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| 1 | Combination of corticosteroids and 5-aminosalicylates or corticosteroids alone for patients with moderate-severe active ulcerative colitis:A global survey of physicians'practice显示文摘AIM To examine treatment decisions of gastroenterologists regarding the choice of prescribing 5-aminosalycilates(5ASA) with corticosteroids(CS) versus corticosteroids alone for patients with active ulcerative colitis(UC). METHODS A cross-sectional questionnaire exploring physicians' attitude toward 5ASA + CS combination therapy vs CS alone was developed and validated. The questionnaire was distributed to gastroenterology experts in twelve countries in five continents. Respondents' agreement with stated treatment choices were assessed by standardized Likert scale. Background professional characteristics of respondents were analyzed for correlation with responses. RESULTS Six hundred and sixty-four questionnaires were distributed and 349 received(52.6% response rate). Of 340 eligible respondents, 221(65%) would continue 5ASA in a patient hospitalized for intravenous CS treatment due to a moderate-severe UC flare, while 108(32%) would stop the 5ASA(P < 0.001), and 11(3%) are undecided. Similarly, 62% would continue 5ASA in an out-patient starting oral CS. However, only 140/340(41%) would proactively start 5ASA in a hospitalized patient not receiving 5ASA before admission. Most(94%) physicians consider the safety profile of 5ASA as very good. Only 52% consider them inexpensive, 35% perceive them to be expensive and 12% are undecided. On multi-variable analysis, less years of practice and perception of a plausible additive mechanistic effect of 5ASA + CS were positively associated with the decision to continue 5ASA with CS. CONCLUSION Despite the absence of data supporting its benefit, most gastroenterologists endorse combination of 5ASA + CS for patients with active moderate-to-severe UC. Randomized controlled trials are needed to assess if 5ASA confer any benefit for these patients. | Shomron Ben-Horin Jane M Andrews Konstantinos H Katsanos Florian Rieder Flavio Steinwurz Konstantinos Karmiris Jae Hee Cheon Gordon William Moran Monica Cesarini Christian D Stone Doron Schwartz Marijana Protic Xavier Roblin Giulia Roda Min-Hu Chen Ofir Har-Noy Charles N Bernstein | 2017 | World Journal of Gastroenterology2017，23，16： | 3 |
| 2 | Confidence inter- val estimation tasks and the economics of overconfidence 显示文摘 | Cesarini D Sandewall O Johannesson M | 2006 | Journal of Economic Behavior Organization2006，61，3： | 1 |
| 3 | Findings and outcome in whiplash-typo neck distortions显示文摘 | Jonsson H Jr Cesarini K Sahlstedt B | 1994 | Spine1994，19，24： | 1 |
| 4 | 用于固定设备盖的高压密封显示文摘一种新型受压自紧密封环被设计用于各种实际应用,这包括近海平台的管道系统。 | James Cesarini Erik Howard Doug Hughes | 2008 | 经济导报(石油天然气)2008，，1： | 1 |
| 5 | 6-Amino-4-oxo-1,3-diphenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonyl derivatives as a new class of potent inhibitors of interleukin-8-induced neutrophil chemotaxis显示文摘 | Cesarini S Spallarossa A Ranise A | 2009 | Bioorg Med Chem2009，17，10： | 1 |
| 6 | Heritability of cooperative behavior in the trust game显示文摘 | Cesarini D Dawes C T Fowler J H | 2008 | PNAS2008，105，10： | 1 |
| 7 | RecA gene sequence and Multiloeus Sequence Typing for species - level resolution of Burkholderia cepacia complex isolates 显示文摘 | Cesarini S Bevivino A Tabacchioni S | 2009 | Lett Appl Microbiol2009，49，5： | 1 |
| 8 | Improved survival after aneurysmal subarachnoid hemorrhage: review of case management during a 12-year period显示文摘 | Cesarini KG Hirdemark HG Persson L | 1999 | J Neurosurg1999，90，4： | 1 |
| 9 | Brake comfort-a review显示文摘 | Cantoni C Cesarini R Mastinu G | 2009 | Vehicle System Dynamics2009，47，： | 1 |
| 10 | Visual function at 35 and 40 weeks' postmenstrual age in low-risk preterm infants显示文摘 | Ricci D Cesarini L Romeo DM | | 0，，： | 1 |
| 11 | Role of P16 (INK4a) cytology testing as an adjunct to enhance the diagnostic specificity and accuracy in human papillomavirus-positive women within an organized cervical cancer screening program 显示文摘 | Gustinucci D Passamonti B Cesarini E | 2012 | Acta Cytol2012，56，5： | 1 |
| 12 | INFORMys:a flexible invoice-like form-reader system显示文摘 | Francesca Cesarini Marco Gori Simone Marinai | 1998 | IEEE Trans on Pattern Analysis and Machine Intelligence1998，20，7： | 1 |
| 13 | Intracerebral microdialysis in neurointensive care:the use of urea as an endogenous reference compound显示文摘 | RONNE-ENGSTROM E CESARINI KG ENBLAD P | 2001 | J Neurosurg2001，94，3： | 1 |
| 14 | Describing database objects in a concept language environment显示文摘 | A Artale F Cesarini G Soda | 1996 | IEEE Trans on Knowledge and Data Engineering1996，8，2： | 1 |
| 15 | Role of p16 (INK4a) cytology testing as an adjunct to enhance the diagnostic specificity and accuracy in human papillomavirus - positive women within an organ- ized cervical cancer screening program显示文摘 | Gustinucci D Passamonti B Cesarini E | 2012 | Acta Cytol2012，56，5： | 1 |
| 16 | Describing database objects in a concept language environment显示文摘 | A Artale F Cesarini G Soda | 1996 | IEEE Trans on Knowledge and Data Engineering1996，8，2： | 1 |
| 17 | Improved survival after aneurysmal subarachnoid hemorrhage:review of case management during a 12-year period显示文摘 | Cesarini KG Hardemark HG Persson L | 1999 | J Neurosurg1999，90，4： | 1 |
| 18 | Deploying a Communicating Automatic Weather Station on an Alpine Glacier显示文摘 | Stefano Abbate Marco Avvenuti Luca Carturan Daniel Cesarini | 2013 | Procedia Computer Science2013，，： | 1 |
| 19 | Hemodynamic changes during celioscopy:a study carried out using thoracic electric bioimpedance显示文摘 | Torrielli R Cesarini M Winnock S | 1990 | Can J Anaesth1990，37，1： | 1 |
| 20 | The co-twin methodology and returns to schooling-testing a critical assumption显示文摘 | Sandewall Cesarini D Johannesson M | 2014 | Labour Economics2014，26，： | 1 |
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