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| 1 | Risk factors and natural history of breast cancer in younger Chinese women显示文摘AIM: To investigate the age differences in the risk factors, clinicopathological characteristics and patterns of treatment of female breast cancer patients. METHODS: Seven thousand one hundred and fiftytwo women with primary breast cancer from the Hong Kong Breast Cancer Registry were recruited after receiving patients' consent, they were asked to complete standardized questionnaires which captured their sociodemographic characteristics and risk factors associated with breast cancer development. Among them, clinicopathological data and patterns of treatment were further collected from medical records of 5523 patients with invasive breast cancers. Patients were divided into two groups according to the age at diagnosis: younger(< 40 years old) vs older patients(≥ 40 years old) for subsequent analyses.RESULTS: Analysis on the sociodemographic characteristics and exposure to risk factors were performed on 7152 women with primary breast cancer and the results revealed that younger patients were more likely to have unhealthy lifestyles; these include a lack of exercise(85.4% vs 73.2%, P < 0.001), having high stress in life(46.1% vs 35.5%, P < 0.001), having dairy/meat-rich diets(20.2% vs 12.9%, P < 0.001),having alcohol drinking habit(7.7% vs 5.2%, P = 0.002). Younger patients were also more likely to have hormone-related risk factors including nulliparity(43.3% vs 17.8%, P < 0.001) and an early age at menarche(20.7% vs 13.2%, P < 0.001). Analyses on clinicopathological characteristics and patterns of treatment were performed on 5523 women diagnosed with invasive breast cancer. The invasive tumours in younger patients showed more aggressive pathological features such as having a higher percentage of grade 3 histology(45.7% vs 36.5%, P < 0.001), having a higher proportion of tumours with lymphovascular invasion(39.6% vs 33.2%, P = 0.003), and having multifocal disease(15.7% vs 10.3%, P < 0.001); they received different patterns of treatment than their older counterparts.CONCLUSION: Younger patients in Hong Kong are more likely to encounter risk factors associated with breast cancer development and have more aggressive tumours than their older counterparts. | Winnie Yeo Hang-Mei Lee Amy Chan Emily YY Chan Miranda CM Chan Keeng-Wai Chan Sharon WW Chan Foon-Yiu Cheung Polly SY Cheung Peter HK Choi Josette SY Chor William WL Foo Wing-Hong Kwan Stephen CK Law Lawrence PK Li Janice WH Tsang Yuk Tung Lorna LS Wong Ting-Ting Wong Chun-Chung Yau Tsz-Kok Yau Benny CY Zee | 2014 | World Journal of Clinical Oncology2014，5，5： | 4 |
| 2 | Frequency and determinants of poststroke dementia in Chinese 显示文摘 | Tang WW Chan SS Chui HF | 2004 | Stroke2004，35，4： | 1 |
| 3 | In vivo cancellous bone remodeling on a Strontium-containing hydroxyapatiteCSr-HA) bioactive cement显示文摘 | Wong CT Lu WW Chan WK | 2004 | Biomed Mater Res2004，68，3： | 1 |
| 4 | Optinal values of flow vebciocity on transcranial Doppler in granding middle cerebralartry stenosis in comparison with magnetic resonce angiography 显示文摘 | Gao S Lam WW Chan YL | 2002 | J Neuroinaging2002，12，3： | 1 |
| 5 | Progression of middle cerebral artery occlusive disease and its relationship with further vascular events after stroke显示文摘 | Wong KS Lam WW Chan YL | 2002 | Stroke2002，33，2： | 1 |
| 6 | Effects of aging and tai ehi on a finger - pointing task with a choice paradigm显示文摘 | Tsang WW Kwok JC Hui -Chan CW | 2013 | Evid Based Complement Alternat Med2013，，： | 1 |
| 7 | Pim family kinase enhance tumor growth of prostate Cancer ceils 显示文摘 | Chen WW Chan DC Donald C | 2005 | Mol Cancer Res2005，3，8： | 1 |
| 8 | In vivo trial comparing pa-tieiils'of Q-switched alexandrite ( QS Alex)and Q-switcihed neodymium:yltrium-aluminum-gainet( QS Nd:YAG)lasers in the treatment of nevus of Ota 显示文摘 | Chan HH King WW Chan ES | 1999 | Lasers Surg Med1999，，24： | 1 |
| 9 | Ocular myasthenia: a rare presentation with MuSK antibody and bilateral extraocular muscle atrophy显示文摘 | Chan JW Orrison WW | 2007 | Br J Ophthalmol2007，91，6： | 1 |
| 10 | Choledocholithiasis: comparison of MR cholangiography and endoscopic retrograde cholangiography显示文摘 | Chan AC Lam WW | 1996 | Radiology1996，200，1： | 1 |
| 11 | Comparative roles of levofloxacin and ofloxacin in the treatment of multidrugresistant tuberculosis: preliminary results of a retrospective study from Hongkong显示文摘 | Yew WW Chan CK Leung CC | 2003 | Chest2003，124，4： | 1 |
| 12 | A new species of Dasyhelea midge reared from Drain in Singapor (Diptera:Ceratopogonidae)显示文摘 | Lee KM WW Wirth and KL Chan | 1989 | Proc Ent Soc Wash1989，91，3： | 1 |
| 13 | Incidence of diabetes among postmenopausal breast cancer survivors显示文摘 | Lipscombe LL Chan WW Yun L | 2013 | Diabetologia2013，56，3： | 1 |
| 14 | Optimal values of flow velocity on tran- seranial Doppler in grading middle eerebral artery stenosis in comparison with magnetic resonance angiography 显示文摘 | Gao S Lam WW Chan YL | 2002 | J Neuroimaging2002，12，3： | 1 |
| 15 | Smoking and tuber eulosis among the elderly in Hong Kong显示文摘 | Leung CC Li T Lain TH Yew WW Law WS Tam CM Chan WM Chan CK Ho KS Chang KC | 2004 | Am J Respir Crit Care Med2004，170，9： | 1 |
| 16 | Ocular- hypertensive response and corneal endothelial changes after in- travitreal triamcinolone injections in Chinese subjects: a 6- months follow-up study 显示文摘 | Chan CK Fan DS Chan WM Lai WW Lee VY Lam DS | 2005 | Eye (Lond)2005，19，6： | 1 |
| 17 | Influence of polymorphisms within the CX3CR1 and MDR-1 genes on initial antiretroviral therapy response显示文摘 | Brumme ZL Dong WW Chan KJ | 2003 | AIDS2003，17，2： | 1 |
| 18 | Evidence for a role of protein kinase-C in His-D-Trp-Ala-Trp-D-Phe-Lys-NH2-induced growth hormone release from rat primary pituitary cells显示文摘 | Cheng K Chan WW Butler B | 1991 | Endocrinology1991，129，： | 1 |
| 19 | Comparative roles of levofloxacin and ofloxacin in the treatment of multidrug-resistant tuberculosis:preliminary results of a retrospective study from Hong Kong显示文摘 | Yew WW Chan CK Leung CC | | 0，，： | 1 |
| 20 | Triple negative status is a poor prognostic indicator in Chinese women with breast cancer:a ten year review显示文摘 | Ma KK Chan WW Wong CH | 2012 | Asian Pac J CancerPrev2012，13，5： | 1 |
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