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| 1 | Programmable time-domain digital-coding metasurface for non-linear harmonic manipulation and new wireless communication systems显示文摘Optical non-linear phenomena are typically observed in natural materials interacting with light at high intensities, and they benefit a diverse range of applications from communication to sensing. However,controlling harmonic conversion with high efficiency and flexibility remains a major issue in modern optical and radio-frequency systems. Here, we introduce a dynamic time-domain digital-coding metasurface that enables efficient manipulation of spectral harmonic distribution. By dynamically modulating the local phase of the surface reflectivity, we achieve accurate control of different harmonics in a highly programmable and dynamic fashion, enabling unusual responses, such as velocity illusion. As a relevant application, we propose and realize a novel architecture for wireless communication systems based on the time-domain digital-coding metasurface, which largely simplifies the architecture of modern communication systems, at the same time yielding excellent performance for real-time signal transmission. The presented work, from new concept to new system, opens new pathways in the application of metamaterials to practical technology. | Jie Zhao Xi Yang Jun Yan Dai Qiang Cheng Xiang Li Ning Hua Qi Jun Chen Ke Guo Dong Bai Shuo Liu Shi Jin Andrea Alù Tie Jun Cui | 2019 | National Science Review2019，6，2： | 46 |
| 2 | Brain-derived neurotrophic factor and its related enzymes and receptors play important roles after hypoxic-ischemic brain damage显示文摘Brain-derived neurotrophic factor(BDNF) regulates many neurological functions and plays a vital role during the recovery from central nervous system injuries. However, the changes in BDNF expression and associated factors following hypoxia-ischemia induced neonatal brain damage, and the significance of these changes are not fully understood. In the present study, a rat model of hypoxic-ischemic brain damage was established through the occlusion of the right common carotid artery, followed by 2 hours in a hypoxic-ischemic environment. Rats with hypoxic-ischemic brain damage presented deficits in both sensory and motor functions, and obvious pathological changes could be detected in brain tissues. The m RNA expression levels of BDNF and its processing enzymes and receptors(Furin, matrix metallopeptidase 9, tissuetype plasminogen activator, tyrosine Kinase receptor B, plasminogen activator inhibitor-1, and Sortilin) were upregulated in the ipsilateral hippocampus and cerebral cortex 6 hours after injury;however, the expression levels of these m RNAs were found to be downregulated in the contralateral hippocampus and cerebral cortex. These findings suggest that BDNF and its processing enzymes and receptors may play important roles in the pathogenesis and recovery from neonatal hypoxic-ischemic brain damage. This study was approved by the Animal Ethics Committee of the University of South Australia(approval No. U12-18) on July 30, 2018. | Liu-Lin Xiong Jie Chen Ruo-Lan Du Jia Liu Yan-Jun Chen Mohammed Al Hawwas Xin-Fu Zhou Ting-Hua Wang Si-Jin Yang Xue Bai | 2021 | Neural Regeneration Research2021，16，8： | 12 |
| 3 | DL-3-n-butylphthalide ameliorates diabetes-associated cognitive decline by enhancing PI3K/Akt signaling and suppressing oxidative stress显示文摘DL3-n-Butylphthalide(DLNBP),a small molecular compound extracted from the seeds of Ap/um graveo/ens Linn(Chinese celery),has been shown to exert neuroprotective effects due to its anti-inflammatory,anti-oxidative and anti-apoptotic activities.DL-NBP not only protects against ischemic cerebral injury,but also ameliorates vascular cognitive impairment in dementia patients including AD and PD.In the current study,we investigated whether and how DL-NBP exerted a neuroprotective effect against diabetes-associated cognitive decline(DACD)in db/db mice,a model of type-2 diabetes,db/db mice were orally administered DL-NBP(20,60,120 mg·kg^(-1)·d^(-1))for 8 weeks.Then the mice were subjected to behavioral test,their brain tissue was collected for morphological and biochemical analyses.We showed that oral administration of DL-NBP significantly ameliorated the cognitive decline with improved learning and memory function in Morris water maze testing.Furthermore,DL-NBP administration attenuated diabetes-induced morphological alterations and increased neuronal survival and restored the levels of synaptic protein PSD95,synaptophysin and synapsin-1 as well as dendritic density in the hippocampus,especially at a dose of 60 mg/kg.Moreover,we revealed that DL-NBP administration suppressed oxidative stress by upregulating Nrf2/HO-1 signaling,and increased brain-derived neurotrophic factor(BDNF)expression by activating PI3K/Akt/CREB signaling in the hippocampus.These beneficial effects of DL-NBP were observed in high glucose-treated PC12 cells.Our results suggest that DL-NBP may be a potential pharmacologic agent for the treatment of DACD. | Bei-ni Wang Cheng-biao Wu Zi-miao Chen Pei-pei Zheng Ya-qian Liu Jun Xiong Jing-yu Xu Pei-feng Li Abdullah Al Mamun Li-bing Ye Zhi-long Zheng Yan-qing Wu Jian Xiao Jian Wang | 2021 | Acta Pharmacologica Sinica2021，42，3： | 11 |
| 4 | Fura-2/AM法测定突触体内游离Ca^(2+)浓度的方法显示文摘采用新型Ca2+荧光指示剂Fura-2,测定冷冻伤性脑水肿时突触体内游离钙的离子浓度。 | Chen Liuhua Yan Yujia He Zhengwen, et al(Neurological and Neurosurgical Institute of Ncurosurgery, Xiangya Hospital, Hunan Medical University, Changsha 410008) | 1998 | 湖南医科大学学报1998，23，4： | 9 |
| 5 | Nuclear transcription factors and lipid homeostasis in liver显示文摘The liver plays a major role in the regulation ofglucose,lipid and energy metabolism.Increasedhepatic fat deposit is a very common feature in obese,insulin-resistant patients,in metabolic syndrome,alcoholic steatohepatitis(ASH)and nonalchoholic fattyliver disaseas(NAFLD).As a central organ for wholebody lipid metabolism,disruption of the normalmechanisms for synthesis,transport and removal/ | CHEN Ya-xi HUANG Ai-long RUAN Xiong-zhong Centre for Lipid Research,Key Laboratory of Molecular Biology on Infectious Diseases,Ministry of Education Second Affiliated Hospital,Chongqing Medical University,Chongqing 400010,China(Chen YX,Huang AL and Ruan XZ) | 2007 | Chinese Medical Journal2007，，24： | 8 |
| 6 | Urbanization reduces resource use efficiency of phytoplankton community by altering the environment and decreasing biodiversity显示文摘Urbanization often exerts multiple effects on aquatic and terrestrial organisms,including changes in biodiversity,species composition and ecosystem functions.However,the impacts of urbanization on river phytoplankton in subtropical urbanizing watersheds remain largely unknown.Here,we explored the effects of urbanization on phytoplankton community structure(i.e.,biomass,community composition and diversity)and function(i.e.,resource use efficiency)in a subtropical river at watershed scale in southeast China over 6 years.A total of 318 phytoplankton species belonging into 120 genera and 7 phyla were identified from 108 samples.Bacillariophyta biomass showed an increasing trend with increasing urbanization level.The phytoplankton community shifted from Chlorophyta dominance in rural upstream waters to Bacillariophyta dominance in urbanized downstream waters.Furthermore,phytoplankton diversity and resource use efficiency(RUE=phytoplankton biomass/total phosphorus)were significantly decreased with increasing urbanization level from upstream to downstream.Phytoplankton RUE exhibited a significant positive correlation with species richness,but a negative correlation with phytoplankton evenness.The variation in environmental factors(turbidity,total nitrogen,NH_(4)^(+)-N,total phosphorus,PO_(4)^(3-)-P and percentage urbanized area)was significantly correlated with phytoplankton diversity and RUE.Overall,our results revealed the influence of urbanization on phytoplankton community structure and ecosystem function was due to its altering the environmental conditions.Therefore,human-driven urbanization may play crucial roles in shaping the structure and function of phytoplankton communities in subtropical rivers,and the mechanism of this process can provide important information for freshwater sustainable uses,watershed management and conservation. | Yigang Yang Huihuang Chen Mamun Abdullah Al Jean Claude Ndayishimiye Jun R Yang Alain Isabwe Anqi Luo Jun Yang | 2022 | Journal of Environmental Sciences2022，34，2： | 4 |
| 7 | Degradation of dye pollutants by immobilized polyoxometalate with H2O2 under visible-light irradiation显示文摘 | Lei P X Chen C C Yang J el al | 2005 | Environmental Science and Technology2005，39，21： | 1 |
| 8 | Identification of a novel splicing product of the RON receptor tyrosine kinase in human colorectal carcinoma cells 显示文摘 | Wang MH Kurtz AL Chen YQ | 2000 | Carcinogenesis2000，21，8： | 1 |
| 9 | A new mixed micellar electrokinetic chromatography method for analysis of natural and synthetic anabolic steroids 显示文摘 | Zhang L Chen J He Y eZ al | 2009 | Talanta2009，77，3： | 1 |
| 10 | Flepeated-bateh production of kojie acid in a cell- retention fermenter using Aspergillus oryzae M3B9 显示文摘 | H M Wan C C Chen R Giridhar el al | 2005 | Ind Mierobiol Biotechnol2005，32，： | 1 |
| 11 | lnterteukin-23 rather than interleukin-12 is the critical eytokine for autoimmune inflammation of the brain显示文摘 | Cua D J Sherlock J Chen Y el al | 2003 | Nature2003，421，6924： | 1 |
| 12 | The MYB transcription factor super-family of Arabidopsis:expression analysis and phylogenetic comparisonwith the rice MYB family显示文摘 | CHEN Y H YANG X Y HE Ke t al | 2006 | Plant Molecular Biology2006，60，： | 1 |
| 13 | Combined anterior and pos- terior surgeries in the treatment of spinal tuberculous Spondylitis 显示文摘 | Chen W J Wu CC Jtmg CH el al | 2002 | Clin Orthop Relat Res2002，39，8： | 1 |
| 14 | Enhancement of pyru- vate production by Torulopsis glabrata using a two-stage oxygen supply control strategy显示文摘 | Li Y Hugenholtz J Chen J et al | 2002 | Chemistry and Mate- rims Science2002，60，： | 1 |
| 15 | Serum thymidine kinase 1 correlates to clinical stagesand clinical reactions and monitors the outcome of therapy of 1247 can-cer patients in routine clinical settings显示文摘 | Chen Y Ying M’el al | 2010 | Int J Clin Oncol2010，15，4： | 1 |
| 16 | Efficacy and safety of sorafenib in patients in the Asia - Pacific region with advanced hepatocellular carcinoma : a phase III randomised, double - blind, placebo con- trolled trial 显示文摘 | Cheng AL Kang YK Chen Z | 2009 | Lancet Onco12009，10，： | 1 |
| 17 | Finite-differencetime-domain analysis of optical bistability with low thresholdin one-dimensional nonlinear photonic crystal with Kerrmedium显示文摘 | CHEN L X DENG X X DING W Q d al | 2002 | Optics Communications >2002，209，4： | 1 |
| 18 | Myosin VI is an actin-based motor that moves backwards显示文摘 | Wells AL Lin AW Chen LQ | 1999 | Nature1999，401，6752： | 1 |
| 19 | Use of antibiotic-impregnated cement in total joint arthroplasty显示文摘 | Joseph TN Chen AL Di Cesare PE | | 0，，01： | 1 |
| 20 | Journal of Physics D: Applied Physics显示文摘 | Fan X A Yang J Y Chen R G e? al | 2006 | 39(4): 7402006，39，4： | 1 |
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