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| 1 | Rhubarb extract partially improves mucosal integrity in chemotherapy-induced intestinal mucositis显示文摘AIM To investigate the effects of orally gavaged aqueous rhubarb extract(RE) on 5-fluorouracil(5-FU)-induced intestinal mucositis in rats. METHODS Female Dark Agouti rats(n = 8/group) were gavaged daily(1 mL) with water, high-dose RE(HDR; 200 mg/kg) or low-dose RE(LDR; 20mg/kg) for eight days. Intestinal mucositis was induced(day 5) with 5-FU(150 mg/kg) via intraperitoneal injection. Intestinal tissue samples were collected for myeloperoxidase(MPO) activity and histological examination. Xenopus oocytes expressing aquaporin 4 water channels were prepared to examine the effect of aqueous RE on cell volume, indicating a potential mechanism responsible for modulating net fluid absorption and secretion in the gastrointestinal tract. Statistical significance was assumed at P < 0.05 by one-way ANOVA. RESULTS B o d y w e i g h t w a s s i g n i f i c a n t l y r e d u c e d i n r a t s administered 5-FU compared to healthy controls(P < 0.01). Rats administered 5-FU significantly increased intestinal MPO levels(≥ 307%; P < 0.001), compared to healthy controls. However, LDR attenuated this effect in 5-FU treated rats, significantly decreasing ileal MPO activity(by 45%; P < 0.05), as compared to 5-FU controls. 5-FU significantly reduced intestinal mucosal thickness(by ≥ 29% P < 0.001) as compared to healthy controls. LDR significantly increased ileal mucosal thickness in 5-FU treated rats(19%; P < 0.05) relative to 5-FU controls. In xenopus oocytes expressing AQP4 water channels, RE selectively blocked water influx into the cell, induced by a decrease in external osmotic pressure. As water efflux was unaltered by the presence of extracellular RE, the directional flow of water across the epithelial barrier, in the presence of extracellular RE, indicated that RE may alleviate water loss across the epithelial barrier and promote intestinal health in chemotherapy-induced intestinal mucositis.CONCLUSION In summary, low dose RE improves selected parameters of mucosal integrity and reduces ileal inflammation, manifesting from 5-FU-induced intestinal mucositis. | Juliana E Bajic Georgina L Eden Lorrinne S Lampton Ker Y Cheah Kerry A Lymn Jinxin V Pei Andrea J Yool Gordon S Howarth | 2016 | World Journal of Gastroenterology2016，22，37： | 3 |
| 2 | Isolation of Neospora caninum from a calf in Malaysia显示文摘 | CHEAH T S MATTSSON J G ZAINI M | 2004 | Vet Parasitol2004，126，3： | 1 |
| 3 | The kinetics of ligand binding by an adeninesensing riboswitch 显示文摘 | Wickiser J K Cheah M T Breaker R R | 2005 | Biochemistry2005，44，13： | 1 |
| 4 | Development and implementation of a clinical pathway programme in an acute care general hospital in Singapore显示文摘 | Cheah J | | 0，，05： | 1 |
| 5 | Induced resistance against Sclerotinia sclerotiorum in carrots treated with enzymatically hydrolysed chitosan显示文摘 | Chris M Cheah L H Koolaard J P | 2004 | Postharvest Biology and Technology2004，33，： | 1 |
| 6 | Rheological properties of high melt strength PET formed by reactive extrusion显示文摘 | Forsythe J S Cheah K Nisbet D R el al | 2006 | Applied Polymer2006，100，5： | 1 |
| 7 | Valuing governmental support in infrastruc- ture projects as real options using Monte Carlo simulation 显示文摘 | Cheah C Y J Liu J | 2006 | Construction Management and Economics2006，24，2： | 1 |
| 8 | Development and implementation of a clinical pathway program in acute care general hospital in Singapore显示文摘 | Cheah J | 2000 | Int Qual Health Care2000，12，5： | 1 |
| 9 | Valuing governmental support in infrastructure projects as real options using Monte Carlo simulation显示文摘 | Cheah C Y J Liu J C | 2006 | Construction Management and Economics2006，，5： | 1 |
| 10 | Clinical pathways - - an evaluation of its impact on the quality of care in an acute care general hospital in Singapore显示文摘 | Cheah J | 2000 | Sin - gapore Med J2000，41，7： | 1 |
| 11 | Induced resis- tance against Sclerotinia sclerotiorumin carrots treated with en- zymaticallyhydrolysed chitusan显示文摘 | Chris M Cheah L H Koolaard J P | 2004 | Postharvest Biology and Tech- nology2004，33，： | 1 |
| 12 | Development and implementation of clinical pathway program in an acute care general hospital in Singapore显示文摘 | Cheah J | 2000 | lnt Qual- Health Care2000，12，5： | 1 |
| 13 | SnO2 nanoparticles with controlled carbon nanocoating as high-capacity anode materials for lithium-ion batteries 显示文摘 | CHEN J S CHEAH Y L CHEN Y T | 2009 | The Journal of Physical Chemistry C2009，113，20： | 1 |
| 14 | Induced resistance against Sclarotinia sclerotiorum in carrots treated with enzymatically hydrolysed chitosan显示文摘 | MOLLOY C CHEAH L H KOOLARD J P | 2004 | Postharv Biol Technol2004，33，： | 1 |
| 15 | Respiration and ethylene Production in kiwifruit following hot water dips显示文摘 | IRVING D E PALLESEN J C CHEAH L H | 1991 | Postharvest Biology Technology1991，1，： | 1 |
| 16 | Reactivity of Aqua Coordinated Monoporphyrinate Lanthanide Complexes: Synthetic, Structural and Photolumineseent Studies of Lanthanide Porphyrinate Dimers 显示文摘 | He H Zhu X Hou A Guo J Wong W K Wong W Y Li K F Cheah K W | 2004 | Dalton Transactions2004，，23： | 1 |
| 17 | Epidemiology of prostatitis: new evidence for a world-wide problem 显示文摘 | Krieger J N Riley D E Cheah P Y | 2003 | World J Urol2003，21，2： | 1 |
| 18 | Induced resistance against Sclerotinia sclerotiorum in carrots treated with enzymatically hydrolysed chitosan显示文摘 | MOLLOY C CHEAH L H KOOLAARD J P | 2004 | Postharvest Biology and Technology2004，33，1： | 1 |
| 19 | Clinical pathways - an evaluation of its impact on the quali- ty of care in an acute care general hospital in Singapore 显示文摘 | Cheah J | 2000 | Singa- pore Med J2000，41，7： | 1 |
| 20 | Clinical pathways:an evaluation of its im pact on the quality of care in an acute care general hospital in Singapore显示文摘 | Cheah J | | 0，，07： | 1 |
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