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| 1 | Cyclooxygenase-2 polymorphisms and the risk of esophageal adeno-or squamous cell carcinoma显示文摘AIM:To determine whether-1195 A→G and/or-765 G→C polymorphisms in Cyclooxygenase-2(COX-2 ) may have a risk modifying effect on the development of esophageal carcinoma in a Dutch Caucasian population.METHODS:Two study groups were recruited, 252 patients with esophageal carcinoma and 240 healthy controls, matched for race, age, gender and recruiting area.DNA was isolated from whole blood and used for genotyping.PCR products were digested with restriction enzymes and products were analyzed by agarose gel electrophoresis.Odds ratios(OR) and 95% confldence intervals(CI) were estimated.RESULTS:The distribution of the-1195 A→G polymorphism was signif icantly different in esophageal cancer patients compared to controls.The-1195 GG genotype resulted in a higher risk of developing esophageal adenocarcinoma(OR = 3.85, 95% CI:1.45-10.3) compared with the-1195 AA genotype as a reference.The-765 G→C genotype distribution was not different between the two groups.The GG/ GG haplotype was present more often in esophageal adenocarcinoma patients than in controls(OR = 3.45, 95% CI:1.24-9.58;with AG/AG as a reference).The same trends were observed in patients with squamous cell carcinomas, however, the results did not reach statistical signif icance.CONCLUSION:Presence of the COX-2-1195 GG genotype and of the GG/GG haplotype may result in a higher risk of developing esophageal carcinoma. | Jón O Kristinsson Paul van Westerveld Rene HM te Morsche Hennie MJ Roelofs T Wobbes Ben JM Witteman Adriaan CITL Tan Martijn GH van Oijen Jan BMJ Jansen Wilbert HM Peters | 2009 | World Journal of Gastroenterology2009，15，28： | 11 |
| 2 | COX-2 polymorphisms-765G→C and-1195A→G and colorectal cancer risk显示文摘AIM:To determine the possible modulating effect of the COX-2 polymorphisms,-765G→C and-1195A→G, on the risk of colorectal cancer(CRC)in a Dutch population. METHODS:This case-control study includes 326 patients with CRC and 369 age-and gender-matched controls.Genotypes of the COX-2 polymorphisms -765G→C and-1195A→G were determined by polymerase chain reaction-based restriction fragment length polymorphism.COX-2 genotypes and haplotypes were analyzed and odds ratios with 95%confi- dence intervals were estimated by logistic regression. RESULTS:The-765GG genotype was associated with an increased risk of developing CRC(OR,1.45; 95%CI,1.03-2.04).No significant difference was observed in the genotype distribution of the-1195A→ G polymorphism between patients and controls.The GG/AC haplotype was present significantly less often in patients than in controls(OR 0.44;95%CI,0.22-0.85). When the AC,AG and GG haplotypes were investigated separately,the AC haplotype showed a tendency to be less frequent in patients than in controls(OR(AG/AC)0.78; 95%CI,0.57-1.06). CONCLUSION:The-765GG genotype is associatedwith an increased risk of developing CRC and the GG/ AC haplotype seems to protect against CRC.These findings suggest a modulating role for the COX-2 polymorphisms-765G→C and-1195A→G in the development of CRC in a Dutch population. | Juliёt H Hoff Rene HM te Morsche Hennie MJ Roelofs Elise MJ van der Logt Fokko M Nagengast Wilbert HM Peters | 2009 | World Journal of Gastroenterology2009，15，36： | 6 |
| 3 | 脑缺血后N-myc下游调控基因2保护血脑屏障完整性显示文摘脑缺血后血脑屏障(BBB)的破坏与外周细胞向脑内浸润、病孔损形成与进展、以及临床病程恶化密切相关。目前BBB完整性的调控机制,尤其是在永久性缺血后的调控机制尚未明确。本研究使用小鼠永久性脑缺血模型进行相关研究,结果显示,星形胶质细胞N-myc下游调控基因2(NDRG2)可能是缺血性脑卒中后BBB通透性的调控分子,该分子与分化和应激相关。免疫组化显示,在永久性大脑中动脉闭塞(MCAO)后,NDRG2在星形胶质细胞中的表达显著增加。敲除NDRG2基因,脑梗死体积增加,免疫细胞在缺血同侧大脑半球积聚增加。MCAO后,NDRG2基因敲除小鼠缺血侧皮质的缺血灶内及灶周血管周围区域内的血清蛋白(包括纤维蛋白原和免疫球蛋白)的外渗增强此之,MCAO后NDRG2基因敲除小鼠体内基质金属蛋白酶(MMPs)的表达也显著增加。在细胞培养中,NDRG2-/-星形胶质细胞中MMP-3的表达和分泌增加,这种增加可被腺病毒介导的NDRG2再表达所逆转。综上所述,脑缺血后,星形胶质细胞内的NDRG2可能通过调节MMP的表达,而在BBB通透性的调节和免疫细胞浸润中起到重要作用。 | Takarada-Iemata M Yoshikawa A Ta HM Okitani N Nishiuchi T Aida Y Kamide T Hattori T Ishii H Tamatani T Le TM Roboon J Kitao Y Matsuyama T Nakada M Hori O 聂昊 | 2018 | 神经损伤与功能重建2018，13，4： | 4 |
| 4 | 农村人口亚临床动脉粥样硬化及其与冠状动脉疾病危险因素的关系显示文摘在美国〈65岁的人群中,包括无症状的个体在内,每年有超过15万的心血管事件发生。冠状动脉钙化(coronary artery calcium,CAC)是冠状动脉疾病(coronary artery disease,CAD)的亚临床指标,可提高无症状个体的危险分层。该研究旨在评估农村人口的CAC发生率,确定CAD传统危险因素和CAC评分之间的相关性。方法:2011年1月至2012年12月,研究人员对来自阿巴拉契亚中部地区无症状个体的CAC情况进行筛查,根据Agatston钙化评分将受试者分为4种CAC水平:无(CAC=0),轻度(CAC=1~99),中度(CAC=100~399)和重度(CAC≥400)。 | 刘莉 叶鹏 Mamudu HM Paul T Veeranki SP Wang L Panchal HB Budoff M | 2015 | 中华高血压杂志2015，23，8： | 3 |
| 5 | Human neural stem cells improve cognitive function of aged brain 显示文摘 | Brannen CL Kim HM | 2001 | Neuroreport2001，12，6： | 1 |
| 6 | Human catechol-O-methyltransferase pharmacogenetics:description of a functional polymorphism and its potential application to neurospychiatric disorders显示文摘 | LACHMAN HM PAPOLOS DF SAITO T | 1996 | Pharmacogenetics1996，6，3： | 1 |
| 7 | Telomerase immortalization of neuronally restricted progenitor cells derived from the human fetal spinal cord 显示文摘 | Roy NS Nakano T Keyoung HM | 2004 | Nat Biotechnol2004，22，： | 1 |
| 8 | Preteim prematurerupture of membranes and neonatal outcome prior to 34weeks of gestation显示文摘 | Tanir HM Sener T Tekiu N | 2009 | Int J Gynecol Obstet2009，82，2： | 1 |
| 9 | Four-year results from a randomized controlled study of knee chondroplasty with concomitant medial meniscectomy:mechanical debridement versus radiofrequency chondroplasty显示文摘 | Spahn G Klinger HM Mückley T | 2010 | Arthroscopy2010，26，9： | 1 |
| 10 | Interleukin 6 and CORTISOL in acute musculoskeletal disorders: results from a case-referent study in Sweden显示文摘 | Theorell T Hasselhorm HM Vingant E | 2000 | Stress Medicine2000，16，： | 1 |
| 11 | Nitric oxide selectively amplifiesFGF-2-induced mitogenesis in primary rat aortic smooth cells显示文摘 | Hassid A Arabshahi HM Bourcier T | 1994 | Am J Physiol1994，2671，040： | 1 |
| 12 | Does anesthesia causepostoperative cognitive dysfunction 显示文摘 | Rasmussen LS Johson T Kuipers HM | 2003 | Acta Anesthesiol Scand2003，47，3： | 1 |
| 13 | Preparation of bioacti-e Ti and its alloys -ia simple chemical surface treatment显示文摘 | Kim HM Miyaji F Kokubo T | 1996 | J BiomedMater Res1996，32，3： | 1 |
| 14 | One share-one vote and the market for corporate control 显示文摘 | Grossman S J Hm't 0 D | 1988 | Journal of Fi- nancial Economics1988，20，： | 1 |
| 15 | The role anterior spine in- strumentation and all graft fibula for the treatment of pott disease显示文摘 | Ozdemir HM Us AK Ogun T | 2003 | Spine2003，28，5： | 1 |
| 16 | Lenalidomide plus prednisone resuhs in durable clinical, histopathologic, and molecular responses in patients with myelofibrosis 显示文摘 | Quintis-Cardama A Kantarjian HM Manshouri T | 2009 | J Clin Oncol2009，27，28： | 1 |
| 17 | Overexpression of vascular endothelial growth factor-B in mouse heart alters cardiac lipid metabolism and induces myocardial hypertro- phy显示文摘 | Karpanen T Bry M Ollila HM | 2008 | Circ Res2008，103，9： | 1 |
| 18 | Does anaes- thesia cause postoperative cognitive dysfunetion?A ran- domised study of regional versus general anaesthesia in 438 elderly patients显示文摘 | Rasmussen LS Johnson T Kuipers HM | 2003 | Acta Anaesthesiol Scand2003，47，3： | 1 |
| 19 | Ef- fect of antibody on the Rickettsia-host cell interaction 显示文摘 | FENG HM WHITWORTH T VSEVOLOD P | 2004 | Infect Immunol2004，72，： | 1 |
| 20 | Dignity in the terminally ill:A developing empirical model显示文摘 | Chochinov HM Hack T McClement S | 2002 | Soc Sci Med2002，54，： | 1 |
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