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| 1 | Multi-scale mechanotransduction of the poroelastic signals from osteon to osteocyte in bone tissue显示文摘In order to quantify the poroelastic mechanical signals conduction and evaluate the biomechanical effectiveness of functional units(osteocyte processes,canaliculi and lacuna)in lacunar-canalicular system(LCS),a multiscale poroelastic finite element model was established by using the Comsol Multiphysics software.The poroelastic mechanical signals(pore pressure,fluid velocity,von-Mises stress,strain)were analyzed inside the osteon-osteocyte system.The effects of osteocyte(OCY)’s shape(ellipse and circle),long axis directions(horizontal and vertical)and mechanical properties(Elastic modulus and permeability)on its poroelastic responses were examined.It is found that the OCY processes is the best mechanosensor compared with the OCY body,lacunae and canaliculi.The mechanotransduction ability of the elliptic shaped OCY is stronger than that of circular shaped.The pore pressure and flow velocity around OCYs increase as the elastic modulus and permeability of OCY increase.The established model can be used for studying the mechanism of bone mechanotransduction at the multiscale level. | Xiaogang Wu Chaoxin Li Kuijun Chen Yuqin Sun Weilun Yu Meizhen Zhang Yanqin Wang Yixian Qin Weiyi Chen | 2020 | Acta Mechanica Sinica2020，36，4： | 2 |
| 2 | Immunometabolism and potential targets in severe COVID-19 peripheral immune responses显示文摘In a recent single cell transcriptomic investigation of the peripheral immune responses of the patients with severe COVID-19[1],no substantial expression of pro-inflammatory cytokines has been identified in the peripheral monocytes and lymphocytes,while these peripheral immune cells exhibit phenotypes of heterogeneously expressed interferon-stimulated genes in certain COVID-19 patients.These genes may contribute to the inhibitory response to the viral entry,translation,replication and egress.Questions remain regarding why the peripheral cytokine production is constrained,what additional roles these peripheral immune cells may play in COVID-19 pathophysiology,and which potential targets can be explored for facilitating COVID-19 therapeutics. | Shanshan Wang Xian Zeng Yali Wang Yuzong Chen Chaoxin Wang Dongzhi Zhuoma Fengying Zhang Yufen Zhao | 2021 | Asian Journal of Pharmaceutical Sciences2021，16，6： | 1 |
| 3 | A fluid flow model in the lacunar-canalicular system under the pressure gradient and electrical field driven loads显示文摘The lacunar-canalicular system(LCS)is acknowledged to directly participate in bone tissue remodeling.The fluid flow in the LCS is synergic driven by the pressure gradient and electric field loads due to the electro-mechanical properties of bone.In this paper,an idealized annulus Maxwell fluid flow model in bone canaliculus is established,and the analytical solutions of the fluid velocity,the fluid shear stress,and the fluid flow rate are obtained.The results of the fluid flow under pressure gradient driven(PGD),electric field driven(EFD),and pressure-electricity synergic driven(P-ESD)patterns are compared and discussed.The effects of the diameter of canaliculi and osteocyte processes are evaluated.The results show that the P-ESD pattern can combine the regulatory advantages of single PGD and EFD patterns,and the osteocyte process surface can feel a relatively uniform shear stress distribution.As the bone canalicular inner radius increases,the produced shear stress under the PGD or P-ESD pattern increases slightly but changes little under the EFD pattern.The increase in the viscosity makes the flow slow down but does not affect the fluid shear stress(FSS)on the canalicular inner wall and osteocyte process surface.The increase in the high-valent ions does not affect the flow velocity and the flow rate,but the FSS on the canalicular inner wall and osteocyte process surface increases linearly.In this study,the results show that the shear stress sensed by the osteocyte process under the P-ESD pattern can be regulated by changing the pressure gradient and the intensity of electric field,as well as the parameters of the annulus fluid and the canaliculus size,which is helpful for the osteocyte mechanical responses.The established model provides a basis for the study of the mechanisms of electro-mechanical signals stimulating bone tissue(cells)growth. | Xiaogang WU Xiyu WANG Chaoxin LI Zhaowei WANG Yuqin SUN Yang YAN Yixian QIN Pengcui LI Yanqin WANG Xiaochun WEI Weiyi CHEN | 2022 | Applied Mathematics and Mechanics(English Edition)2022，43，6： | 0 |
| 4 | Comparative Metabolomics Analysis between Red- and White-Flowered Common Buckwheat Cultivars显示文摘Common buckwheat(Fagopyrum esculentum),a specialty crop in southwest China,is not only used as a supplement to primary grain crops but also to produce beverages,such as tea and wine.To fully exploit the products made from common buckwheat flower,ultra-performance liquid chromatography–electrospray ionization–tandem mass spectrometry(UPLC–ESI–MS/MS)was conducted to analyze the metabolites in red-(‘Guihong 2’)and white-flowered(‘Fengtian 1’)buckwheat cultivars.A total of 784 metabolites were identified of which flavonoids were the largest group with 191 components,followed by organic acids and derivatives(126),and amino acids and derivatives(95).Besides,dozens of phenylpropanoids,nucleotides and derivates,lipids,alkaloids as well as several kinds of indole derivatives and sterides were detected.Among these rich varieties of metabolites,24 metabolites were only detected in the red flower that mainly included 8 anthocyanins and 6 flavones,while 22 metabolites were only detected in the white flower,which mainly contained 5 lipids,5 flavonoids,and 5 organic acids and derivatives.Our results enrich the metabolites’information of buckwheat and may be helpful for the exploitation of products from common buckwheat flowers. | Jiao Deng Fen Dong Chaoxin Wu Jiali Zhao Hongyou Li Juan Huang Taoxiong Shi Ziye Meng Fang Cai Qingfu Chen Pingfang Yang | 2021 | Phyton-International Journal of Experimental Botany2021，90，3： | 0 |
| 5 | Blood compatible heteratom-doped carbon dots for bio-imaging of human umbilical vein endothelial cells显示文摘Carbon dots have unique advantages in biological applications owing to their excellent optical prope rties.However,the biosafety evaluation of carbon dots has limitations owing to cytotoxicity in vitro,and the re is little pre-safety evaluation before in vivo and clinical applications.Whether the carbon dots are or not suitable for applications in vivo,evaluation analysis can be made based on hemolysis and changes in erythrocyte morphology.In this work,a green fluorescent N,S-doped carbon dots(N,S-CDs)were obtained by hydrothermal method,tobias acid,and m-phenylenediamine as precursors.N,S-CDs not only possessed excellent dispersibility,uniform particle size,high quantum yield(37.2%)and stable photoluminescence property but also retain their photostability and stro ng fluorescence intensity in the acid/alkaline solutions,different ionic strengths(NaCl)and under 365 nm UV illumination.Moreove r,the N,S-CDs displayed low cytotoxicity and high cellular uptake efficiency in human umbilical vein endothelial cells(HUVEC)and excellent blood compatibility to the erythrocyte.It is foreseeable that N,S-CDs could be further studied as a promising biological imaging agent in vivo. | Jian Zhong Xinmian Chen Miaoran Zhang Chaoxin Xiao Lulu Cai Waleed Ali Khan Kaixuan Yu Jiayi Cui Lin He | 2020 | Chinese Chemical Letters2020，31，3： | 0 |
| 6 | The Characteristics of Sulfur and Lead Isotope Geochemistry of Laozhaiwan Gold Deposit,Yunnan Province显示文摘1 Introduction Laozhaiwan gold deposit,a part of'Golden Triangle'in Yunnan-Guizhou-Guangxi,was located in Jiumo village in Guangnan county,Yunnan province.The main ore-bearing stratum of the deposit was Posongchong Formation(D1 ps)of the lower Devonian.The structure was well-developed in this area,the ore bodies produced which mainly controlled by the faults.There was a diabasic dike in the northwest of this area,where the grade of the ore bodies was higher.2 S isotope geochemistry The composition ofδ34S in pyrites was 5. | Zhao Dekun Chen Cuihua Gu Xuexiang Dai HongZhang He Chaoxin | 2012 | 地球科学进展2012，27，S1： | 0 |
| 7 | Study of the spatial growth of stimulated Brillouin scattering in a gas-filled hohlraum via detecting the driven ion acoustic wave显示文摘In an experiment performed on the Shenguang-III prototype laser facility, collective Thomson scattering (TS) is used to study the spatialgrowth of stimulated Brillouin scattering (SBS) in a gas-filled hohlraum by detecting the SBS-driven ion acoustic wave. High-quality timeresolved SBS and TS spectra are obtained simultaneously in the experiment, and these are analyzed by a steady-state code based on theray-tracing model. The analysis indicates that ion–ion collisions may play an important role in suppressing SBS growth in the Au plasma;as aresult, the SBS excited in the filled gas region is dominant. In the early phase of the laser pulse, SBS originates primarily from the high-densityplasma at the edges of the interaction beam channel, which is piled up by the heating of the interaction beam. Throughout the duration of thelaser pulse, the presence of the TS probe beam might mitigate SBS by perturbing the density distribution around the region overlapping withthe interaction beam. | Chaoxin Chen Tao Gong Zhichao Li Liang Hao Yonggang Liu Xiangming Liu Hang Zhao Yaoyuan Liu Kaiqiang Pan Qi Li Sanwei Li Zhijun Li Sai Jin Feng Wang Dong Yang | 2024 | Matter and Radiation at Extremes2024，9，2： | 0 |
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