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| 1 | 非维生素K拮抗与维生素K拮抗口服抗凝剂与脑出血患者住院死亡之间的关系显示文摘尽管非维生素K拮抗口服抗凝剂(non-vitamin K antagonist oral anticoagulants, NOACs)越来越多地应用于预防血栓栓塞性疾病,但关于NOACs相关性脑出血的数据仍然有限。 | 刘青 叶鹏 Inohara T Xian Y Liang L Matsouaka RA Saver JL Smith EE Schwamm LH Reeves MJ Hernandez AF Bhatt DL Peterson ED Fonarow GC | 2018 | 中华高血压杂志2018，26，2： | 16 |
| 2 | Mechanism of frost heave by film water migration under temperature gradient显示文摘IT is well known that there exists unfrozen film water in frozen soils due to the action of sur-face energy among soil particles and frost heave occurs by water migration under the tempera-ture gradient. The problem is how to determine the amount of frost heave quantitatively. The amount of frost heave induced by ice segregation can be calculated by the following e-quations: | Xu, XZ Wang, JC Zhang, LX Deng, YS Chuvilin, EM Yershov, ED Ishizaki, T Fukuda, M | 1997 | Chinese Science Bulletin1997，42，15： | 6 |
| 3 | 危重病人的营养支持显示文摘救治危重病人过程不应疏忽经肠道或非肠道的营养支持,因为营养影响病人的转归。关键是要了解什么时候开始进食和如何计算必需的蛋白质和热卡的量。病人状态及营养需要开始营养支持之前,先要估计病人的代谢和营养状况,败血症或损伤均对代谢和营养需求有一定影响。饥饿和分解代谢是有差异的。单纯饥饿时储存的脂肪可提供几天或几周的热卡。 | Edes T E 佟萍霞 | 1992 | 国外医学(护理学分册)1992，11，3： | 3 |
| 4 | Extracellular histones stimulate collagen expression in vitro and promote liver fibrogenesis in a mouse model via the TLR4-MyD88 signaling pathway显示文摘BACKGROUND Liver fibrosis progressing to liver cirrhosis and hepatic carcinoma is very common and causes more than one million deaths annually.Fibrosis develops from recurrent liver injury but the molecular mechanisms are not fully understood.Recently,the TLR4-MyD88 signaling pathway has been reported to contribute to fibrosis.Extracellular histones are ligands of TLR4 but their roles in liver fibrosis have not been investigated.AIM To investigate the roles and potential mechanisms of extracellular histones in liver fibrosis.METHODS In vitro,LX2 human hepatic stellate cells(HSCs)were treated with histones in the presence or absence of non-anticoagulant heparin(NAHP)for neutralizing histones or TLR4-blocking antibody.The resultant cellular expression of collagen I was detected using western blotting and immunofluorescent staining.In vivo,the CCl4-induced liver fibrosis model was generated in male 6-week-old ICR mice and in TLR4 or MyD88 knockout and parental mice.Circulating histones were detected and the effect of NAHP was evaluated.RESULTS Extracellular histones strongly stimulated LX2 cells to produce collagen I.Histone-enhanced collagen expression was significantly reduced by NAHP and TLR4-blocking antibody.In CCl4-treated wild type mice,circulating histones were dramatically increased and maintained high levels during the duration of fibrosisinduction.Injection of NAHP not only reduced alanine aminotransferase and liver injury scores,but also significantly reduced fibrogenesis.Since the TLR4-blocking antibody reduced histone-enhanced collagen I production in HSC,the CCl4 model with TLR4 and MyD88 knockout mice was used to demonstrate the roles of the TLR4-MyD88 signaling pathway in CCl4-induced liver fibrosis.The levels of liver fibrosis were indeed significantly reduced in knockout mice compared to wild type parental mice.CONCLUSION Extracellular histones potentially enhance fibrogenesis via the TLR4–MyD88 signaling pathway and NAHP has therapeutic potential by detoxifying extracellular histones. | Zhi Wang Zhen-Xing Cheng Simon T Abrams Zi-Qi Lin ED Yates Qian Yu Wei-Ping Yu Ping-Sheng Chen Cheng-Hock Toh Guo-Zheng Wang | 2020 | World Journal of Gastroenterology2020，26，47： | 3 |
| 5 | Prop- ranolol for severe hemangiomas of infancy 显示文摘 | L6aut6-Labrbze C Dumas dela Roque ED Hubiche T | 2008 | N Engl J Med2008，358，24： | 1 |
| 6 | Physical activity behaviour and coronary heart disease mortality among South Asi an people in the UK: an observational longitudinal study 显示文摘 | Williams ED Stamatakis E Chandola T | 2011 | Heart2011，97，8： | 1 |
| 7 | Proposed network centric warfare metrics: from connectivity to the OODA cycle 显示文摘 | Ling MF MOON T Kruzins ED | 2005 | MORS Journal2005，10，1： | 1 |
| 8 | Organization of Ca^2 + release units in excitable smooth muscle of the guinea - pig urinary bladder 显示文摘 | Moore ED Voigt T Kobayashi YM | 2004 | Biophys J2004，87，3： | 1 |
| 9 | Effect of pulse dura·tion on bubble formation and laser induced pressure waves duringholmium laser ablation显示文摘 | Janxen ED Asshaucer T Frenz M | | 0，，03： | 1 |
| 10 | Coordinated epigenetic repression of the miR-200 family and miR-205 in invasive bladder cancer显示文摘 | Wiklund ED Bramsen JB Hulf T | 2011 | Int J Cancer2011，128，6： | 1 |
| 11 | Acute pancreatitis in human immunodeficiency virus-infected patients: a review显示文摘 | Dassopoulos T Ehrenpreis ED | 1999 | Am J Med1999，107，1： | 1 |
| 12 | A cytomegalovirus-encoded mitochondria-localized inhibitor of apoptosis structurally unrelated to Bcl-2 显示文摘 | Goldmacher VS Battle LM Skaletskaya A Dionne CA Kedersha NL Vater CA Han JW Lutz RJ Watanabe S Cahir McFarland ED Kieff ED Mocarski ES Chittenden T | 1999 | Proc Natl Acad Sci USA1999，96，12： | 1 |
| 13 | The effect of nitrogen ion implantation on the photoaetivity of TiO2 rutile single crystals显示文摘 | Diwald O Thompson T L Goralski Ed G | 2004 | J Phys Chem B2004，108，1： | 1 |
| 14 | Rapid dendritic cell recruitment to the bronchial mucosa of patients with atopic asthma in response to local allergen challenge显示文摘 | Jahnsen FL Moloney ED Hogan T | 2001 | Thorax2001，56，11： | 1 |
| 15 | Low cost composite fabrication methods applied to low observable structure显示文摘 | Guy T A Sanger K B Ruskowski Ed | 1995 | AIAA-95-11561995，，： | 1 |
| 16 | The Egr-ltranscription factor directly activates PTEN during irradiation-induced signaling 显示文摘 | Virolle T Adamson ED Baron V | 2001 | Nat Cell Biol2001，3，12： | 1 |
| 17 | Reducing endogenous tau ameliorates amyloid beta-in- duced deficits in an Alzheimer' s disease mouse model显示文摘 | Roberson ED Scearce-Levie K Palop JJ Yan F Cheng IH Wu T | 2007 | Sc/- ence2007，316，5825： | 1 |
| 18 | Allogeneic stem cell transplantation for adults with myelodysplastic syndromes:importance of pretransplant disease burden显示文摘 | Warlick ED Cioc A Defor T | | 0，，01： | 1 |
| 19 | Netrin-1 is required for commissural axon guidance in thedeveloping vertebrate nervous system 显示文摘 | Serafini T Sophia A Colamarino ED | 1996 | Cell1996，87，6： | 1 |
| 20 | Acute systemic organ injury in term infants after asphyxia显示文摘 | Perlman jM Tack ED Martin T | 1989 | Am J Dis Child1989，143，5： | 1 |
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