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438篇 您的检索式:作者名="t WS"
    题名 作者 年代 出处 被引量
1星形胶质细胞转录组分析指导的脑卒中靶标鉴定显示文摘星形胶质细胞支持正常的脑功能,但在卒中等病理条件下,星形胶质细胞反应性激活,其也可能参与神经退行性改变。反应性星形胶质细胞增生对机体有益或有害,与环境背景有关,但其分子基础仍未得到充分解释。借助RiboTag技术,我们在特异性地短暂性大脑中动脉闭塞(tMCAO)72h后的小鼠星形胶质细胞中,纯化翻译mRNA,构建卒中特异性星形胶质细胞翻译组数据库。我们发现,与对照组脑组织相比,tMCAO后的反应性星形胶质细胞显示与A2表型相关的转录物的富集,这与神经保护相关。星形胶质细胞也会上调大量潜在的神经毒性基因。我们共鉴定了1003个基因和38个转录因子的差异表达,其中Stat3,Sp1和Spi1变化最明显。为了进一步探索Stat3介导的通路对卒中发病机制的影响,我们选择星形胶质细胞特异性条件性缺失Stat3的小鼠制造tMCAO模型,发现这些小鼠的局灶性缺血卒中体积减少,且梗死72h后小鼠的运动结果改善。综上所述,本研究扩展了新兴的星形胶质细胞特异性靶向卒中治疗数据库,并肯定了星形胶质细胞是脑功能的关键保障细胞。Rakers C Schleif M Blank N Matu?ková H Ulas T H?ndler K Torres SV Schumacher T Tai K Schultze JL Jackson WS Petzold GC 聂昊 2019神经损伤与功能重建2019,14,6:2
2Hypereosinophilic syndrome:a case series显示文摘Aziz M Khan WS Ammar T el al 2009Biomedica2009,25,3:1
3WAF1,a potential mediator of p53 tumor suppression 显示文摘El-deiry WS Tokino T Velculescu VE 1993Cell1993,75,:1
4WAF1, a potential Mediator of P53 tumor suppression显示文摘EL-Deiry WS Tokino T Veleculescu VE 1993Cell1993,75,:1
5Molecular cloning of a ligand for the inducible T cell gene 4-1BB: A member of an emerging family of cytokines with homology to tumor necrosis factor显示文摘Goodwin RG Din WS Davis-Smith T 1993Eur J lmmunol1993,23,10:1
6SeroIogical reactions in pneumonia with a non-protein somatic fraction of pneumococcus 显示文摘Tillett WS Francis T 1930J Exp Med1930,52,4:1
7Fatigue behavior of steel fiber reinforced concrete in uniaxial and biaxial compression显示文摘 Hsu T TC 1995ACI Materials Journal1995,7180,:1
8Weight reduction increases plasma levels of an adipose- derived anti- inflammatory protein, adiponectin显示文摘Yang WS Lee W J Funahashi T 2001Clin Endocrinol Metab2001,86,:1
9Weight reduction increases plasma levels of an adipose-derived anti-inflammatory protein,adiponectin显示文摘Yang WS Lee WJ Funahashi T 2001J Clin Endocrinol Metab2001,86,:1
10Uncoupling protein-2 polymorphisms in type 2 diabetes, obesity, and insulin secretion显示文摘Wang H Chu WS Lu T 2004Am J Physiol Endocrinol Metab2004,286,1:1
11Complications of laparoscopic paraesophageal hernia repair显示文摘Trus TL Bax T Richardson WS 1997J Gastmintest Surg1997,1,3:1
12Elimination of laboratory ozone leads to a dramatic improvement in the reproducibility of microarray gene expression measurements显示文摘Branham WS Melvin CD Han T 2007BMC Biotech2007,7,1:1
13Endostatin: an endogenous inhibitor of angiogenesis and tumor growth显示文摘O' Reilly MS Boehm T Shing Y Fukai N Vasios G Lane WS 1997Cell1997,88,2:1
14Prostaglandins promote colon cancer cell invasion;signaling by cross-talk between two distinct growth factor receptors 显示文摘Pai R Nakamura T Moon WS 2003FASEB J2003,17,:1
15P21WAF1,a potential mediator of p53 tumor suppression显示文摘EL-Deiry WS Tokino T Velculescu VE 1993Cell1993,75,4:1
16Lactoferrin-binding proteins in Bifidobacterium bifidum显示文摘Kim WS Tanaka T Kumura H 2002Biochem Cell Biol2002,80,1:1
17显示文摘Yang WS Lee WJ Funahashi T 2002J Clin Endocrinal Metab2002,87,4:1
18Defect in peroxisome prolifera- tor-activated receptor alpha-inducible fatty acid oxidation determines the severity of hepatic steatosis in response to fasting 显示文摘Hashimoto T Cook WS Qi C 2000J Biol Chem2000,275,28:1
19Serological reactions in pneumonia with a non-protein somatic reaction of pnewmococcus 显示文摘Tillett WS Francis T 1930J Exp Med1930,52,:1
20Weight reduction increases plasma levels of an adipose-derived ant/inflammatory protein, adiponectin 显示文摘yang ws Lee WJ Funahashi T 2001J Clin Endocrinol Metab2001,86,:1
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