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| 1 | A CRISPR/Cas12a-empowered surface plasmon resonance platform for rapid and specific diagnosis of the Omicron variant of SARS-CoV-2显示文摘The outbreak of the COVID-19 pandemic was partially due to the challenge of identifying asymptomatic and presymptomatic carriers of the virus,and thus highlights a strong motivation for diagnostics with high sensitivity that can be rapidly deployed.On the other hand,several concerning SARS-CoV-2 variants,including Omicron,are required to be identified as soon as the samples are identified as‘positive’.Unfortunately,a traditional PCR test does not allow their specific identification.Herein,for the first time,we have developed MOPCS(Methodologies of Photonic CRISPR Sensing),which combines an optical sensing technology-surface plasmon resonance(SPR)with the‘gene scissors’clustered regularly interspaced short palindromic repeat(CRISPR)technique to achieve both high sensitivity and specificity when it comes to measurement of viral variants.MOPCS is a low-cost,CRISPR/Cas12a-systemempowered SPR gene-detecting platform that can analyze viral RNA,without the need for amplification,within 38 min from sample input to results output,and achieve a limit of detection of 15 fM.MOPCS achieves a highly sensitive analysis of SARS-CoV-2,and mutations appear in variants B.1.617.2(Delta),B.1.1.529(Omicron)and BA.1(a subtype of Omicron).This platform was also used to analyze some recently collected patient samples from a local outbreak in China,identified by the Centers for Disease Control and Prevention.This innovative CRISPR-empowered SPR platform will further contribute to the fast,sensitive and accurate detection of target nucleic acid sequences with single-base mutations. | Zhi Chen Jingfeng Li Tianzhong Li Taojian Fan Changle Meng Chaozhou Li Jianlong Kang Luxiao Chai Yabin Hao Yuxuan Tang Omar AAl-Hartomy Swelm Wageh Abdullah GAl-Sehemi Zhiguang Luo Jiangtian Yu Yonghong Shao Defa Li Shuai Feng William J.Liu Yaqing He Xiaopeng Ma Zhongjian Xie Han Zhang | 2022 | National Science Review2022，9，8： | 3 |
| 2 | Hard car- bon wrapped in graphene networks as lithum ion battery anode显示文摘 | Zhang Xiang Fan Changling Li Lingfang | 2014 | Electrochimica Acta2014，149，： | 1 |
| 3 | Effect of spleen-invigorating, Qi-replenishing and blood-arresting formula on zebrafish models with simvastatin-induced hemorrhage caused by spleen failing to control blood, in terms of theory of Traditional Chinese Medicine显示文摘OBJECTIVE: To investigate the hemostasis effect of spleen-invigorating, Qi-replenishing and blood-arresting formula, on a zebrafish models with simvastatin-induced hemorrhage, and with symptom pattern caused by spleen failing to control blood, in terms of theory of Traditional Chinese Medicine(TCM).METHODS: In the first experiment, 60 AB strain wild type zebrafishes were randomly assigned into two groups: normal group and model group. The model group was treated with 50 μM simvastatinfor 24 h. The second experiment: The melanin allele mutated Albino strain zebrafishes were divided into normal, model, A group and B group. The observational parameters were as follows: blood flow, velocity of movement, hemorrhage ratio and improvement ratio of hemorrhage.RESULTS: Hemorrhage ratio: in the first experiment, brain hemorrhage ratio was 75%. In the second experiment, heart hemorrhage ratio was 65%.Blood flow: compared with the normal group,there was a significantly decrease in the model group(P < 0.001). Velocity of movement: in the first experimental, compared with the normal group,there was a significantly decrease in the model group(P < 0.001). Improvement ratio of hemorrhage: agents A had little effect in heart hemorrhage of the zebrafish; agents B could reduce heart hemorrhage ratio of the zebrafish, and increase the improvement ratio of hemorrhage.CONCLUSION: The manifestation of zebrafish model with simvastatin-induced hemorrhage is basically similar to that of the clinical symptom pattern caused by spleen's failure to control blood. The Spleen-invigorating, Qi-replenishing and Blood-arresting Formula can reduce the heart hemorrhage ratio of zebrafish induced by simvastatin, and increase the Improvement ratio of hemorrhage. | Gao Chong Wang Jun Wang Jia Zhu Xiaoyu Zhu Changle Guo Shengya Wang Chong Fan Qiuyue Zhang Jianuo Xia Bo Chen Xinyi | 2018 | Journal of Traditional Chinese Medicine2018，38，3： | 1 |
| 4 | A novel approach to the attitude stabilization structure for ducted-fan operative aerial robots:Finding improvements for modeling error and strong external transient disturbance显示文摘This research concerns a novel attitude stabilization structure for a ducted-fan aerial robot to work against modeling error and strong external transient disturbance,and it focuses on two main control targets:modeling error compensation,and the improvement of disturbance resistance along the rolling channel.For the first research objective,we proposed an adaptive nominal controller with the reconfigurable control law design based on the estimation of the modeling error found in the closed-loop.Results of simulations and corresponding flight tests verified that the proposed adaptive control structure is robust against both constant and time-varying modeling error.For the other research objective,a SAC(Stability Augmentation Control)structure was devised based on the CMG(Control Moment Gyroscope)theory in order to provide extra moment which effectively withstands the transient disturbance beyond the CDG(Critical Disturbance Gain).Furthermore,we studied the corresponding controller for the SAC via the SMC(sliding mode control)theory,while the working mechanism and performance of the SAC were verified through a specially devised prototype. | Wei FAN Bin XU Changle XIANG Yibo ZHANG Haiyang YANG | 2022 | Chinese Journal of Aeronautics2022，35，2： | 1 |
| 5 | Observation of electron weak localization and correlation effects in disordered graphene显示文摘We have studied the electron transport properties of a disordered graphene sample, where the disorder was intentionally strengthened by Ga+ ion irradiation. The magneto-conductance of the sample exhibits a typical two-dimensional electron weak localization behavior, with electron-electron interaction as the dominant dephasing mechanism. The absence of electron anti-weak localization in the sample implies strong intersublattice and/or intervalley scattering caused by the disorders. The temperature and bias-voltage dependencies of conductance clearly reveal the suppression of conductance at low energies, indicating opening of a Coulomb gap due to electron-electron interaction in the disordered graphene sample. | TAN ChangLing TAN ZhenBing MA Li QU FanMing YANG Fan CHEN Jun LIU GuangTong YANG HaiFang YANG ChangLi LU Li | 2009 | Science China(Physics,Mechanics & Astronomy)2009，52，9： | 1 |
| 6 | Moisture-proof and Enhanced Effect of Inorganic Coating on Porous Si_3N_4 Ceramic显示文摘Inorganic coating was fabricated on the surface of the porous Si3N4 ceramic by polymer derived(PD) and spraying technology, via using vinyl-polysilazane(PSN-1) as a preceramic polymer and Si3N4 and lithium aluminosilicate(LAS) powders as fillers. The phase and microstructure of the coatings were analyzed by X-ray diffraction(XRD) analysis and scanning electron microscopy(SEM), respectively. The effect of the coatings on mechanical property and humidity resistance of the porous Si3N4 ceramic was investigated. The experimental results showed that we successfully fabricated the uniform and dense coating which preferably combined with the substrate upon the addition of fillers. The bending strength of the porous Si3N4 ceramic sprayed the coating increased by more than 18%, and the surface hardness increased by 1.7 times. The apparent porosity of the materials reduced by an average of 97.7%, and water absorption was below 0.5%. Therefore, the prepared coating with preferable density had an obviously moisture-proof and enhanced effect on the porous Si3N4 ceramic. | 程传兵 FAN Runhua WANG Chonghai WANG Hongsheng ZHOU Changling 刘福田 | 2015 | Journal of Wuhan University of Technology(Materials Science)2015，30，2： | 1 |
| 7 | Influence of Wall Effect on Comprehensive Controllability for Ducted Fan Aircraft显示文摘A novel coaxial ducted fan structure aircraft is proposed to enable the aircraft near vertical walls at high altitudes.The state space equation of the system can be obtained by correlation deduction and identification of the whole prototype model.Based on the duct test bench experiment and computational fluid dynamics(CFD)simulation analysis,the expressions between the different distances dWE from the rotor center of the prototype to the wall and the thrust,reaction torque,and tilting moment of the system under hovering conditions are obtained.The influence of the wall effect of the prototype is incorporated into the system model to analyze the relationship between distance dWE and the comprehensive controllability of the system.The results show that the system comprehensive controllability vector of other channels changes little with the decrease of the distance dWE,and only the controllability vector of the rolling channel increases significantly.At the same time,the tilting moment also increases significantly,which strengthens the tendency of the prototype to tilt towards the wall. | Tianfu Ai Changle Xiang Bin Xu Wei Fan Yibo Zhang | 2020 | Journal of Beijing Institute of Technology2020，29，4： | 0 |
| 8 | Dual-salt assisted synergistic synthesis of Prussian white cathode towards high-capacity and long cycle potassium ion battery显示文摘Prussian blue analogues(PBAs) are considered as superior cathode materials for potassium-ion batteries(PIBs) because of their three-dimensional open framework structure,high stability,and low cost.However,the intrinsic lattice defects and low potassium content typically results in poor rate and cycling performance,thus limited their practical applications.In this work,high-quality K1.64FeFe(CN)6(PW-HQ)material with less crystalline water(6.21%) and high potassium content(1.64 mol^(-1)) was successfully synthesized by a novel coprecipitation method with potassium citrate(K-CA) and potassium chloride(KCl) addition.Specifically,the electrode delivers a reversible capacity of 113.1 mA h g^(-1)at the current rate of 50 mA g^(-1)with~100% coulombic efficiency.Besides,the electrode retained 90% reversible capacity at 500 mA g^(-1)current density after 1000 cycles,indicating only 0.01% capacity decay per cycle.Moreover,we have revealed that the introduction of K-CA controlled the chelating rate of Fe(Ⅱ) and the addition of KCl increased the K+content,hence improving the capacity and stability of the asprepared electrodes.Structural evolution and potassium storage mechanism were further investigated by detailed ex-situ X-ray diffraction and in-situ Raman measurements,which demonstrated reversible potassiation/depotassiation behavior and negligible volume change during the electrochemical process.In general,this work provides an efficient strategy to eliminate water contents in Prussian blue cathode and improve its electrochemical performance,which plays a key role in promoting the industrialization of potassium ion batteries. | Rui Ma Zixing Wang Qingfeng Fu Wang Zhou Ying Mo Jian Tu Zhiyong Wang Peng Gao Changling Fan Jilei Liu | 2023 | Journal of Energy Chemistry2023，，8： | 0 |
| 9 | Dysfunctional resting-state EEG microstate correlated with the severity of cigarette exposure in nicotine addiction显示文摘Dear editor,Nicotine is a significant cause of severe physical and psychiatric disorders.Evidence suggests that smokers have poorer global cognitive functioning in later life,as well as lower average scores in several cognitive domains,including cognitive flexibility and memory [1]. | Yan CHENG Junjie BU Nan LI Jian LI Huixing GOU Shinan SUN Chang LIU Zida JIN Changle HE Chuan FAN Chialun LIU Xiaochu ZHANG | 2020 | Science China(Information Sciences)2020，63，7： | 0 |
| 10 | Theoretical and Experimental Investigations of Gyroplane Jump Takeoff Dynamics显示文摘A nonlinear and time-varying gyroplane jump takeoff dynamics model considering the unsteady ground effect and the rapid blade-pitch increase(RBPI) is developed and validated against the experiment data.The precisions of the proposed model,an experienced Hollmann model and three other simplified models are compared by displaying the height and rpm time histories of those models and the experimental data.The mean square errors(MSE) of the height histories and maximum height errors(MHE) between those models are calculated and given out.The statistics provide a kind of evaluation method of importance of the unsteady ground effect,RBPI,and the induced velocity on jump takeoff performance in vertical phase.The impact of the unsteady ground effect and RBPI on the thrust and induced velocity of the experimental rotor of a small scale platform is analyzed.The study indicates that the proposed model agrees better with the experimental data than other models.It is useful for predicting the gyroplane jump takeoff performance for design. | Xingbang Yang Changle Xiang Bin Xu Wei Fan | 2017 | Journal of Harbin Institute of Technology(New Series)2017，24，3： | 0 |
| 11 | Identification of potential interdisciplinary cooperative topics based on co-word network:Taking LIS and computer science as an example显示文摘[Purpose/significance]Interdisciplinary knowledge fusion plays a key role in promoting the development of interdisciplinary integration and providing new ideas for interdisciplinary cooperative research.This study sets out to identify potential interdisciplinary cooperative topics between Library and Information Science(LIS)and Computer Science.[Method/Process]We built an interdisciplinary co-word network to identify potential interdisciplinary cooperative topics by closed and opened irrelevant knowledge discovery methods.We also constructed the topic interdisciplinary cooperation potential index(TICPI)to calculate the interdisciplinary cooperation potential of the topic and found the best contact path of the cooperation topic by constructing the practicable value(PV)of the contact patch.[Result/Conclusion]The experimental data suggested that both methods can identify the same potential interdisciplinary cooperative topics,such as knowledge service&matrix decomposition,online comments&social media processing,academic text&generative adversarial network,network public opinion&smart home.Exploiting the cooperation potential of these topics can help the knowledge fusion between disciplines. | Changling Li Guoyang Rong Kun Luan Xinxin Wang Lixu Shen Qingqing Fan | 2022 | Data Science and Informetrics2022，2，3： | 0 |
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