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| 1 | Deficient DNA mismatch repair is associated with favorable prognosis in Thai patients with sporadic colorectal cancer显示文摘AIM:To determine the prognostic significance of deficient mismatch repair(d MMR) and BRAF V600 E in Thai sporadic colorectal cancer(CRC) patients.METHODS:We studied a total of 211 out of 405 specimens obtained from newly diagnosed CRC patients between October 1,2006 and December 31,2007 at Siriraj Hospital,Mahidol University.Formalinfixed paraffin-embedded blocks of CRC tissue samples w e re a n a l y ze d fo r d M M R b y d e t e c t i o n o f M M R protein expression loss by immunohistochemistry or microsatellite instability using polymerase chain reaction(PCR)-DHPLC.BRAF V600 E mutational analysis was performed in DNA extracted from the same archival tissues by two-round allele-specific PCR and analyzed by high sensitivity DHPLC.Associations between patient characteristics,MMR and BRAF status with diseasefree survival(DFS) and overall survival(OS) were determined by Kaplan-Meier survival plots and log-rank test together with Cox's proportional hazard regression.RESULTS:d MMR and BRAF V600 E mutations were identified in 31 of 208(14.9%) and 23 of 211(10.9%) tumors,respectively.d MMR was more commonly found in patients with primary colon tumors rather than rectal cancer(20.4% vs 7.6%,P =0.01),but there was no difference in MMR status between the right-sided and left-sided colon tumors(20.8% vs 34.6%,P = 0.24).d MMR was associated with early-stage rather than metastatic disease(17.3% vs 0%,P = 0.015).No clinicopathological features such primary site or tumor differentiation were associated with the BRAF mutation.Six of 31(19.3%) samples with d MMR carried the BRAFmutation,while 17 of 177(9.6%) with proficient MMR(p MMR) harbored the mutation(P = 0.11).Notably,patients with d MMR tumors had significantly superior DFS(HR = 0.30,95%CI:0.15-0.77; P = 0.01) and OS(HR = 0.29,95%CI:0.10-0.84; P = 0.02) compared with patients with p MMR tumors.By contrast,the BRAF V600 E mutation had no prognostic impact on DFS and OS.CONCLUSION:The prevalence of d MMR and BRAF V600 E in Thai sporadic CRC patients was 15% and 11%,respectively.The d MMR phenotype was associated with a favorable outcome. | Krittiya Korphaisarn Ananya Pongpaibul Chanin Limwongse Ekkapong Roothumnong Wipawi Klaisuban Akarin Nimmannit Artit Jinawath Charuwan Akewanlop | 2015 | World Journal of Gastroenterology2015，21，3： | 4 |
| 2 | Novel chemical scaffolds of the tumor marker AKRIBIO inhibitors discovered by 3D QSAR pharmacophore modeling显示文摘目的: 最近的证据建议 aldo-keto reductase 家庭 1 B10 (AKR1B10 ) 可以是禁止者为人的癌症的许多类型的治疗为一种有希望的选择提供的人的肿瘤,和那 AKR1B10 的一个潜在的诊断或预示的标记。这研究的目的是识别在 silico 途径使用的 AKR1B10 禁止者的新奇化学脚手架。 | Raj KUMAR Minky SON Rohit BAVI Yuno LEE Chanin PARK Venkatesh ARULALAPPERUMAL Guang Ping CAO Hyong-ha KIM Jung-keun SUH Yong-seong KIM Yong Jung KWON Keun Woo LEE | 2015 | Acta Pharmacologica Sinica2015，36，8： | 4 |
| 3 | A Thai family with hereditary pancreatitis and increased cancer risk due to a mutation in PRSS1 gene显示文摘AIM: To investigate mutation of serine protease 1-cationic trypsinogen (CT, PRSS1) gene in members of a Thai family with hereditary pancreatitis and pancreatic cancer.METHODS: Polymerase chain reaction and direct sequencing were performed to analyze the PRSS1 gene in two members of the family affected by pancreatitis.Allele specific amplification (ASA) method was then developed to detect the mutation of the PRSS1 gene in all available members of the family and normal control subjects.RESULTS: A cytosine (C) to thymine (T) mutation at position 2441 (g.2441C>T) of the PRSS1 gene, which results in a substitution of arginine by cysteine at position 116 (R116C) of CT, was identified by direct sequencing in both clinically affected members of the family but was not found in the unaffected member. This mutation, which might be arising from deamination of methylated cytosine in CpG dinucleotide of codon 116 (CGT>FGT), was also detected by the ASA method in the two affected members and a proband's brother but was not observed in unaffected members and 54 normal control subjects.CONCLUSION: Autosomal dominant pancreatitis with increased cancer risk in the studied Thai family is most likely due to missense (R116C) mutation in the PRSS1gene. | Theeraphong Pho-Iam Wanna Thongnoppakhun Pa-Thai Yenchitsomanus Chanin Limwongse | 2005 | World Journal of Gastroenterology2005，11，11： | 3 |
| 4 | Systematic geometric rigid body error identifieation of 5-axis milling machines显示文摘 | BOHEZ E J BANCHA A CHANIN S | | 0，，04： | 1 |
| 5 | A method of sensor fault detection and identification显示文摘 | Nasir M Masoud S Chanin P | 2005 | Journal of Process Control2005，15，3： | 1 |
| 6 | Recent developments in biomarkers for the early detection of lung cancer: perspectives based on publications 2003 to present 显示文摘 | Chanin TD Merrick | 2004 | Curr Opin Pulm Med2004，10，4： | 1 |
| 7 | Description of a Doppler Rayleigh lidar for measuring winds in the middle atmosphere显示文摘 | Garnier A Chanin M L | 1992 | Appl Phys B1992，55，： | 1 |
| 8 | Modeling the activity of furin inhibitors using artificial neural network 显示文摘 | APILAK W CHANIN N THANAKORN N | 2009 | Eur J Med Chem2009，44，4： | 1 |
| 9 | Rotational Raman lidar to measure the atmospheric temperature from the ground to 30 km显示文摘 | Dusan Nedeljkovic Alain Hauchecorne Marie-Lise Chanin | | 0，，01： | 1 |
| 10 | Radiofrequency ablation of hepatic tumors adjacent to the gallbladder: feasibility and safety 显示文摘 | Chopra S Dodd Ill GD Chanin MP | 2003 | Am J Roentgenol2003，180，3： | 1 |
| 11 | The final stage of the collapse a cavitation bubble near a rigid wall显示文摘 | ZHANG DUNCAN H CHANINE L | 1993 | J Fluid Mech1993，257，： | 1 |
| 12 | Clinical signifi- cances of scram total sialic acid in cholangiocarcinoma显示文摘 | Wongkham S Shudhieawasdi V Chanin S | 2003 | Clin Chimica Acta2003，327，12： | 1 |
| 13 | Lidar studies of temperature and density using Rayleigh scattering 显示文摘 | Chanin M L Haucherocome A | 1984 | Hand Map1984，13，： | 1 |
| 14 | Stratospheric temperature trends: ()bservations and model simulations显示文摘 | Ramaswamy V Chanin M L Angell J | 2001 | Rez Geophys2001，39，1： | 1 |
| 15 | Recent developments in biomarkers for the early detection of lung cancer:perspectives based on publications 2003 to present显示文摘 | Chanin T D Merrick D T Franklin W A Hirsch F R | 2004 | Curr Opin Pulm Med2004，10，： | 1 |
| 16 | Description of a Doppler rayleigh LIDAR for measuring winds in the middle atmosphere 显示文摘 | Gamier A L Chanin M | 1992 | Applied Physics B1992，55，1： | 1 |
| 17 | Copper complexes of pyridine derivatives with superoxide scavenging and antimicrobial activities显示文摘 | Thummaruk S Supaluk P Chanin N | 2009 | European Journal of Medicinal Chemistry2009，44，8： | 1 |
| 18 | Novel Inflammatory Bio- Potential Therapeutic Approa-,,hes 显示文摘 | Voudris KV Chanin J Feldman DN markers in Coronary Artery Disease: | 2015 | Curr Med Chem2015，22，22： | 1 |
| 19 | Rota tional Raman lidar to measure the atmospheric temper ature from the ground to 30 km显示文摘 | Nedeljkovic D Hauchecorne A Chanin M L | 1993 | IEEE Trans Geos ci Remote Sens1993，31，1： | 1 |
| 20 | Loss of system in endothelialfunction post-PCI显示文摘 | Han B Chanin D Peleg A | 2008 | Acute Card Care2008，10，2： | 1 |
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