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| 1 | Transient micro-elastography:A novel non-invasive approach to measure liver stiffness in mice显示文摘AIM:To develop and validate a transient micro-elastography device to measure liver stiffness(LS) in mice.METHODS:A novel transient micro-elastography(TME) device,dedicated to LS measurements in mice with a range of measurement from 1-170 kPa,was developed using an optimized vibration frequency of 300 Hz and a 2 mm piston.The novel probe was validated in a classical fibrosis model(CCl4) and in a transgenic murine model of systemic amyloidosis.RESULTS:TME could be successfully performed in control mice below the xiphoid cartilage,with a mean LS of 4.4 ± 1.3 kPa,a mean success rate of 88%,and an excellent intra-observer agreement(0.98).Treatment with CCl4 over seven weeks drastically increased LS as compared to controls(18.2 ± 3.7 kPa vs 3.6 ± 1.2 kPa).Moreover,fibrosis stage was highly correlated with LS(Spearman coefficient = 0.88,P < 0.01).In the amyloidosis model,much higher LS values were obtained,reaching maximum values of > 150 kPa.LS significantly correlated with the amyloidosis index(0.93,P < 0.0001) and the plasma concentration of mutant hapoA-□(0.62,P < 0.005).CONCLUSION:Here,we have established the first non-invasive approach to measure LS in mice,and have successfully validated it in two murine models of high LS. | Cécile Bastard Matteo R Bosisio Michèle Chabert Athina D Kalopissis Meriem Mahrouf-Yorgov Hélène Gilgenkrantz Sebastian Mueller Laurent Sandrin | 2011 | World Journal of Gastroenterology2011，17，8： | 4 |
| 2 | Pleiotropy of insecticide resistance in the codling moth, Cydia pomonella 显示文摘 | Boivin T Chabert d' Hieres C Bouvier J C | 2001 | Entomologia Experimentalis et Applicata2001，99，： | 1 |
| 3 | New experimentalsetup for wettability characterization under monitored oxygenactivity: II, wettability of sapphire by silver-oxygenmelts 显示文摘 | Chatain D Chabert F Ghetta V | 1994 | Journal of the American Ceramic Society1994，77，1： | 1 |
| 4 | Interval method for calibration ofparallel robots: Vision-based experiments 显示文摘 | Daney D AndreffN Chabert Q | 2006 | Mechanism andMachine Theory (S0094-114x)2006，41，8： | 1 |
| 5 | Interval method for calibration of parallel robots: vision-based experi- ments 显示文摘 | DANEY D ANDREFF D CHABERT G | 2006 | Mechanism and Machine Theory2006，41，： | 1 |
| 6 | A chemical proteomics approach to phosphatidylinositol 3 - kinase signaling in macrophages 显示文摘 | Pasquali C Bertschy -Meier D Chabert C | 2007 | Mol Cell Proteomics2007，6，11： | 1 |
| 7 | An evaluation of stresses and deflection of spur gear teeth under strain显示文摘 | Chabert G Tran T D Mathis R | 1974 | ASME Journal Engineering for Industry1974，，： | 1 |
| 8 | A chemical proteomics approach to phosphatidylinositol 3-kinase signaling in macrophages显示文摘 | Pasquali C Bertschy-Meier D Chabert C | | 0，，11： | 1 |
| 9 | Interval method for calibration of parallel robots: Vision-based ex- periments显示文摘 | DANEY D ANDREFF N CHABERT G | 2006 | Mechanism and Machine Theory2006，41，8： | 1 |
| 10 | Unsuccessful rescue therapy with adefovir dipivoxil for lamivudine resistant HBV in a patients with liver failure显示文摘 | Thabut D Ratziu V Bernard - Chabert B | 2003 | Gastroenterology2003，52，： | 1 |
| 11 | Pore-forming activity of type Ⅲ system-secreted proteins leads to oncosis of Pseudomonas aeruginosa-infected macrophages 显示文摘 | Dacheux D Goure J Chabert J | 2001 | Mol Microbiol2001，40，1： | 1 |
| 12 | Long term therapy with Lamivudine in renal transplant recipients with chronic hepatitis B显示文摘 | Thabut D Thibault V Bernard Chabert B | 2004 | Eur J Gastroenterol Hepatol2004，16，： | 1 |
| 13 | Droplet fusion by alternating current (Ac) field electrocoalescence in microchannels显示文摘 | Chabert M Dorfman K D Viovy J L | 2005 | Electrophoresis2005，26，： | 1 |
| 14 | Contamination-free Continuous Flow Microfluidic Polymerase Chaiu Reaction for Quantitative and Clinical Applications显示文摘 | DORFMAN K D CHABERT M CODARBOX J H | 2005 | Analytical Chemistry2005，77，11： | 1 |
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