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| 1 | 藿香和广藿香挥发油对皮肤癣菌和条件致病真菌的抑制作用显示文摘目的 :筛选天然抗皮肤真菌新药和开发芳香油植物资源。方法 :利用培养基药物浓度稀释法和气相色谱 质谱联用技术 ,研究了藿香和广藿香挥发油对 12种皮肤癣菌和条件致病真菌的体外抑制作用和主要化学成分 ,比较了 3种不同地理来源(中国、印度和印度尼西亚爪哇 )广藿香油的抗真菌活性。结果 :这 4种挥发油都可以选择性地完全抑制皮肤癣菌的生长繁殖 ,其中中国广藿香油的活性最强 ,其最低抑制浓度 (MIC) 5 0~ 4 0 0 μl·L-1,主要化学成分为广藿香醇、异愈创木烯和广藿香烯。藿香油最弱 ,MIC位于 70 0~ 10 0 0 μl·L-1,主要成分是薄荷酮类化合物。结论 :证明了广藿香油的选择性皮肤癣菌抑制作用 ,为进一步筛选抗真菌外用新药提供了重要依据。 | 杨得坡 Chaumont Jean-Pierre Millet Jolle | 2000 | 中国药学杂志2000，35，1： | 75 |
| 2 | 黄芩甙元和黄芩甙对皮肤真菌与细菌抑制作用的研究显示文摘本文研究了黄芩甙和黄芩甙元对十七种皮肤致病真菌与十六种皮肤细菌的抑制活性。在琼脂药物培养基上,黄芩甙元表现出了对酵母型真菌高度的选择抑制作用,其最低抑制浓度MIC在70~100μg/ml之间,而对皮肤癣菌和丝状霉菌没有活性;黄芩甙则对所有的供试真菌几乎没有作用。另外,与脚气和腋臭有关的负责菌如固着微球菌、表皮葡萄球菌、人型葡萄球菌和干燥棒杆菌等,在黄苓甙元浓度为250μg/ml的条件下,其生长繁殖也能完全抑制。黄芩甙元的抗菌活性可能与其结构第七位羟基的存在有关。 | 杨得坡 胡海燕 黄世亮 Jean-Pierre Chaumont Joělle Millet | 2000 | 中药材2000，23，5： | 64 |
| 3 | Single Mutations in the Transmembrane Domains of Maize Plasma Membrane Aquaporins Affect the Activity of Monomers within a Heterotetramer显示文摘Aquaporins 是越过生物的膜便于水或小无电荷的溶质的散开的隧道。他们作为 homotetramers 集合,但是他们中的一些也形成 heterotetramers,特别在植物。在 Zea mays,属于血浆膜的 aquaporins 当在 Xenopus 卵母细胞表示了时,内在的蛋白质(果仁) 亚科被聚类进二个组, PIP1 和 PIP2,它展出不同水隧道活动。当 PIP1 和 PIP2 isoforms 被共同表示时,他们身体上交往调制他们的 subcellular 本地化和隧道活动。这里,我们由亲密关系层析纯化证明当在 Xenopus 卵母细胞共同表示时,玉米 PIP1; 2 并且 PIP2; 5 isoforms 作为人集合 -- 并且在 heterotetramers 以内的 heterodimers。我们由根据菠菜 SoPIP2 的比较建模造了如此的 heterotetramers 的 3D 结构;在通常认为地在在单体之间的接口交往的 transmembrane 域的 1 X 光检查结构和识别氨基酸残余。他们在水隧道活动, subcellular 本地化,蛋白质丰富,和物理相互作用的角色被 mutagenesis 调查。我们加亮也使 PIP2 失去活性的单个残余的替换; 5 或激活的 PIP1; 2 没有影响他们的相互作用。有趣地,在 transmembrane 领域的 Phe220Ala 变化 5 PIP1; 2 激活它的水隧道活动并且同时,使 PIP2 失去活性; 5 在 heterotetramer 以内。总的来说,这些数据在他们的水隧道活动贡献在果仁 isoforms 和 heterotetramerization 的角色之间的相互作用机制的更好的理解。 | Marie C. Berny Dimitri Gilis Marianne Rooman Francois Chaumont | 2016 | Molecular Plant2016，9，7： | 5 |
| 4 | Relaxor behaviour and phase transition of perovskite ferroelectrics-type complex oxides(1–x)Na_(0.5)Bi_(0.5)TiO_3–xCaTiO_3 system显示文摘Polycrystalline powders of (1–x)Na_(0.5)Bi_(0.5)TiO_3–xCaTiO_3 ((1–x)NBT–xCT, 0 ≤ x ≤ 0.55) have been synthesized by solid state route. The effects of simultaneous substitution of Na^+/Bi^(3+) at A-site in NBT on structural and dielectric properties were investigated. X-ray diffraction analysis revealed the phase transition from rhombohedral structure(x = 0) to orthorhombic structure(x ≥0.15). A distinct behaviour in dielectric properties was obtained, where for x = 0, a normal ferroelectric behaviour was observed, whereas for x ≥ 0.15, a broad dielectric anomaly was revealed such that the maximum temperature(T_m) strongly depended on the frequency and shifted towards low temperature with CT. The dielectric dispersion indicated a relaxor behaviour revealed by the degree of diffuseness and modelled via Vogel–Fulcher relation. The study highlighted the relaxor behaviour as a function of frequency and proved the transformation from a relaxor high-frequency dependence to a paraelectric phase at temperature T_s. The distinct variation of the Raman spectra at room temperature was correlated with X-ray diffraction results and proved the already mentioned transition. On heating(-193–500 ℃), the Raman spectra confirmed the structural stability(Pnma) of the materials. The phonon behaviour for x = 0.15 was discussed in terms of the appearance of polar nanoregions(PNRs) into a non-polar orthorhombic matrix responsible of the relaxor behaviour. For x = 0.20, unchanged phonon behaviour confirmed the variation in dielectric behaviour where the solids transformed from a relaxor to a paraelectric state without structural phase transition. | Roy ROUKOS Nissrine ZAITER Denis CHAUMONT | 2018 | Journal of Advanced Ceramics2018，7，2： | 4 |
| 5 | 角蛋白酶在真菌侵染皮肤过程中的作用显示文摘具有高度交联三维结构的角蛋白对各种物理、化学和一般性的蛋白水解酶攻击具有很强的抗性,但在底物的诱导下,皮肤真菌分泌的用蛋白酶可特异性地水解该蛋白。在真菌感染皮肤过程中,用蛋白酶与菌丝的机械侵入和化学还原作用配合,使病原菌获得营养和侵入皮肤。在抗真菌药物的配方中,加入角蛋白酶,可帮助活性因子通过皮肤屏障或抑制病原菌繁殖。 | 杨得坡 Jean-Pierre Chaumont 彭劲甫 王发松 Joёlle Millet | 2000 | 微生物学杂志2000，20，2： | 3 |
| 6 | Use of caryophyllene oxide as an antifungal agent in an in vitro experimental model of onychomycosis显示文摘 | Depo Y Laura M Jean-Pierre Chaumont | 1999 | Mycopathologia1999，148，： | 1 |
| 7 | Apigenin and tangeretin enhance gap junction intracellular communication in rat liver epithelial cells显示文摘 | Chaumontent C Bex V Gallard-Sanchez I | 1994 | Carcinogenesis1994，15，： | 1 |
| 8 | Chalcopyrite thin film solar cells by electrodeposition 显示文摘 | LINCOT D GUILLEMOLESA J F TAUNIER S GUIMARD D SICX-KURDI J CHAUMONT A ROUSSEL O RAMDANI O HUBERT C FAUVARQUE J P BODEREAU N PARISSI L PANHELEUX P FANOUILLERE P NAGHAVI N GRAND P P BENFARAH M MOGENSEN P KERREC O | 2004 | Solar Energy2004，77，： | 1 |
| 9 | Characterization of a new vacuolar membrane aquaporin sensitive to mercury at a unique site显示文摘 | DANIELS M J CHAUMONT F MIRKOV T E | 1996 | Plant Cel1996，8，4： | 1 |
| 10 | Delivery systems for antisense oligodeoxynudeotide显示文摘 | CHAUMONT C G SEKSEK O GRZYBOWSKA J | 2000 | Pharmacology & Therapeutics2000，87，3： | 1 |
| 11 | Aquaporins constitute a large and highly divergent protein family in maize 显示文摘 | Chaumont F Barrieu F Wojcik E | 2001 | Plant Physiology2001，125，： | 1 |
| 12 | Solvation of 'big' spherical solutes in room temperature ionic liquids and at their aqueous interface: A molecular dynamicssimulationstudy显示文摘 | Chaumont A Wipff G | 2007 | JournalofMolecularLiquids2007，13，： | 1 |
| 13 | Effect of exercise training on metallothionein levels of hypertensive rats 显示文摘 | Bobillier Chaumont S Maupoil V Jacques Lahet J | 2001 | Med Sci Sports Exerc2001，33，5： | 1 |
| 14 | Aquaporins: a family of highlyregulated muhifunctional channels显示文摘 | Hachez C Chaumont F | 2010 | Advances in Ex- perimental Medicine Biology2010，679，： | 1 |
| 15 | Plasma membrane intrinsic proteins from maize cluster in two sequence subgroups with differential aquaporin activity显示文摘 | Chaumont F Barrieu F Jung R | 2000 | Plant Physiology2000，，122： | 1 |
| 16 | Crosslinking of ethylene-octene copolymers under dynamic conditions: A new way to access polymeric hyperbranched structure 显示文摘 | MSAKNI A CHAUMONT P CASSAGNAU P | 2006 | Polym Eng Sci2006，46，11： | 1 |
| 17 | Hepatic tumors in children: ultrasonic differentiation of malignant from benign lesions显示文摘 | Brunelle F Chaumont P | 1984 | Radiology1984，150，： | 1 |
| 18 | Carotenoid content in growing cells of Haematococcus pluσialis during a sunlight cycle 显示文摘 | Chaumont D Thepenier C | 1995 | J Appl Phycol1995，，7： | 1 |
| 19 | Aquaporins constitute a large and highly divergent protein family in maize显示文摘 | Chaumont F Barrieu F Wojcik E | 2001 | Plant Physiol2001，125，3： | 1 |
| 20 | Evaluation of the sap flow determined with a heat balance method to measure the transpiration of a sugarcane canopy显示文摘 | Rosanne Chabot Sami Bouarfa Daniel Zimmer Cédric Chaumont Sylvain Moreau | 2005 | Agricultural Water Management2005，，1： | 1 |
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