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| 1 | TOTAL SYNTHESIS OF CLAUSENAMIDE显示文摘TOTAL SYNTHESIS OF CLAUSENAMIDETOTALSYNTHESISOFCLAUSENAMIDE￥ErChangRAO;HaoHONG;JiaChongCHENG;GuangZhongYANG;HanSenLIN;andLian... | Er Chang RAO Hao HONG Jia Chong CHENG Guang Zhong YANG Han Sen LIN andLiang HUANG(Institute of Mareia Medica. Chinese Academy of Medical Sciences1 Xian Nong Tan St .Beijing 100050) | 1994 | Chinese Chemical Letters1994，5，4： | 4 |
| 2 | Human Immunodeficiency Virus Infection-Associated Mortality during Pulmonary Tuberculosis Treatment in Six Provinces of China显示文摘Objective To investigate the risk factors attributable to tuberculosis-related deaths in areas with human immunodeficiency virus(HIV) infection epidemics. Methods A prospective cohort study of newly registered patients in tuberculosis(TB) dispensaries in six representative Chinese provinces was conducted from September 1, 2009 to August 31, 2011. Risk factors for TB-associated death were identified through logistic regression analysis. Results Of 19,103 newly registered pulmonary TB patients, 925(4.8%) were found to be HIV-positive. Miliary TB and acid-fast bacillus smear-negative TB were more common among these patients. Out of a total of 322(1.7%) deaths that occurred during TB treatment, 85(26%) of the patients were co-infected with HIV. Multivariate analysis revealed that HIV infection was the strongest predictor of death [adjusted odds ratio(aO R) 7.86]. Other significant mortality risk factors included presentation with miliary TB(aO R 4.10; 95% confidence interval: 2.14-7.88), ≥35 years of age(aO R 3.04), non-Han ethnicity(aO R 1.67), and farming as an occupation(aO R 1.59). For patients with TB/HIV co-infection, miliary TB was the strongest risk factor for death(aO R 5.48). A low CD4 count(≤ 200 cells/μL)(aO R 3.27) at the time of TB treatment initiation and a lack of antiretroviral therapy(ART) administration(aO R 3.78) were also correlated with an increased risk of death. Conclusion Infection with HIV was independently associated with increased mortality during TB treatment. Offering HIV testing at the time of diagnosis with TB, early TB diagnosis among HIV/acquired immunodeficiency syndrome patients, and the timely provision of ART were identified as the key approaches that could reduce the number of HIV-associated TB deaths. | LAI Yu Ji LIU Er Yong WANG Li Ming Jamie P MORANO WANG Ning Kaveh KHOSHNOOD ZHOU Lin CHENG Shi Ming | 2015 | Biomedical and Environmental Sciences2015，28，6： | 4 |
| 3 | NS1-binding protein radiosensitizes esophageal squamous cell carcinoma by transcriptionally suppressing c-Myc显示文摘Background:Cisplatin-based chemotherapy with concurrent radiotherapy is a standard treatment for advanced esophageal squamous cell carcinoma(ESCC).NS1-binding protein(NS1-BP),a member of the BTB-kelch protein fam-ily,has been shown to inhibit the proliferation of Hela cells by suppressing c-Myc.In the present study,we examined the potential function role of NS1-BP expression in ESCC,and particularly,the sensitivity of ESCC to radiotherapy.Methods:NS1-BP expression was examined using immunohistochemistry in two cohorts(n=98 for the training cohort;n=46 for independent validation cohort)of ESCC patients receiving cisplatin-based chemotherapy and con-current radiotherapy.Normal esophageal mucosal tissue blocks were used as a control.We also conducted a series of in vitro and in vivo experiments to examine the potential effects of over-expressing NS1-BP on ESCC cells,and particu-larly their sensitivity to ionizing irradiation.Results:In the training cohort,NS1-BP downregulation was observed in 59%(85/144)of the ESCC specimens.NS1-BP downregulation was associated with chemoradiotherapeutic resistance and shorter disease-specific survival(DSS)in both the training and validation cohorts.Over-expressing NS1-BP in cultured ESCC cells substantially increased the cellular response to irradiation both in vitro and in vivo.NS1-BP also significantly enhanced IR-induced apoptosis,and abrogated IR-induced G2/M cell-cycle arrest and ATM/Chk1 phosphorylation.Immunoprecipitation assays indicated that NS1-BP could interact with c-Myc promoter regions to inhibit its transcription.In ESCC tissues,c-Myc expression was inversely correlated with NS1-BP levels,and was associated with a shorter DSS.Conclusions:Our findings highlight the role and importance of NS1-BP in radiosensitivity of ESCC.Targeting the NS1-BP/c-Myc pathway may provide a novel therapeutic strategy for ESCC. | Yuwen Wang Jingjing Cheng Dan Xie Xiaofeng Ding Hailing Hou Xi Chen Puchun Er Furong Zhang Lujun Zhao Zhiyong Yuan Qingsong Pang Ping Wang Dong Qian | 2018 | Cancer Communications2018，38，1： | 4 |
| 4 | NS1结合蛋白通过转录抑制c-Myc增强食管鳞状细胞癌的放疗敏感性显示文摘背景与目的基于顺铂的化疗联合放疗是晚期食管鳞状细胞癌(esophageal squamous cell carcinoma,ESCC)的标准疗法。NS1结合蛋白(NS1-binding protein,NS1-BP)是BTB-kelch蛋白家族中的一员,已被证明可通过抑制c-Myc进而抑制HeLa细胞增殖。在本研究中,我们检测NS1-BP表达在ESCC中的潜在作用,特别是其在ESCC放疗敏感性方面的作用。方法对于两组接受基于顺铂化疗且联合放疗的ESCC患者(研究组n=98;验证组n=46),采用免疫组化方法分别检测NS1-BP表达。使用正常食管黏膜组织块作为对照。我们也进行了一系列体外和体内实验来检测过表达NS1-BP对ESCC细胞各方面的潜在影响,尤其关注的是对电离辐射的敏感性方面的影响。结果在研究组中,59%(85/144)的ESCC样本观察到了NS1-BP下调。在研究组和验证组中,NS1-BP下调与放化疗抵抗和较短的疾病特异生存期(disease-specific survival,DSS)均具有相关性。体内和体外培养条件下过表达NS1-BP均能大幅度提高ECSS细胞对放疗的敏感性。NS1-BP也显著增强IR诱导的凋亡,阻断IR诱导的G2/M细胞周期阻滞和ATM/Chk1磷酸化。免疫沉淀反应显示NS1-BP可以与c-Myc启动子区相互作用从而抑制其转录。在ESCC组织中,c-Myc表达与NS1-BP水平负相关,与较短的疾病特异生存期相关。结论我们的研究结果显示了NS1-BP在ESCC放疗敏感性中的作用和重要性。以NS1-BP/c-Myc通路为靶标有望开发一种新的ESCC治疗策略。 | Yuwen Wang Jingjing Cheng Dan Xie Xiaofeng Ding Hailing Hou Xi Chen Puchun Er Furong Zhang Lujun Zhao Zhiyong Yuan Qingsong Pang Ping Wang Dong Qian | 2019 | 癌症2019，38，2： | 2 |
| 5 | Extraction of coal-tar pitch using NMP/ILs mixed solvents显示文摘Coal-tar pitch(CP)is a promising carbon raw material for producing needle coke,carbon fiber etc.During processing,the H/C ratio,ash content,and quinoline insoluble(QI)in the CP are the key factors that influence the material preparation.In this study,NMP was selected to extract CP first;then[BMIM]Cl/NMP mixed solvent was used;and finally a series of ionic liquids(ILs)mixtures with NMP were developed for the extraction of CP to obtain the refined pitch.The extracts were analyzed via elemental analysis,TGA,FT-IR,and 13C-NMR.Results indicate that different NMP/IL mass ratios or different kinds of ILs have impact on the extraction yield.The relationship of the hydrogen to carbon(H/C)ratio changed with different solvents and QI extracts were obtained.Results showed that the H/C ratios changed little between NMP extracts and could be adjusted by changing the NMP/ILs mass ratio or using different ILs.The extracts are suitable for preparation mesophase pitch because of no ash content,low QI,and appropriate H/C ratios.As a result,NMP can be used to refine pitch.In addition,[BMIM]Cl is good mixed with NMP for CP extraction,because it can obtain a relatively high yield under the same extraction conditions. | HUANG Jin Cheng LI Chun Shan BAI Lu NIE Yi WANG Er Qiang HE Yu Jian ZHANG Suo Jiang | 2014 | Science China Chemistry2014，57，12： | 2 |
| 6 | Number of central lymph node metastasis for predicting lateral lymph node metastasis in papillary thyroid microcarcinoma显示文摘 | Rui‐chao Zeng Wei Zhang Er‐li Gao Pu Cheng Guan‐li Huang Xiao‐hua Zhang Quan Li | 2014 | Head Neck2014，，： | 1 |
| 7 | Large-scale, solution-phase growth of single-crystalline SnO, nanorods显示文摘 | CHENG B RUSSELLJ M SHI W S er al | 2004 | J Am Chern Soc2004，126，19： | 1 |
| 8 | A CIDNP STUDY OF THE PHOTOREACTIONS OF METHYLFURANS WITH CHLORANIL显示文摘The CIDNP observations indicated that photoreaction of methylfurans with chloranilresulted not only furylmethyl hydroxyphenyl ethers via radical pairs but inducedfuryl radical isomerization to the derivatives of cyclopropene,propadiene and pyran. | Ling jiang CHENG~(1,2) Han Cheng YUAN~3 Er Cheng LI~2 Bao Zhen YAN~3 Jian Hua XU~4 Guang Zhi XU~2 1 Institute of Photographic Chemistry,Chinese Academy Of Sciences,Beijing 100101 2 Institute of Chemistry,Chinese Academy of Sciences,Beijing 100080 3 Department of Applied Chemistry,Beijing Institute of Chemical Technology,Beijing 100029 4 Department of Chemistry,Nanjing University,Nanjing,Jiangsu 210008 | 1993 | Chinese Chemical Letters1993，4，4： | 1 |
| 9 | PHOTO-CIDNP STUDIES OF PHTHALIMIDE DERIVATIVES IN THE PRESENCE OF TRIETHYLAMINE显示文摘The photoreactivity of some phthalimides was tested by CIDNP studies on the reactionswith triethylamine. | Ling Jiang CHENG~(1,2) Han Cheng YUAN~3 Hua Pin PU~4 Bao Zhen YAN~3 Er Cheng LI~2 Jian Hua XU~4 Jin Shi MA~1 Guang Zhi XU~2 1 Institute of Photographic Chemistry,Chinese Academy Of Sciences,Beijing 100101 2 Institute of Chemistry,Chinese Academy of Sciences,Beijing 100080 3 Department of Applied Chemistry,Beijing Institute of Chemical Technology,Beijing 100029 4 Department of Chemistry,Nanjing University,Nanjing,Jiangsu 210008 | 1993 | Chinese Chemical Letters1993，4，4： | 1 |
| 10 | miR‐148a regulates osteoclastogenesis by targeting V‐maf musculoaponeurotic fibrosarcoma oncogene homolog B显示文摘 | Peng Cheng Chao Chen Hong‐Bo He Rong Hu Hou‐De Zhou Hui Xie Wu Zhu Ru‐Chun Dai Xian‐Ping Wu Er‐Yuan Liao Xiang‐Hang Luo | 2013 | J Bone Miner Res2013，，5： | 1 |
| 11 | IntCall 3 and Marine 13 Radicarxm Age Calibration Curves 0-50,000 Years cal BP显示文摘 | REIMER P J BARD E BAYLISS A BECK J W BLACKWELL P G RAMSEY C B BUCK C E CHENG H EDWARDS R L FRIEDRICH M GROOTES P M GUILDERSON T P HAFLIDASON H HAJDAS 1 HATTt C HEATON T J HOFFMANN 1) L HOGG A G HUGHEN K A KAISER K F KROMER B MANNING S M NIU M REIMER R W RICHARDS D A SCOTF EM SOUTHON J R STAFF R A TURN EY CSM VAN I)ER Plicht | 2013 | Radiocarbon2013，55，： | 1 |
| 12 | Feasibility of ultrasound- guided peripheral nerve block catheters for pain control on pediatric medical missions in developing countries 显示文摘 | Mariano ER llfeld BM Cheng GS | 2008 | Paediatr Anaesth2008，18，7： | 1 |
| 13 | Preconception mental health predicts pregnancy complications and adverse birth outcomes:A National Population-Based Study显示文摘 | Witt WP Wisk LE Cheng ER | 2012 | Matern Child Health J2012，16，7： | 1 |
| 14 | MiR‐503 Regulates Osteoclastogenesis via Targeting RANK显示文摘 | Chao Chen Peng Cheng Hui Xie Hou‐De Zhou Xian‐Ping Wu Er‐Yuan Liao Xiang‐Hang Luo | 2014 | J Bone Miner Res2014，，2： | 1 |
| 15 | Measuring stress before and during pregnancy:a review of population-based studies of obstetric outcomes显示文摘 | Witt PW Litzelman K Cheng ER | 2014 | Maternal and Child Health Journal2014，18，1： | 1 |
| 16 | Yellow ginger processing wastewater treatment by a hybrid biological process显示文摘 | ZHAO Huazhang CHENG Peng ZHAO Bin er al | | 0，，12： | 1 |
| 17 | Poor prepregnancy and antepartum mental health predicts postpartum mental health problems among US women:A nationally representative population-based study显示文摘 | Witt WP Wisk LE Cheng ER | 2011 | Womens Health Issues2011，21，： | 1 |
| 18 | Formation of Porous Crystals by Coupling of Dissolution and Nucleation Process inFractional Crystallization显示文摘 | Liu C Cheng F Q Lu X H er al | 2007 | Fluid Phase Equilibria2007，261，： | 1 |
| 19 | Preconception mental health predicts pregnancy complications and adverse birth outcomes:A National Population-Based Study显示文摘 | Witt WP Wisk LE Cheng ER | 2012 | Matem Child Health J2012，16，7： | 1 |
| 20 | The study of cooling channel optimization in blast furnace cast steel stave based on heat transfer analysis显示文摘 | WU Li-jun ZHOU Wei-guo CHENG Hui' er | 2006 | The International Journal of Advanced Manufacturing Technology2006，29，12： | 1 |
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