|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Apoptotic cell death and its relationship to gastric carcinogenesis显示文摘AIM: To investigate the apoptotic process of cells with in the intestinal metaplasia areas co-localizing with chronic gastritis and gastric carcinomas and to analyze the involvement of proteins regulating apoptosis in the process of intestinal metaplasia related gastric carcinogenesis. METHODS: Forty-two gastric carcinoma and seventeen chronic gastritis cases were included in this study. All cases were examined for the existence of intestinal metaplasia. Ten cases randomly selected from each group were processed for TUNEL assay. TUNEL positive cells within the intestinal metaplasia areas, co-localizing either to gastric carcinoma or chronic gastritis, were counted and converted to apoptotic indices. In addition, p53, bcl-2 and bax expression patterns within these tissues were analyzed on the basis of immunohistochemistry. RESULTS: Twenty-eight of the cases were intestinal and 14 of the cases were diffuse type adenocarcinomas. 64% (27/42) of the gastric carcinoma cases had intestinal metaplasia. Intestinal metaplasia co-localized more with intestinal type carcinomas compared with diffuse type carcinomas [75% (21/28) vs 42% (6/14), respectively; P ≤0.05]. The mean apoptotic index in tumor cells was 0.70±0.08. The mean apoptotic index in intestinal metaplasias co-localizing to tumors was significantly higher than that of intestinal metaplasias co-localizing to chronic gastritis (0.70±0.03 vs 0.09±0.01, respectively; P≤0.05). p53 positivity was not observed in areas of intestinal metaplasia adjacent to tumors or chronic gastritis. Intestinal metaplasia areas adjacent to tumors showed lower cytoplasmic bcl-2 positivity compared to intestinal metaplasia areas adjacent to chronic gastritis [55.5% (15/27) vs 70.5% (12/17), respectively]. On the other hand, intestinal metaplasia areas adjacent to tumors showed significantly higher cytoplasmic bax positivity compared to intestinal metaplasia areas adjacent to chronic gastritis [44.4% (12/27) vs 11.7% (2/17), respectively; P ≤0.05]. CONCLUSION: Existence of apoptotic cells on the basis of TUNEL positivity is shown in intestinal metaplasias co-localizing to both diffuse and intestinal type gastric cancers in this study. Our results also suggested bax expression dependent induction of apoptosis especially in intestinal metaplasia areas adjacent to tumors. These findings strongly support the involvement of apoptotic mechanisms in the process of gastric carcinogenesis especially in the transition from intestinal metaplasia to gastric cancer. It may be suggested that induction of apoptosis in intestinal metaplasia areas adjacent to tumors may involve different mechanisms than induction by chronic inflammation. | Ferda Bir Nese Calli-Demirkan A Cevik Tufan Metin Akbulut N Lale Satiroglu-Tufan | 2007 | World Journal of Gastroenterology2007，13，23： | 2 |
| 2 | Interrelation between the Poisoning Severity Score,carboxyhaemoglobin levels and in-hospital clinical course of carbon monoxide poisoning显示文摘 | Cevik A A Unluoglu I Yanturali S | 2006 | Int J Clin Pract2006，60，12： | 1 |
| 3 | The effects of abdominal compartMent syndrome on the summ urea and creatinine levels J 显示文摘 | Kucuk HF Cevik a Kurt N | 2002 | Ulus Travma Derg2002，8，1： | 1 |
| 4 | An interactive approach for hierarchical analysis of helicopter logistics in disaster relief operations显示文摘 | BARBAROSOGLU G OZDAMAR L CEVIK A | 2002 | European Journal of Operational Research2002，140，1： | 1 |
| 5 | Jet scour around vertical piles and pile groups显示文摘 | YUKSEL A CELIKOGLU Y CEVIK E | 2005 | Ocean Engineering2005，32，： | 1 |
| 6 | The effect of calcitonin on biochemical markers and zinc excretion in postmenopausal osteoporosis 显示文摘 | Colpan L Gur A Cevik R | 2005 | Maturitas2005，51，3： | 1 |
| 7 | A two-stage stochastic programming framework for transportation planning in disaster response显示文摘 | Barbarosoglu G Ozdamar L Cevik A | 2004 | Journal of the Operational Research Society2004，55，1： | 1 |
| 8 | An Interactive Approach for Hierarchical Analysis of Helicopter Logistics in Disaster Relief显示文摘 | Barbarosoglu G Ozdamar L Cevik A | 2002 | European Journal of Operational Research2002，140，1： | 1 |
| 9 | An interactive approach for hierarchical analysis of helicopter logistics in disaster relief operations显示文摘 | Barbarosoglu G Ozdamar L Cevik A | 2002 | European Journal of Operational Research2002，140，11： | 1 |
| 10 | An interactive approach for hierarchical analysis of helicopter logistics in disaster relief operations显示文摘 | Barbarosoglu G Ozdamar L Cevik A | 2002 | European Journal of Operational Research2002，140，1： | 1 |
| 11 | Estimation of wave parameters based on nearshore wind wave correlations显示文摘 | An Guner H A Yuksel Y Ozkan Cevik E | 2013 | Ocean Engineering2013，63，： | 1 |
| 12 | Successful endovascular stenting of total juxtarenal aortic occlusion performed through brachial and femoral access显示文摘 | Otahbachi M Kumar A Cevik C | 2009 | J Card Surg2009，24，： | 1 |
| 13 | An interactive approach for hierarch- ical analysis of helicopter logistics in disaster relief operations 显示文摘 | Barbarosoglu G 0zdamar L Cevik A | 2002 | European Journal of Operational Research2002，140，1： | 1 |
| 14 | Effects of in enzyme activities of myrtle oil in and alloxan diabetic rabbits 显示文摘 | Sepici-Dincel A vivo antioxidant normoglycaemic Ethnopharmacol Agikg6z S Cevik C | 2007 | J2007，110，3： | 1 |
| 15 | Cortisol and hypothalamic-pituitary-gonadal axis hormones in follIcular-phase women with fibromyalgia and chronic fatigue syndrome and effect of depressive symptoms on these hormones显示文摘 | Gut A Cevik R Nas K | 2004 | Arthritis Res Ther2004，6，： | 1 |
| 16 | An interactive approach for hierarchical analysis of nencopter iogisucs in disaster relief operations显示文摘 | Barbarosoglu G Ozdamar L Cevik A | 2002 | European Journal of Operational Research2002，140，1： | 1 |
| 17 | Hypoglycaemic effects of myrtle oil in normal and alloxan-diabetic rabbits 显示文摘 | Sepici A Gfirbtiz I Cevik C | 2004 | J Ethnopharmacol2004，93，23： | 1 |
| 18 | Prophylactic implantation of cardioverter defibrillators in idiopathic nonischemic cardiomyopathy for the primary prevention of death : a narrative review 显示文摘 | Cevik C Nugent K Perez-Verdia A | 2010 | Clin Cardiol2010，33，5： | 1 |
| 19 | Is stent placement necessary after uncompli- cated ureterocoy for removal of impacted ureteral stones 显示文摘 | Cevik I Dillioglugil O Akdas A | 2010 | Journal of Endourology2010，24，8： | 1 |
| 20 | Non-invasive evaluation ot' ver- tebral artery blood flow in ;ervical spondylosis with and without vertigo and association with degenerative changes 显示文摘 | Cevik R Bilici A Nas K | 2010 | Clin Rheumatol2010，29，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员