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60篇 您的检索式:作者名="Chad C"
    题名 作者 年代 出处 被引量
1An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley 2014Cell Research2014,24,7:10
2First flush concepts for suspended and dissolved solids in small impervious watersheds显示文摘John J S Chad M C 2004Journal of Environmental Engineering2004,130,:1
3Antibiotic susceptibility profiles of Escherichia coli strains lacking multidrug efflux pump gene显示文摘Mark CS Chad H Cramer C 2001Antimicrob Agents Chemother2001,45,4:1
4A comparative evaluation of hexavalent chromium treatment in contaminated soil by calcium polysulfide and green-tea nanoscale zero-valent iron显示文摘MARIA C CHAD P J GEETA D 2012Journal of Hazardous Materials2012,02,:1
5Worldwild blackberry production显示文摘Bernadine C S John R C Chad E F 2007Hort Technology2007,17,2:1
6Aerobic transformation of zinc into metal sulfide by photosynthetic microorganisms显示文摘Chad D Edwards Joseph C Beatty Jacqueline B R Loiselle 2013Applied Microbiology and Biotechnology2013,97,8:1
7Photoinduced conversion of silver nanospheres to nanoprisms显示文摘JIN R C CAO Y W CHAD A M 0,,30:1
8Worldwild blackberry produc显示文摘BERNADINE C S TOHN R C CHAD E F 2007Hort Technology2007,17,2:1
9Effective property of tooth en- amel: Monoclinic behaviour 显示文摘Lu C Y Nakamura T Chad S K 2012Journal of Biomechanics2012,45,:1
10Blobworld:Image segmentation using expectation-maximization and its application to image querying显示文摘CHAD C SERGE B HAYIT G 2002IEEE Trans on Pattern Analysis and Machine Intelligence2002,24,8:1
11Conical - nanotube ion - current rectifiers : the role of surface charge 显示文摘ZUZANNA S ELIZABETH H CHAD H C 2004J Am Chem Soc2004,126,10:1
12Cytoprotective effects of adrenomedullin in glomeular cell injury: central role of CAMP signaling pathway显示文摘Eduardo N Clandia C Chad B 1997Kidney Int1997,52,:1
13Microstructural characterization of as-cast Cr-B alloys显示文摘Gigolotti J C J Chad V M Faria M I S T 2008Materials Characterization2008,59,1:1
14Nanoparticle - Based Bio - Bar Codes for the Ultrasensitive Detection of Proteins 显示文摘Nam Jwa- Min Thaxton C Shad Mirkin Chad A 2003Science2003,301,:1
15Use of fetal pulse oximetry among high-rlsk women in labor: a randomized clinical trial 显示文摘Chad K K Erin E C Suneet P C 2005Am J Ohstet Gynecol2005,192,6:1
16The advantages of microflow LC–MS/MS compared with conventional HPLC–MS/MS for the analysis of methotrexate from human plasma显示文摘Chad C Christianson Casey JL Johnson Shane R Needham 2013Bioanalysis2013,,11:1
17Worldwild blackberry pro- duetionp 显示文摘Bemadine C Tohn R C Chad E F 2007Hort Technology2007,17,2:1
18The role of epithelial-mesenchymal transition programming in invasion and metastasis:a clinical perspective显示文摘CHAD J C DON L G JONATHAN M K 2013Cancer Management and Research2013,5,7:1
19Volatile composition and odour-activity value of thornless ' Black Diamond' and 'Marion' blackberries 显示文摘Du Xiaofen Chad E Finn Michael C Qian 2010Food Chemistry2010,119,3:1
20Calcium polysulfide treat- ment of Cr( Ⅵ) -contaminated soil显示文摘Maria C Daniel 1L F Chad P J 2010Journal of Hazard- ous Materials2010,179,:1
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