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| 1 | Protective effect of early enteral feeding on postburn impairment of liver function and its mechanism in rats显示文摘AIM To study the protective effect of earlyenteral feeding(EEF)on the postburnimpairment of liver function and its mechanism.METHODS Wistar rats with 30% of total bodysurface area(TBSA)full-thickness burn wereemployed.The effects of EEF on the postburnchanges of gastric intramucosal pH,endotoxinlevels in portal vein,water contents of hepatictissue,blood concentrations of tumor necrosisfactor(TNF-α),plasma activities of alanineaminotransferase(ALT)and asparateaminotransferase(AST),as well as the bloodcontents of total(TB)and direct bilirubin(DB),total protein(TP)and albumin(ALB)wereserially determined within 48h postburn.RESULTS EEF could significantly improvegastric mucosal acidosis,reduce portal veinendotoxin level and water content of hepatictissue,as well as plasma concentrations of TNF-α at all timepoints after severe burns(P<0.01);postburn elevation of the plasma activities ofALT,AST and the contents of TB,DB wereeffectively prevented,whereas the plasmaconcentrations of TP and ALB were markedlyincreased 24 h and 48 h posturn in EEF groupcompared with that of the burn without EEFgroup(P<0.01).CONCLUSION EEF has significant beneficialeffects on the improvement of hepatic function in rats after severe burn,and is probably relatedwith an increase in splanchnic blood flow,reduction of the absorption of gut-originendotoxin and the consequent release ofinflammatory mediators. | Zhu L Yang ZC Li A Cheng DC | 2000 | World Journal of Gastroenterology2000，6，1： | 10 |
| 2 | Reduced gastric acid production in burn shock period and its significance in the prevention and treatment of acute gastric mucosal lesions显示文摘AIM To investigate the changes of gastric acidproduction and its mechanism in shock period ofsevere burn in rats.METHODS A rat model with 30% TBSA full-thickness burn injury was employed and thegastric acid production,together with gastricmucosal blood flow(GMBF)and energy charge(EC)were measured serially within 48hpostburn.RESULTS The gastric acid production in theacute shock period was markedly inhibited aftersevere burn injury.At the 3rd h postburn,thegastric juice volume,total acidity and acidoutput were already significantly decreased(P<0.01),and reached the lowest point,0.63mL/L±0.20mL/L,10.81mmol/L±2.58mmol/L and 2.23mmol/h±0.73mmol/hrespectively,at the 12th h postburn.Althoughrestored to some degree 24 h after thermalinjury,the variables above were stillstatistically lower,compared with those ofcontrol animals at the 48th h postburn.TheGMBF and EC were also significantly reducedafter severe burns,consistent with the trend ofgastric acid production changes.CONCLUSION Gastric acid production,as wellas GMBF and EC was predominantly decreased in the early postburn stage,suggesting that gastricmucosal ischemia and hypoxia with resultantdisturbance in energy metabolism,but notgastric acid proper,might be the decisive factorin the pathogenesis of AGML after thermalinjury,and that the preventive use of anti-aciddrugs during burn shock period wasunreasonable in some respects.Therefore,taking effective measures to improve gastricmucosal blood perfusion as early as possiblepostburn might be more preferable for the AGMLprevention and treatment. | Zhu L Yang ZC Li A Cheng DC | 2000 | World Journal of Gastroenterology2000，6，1： | 7 |
| 3 | 横纹肌样及未分化表型的肾细胞癌:32例分析提示未分化肿瘤具有与SWI/SNF复合体缺陷有关的不同于常见的分化通路显示文摘肾细胞癌出现未分化(间变性)和横纹肌样细胞特征时被公认为预后不良,其分子机制尚未充分阐明。近期研究发现SWI/SNF染色质重塑复合体是不同器官具有未分化和横纹肌样特征癌的分子机制。本文对32例未分化肾细胞癌(均具有未分化和明显横纹肌样特征,可有或无普通型肾细胞癌成分)的分子特征进行分析。 | Agaimy A Cheng L Egevad L 向娟 余英豪 | 2017 | 临床与实验病理学杂志2017，33，7： | 2 |
| 4 | Preparation and hybridization analysis of DNA/RNA from E. coli on microfabricated bioelectronic chips显示文摘 | Cheng Jing Sheldon E L Wu Lei Uribe A Gerrue L O Carrino J Heller M J O'Connell J P | | 0，，： | 2 |
| 5 | Thyroid hormone stimulates hepatic lipid catabolism via activation of autophagy显示文摘 | Sinha Rohit Anthony You Seo-Hee Zhou Jin Siddique Mobin M Bay Boon-Huat Zhu Xuguang Privalsky Martin L Cheng Sheue-Yann Stevens Robert D Summers Scott A Newgard Christopher B Lazar Mitchell A Yen Paul M | 2012 | EN2012，，7： | 2 |
| 6 | 收缩压和舒张压变异性对脑卒中患者血管事件的不同影响显示文摘较高的血压变异性(blood pressure variability,BPV)是心血管病的危险因素。然而,在引发不同的血管事件时,收缩压变异性(systolic blood pressure variability,SBPV)和舒张压变异性(diastolic blood pressure variability,DBPV)是否存在不同作用仍不清楚。本研究旨在探讨SBPV或DBPV对急性缺血性脑卒中(acute ischaemic stroke,IS)或短暂性脑缺血发作(transient ischaemic attack,TIA)患者血管事件的作用是否存在区别。 | 周卫(译) 袁源(摘) 叶鹏(审校) Dai L Cheng A Hao X Xu J Zuo Y Wang A Meng X Li H Wang Y Zhao X Wang Y | 2020 | 中华高血压杂志2020，28，11： | 2 |
| 7 | Nutrient removal from swine lagoon liquid by Lemna minor 8627显示文摘 | CHENG J LANDESMAN L BERGMANN B A | 2002 | Trahsaction of the ASAE2002，45，4： | 1 |
| 8 | Efficacy and safety of sorafenib in patients in the Asia Pacific region with advanced hepatocellular carcinoma: a phase Ⅲ randomised,double-blind, placebo controlled trial显示文摘 | Cheng A L Kang Y K Chen Z Tsao C J Qin S Kim J S | 2009 | Lancet Oncol2009，10，： | 1 |
| 9 | Optimal trajectory syn-thesis for terrain-following flight显示文摘 | Menon P K A Kim E Cheng V H L | 1991 | Journal of Guidance Control and Dynamics1991，14，4： | 1 |
| 10 | A dominant negative cadherin inhibits osteoblast differrentiation 显示文摘 | Cheng S L Shin C S Towler D A | 2000 | J Bone Miner Res2000，15，12： | 1 |
| 11 | The half-lives of uranium-234 and thorium-230显示文摘 | Cheng H Edwards R L Hoff J A | 2000 | Chem Geol2000，169，： | 1 |
| 12 | Yogurts from skim milk- whey protein concentrate blends显示文摘 | Cheng L J Augustina M A Clarke P T | 2000 | Austealian Journal of Dairy Technology2000，，55： | 1 |
| 13 | Changes in venous hemody-namics after superficial vein surgery for mixed superficial and deep ve-nous insufficiency显示文摘 | Ting A C Cheng S W Wu L L | 2001 | World J Surg2001，25，2： | 1 |
| 14 | In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Can- dida albicans显示文摘 | Sun L Sun S Cheng A | 2009 | Antimicrob Agents Chemother2009，53，4： | 1 |
| 15 | Selective adsorption of hydrocarbon gases on clays and organic matter显示文摘 | CHENG A L HUANG W L | 2004 | Organic Geochemistry2004，35，： | 1 |
| 16 | Soil acid and alkaline phosphatase activity as pH adjustment indicators显示文摘 | Dicka W A Cheng L Wang P | 2000 | Soil Biology and Biochemistry2000，32，13： | 1 |
| 17 | Characterisation of composite films made of konjac glucomannan (KGM), carboxymethyl cellulose (CMC) and lipid 显示文摘 | Cheng L H Karim A A Seow C C | 2008 | Food Chem2008，107，1： | 1 |
| 18 | Histologic variants of urothelial carcinoma:differential diagnosis and clinical implications显示文摘 | Lopez- Beltran A Cheng L | 2006 | Hum Pathol2006，37，11： | 1 |
| 19 | Use of green fluorescent protein variants to monitor gene transfer and expression in mammalian cells显示文摘 | Cheng L Fu J Tsukamoto A | 1996 | Nature Biotechnology1996，14，： | 1 |
| 20 | A New Measure of Process Capability:Cpm显示文摘 | Cheng SW Spiring F A | 1998 | Journal of Quality Technology1998，30，2： | 1 |
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