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| 1 | Two gap-free reference genomes and a global view of the centromere architecture in rice显示文摘Rice(Oryza sativa),a major staple throughout the world and a model system for plant genomics and breeding,was the first crop genome sequenced almost two decades ago.However,reference genomes for all higher organisms to date contain gaps and missing sequences.Here,we report the assembly and analysis of gap-free reference genome sequences for two elite O.sativa xian/indica rice varieties,Zhenshan 97 and Minghui 63,which are being used as a model system for studying heterosis and yield.Gap-free reference genomes provide the opportunity for a global view of the structure and function of centromeres.We show that all rice centromeric regions share conserved centromere-specific satellite motifs with different copy numbers and structures.In addition,the similarity of CentO repeats in the same chromosome is higher than across chromosomes,supporting a model of local expansion and homogenization.Both genomes have over 395 non-TE genes located in centromere regions,of which∼41%are actively transcribed.Two large structural variants at the end of chromosome 11 affect the copy number of resistance genes between the two genomes.The availability of the two gap-free genomes lays a solid foundation for further understanding genome structure and function in plants and breeding climate-resilient varieties. | Jia-Ming Song Wen-Zhao Xie Shuo Wang Yi-Xiong Guo Dal-Hoe Koo Dave Kudrna Chenbo Gong Yicheng Huang Jia-Wu Feng Wenhui Zhang Yong Zhou Andrea Zuccolo Evan Long Seunghee Lee Jayson Talag Run Zhou Xi-Tong Zhu Daojun Yuan Joshua Udall Weibo Xie Rod AWing Qifa Zhang Jesse Poland Jianwei Zhang Ling-Ling Chen | 2021 | Molecular Plant2021，14，10： | 9 |
| 2 | 儿童NTRK重排间叶源性肿瘤临床病理学观察显示文摘目的:探讨儿童NTRK重排间叶源性肿瘤临床和病理学特征,以提高对该类疾病的认识。方法:收集上海交通大学医学院附属上海儿童医学中心及新加坡KK Women′s and Children′s Hospital从2017年1月至2019年9月5例手术切除标本,采用EnVision法检测免疫组织化学表型,荧光原位杂交(FISH)检测相关基因并对NTRK基因重排进行克隆性分析。结果:该组5例患儿,3例男性,2例女性。年龄从3个月到13岁,部位包括软组织(膝、胸腔、腹壁)和肾,肿瘤大小为4.5~12.5 cm。组织学检查主要呈梭形细胞肿瘤,浸润性生长,可伴有炎性细胞。免疫表型上,肿瘤细胞阳性表达Pan-TRK,分子检测均存在NTRK基因重排,包括DCTN1-NTRK1的发现。除2例目前接受靶向药物治疗,其余均为无疾病进展病例,随访时间9~29个月。结论:NTRK重排间叶源性肿瘤,其肿瘤发生部位广泛,组织学图像多变。免疫组织化学Pan-TRK可以帮助诊断,NTRK基因检测确认其存在重排是诊断的金标准,对不能完整切除或有复发、转移病例建议靶向药物治疗。 | 殷敏智 马靖 何巧 沈萍 陈洁枫 金晓婷 张忠德 Chik Hong Kuick Chen Huiyi Eileen Hui Qi Ng Sze Jet Aw Kenneth Tou En Chang | 2020 | 中华病理学杂志2020，49，7： | 6 |
| 3 | Application of a visible simulation surgery technique in preoperation planning for intahepatic calculi显示文摘 | Fang CH Xie AW Chen ML | 2010 | World J Surg2010，34，： | 1 |
| 4 | Myosin VI is an actin-based motor that moves backwards显示文摘 | Wells AL Lin AW Chen LQ | 1999 | Nature1999，401，6752： | 1 |
| 5 | Assessment of a three-dimensional operating system with skill tests in a pelvictrainer显示文摘 | Sun CC Chiu AW Chen KK | 2000 | Urol Int2000，64，3： | 1 |
| 6 | Clopidogrel and bleeding in patients undergoing elective coronary artery bypass grafting显示文摘 | Chen L Bracey AW Radovancevic R | 2004 | J Thorac Cardiovasc Surg2004，128，： | 1 |
| 7 | Application of a visible simulation surgery teehnique in preoperation planning for intrahepatie caieuli 显示文摘 | Fang CH Xie AW Chen ML | 2010 | World J Surg2010，34，2： | 1 |
| 8 | Functional consequences of directed mutations in human papillomavirus E6 proteins: abrogation of p53-mediated cell cycle arrest correlates with p53 binding and degradation in vitro显示文摘 | Slebos R J Kessis TD Chen AW | 1995 | Virology1995，208，1： | 1 |
| 9 | Application of a visible simulation surgery technique in preoperation planning for intrahepatic calculi显示文摘 | Fang CH Xie AW Chen ML | | 0，，： | 1 |
| 10 | Evaluation of plasma lysophospholipids for diagnostic significance using electro spray ionization mass spectrometry(ESI MS)analyses显示文摘 | Xiao Y Chen Y Kennedy AW | | 0，，： | 1 |
| 11 | Practical clinical approaches to functional visual loss显示文摘 | Chen CS Lee AW Karagiannis A | 2007 | J Clin Neurosci2007，14，1： | 1 |
| 12 | Retention of endocrine function in the SCID-Hu mouse - a model for the development of human fetal islet tissue 显示文摘 | Chen KE Weide LG | 1995 | Transplantation1995，59，10： | 1 |
| 13 | A review of the mammalian unfolded protein response显示文摘 | Chakrabarti A Chen AW Varner JD | 2011 | Biotechnol Bioeng2011，108，12： | 1 |
| 14 | Central thoracic lesions treated with hypofractionated stereotactic body radiotherapy 显示文摘 | Milano MT Chen Y Katz AW | 2009 | Radiother 0ncol2009，91，： | 1 |
| 15 | Resveratrol Attenuates Ear- ly Brain Injury After Subarachnoid Hemorrhage Through Inhibi- tion of NF - KB - Dependent Inflammatory/MMP - 9 Pathway 显示文摘 | SHAO AW WU HJ CHEN S | 2014 | CNS Neurosci & Ther2014，20，2： | 1 |
| 16 | Laparoscopic nephrolysis for chyluria: case report of long-term success显示文摘 | Chiu AW Chen MT Chang LS | 1995 | J Endourol1995，9，4： | 1 |
| 17 | Platinum adduct formation in mitochondrial DNA may underlie the phenomenon of coasting显示文摘 | Podratz JL Schlattau AW Chen M | 2007 | Peripher Nerv Syst2007，12，： | 1 |
| 18 | Application of a visible simulation surgery technique in preoperation planning for intrahepatic calculi显示文摘 | Fang CH Xie AW Chen ML | 2010 | World J Surg2010，34，2： | 1 |
| 19 | Ocular neovascularization follow-ing central retinal artery occlusion : Prevalence and timing ofonset 显示文摘 | Rudkin AK Lee AW Chen CS | 2010 | Eur J Ophthalmol2010，20，6： | 1 |
| 20 | Community-based stroke incidence in a Scottish population:the Scottish Borders Stroke Study显示文摘 | Syme PD Byrne AW Chen R | | 0，，： | 1 |
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