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| 1 | Combination of corticosteroids and 5-aminosalicylates or corticosteroids alone for patients with moderate-severe active ulcerative colitis:A global survey of physicians'practice显示文摘AIM To examine treatment decisions of gastroenterologists regarding the choice of prescribing 5-aminosalycilates(5ASA) with corticosteroids(CS) versus corticosteroids alone for patients with active ulcerative colitis(UC). METHODS A cross-sectional questionnaire exploring physicians' attitude toward 5ASA + CS combination therapy vs CS alone was developed and validated. The questionnaire was distributed to gastroenterology experts in twelve countries in five continents. Respondents' agreement with stated treatment choices were assessed by standardized Likert scale. Background professional characteristics of respondents were analyzed for correlation with responses. RESULTS Six hundred and sixty-four questionnaires were distributed and 349 received(52.6% response rate). Of 340 eligible respondents, 221(65%) would continue 5ASA in a patient hospitalized for intravenous CS treatment due to a moderate-severe UC flare, while 108(32%) would stop the 5ASA(P < 0.001), and 11(3%) are undecided. Similarly, 62% would continue 5ASA in an out-patient starting oral CS. However, only 140/340(41%) would proactively start 5ASA in a hospitalized patient not receiving 5ASA before admission. Most(94%) physicians consider the safety profile of 5ASA as very good. Only 52% consider them inexpensive, 35% perceive them to be expensive and 12% are undecided. On multi-variable analysis, less years of practice and perception of a plausible additive mechanistic effect of 5ASA + CS were positively associated with the decision to continue 5ASA with CS. CONCLUSION Despite the absence of data supporting its benefit, most gastroenterologists endorse combination of 5ASA + CS for patients with active moderate-to-severe UC. Randomized controlled trials are needed to assess if 5ASA confer any benefit for these patients. | Shomron Ben-Horin Jane M Andrews Konstantinos H Katsanos Florian Rieder Flavio Steinwurz Konstantinos Karmiris Jae Hee Cheon Gordon William Moran Monica Cesarini Christian D Stone Doron Schwartz Marijana Protic Xavier Roblin Giulia Roda Min-Hu Chen Ofir Har-Noy Charles N Bernstein | 2017 | World Journal of Gastroenterology2017，23，16： | 3 |
| 2 | Confidence inter- val estimation tasks and the economics of overconfidence 显示文摘 | Cesarini D Sandewall O Johannesson M | 2006 | Journal of Economic Behavior Organization2006，61，3： | 1 |
| 3 | Heritability of cooperative behavior in the trust game显示文摘 | Cesarini D Dawes C T Fowler J H | 2008 | PNAS2008，105，10： | 1 |
| 4 | Visual function at 35 and 40 weeks' postmenstrual age in low-risk preterm infants显示文摘 | Ricci D Cesarini L Romeo DM | | 0，，： | 1 |
| 5 | Role of P16 (INK4a) cytology testing as an adjunct to enhance the diagnostic specificity and accuracy in human papillomavirus-positive women within an organized cervical cancer screening program 显示文摘 | Gustinucci D Passamonti B Cesarini E | 2012 | Acta Cytol2012，56，5： | 1 |
| 6 | Role of p16 (INK4a) cytology testing as an adjunct to enhance the diagnostic specificity and accuracy in human papillomavirus - positive women within an organ- ized cervical cancer screening program显示文摘 | Gustinucci D Passamonti B Cesarini E | 2012 | Acta Cytol2012，56，5： | 1 |
| 7 | The co-twin methodology and returns to schooling-testing a critical assumption显示文摘 | Sandewall Cesarini D Johannesson M | 2014 | Labour Economics2014，26，： | 1 |
| 8 | Use of cytolo-gy,E6/E7mRNA,and p16INK4a-Ki-67to define the man-agement of human papillomavirus(HPV)-positive women incervical cancer screening显示文摘 | Gustinucci D Giorgi Rossi P Cesarini E | 2016 | Am J Clin Pathol2016，145，1： | 1 |
| 9 | Role of p16lr' cy- tology testing as an adjunct to enhance the diagnostic specificity and accuracy in human papillomavims-pesitive women within an organ- id cervical cancer screening program显示文摘 | Gustinueei D Passamonti B Cesarini E eta/ | 2012 | Acta Cytol2012，56，5： | 1 |
| 10 | Use of cytolo- gy, E6/E7 mRNA, and p16^INK4n-Ki-67 to define the manage- ment of human papillomavirus (HPV)-positive women in cervi- cal cancer screening显示文摘 | Gustinucci D Giorgi Rossi P Cesarini E | 2016 | Am J Clin Pathol2016，145，1： | 1 |
| 11 | Melanins and their possible roles through biological evolution显示文摘 | J P Cesarini M D I N S E R M | 1996 | Adv Space Res1996，18，12： | 1 |
| 12 | Use of Cytol ogy, E6/E7 mRNA, and p16INK4a-Ki-67 to Define the Man- agement of Human Papillomavirus(HPV) Positive Women in Cervical Cancer Screening显示文摘 | Gustinueci D Giorgi Rossi P Cesarini E | 2016 | Am J Clin Pathol2016，145，1： | 1 |
| 13 | Genetic variation in financial decision-making 显示文摘 | Cesarini D Johannesson M Lichtenstein P Sandewall O Wallace B | 2010 | Journal of Finance2010，65，5： | 1 |
| 14 | Role of pi 6(INK4a)cytology testing as an adjunct to enhance the diagnosticspecificity and accuracy in human papillomavirus-positive womenwithin an organized cervical cancer screening program显示文摘 | Gustinucci D Passamonti B Cesarini E | 2012 | ActaCytol2012，56，5： | 1 |
| 15 | Heritability of ultimatum game responder behavior 显示文摘 | WALLACE B CESARINI D LICHTENSTEI P | 2007 | Proceedings of the National Academy of Sciences2007，104，15： | 1 |
| 16 | Heritability ofcooperative behavior in the trust game 显示文摘 | Cesarini D Dawes C T Fowler J H | 2008 | Proceedings of theNational Academy of Sciences of the United States of America2008，105，10： | 1 |
| 17 | Heritability of ultimatum game responder behavior显示文摘 | WALLACE B CESARINI D LICHTENSTEI P | 2007 | Proceedings of the National Academy of Sciences2007，104，15： | 1 |
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