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| 1 | Normalized mutual information feature selection显示文摘 | ESTEVEZ P A TESMER M PEREZ C A | 2009 | IEEE Transactions on Pattern Analysis and Machine Intelligence2009，20，2： | 1 |
| 2 | Thl7 cells in human disease 显示文摘 | Tesmer LA Lundy SK Sarkar S | 2008 | Immunol Rev2008，223，： | 1 |
| 3 | Demethylation of CD40LG on the inactive X in T Cells from Women with Lupus显示文摘 | Lu Q Wu A Tesmer L | | 0，，09： | 1 |
| 4 | Normalized mutual information feature selection 显示文摘 | ESTEVEZ P A TESMER M PEREZ C A | 2009 | IEEE Tmns on Neural Netw2009，20，2： | 1 |
| 5 | G protein- coupled receptor kinases: More than just kinases and notonly for GPCRs 显示文摘 | Gurevich EV Tesmer JJ Mushegian A | 2012 | Pharmacol Ther2012，133，1： | 1 |
| 6 | Demethylation of CD40LG on the in- active X in T ceils from women with lupus 显示文摘 | Lu Q Wu A Tesmer L | 2007 | Immunol2007，179，： | 1 |
| 7 | Normalized mutual information feature selection显示文摘 | Estévez P Tesmer M Perez C | | 0，，02： | 1 |
| 8 | Demethylation of CD40LG on the inactive X in T cells from women with lupus显示文摘 | Lu QJ Wu AL Tesmer L etal | 2007 | J Im- munol2007，179，9： | 1 |
| 9 | 基于G-蛋白偶联受体激酶2抑制剂治疗心力衰竭的合理药物设计(英文)显示文摘G protein-coupled receptors(GPCRs)convert extracellular stimuli in the form of hormones,odorants and light into profound changes in cell homeostasis.Their timely desensitization is critical for cells to rapidly respond to changes in their environment and to avoid damage from sustained signaling.Seven GPCR kinases(GRKs)phosphorylate and regulate the activity of most of the^800 GPCRs in the human genome.Although GRKs normally play an adaptive role,in conditions such as chronic heart failure they are overexpressed and linked to disease progression.GRK2 and GRK5 have thus become important targets for the treatment of heart failure and pathological cardiac hypertrophy,respectively.Our lab has determined atomic structures representing all three vertebrate GRK subfamilies,and is now in the midst of a campaign to develop selective inhibitors of these enzymes using structure-based rational design.We have identified the FDA approved drug paroxetine as a selective GRK2 inhibitor,determined the crystal structure of the GRK2·paroxetine complex and,in collaboration with the Koch lab,showed that the drug improves contractility in myocytes and,most impressively,recovery in postmyocardial infarcted mice.Since then,we have identified additional chemical scaffolds that exhibit even higher potency and/or selectivity for GRK5.Using a'hybrid'inhibitor design approach we have generated GRK selective chemical probes that exhibit improved potency and stability and are able to increase inotropy and dampen the hypertrophic response in cardiomyocytes and small animal models.Structural analysis has revealed the molecular basis for selectivity and potency in many of these compounds,allowing for the design of future generations of GRK chemical probes. | John J TESMER Helen V WALDSCHMIDT Marie C CATO Renee BOULEY Osvaldo CRUZ-RODRIGUEZ Scott D LARSEN | 2017 | 中国药理学与毒理学杂志2017，31，10： | 1 |
| 10 | Both transcriptional and posttranscriptional mechanisms regulate human telomerase template RNA levels 显示文摘 | Tesmer VM Savre Train-I | 1999 | Mol Cell Biol1999，19，6： | 1 |
| 11 | Normalized mu- tual information feature selection 显示文摘 | ESTEVEZ P A TESMER M PEREZ C A | 2009 | IEEE Transactions on Neural Networks2009，20，2： | 1 |
| 12 | Normal human chromosomes have long G-rich telomeric overhang at one end显示文摘 | Tesmer V M | 1997 | Genes Dev1997，11，： | 1 |
| 13 | Th17 ceils in human disease显示文摘 | Tesmer LA Lundy SK Sarkar S | 2008 | Immunol Rev2008，223，： | 1 |
| 14 | Near- surface thermal characterization of plasma facing components using the 3-omega method 显示文摘 | DECHAUMPHAI E BARTON J L TESMER J R | 2014 | Journal of Nuclear Materials2014，455，13： | 1 |
| 15 | Th17 cells in human disease显示文摘 | Tesmer LA Lundy SK Sarkar S | 2008 | Immunol Rev2008，223，1： | 1 |
| 16 | Thl7 cells in human disease 显示文摘 | Tesmer LA Lundy SK Sarkar S | 2008 | Immunol Rev2008，223，1： | 1 |
| 17 | Normal human telomeres are not late replicating显示文摘 | Wright W E Tesmer V M Liao M L | 1999 | Exp Cell Res1999，251，： | 1 |
| 18 | Regulation of HIV-1 transcription by NF-IL6 in activated Jurkat T cells显示文摘 | Buckner AE Tesmer VM Bina M | 2002 | Virus Res2002，89，1： | 1 |
| 19 | Normal human chromosomes have long G-rich telomeric overhangs at one end显示文摘 | Wright WE Tesmer VM Huffman KE | 1997 | Genes Dev1997，11，： | 1 |
| 20 | Thl7 cells in human disease显示文摘 | Tesmer LA Lundy SK Sarkar S | 2008 | Immunol Rev2008，223，： | 1 |
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