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| 1 | Use of blood-based biomarkers for early diagnosis and surveillance of colorectal cancer显示文摘Early screening for colorectal cancer(CRC) holds the key to combat and control the increasing global burden of CRC morbidity and mortality. However, the current available screening modalities are severely inadequate because of their high cost and cumbersome preparatory procedures that ultimately lead to a low participation rate. People simply do not like to have colonoscopies. It would be ideal, therefore, to develop an alternative modality based on blood biomarkers as the first line screening test. This will allow for the differentiation of the general population from high risk individuals. Colonoscopy would then become the secondary test, to further screen the high risk segment of the population. This will encourage participation and therefore help to reach the goal of early detection and thereby reduce the anticipated increasing global CRC incidence rate. A blood-based screening test is anappealing alternative as it is non-invasive and poses minimal risk to patients. It is easy to perform, can be repeated at shorter intervals, and therefore would likely lead to a much higher participation rate. This review surveys various blood-based test strategies currently under investigation, discusses the potency of what is available, and assesses how new technology may contribute to future test design. | Ganepola AP Ganepola Joel Nizin John R Rutledge David H Chang | 2014 | World Journal of Gastrointestinal Oncology2014，6，4： | 11 |
| 2 | Novel blood-based microRNA biomarker panel for early diagnosis of pancreatic cancer显示文摘AIM:To develop a panel of blood-based diagnostic biomarkers consisting of circulating microRNAs for the detection of pancreatic cancer at an early stage.METHODS:Blood-based circulating microRNAs were profiled by high throughput screening using microarray analysis,comparing differential expression between early stage pancreatic cancer patients(n = 8) and healthy controls(n = 11).A panel of candidate microRNAs was generated based on the microarray signature profiling,including unsupervised clustering and statistical analysis of differential expression levels,and findings from the published literature.The selected candidate microRNAs were then confirmed using TaqMan real-time quantitative reverse transcription polymerase chain reaction(RT-qPCR) to further narrow down to a three-microRNA diagnostic panel.The three-microRNA diagnostic panel was validated with independent experimental proce-dures and instrumentation of RT-qPCR at an independent venue with a new cohort of cancer patients(n = 11),healthy controls(n = 11),and a group of high risk controls(n = 11).Receiver operating characteristic curve analysis was performed to assess the diagnostic capability of the three-microRNA panel.RESULTS:In the initial high throughput screening,1220 known human microRNAs were screened for differential expression in pancreatic cancer patients versus controls.A subset of 42 microRNAs was then generated based on this data analysis and current published literature.Eight microRNAs were selected from the list of 42 targets for confirmation study,and three-microRNAs,miR-642b,miR-885-5p,and miR-22,were confirmed to show consistent expression between microarray and RT-qPCR.These three microRNAs were then validated and evaluated as a diagnostic panel with a new cohort of patients and controls and found to yield high sensitivity(91%) and specificity(91%) with an area under the curve of 0.97(P < 0.001).Compared to the CA19-9 marker at 73%,the three-microRNA panel has higher sensitivity although CA19-9 has higher specificity of 100%.CONCLUSION:The identified panel of three microRNA biomarkers can potentially be used as a diagnostic tool for early stage pancreatic cancer. | Ganepola AP Ganepola John R Rutledge Paritosh Suman Anusak Yiengpruksawan David H Chang | 2014 | World Journal of Gastrointestinal Oncology2014，6，1： | 9 |
| 3 | Comparative study of human eutopic and ectopic endometrial mesenchymal stem cells and the development of an in vivo endometriotic invasion model显示文摘 | Kao AP Wang KH Chang CC | | 0，，04： | 1 |
| 4 | A sensitive non-radioactive northern blot method to detect small RNAs显示文摘 | Kim SW Li Z Moore PS Monaghan AP Chang Y Nichols M John B | | 0，，07： | 1 |
| 5 | Comparative study of human eutopic and ectopic endometrial mesenchymal stem cells and the development of an in vivo endometriotic invasion model 显示文摘 | Kao AP Wang KH Chang CC | 2011 | Fertil Steril2011，95，4： | 1 |
| 6 | increasing CD44+/CD24- tu- mor stem cells,and up-regulation of COX-2 and HDAC6,as major functions of HER2 in breast tumorigenesis 显示文摘 | ang KH Kao AP Chang CC | 2010 | Mol Cancer2010，9，： | 1 |
| 7 | Validation of the Taiwanese version of the Brief Fatigue Inventory显示文摘 | Lin CC Chang AP Chen ML | 2006 | J Pain Symptom Man- age2006，32，1： | 1 |
| 8 | Irritable bowel syndrome in the United States:prevalence,symptom patterns and impact显示文摘 | Hungin AP Chang L Locke GR | 2005 | Aliment Pharmacol Ther2005，21，11： | 1 |
| 9 | NQO1 polymorphisms and de novo childhood leukemia: a HuGE review and meta-analysis 显示文摘 | Guha N Chang JS Chokkalingam AP | 2008 | Am J Epidemiol2008，168，11： | 1 |
| 10 | Comparative study of human eutopic and ectopie endometrial mesenehymal stem cells and the development of an in vivo endometriotie invasion model显示文摘 | Kao AP Wang KH Chang CC | 2011 | Fertil Steril2011，95，4： | 1 |
| 11 | Proteome-wide analysis of chaperonin-dependent protein folding in Escherichia coli显示文摘 | Kerner MJ Naylor DJ Ishihama Y Maier T Chang HC Stines AP Georgopoulos C Frishman D Hartl MH Mann M Hartl FU | 2005 | Cell2005，122，2： | 1 |
| 12 | Validation of the Tai- wanese version of the brief fatigue inventory显示文摘 | Lin CC Chang AP Chen ML | 2006 | J Pain Sy- mptom Manage2006，32，1： | 1 |
| 13 | Cytokine production from pe- ripheral blood mononuclear cells in patients with ankylosing spondy- litis and their first-degree relatives 显示文摘 | Chou CT Huo AP Chang HN | 2007 | Arch Med Res2007，38，2： | 1 |
| 14 | Nipple-sparing mastectomy :where are we now?显示文摘 | Chang AP Sacchini V | 2008 | Surg Oncol2008，17，4： | 1 |
| 15 | Pharmacological pleiotropism of the human recombinant alphal A-adrenocep- for: implications for alphal-adrenoeeptor classification显示文摘 | Ford AP Daniels DV Chang D J | 1997 | Br J Pharmacol1997，121，6： | 1 |
| 16 | Repression of NHE1 expression by PPARgamma activation is a potential new approach for specific inhibition of the growth of tumor cells in vitro and in vivo 显示文摘 | Kumar AP Quake AL Chang MK | 2009 | Cancer Res2009，69，22： | 1 |
| 17 | Electron probe anlysis,Xray mapping,and electron energy-loss spectroscopy of calcium,magnesium,and monovalent ions in log-phase and in dividing Escherichia coli B cells显示文摘 | Chang CF Suman H Somlyo AP | 1986 | J Bacteriol1986，167，： | 1 |
| 18 | NQO1 polymorphisms and de novo childhood leukemia: a Huge review and meta-analysis显示文摘 | Guha N Chang JS Chokkalingam AP | 2008 | Am J Epidemiol2008，168，11： | 1 |
| 19 | Increasing CD44 +/ CD24(-) tumor stem cells, and upregulation of COX-2 and HDAC6 , as major functions of Her2 in breast tumorigenesis显示文摘 | Wang KH Kao AP Chang CC | 2010 | Mol Cancer2010，9，： | 1 |
| 20 | Irritable bowel syn- drome in the United States: prevalence, symptom patterns and impact显示文摘 | Hungin AP Chang L Locke GR | 2005 | Aliment Pharmacol Ther2005，21，： | 1 |
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