T C E | 1994 | International Journal of Production economics1994，，36： | 2 |
| 15 | The epoxyeicosatrienoic acid-stimulated phosphorylation of EGF-R involves the activation of metalloproteinases and the release of HB-EGF in cancer cells显示文摘 | Li-ming CHENG Jian-gang JIANG Zi-yong SUN Chen CHEN Ryan T DACKOR Darryl C ZELDIN Dao-wen WANG | 2010 | Acta Pharmacologica Sinica2010，31，2： | 2 |
| 16 | Characteristics of gas-liquid two-phase flow in small diameter inclined tubes显示文摘 | Cheng T W Lin T L | 2001 | Chem Eng Sci2001，，56： | 2 |
| 17 | Reinforced concrete members subject to combined biaxial bending and tension显示文摘 | CHENG T T H | 1986 | ACI Structural Journal1986，83，1： | 2 |
| 18 | T-shaped reinforced concrete members subject to bending and axial compression 显示文摘 | CHENG T T H | 1989 | ACI Structural Journal1989，86，4： | 2 |
| 19 | A MyD88-dependent IFNyR-CCR2 signaling circuit is required for mobilization of monocytes and host defense against systemic bacterial challenge显示文摘 | Eric M Pietras Lloyd S Miller Carl T Johnson Ryan M O'Connell Paul W Dempsey Genhong Cheng | 2011 | Cell Research2011，21，7： | 2 |
| 20 | Telomerase activity in pleural effusions diagnostic significance显示文摘 | CHENG T Y LEE M H LAN R S | 1998 | J Clin Oncol1998，16，4： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员