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| 1 | Neurotrophic and metabotrophic potential of nerve growth factor and brain-derived neurotrophic factor: Linking cardiometabolic and neuropsychiatric diseases显示文摘One of biggest recent achievements of neurobiology is the study on neurotrophic factors. The neurotrophins are exciting examples of these factors. They belong to a family of proteins consisting of nerve growth factor(NGF), brain-derived neurotrophic factor(BDNF), neurotrophin-3(NT-3), NT-4/5, NT-6, and NT-7. Today, NGF and BDNF are well recognized to mediate a dizzying number of trophobiological effects, ranging from neurotrophic through immunotrophic and epitheliotrophic to metabotrophic effects. These are implicated in the pathogenesis of various diseases. In the same vein, recent studies in adipobiology reveal that this tissue is the body's largest endocrine and paracrine organ producing multiple signaling proteins collectively termed adipokines, with NGF and BDNF being also produced from adipose tissue. Altogether, neurobiology and adipobiology contribute to the improvement of our knowledge on diseases beyond obesity such as cardiometabolic(atherosclerosis, type 2 diabetes, and metabolic syndrome) and neuropsychiatric(e.g., Alzheimer's disease and depression) diseases. The present review updates evidence for(1) neurotrophic and metabotrophic potentials of NGF and BDNF linking the pathogenesis of these diseases, and(2) NGF- and BDNF-mediated effects in ampakines, NMDA receptor antagonists, antidepressants, selective deacetylase inhibitors, statins, peroxisome proliferator-activated receptor gamma agonists, and purinergic P2X3 receptor up-regulation. This may help to construct a novel paradigm in the field of translational pharmacology of neuro-metabotrophins, particularly NGF and BDNF. | Stanislav Yanev Luigi Aloe Marco Fiore George N Chaldakov | 2013 | World Journal of Pharmacology2013，2，4： | 2 |
| 2 | NGF and BDNF: from nerves to adipose tissue, from neurokines to metabokines显示文摘 | Chaldakov GN Tonchev AB Aloe L | 2009 | Riv Psichiatr2009，44，2： | 1 |
| 3 | Adipobiology of disease:adipokines and adipokine-targeted pharmacology显示文摘 | Chaldakov GN Stankulov IS Hristova M | 2003 | Curr Pharm Des2003，9，12： | 1 |
| 4 | Metabotrophic potential of neurotrophins:implication in obesity and related diseases显示文摘 | Chaldakov GN Fiore M Hristova MG | 2003 | Med Sci Monit2003，9，10： | 1 |
| 5 | NGF and BDNF: from nerves to adipose tissue,from neurokines to metabokines 显示文摘 | Chaldakov GN Tonchev AB Aloe L | 2009 | Riv Psichiatr2009，44，2： | 1 |
| 6 | Neurotrophin presence in human coronary atherosclerosis and metabolic syndrome:a role for NGF and BDNF in cardiovascular disease显示文摘 | Chaldakov GN Fiore M Stankulov IS | 2004 | Prog Brain Res2004，146，： | 1 |
| 7 | NGF,BDNF,leptin,and mast cells in human coronary atherosclerosis and metabolic syndrome显示文摘 | Chaldakov GN Fiore M Stankulov IS | 2001 | Arch Physiol Biochem2001，109，4： | 1 |
| 8 | Distribution and phe- notype of proliferating cells in the forebrain of adult macaque mon- keys after transient global cerebral ischemia 显示文摘 | Tonchev AB Yamashima T Chaldakov GN | 2007 | A dv Anat Embry- ol Cell Biol2007，191，1： | 1 |
| 9 | Opposite effects of pravastatln and atorvastatin on insulin sensitivity in the rat: role of vitamin D metabolites显示文摘 | Bel'towski J Atanassova P Chaldakov GN | 2011 | Atherosclerosis2011，219，2： | 1 |
| 10 | Distributionand phenotype of proliferating cells in the forebrain of adultmacaque monkeys after transient global cerebral ischemia 显示文摘 | Tonchev AB Yamashima T Chaldakov GN | 2007 | Adv Anat Embryol Ceil Biol2007，191，： | 1 |
| 11 | NGF and BDNF: from nerves to adipose tissue, from neurokines to metabokines 显示文摘 | Chaldakov GN Tonehev AB Aloe L | 2009 | Riv Psiehiatr2009，44，： | 1 |
| 12 | Adipoparacri- nology--vascular periadventitial adipose tissue ( tunica ad- iposa) as an example 显示文摘 | Chaldakov GN Beltowsky J Aloe L | 2012 | Cell Biol Int2012，36，： | 1 |
| 13 | Nerve growth factor as a signaling molecule for nerve ceils and also for the neuroen- docrine - immune systems 显示文摘 | Fiore M Chaldakov GN Aloe L | 2009 | Rev Neurosci2009，20，2： | 1 |
| 14 | Opposite effects of pravastatin and atorvastatin on insulin sensitivity in the rat : role of vi- tamin D metabolites显示文摘 | Beltowski J Atanassova P Chaldakov G N | 2011 | Atheroselerosis2011，219，2： | 1 |
| 15 | Adipoparacrinology- vascular periadventitial adipose tissue (tuniea adiposa) as an example显示文摘 | Chaldakov GN Beltowsky J Ghenev PI | 2012 | Cell Bio Int2012，36，3： | 1 |
| 16 | Streptozotocin-induced diabetes is associated with changes in NGF levels in pancreas and brain显示文摘 | Sposato V Manni L Chaldakov G N | | 0，，02： | 1 |
| 17 | Nerve growth factor as a signaling molecule for nerveceils and also for the neuroendocrine-immune systems显示文摘 | Fiore M Chaldakov GN Aloe L | 2009 | Rev Neurosci2009，20，： | 1 |
| 18 | Adipobiology of disease:adipokines and adipokine-targeted pharmacology显示文摘 | Chaldakov GN Stankulov IS Hristova M | | 0，，： | 1 |
| 19 | The metabotrophic NGF and BDNF : an emerging concept 显示文摘 | Chaldakov G | 2011 | Arch Ital Biol2011，149，2： | 1 |
| 20 | The metabgtrophie NGF and BDNF: an emer- ging concept 显示文摘 | Chaldakov G | 2011 | Arch Ital Biol2011，149，2： | 1 |
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