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您的检索式：作者名="Changgui Shi"
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| 1 | Curcumin promotes apoptosis in human lung adenocarcinoma cells throughmiR-186* signaling pathway显示文摘 | Jian Zhang Yongping Du Changgui Wu Xinling Ren Xinyu Ti Jieran Shi Feng Zhao Hong Yin | 2010 | Oncology Reports2010，，5： | 1 |
| 2 | Formulation of pH-responsive PEGylated nanoparticles with high drug loading capacity and programmable drug release for enhanced antibacterial activity显示文摘In the current global crisis of antibiotic resistance,delivery systems are emerging to combat resistant bacteria in a more efficient manner.Despite the significant advances of antibiotic nanocarriers,many challenges like poor biocompatibility,premature drug release,suboptimal targeting to infection sites and short blood circulation time are still challenging.To achieve targeted drug delivery and enhance antibacterial activity,here we reported a kind of pH-responsive nanoparticles by simply self-assembly of an amphiphilic poly(ethylene glycol)-Schiff-vancomycin(PEG-Schiff-Van)prodrug and free Van in one drug delivery system.The acid-liable Schiff base furnished the PEG-Schiff-Van@Van with good storage stability in the neutral environment and susceptible disassembly in response to faintly acidic condition.Notably,on account of the combination of physical encapsulation and chemical conjugation of vancomycin,these nanocarriers with favorable biocompatibility and high drug loading capacity displayed a programmed drug release behavior,which was capable of rapidly reaching high drug concentration to effectively kill the bacteria at an early period and continuously exerting an bacteria-sensitive effect whenever needed over a long period.In addition,more Schiff-base moieties within the PEG-Schiff-Van@Van nanocarriers may also make great contributions on promoting the antimicrobial activity.Using this strategy,this system was designed to have programmable structural destabilization and sequential drug release due to changes in pH that were synonymous with bacterial infection sites,thereby presenting prominent antibacterial therapy both in vitro and in vivo.This work represents a synergistic strategy on offering important guidance to rational design of multifunctional antimicrobial vehicles,which would be a promising class of antimicrobial materials for potential clinical translation. | Dawei Li Guoke Tang Hui Yao Yuqi Zhu Changgui Shi Qiang Fu Fei Yang Xing Wang | 2022 | Bioactive Materials2022，7，10： | 1 |
| 3 | An efficient MPEG video encryption algorithm 显示文摘 | Changgui Shi Bharat Bhargava | 1998 | In : Bristol United Kingdom Proceedings of the 6th ACM International Multimedia Conference1998，，9： | 1 |
| 4 | Curcumin promotes apoptosis in A549/DDP multidrug-resistant human lung adenocarcinoma cells through an miRNA signaling pathway显示文摘 | Jian Zhang Tao Zhang Xinyu Ti Jieran Shi Changgui Wu Xinling Ren Hong Yin | 2010 | Biochemical and Biophysical Research Communications2010，，1： | 1 |
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