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| 1 | The recommendations of Chinese Parkinson’s disease and movement disorder society consensus on therapeutic management of Parkinson’s disease显示文摘Background:Parkinson’s disease(PD)is a chronic,progressive and debilitating disease,which affects over 2.5 million people in China.PD is characterized clinically by resting tremor,muscular rigidity,bradykinesia and postural instability.As the disease progresses,additional complications can arise such as non-motor and neurobehavioral symptoms.Pharmacological treatment and surgical intervention for PD have been implemented in China.Until 10 years ago,there was lack of standardization for the management of PD in different regions and among different physicians,leading to different treatment levels in different regions and different physicians.Since then,the Chinese Parkinson’s Disease and Movement Disorder Society have published three versions of guidelines for the management of PD in China,in 2006,2009 and 2014,respectively.Correspondingly,the overall level of treatment for PD in China improved.Objectives:To update the treatment guidelines based on current foreign and domestic practice guidelines and clinical evidence,and to improve the treatment options available to physicians in the management of PD.Summary:A variety of treatment recommendations in the treatment guidelines have been proposed,including physical activity and disease-modifying medication,which should be initiated at the early-stage of the disease.The principles of dosage titration should be followed to avoid acute adverse reactions to the drugs,to achieve a satisfactory clinical effect with a low dose and to reduce the incidence of long-term motor complications.Moreover,different treatment strategies should be considered at different stages of the disease.Importantly,treatment guidelines and personalized treatments should be valued equally.A set of treatment recommendations has been developed to assist physicians to improve and optimize clinical outcomes for patients with PD in China. | Shengdi Chen Piu Chan Shenggang Sun Haibo Chen Baorong Zhang Weidong Le Chunfeng Liu Guoguang Peng Beisha Tang Lijuan Wang Yan Cheng Ming Shao Zhenguo Liu Zhenfu Wang Xiaochun Chen Mingwei Wang Xinhua Wan Huifang Shang Yiming Liu Pingyi Xu Jian Wang Tao Feng Xianwen Chen Xingyue Hu Anmu Xie Qin Xiao | 2016 | Translational Neurodegeneration2016，5，1： | 23 |
| 2 | High-sensitivity, high-spatial-resolution distributed strain sensing based on a poly(methyl methacrylate) chirped fiber Bragg grating显示文摘In this study,a high-sensitivity,high-spatial-resolution distributed strain-sensing approach based on a poly(methyl methacrylate)chirped fiber Bragg grating(CFBG)is proposed and experimentally demonstrated.Linearly chirped FBGs in a polymer optical fiber provide an alternative to the silica fiber owing to the lower Young’s modulus,which can yield a higher stress sensitivity under the same external force.According to the spatial wavelength-encoded characteristic of the CFBG,a fully distributed strain measurement can be achieved by optical frequency-domain reflectometry.Through time-/space-resolved short-time Fourier transform,the applied force can be located by the beat frequency originated from the space-induced time delay and measured by the differential frequency offset originated from the strain-induced dispersion time delay.In a proof-of-concept experiment,a high spatial resolution of 1 mm over a gauge length of 40 mm and a strain resolution of 0.491 Hz/μεwere achieved. | Chengang Lyu Ziqi Liu Ziqiang Huo Chunfeng Ge Xin Cheng Haw-Yaw Tam | 2020 | Photonics Research2020，8，7： | 2 |
| 3 | Analysis of deep earth pressure around cast - in - place pile considering concrete property variation 显示文摘 | ZHAO Chunfeng Yang Yanzong ZHAO Cheng etal | 2013 | KSCE2013，17，1： | 1 |
| 4 | African swine fever virus MGF505-3R inhibits cGAS-STING-mediated IFN-βpathway activation by degrading TBK1显示文摘African swine fever virus(ASFV)is an important pathogen causing acute infectious disease in domestic pigs and wild boars that seriously endangers the global swine industry.As ASFV is structurally complex and encodes a large number of functional proteins,no effective vaccine has been developed to date.Thus,dissecting the mechanisms of immune escape induced by ASFV proteins is crucial.A previous study showed that the ASFV-encoded protein is an important factor in host immunity.In this study,we identified a negative regulator,MGF505-3R,that significantly downregulated cGAS/STING-and poly(dG:dC)-mediated IFN-βand interferon stimulation response element(ISRE)reporter activity and suppressed IFNB1 and IFIT2 mRNA levels.In addition,TBK1,IRF3 and IκBαphosphorylation levels were also inhibited.Mechanistically,MGF505-3R interacted with cGAS/TBK1/IRF3 and targeted TBK1 for degradation,thereby disrupting the cGAS-STING-mediated IFN-βsignaling pathway,which appears to be highly correlated with autophagy.Knockdown MGF505-3R expression enhanced IFN-βand IL-1βproduction.Taken together,our study revealed a negative regulatory mechanism involving the MGF505-3R-cGAS-STING axis and provided insights into an evasion strategy employed by ASFV that involves autophagy and innate signaling pathways. | Mingyang Cheng Jiawei Luo Yuetong Duan Yu Yang Chunwei Shi Yu Sun Yiyuan Lu Junhong Wang Xiaoxu Li Jianzhong Wang Nan Wang Wentao Yang Yanlong Jiang Guilian Yang Yan Zeng Chunfeng Wang Xin Cao | 2022 | Animal Diseases2022，2，3： | 1 |
| 5 | A nonlinear equalization method based on multilayer perception for OFDM power-line communication显示文摘 | Luo Chunfeng Cheng Shijie Xiong Lan | 2005 | IEEE Transactions on Power Delivery2005，20，4： | 1 |
| 6 | Selegiline improves excessive daytime sleepiness in Parkinson’s disease:an open-label observational study显示文摘To the Editor:Parkinson’s disease(PD)is the second most common neurodegenerative disorder,and sleep disturbance is a major disabling non-motor symptom.[1]Excessive daytime sleepiness(EDS)is defined as inappropriate and undesirable sleepiness during waking hours,which may occur during activities such as talking or driving.In PD patients,EDS increased the risk of accidents and resulted in a poor quality of life.[2] | Jinru Zhang Juping Chen Jia Li Jian Li Hong Miao Xiangyang Zhu Meng Meng Yang Han Jing Chen Xiaoyu Cheng Kangping Xiong Hong Jin Weifeng Luo Chengjie Mao Chunfeng Liu | 2022 | Chinese Medical Journal2022，，14： | 0 |
| 7 | Conventional type 1 dendritic cells in protective antitumor immunity and its potential in hepatocellular carcinoma显示文摘Immunotherapy is revolutionizing the clinical management of cancer patients by modulating T cells and natural killer cells.Dendritic cells(DCs)have the capacity to orchestrate the expansion and function of these effector cells both in lymphoid and non-lymphoid tissues of cancer patients.Distinct subtypes of DCs have various capacities to prime and activate different T cell responses.Here,we review conventional type 1 dendritic cells(cDC1s)and their crucial role in protective anti-tumor immunity.Targeting cDC1s as a cancer vaccine against the development of hepatocellular carcinoma will be discussed. | Chunfeng Qu Kun Chen Shao-Yan Cheng | 2020 | Hepatoma Research2020，6，7： | 0 |
| 8 | Correlation between sarcopenia and vital capacity in elderly people in Nanning显示文摘To investigate therelationship between sarcopenia and vital capacity(VC)in older adults in Nanning by investigating their humanbody composition and VC.A total of 355 middle-aged and elderly people(male 86,female 269)in Nanning wererandomly selected,their VC and body composition were measured by using the vital capacity tester and bodycomposition analyzer.①VC,BMI,skeletal muscle mass index(SMI)of male were higher than those of female,but the fat mass(FM)and body fat rate(BF%)were lower than that of female.②The VC in the male sarcopeniagroup was lower than that of the control group.③BMI and systemic muscle mass(SMM)in the male and femalesarcopenia group were lower than those in the control group,and the FM and trunk muscle mass(TMM)in thefemale group were lower than those in the control group. | Wu Siyi Cheng Chunfeng Liu Qi Jiang Jiayang He Kuntu Chen Xingcai Xu Lin Deng Qiongying | 2021 | 解剖学杂志2021，44，S01： | 0 |
| 9 | Amorphous Sn(HPO_(4))_(2)-derived phosphorus-modified Sn/SnO_(x) core/shell catalyst for efficient CO_(2) electroreduction to formate显示文摘Simultaneously achieving high activity,selectivity and stability for electrochemical CO_(2)reduction reaction(CO_(2)RR)remains great challenges.Herein,a phosphorus-modified Sn/Sn Oxcore/shell(P-Sn/SnO_x)catalyst,derived from in situ electrochemical reduction of an amorphous Sn(HPO_(4))_(2) pre-catalyst,exhibits high CO_(2)RR performance.The total Faradaic efficiency(FE)of C_(1) products is close to 100%in a broad potential range from-0.49 to-1.02 V vs.reversible hydrogen electrode,and a total current density of 315.0 m A cm^(-2)is achieved.Moreover,the P-Sn/SnO_(x) catalyst maintains a formate FE of~90%for 120 h.Density functional theory calculations suggest that the phosphorus-modified Sn/SnO_(x) core/shell structure effectively facilitates formate production by enhancing CO_(2)adsorption and improving free energy profile of formate formation. | Chunfeng Cheng Tianfu Liu Yi Wang Pengfei Wei Jiaqi Sang Jiaqi Shao Yanpeng Song Yipeng Zang Dunfeng Gao Guoxiong Wang | 2023 | Journal of Energy Chemistry2023，，6： | 0 |
| 10 | A 1-bp deletion in the MC04g1399 is highly associated with failure to produce fruit wart in bitter gourd显示文摘Fruit wart is an important appearance trait influencing consumer preferences of bitter gourd(Momordica charantia L.).The molecular genetic mechanisms underlying fruit wart formation in bitter gourd are largely unknown.In this study,genetic analysis based on four generations showed that fruit wart formation in bitter gourd was controlled by a single dominant locus named as Fwa.The Fwa locus was initially mapped into a 4.82 Mb region on pseudochromosome 4 by BSA-seq analysis and subsequently narrowed down to a 286.30 kb region by linkage analysis.A large F2population consisting of 2360 individuals was used to screen recombinants,and the Fwa locus was finally fine mapped into a 22.70 kb region harboring four protein-coding genes through recombination analysis.MC04g1399,encoding an epidermal patterning factor 2-like protein,was proposed as the best candidate gene for Fwa via sequence variation and expression analysis.In addition,a 1-bp insertion and deletion(InDel)variation within MC04g1399 was converted to a cleaved amplified polymorphic sequence(CAPS)marker that could precisely distinguish between the warty and non-warty types with an accuracy rate of 100%among a wide panel of 126 bitter gourd germplasm resources.Our results not only provide a scientific basis for deciphering the molecular mechanisms underlying fruit wart formation but also provide a powerful tool for efficient genetic improvement of fruit wart via marker-assisted selection. | Jia Liu Junjie Cui Jichi Dong Jian Zhong Chunfeng Zhong Fanchong Yuan Wendong Guan Fang Hu Jiaowen Cheng Kailin Hu | 2024 | Horticultural Plant Journal2024，10，1： | 0 |
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