|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Mediterranean Berries as Inhibitors of Lipid Oxidation in Porcine Burger Patties Subjected to Cooking and Chilled Storage显示文摘The efficiency of extracts from Arbutus unedo L.(AU),Crataegus monogyna L.(CM),Rosa canina L.(RC),and Rubus ulmifolius Schott.(RU)to inhibit lipid oxidation in raw,cooked and cooked and chilled(2°C/12 d)porcine burger patties,was investigated.The modification of the fatty acid profile during processing treatments(cooking and chilling),the quantitative measurements of thiobarbituric acid reactive substances(TBA-RS),and lipid-derived volatiles,were used as indicators of lipid oxidation.Polyunsaturated fatty acids(PUFA)gradually decreased during cooking and the subsequent storage of cooked burger patties with this decrease being significantly greater(P<0.05)in control patties than in those with added berry extracts.In accordance,the control patties showed significantly higher TBA-RS numbers and counts of lipid-derived volatiles in all treatments when compared to the berry-added counterparts(P<0.05).Results from the present work show,for the first time,that extracts from A.unedo,C.monogyna,R.canina,and R.ulmifolius are promising antioxidants which could enhance the nutritional,safety and sensory properties of porcine burger patties. | Rui Ganho Mario Estévez Mónica Armenteros David Morcuende | 2013 | Journal of Integrative Agriculture2013，12，11： | 16 |
| 2 | Dual destructive and protective roles of adaptive immunity in neurodegenerative disorders显示文摘Inappropriate T cell responses in the central nervous system(CNS)affect the pathogenesis of a broad range of neuroinflammatory and neurodegenerative disorders that include,but are not limited to,multiple sclerosis,amyotrophic lateral sclerosis,Alzheimer’s disease and Parkinson’s disease.On the one hand immune responses can exacerbate neurotoxic responses;while on the other hand,they can lead to neuroprotective outcomes.The temporal and spatial mechanisms by which these immune responses occur and are regulated in the setting of active disease have gained significant recent attention.Spatially,immune responses that affect neurodegeneration may occur within or outside the CNS.Migration of antigen-specific CD4+T cells from the periphery to the CNS and consequent immune cell interactions with resident glial cells affect neuroinflammation and neuronal survival.The destructive or protective mechanisms of these interactions are linked to the relative numerical and functional dominance of effector or regulatory T cells.Temporally,immune responses at disease onset or during progression may exhibit a differential balance of immune responses in the periphery and within the CNS.Immune responses with predominate T cell subtypes may differentially manifest migratory,regulatory and effector functions when triggered by endogenous misfolded and aggregated proteins and cell-specific stimuli.The final result is altered glial and neuronal behaviors that influence the disease course.Thus,discovery of neurodestructive and neuroprotective immune mechanisms will permit potential new therapeutic pathways that affect neuronal survival and slow disease progression. | Kristi M Anderson Katherine E Olson Katherine A Estes Ken Flanagan Howard E Gendelman R Lee Mosley | 2014 | Translational Neurodegeneration2014，3，1： | 8 |
| 3 | Application of Natural Antioxidants from Strawberry Tree(Arbutus unedo L.) and Dog Rose(Rosa canina L.) to Frankfurters Subjected to Refrigerated Storage显示文摘The effect of the addition of natural antioxidants from strawberry tree(Arbutus unedo L.;AU)and dog rose(Rosa canina L.;RC),in frankfurters elaborated with or without the addition of antioxidant additives(sodium ascorbate and nitrite)was studied.Six different types of experimental frankfurters were prepared depending on the addition of phenolic-rich extracts from RC and AU and the presence(P)or absence(C)of antioxidant additives.Thiobarbituric acid reactive substances(TBARS)-numbers significantly increased during chilled storage of C-frankfurters while additives and fruit phenolics inhibited lipid oxidation in P-frankfurters.The amount of protein carbonyls significantly increased in all treatments except in P-AU frankfurters.The discoloration process that occurred during the chilled storage was reduced by the addition of substances with proven antioxidant activity(P-frankfurters).Texture characteristics as hardness,springiness,cohesiveness and gumminess also suffered a significant deterioration in C-frankfurters.The use of phenolic fruit extracts in combination with traditional antioxidant additives is a successful strategy to enhance the oxidative stability of frankfurters without modifying their color and texture properties. | Mónica Armenteros David Morcuende Sonia Ventanas Mario Estévez | 2013 | Journal of Integrative Agriculture2013，12，11： | 4 |
| 4 | Chronic myeloid leukemia-from the Philadelphia chromosome to specific target drugs:A literature review显示文摘Chronic myeloid leukemia(CML)is a myeloproliferative neoplasm and was the first neoplastic disease associated with a well-defined genotypic anomaly―the presence of the Philadelphia chromosome.The advances in cytogenetic and molecular assays are of great importance to the diagnosis,prognosis,treatment,and monitoring of CML.The discovery of the breakpoint cluster region(BCR)-Abelson murine leukemia(ABL)1 fusion oncogene has revolutionized the treatment of CML patients by allowing the development of targeted drugs that inhibit the tyrosine kinase activity of the BCR-ABL oncoprotein.Tyrosine kinase inhibitors(known as TKIs)are the standard therapy for CML and greatly increase the survival rates,despite adverse effects and the odds of residual disease after discontinuation of treatment.As therapeutic alternatives,the subsequent TKIs lead to faster and deeper molecular remissions;however,with the emergence of resistance to these drugs,immunotherapy appears as an alternative,which may have a cure potential in these patients.Against this background,this article aims at providing an overview on CML clinical management and a summary on the main targeted drugs available in that context. | Mariana Miranda Sampaio Maria Luísa Cordeiro Santos Hanna Santos Marques Vinícius Lima de Souza Gonçalves Glauber Rocha Lima Araújo Luana Weber Lopes Jonathan Santos Apolonio Camilo Santana Silva Luana Kauany de SáSantos Beatriz Rocha Cuzzuol Quézia Estéfani Silva Guimarães Mariana Novaes Santos Breno Bittencourt de Brito Filipe Antônio França da Silva Márcio Vasconcelos Oliveira Cláudio Lima Souza Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，2： | 3 |
| 5 | Radioimmunotherapywithiodine(131) I tositumomab for relapsed or refractory B-cell non-Hodgkin's lymphoma:updated results and long-term follow-up of the University ofMichigon experience显示文摘 | Kaminski M S Estes J Zasadny K R | 2000 | Blood2000，96，4： | 1 |
| 6 | Load rating versus reliabilityanalysis显示文摘 | Estes A C Frangopol D M | 2005 | Journal of Structural Engineering2005，131，5： | 1 |
| 7 | Spatial structure,sampling design and scale in remotely-sensed imagery of a california savanna woodland显示文摘 | McGwire K Friedl M Estes J E | 1993 | International Journal of Remote Sensing1993，14，11： | 1 |
| 8 | Sequence analysis of the serotype sperific gene fragment of VP4显示文摘 | ESTES M K COHEN J | 1989 | Microbiol Rev1989，，53： | 1 |
| 9 | RNA interference of HIV replication显示文摘 | Martinez M A Cohet B Este J A | 2002 | Trends Immunology2002，23，12： | 1 |
| 10 | Evolutionary traceresidues in Noroviruses : importance in receptor binding, antigenicity, virion assembly, and strain diversity 显示文摘 | Chakravarty S Hutson A M Estes M K | 2005 | J Virol2005，79，1： | 1 |
| 11 | Protein carbonyls in meat systems: A review 显示文摘 | EST VEZ M | 2011 | Meat Science2011，89，3： | 1 |
| 12 | Smart wearable systems: Current status and future challenges显示文摘 | Chan M Est~ve D Fourniols J Y | 2012 | Artificial intelligence in medicine2012，56，3： | 1 |
| 13 | Regulation of IgA responses in cattle,humans and mice显示文摘 | ESTES D M | 2010 | Vet Immunol Immunopathol2010，138，： | 1 |
| 14 | DNA and a CpG oligonucleotide derived from babesia bovis are mitogenic for bovine B cells显示文摘 | Brown W C Estes D M Chantler S E | 1998 | Infect Immun1998，66，： | 1 |
| 15 | 1311-tositumomab therapy as initial treatment for follicular lymphoma显示文摘 | Kaminski MS Tuck M Estes J | 2005 | N Engl J Med2005，352，5： | 1 |
| 16 | Ganglioglioma and intractable epilepsy:clinical and neurophysiologic features and predictors of outcome after surgery显示文摘 | Morris H Matkovic Z Estes M | 1998 | Epilepsia1998，39，3： | 1 |
| 17 | Inhibition of overactivated p38 MAPK can restore hematopoiesis in myelodysplastic syndrome progenitors 显示文摘 | Navas TA Mohindru M Estes M | 2006 | Blood2006，108，： | 1 |
| 18 | Rotavirus gene structure anti function 显示文摘 | Estes M K Cohen J | 1989 | Mi- crobiol Rev1989，53，4： | 1 |
| 19 | Normalized mutual information feature selection显示文摘 | Estévez P Tesmer M Perez C | | 0，，02： | 1 |
| 20 | Sudden cardiac death in athletes显示文摘 | Link M S Mark Estes N A 3rd | 2008 | Prog Cardiovasc Dis2008，51，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员