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| 1 | Pioglitazone, a specific ligand of peroxisome proliferator-activated receptor-gamma, protects pancreas against acute cerulein-induced pancreatitis显示文摘ABM: To determine the effect of pioglitazone, a specific peroxisome proliferator-activated receptor-γ(PPARγ) ligand, on the development of acute pancreatitis (AP) and on the expression of heat shock protein 70 (HSP70) in the pancreas. METHODS: AP was induced in rats by subcutaneous infusion of cerulein for 5 h. Pancreatic blood flow was measured by laser Doppler flowmetry. Plasma lipase activity, interleukin-1β (IL-1β) and IL-10 were determined, Pancreatic weight and histology were evaluated and pancreatic DNA synthesis and blood flow as well as pancreatic mRNA for IL-1β and HSP70 were assessed in rats treated with pioglitazone alone or in combination with cerulein. RESULTS: Pioglitazone administered (10-100 mg/kg i.g.) 30 min before cerulein, attenuated dose-dependently the pancreatic tissue damage in cerulein-induced pancreatitis (CIP) as demonstrated by the improvement of pancreatic histology, reduction in plasma lipase activity, plasma concentration of pro-inflammatory IL-1β and its gene expression in the pancreas and attenuation of the pancreatitis-evoked fall in pancreatic blood flow. CIP increased pancreatic HSP70 mRNA and protein expression in the pancreas and this effect was enhanced by pioglitazone treatment. CONCLUSION: Pioglitazone attenuates CIP and the beneficial effect of this pioglitazone is multifactorial probably due to its anti-inflammatory activities, to the suppression of IL-1β and to the over-expression of HSP70. PPARγ ligands could represent a new therapeutic option in the treatment of AP. | Peter C Konturek Artur Dembinski Zygmunt Warzecha Grzegorz Burnat Piotr Ceranowicz Eckhart G Hahn Marcin Dembinski Romana Tomaszewska Stanislaw J Konturek | 2005 | World Journal of Gastroenterology2005，11，40： | 7 |
| 2 | Ischemic preconditioning inhibits development of edematous cerulein-induced pancreatitis: Involvement of cyclooxygenases and heat shock protein 70显示文摘AIM: To determine whether ischemic preconditioning (IP)affects the development of edematous cerulein-induced pancreatitis and to assess the role of cyclooxygenase-1 (COX-1), COX-2, and heat shock protein 70 (HSP 70) in this process.METHODS: In male Wistar rats, IP was performed by damping of celiac artery (twice for 5 min at 5-min intervals).Thirty minutes after IP or sham operation, acute pancreatitis was induced by cerulein. Activity of COX-1 or COX-2 was inhibited by resveratrol or rofecoxib, respectively (10 mg/kg).RESULTS: IP significantly reduced pancreatic damage in cerulein-induced pancreatitis as demonstrated by the improvement of pancreas histology, reduction in serum lipase and poly-C ribonuclease activity, and serum concentration of pro-inflammatory interleukin (IL)-1β.Also, IP attenuated the pancreatitis-evoked fall in pancreatic blood flow and pancreatic DNA synthesis.Serum level of anti-inflammatory IL-10 was not affected by IP. Cerulein-induced pancreatitis and IP increased the content of HSP 70 in the pancreas. Maximal increase in HSP 70 was observed when IP was combined with cerulein-induced pancreatitis. Inhibition of COXs, especially COX-2, reduced the protective effect of IP in edematous pancreatitis.CONCLUSION: Our results indicate that IP reduces pancreatic damage in cerulein-induced pancreatitis and this effect, at least in part, depends on the activity of COXs and pancreatic production of HSP 70. | Zygmunt Warzecha Artur Dembinski Piotr Ceranowicz Stanislaw J Konturek Marcin Dembinski Wieslaw W Pawlik Romana Tomaszewska Jerzy Stachura Beata Kusnierz-Cabala Jerzy W Naskalski Peter C Konturek | 2005 | World Journal of Gastroenterology2005，11，38： | 2 |
| 3 | Inhibition of cyclooxygenase-2 reduces the protective effect of hepatocyte growth factor in experimental pancreatitis 显示文摘 | Warzecha Z Dembinski A Ceranowicz P | 2004 | Eur J Pharmacol2004，486，1： | 1 |
| 4 | Calcitonin gene related peptide can attenuate or augment pancreatic damage in caerulein-induced pancreatitis in rats显示文摘 | Warzecha Z Dembinski A Ceranowicz P | 1999 | J Physiol Pharmacoi1999，50，1： | 1 |
| 5 | Role of growth hormone and insulin-like growth factor-1 in the protective effect of ghrelin in ischemia/reperfusion-induced acute pancreatitis 显示文摘 | Dembinski A Warzecha Z Ceranowicz P | 2006 | Growth Horm IGF Res2006，16，56： | 1 |
| 6 | Influence of leptin administration on the course of acute ischemic pancreatitis显示文摘 | Warzecha Z Dembinski A Ceranowicz P | 2002 | J Physiol Pharmacol2002，53，42： | 1 |
| 7 | Protective and therapeutic effect of leptin in acute pancreatitis evoked by ischemia/reperfusion显示文摘 | Ceranowicz P Warzecha Z Dembi(n)ski A | 2003 | Folia Med Cracov2003，44，12： | 1 |
| 8 | IGF-1 stimulates production of interleukin-10 and inhibits development of caeruleininduced pancreatitis显示文摘 | Warzecha Z Dembinski A Ceranowicz P | | 0，，04： | 1 |
| 9 | Ghrelin attenuates the development of acute pancreatitis in rat 显示文摘 | Dembinski A Warzecha Z Ceranowicz P | 2003 | J Physiol Pharmacol2003，54，： | 1 |
| 10 | Ghrelinattemates the development of acute pancrealitis in rat显示文摘 | Dembinski A Warzecha Z Ceranowicz P | 2003 | J Physiol Pharmacol2003，54，4： | 1 |
| 11 | Influence of leptin administration on the course of acute ischemic pancre-atitis显示文摘 | Warzecha Z Dembinski A Ceranowicz P | 2002 | J Physiol Pharmacol2002，53，42： | 1 |
| 12 | Heparin inhibits protective effect of ischemic preconditioning in ischemia/reperfusion-induced acute pancreatitis显示文摘 | Warzecha Z Dembinski A Ceranowicz P | 2012 | J Physiol Pharmacol2012，63，4： | 1 |
| 13 | Protective and therapeutic effect of leptin acute pancreatitis evoked by ischemia/ reperfusion 显示文摘 | Ceranowicz P Warzecha Z Dembifiski A | 2003 | Folia Med Cracov2003，44，12： | 1 |
| 14 | Role of growth hormone and insulin-like growth factor-1 in the protective effect of ghrelin in ischemia/reperfusion-induced acute pancreatitis显示文摘 | Dembinski A Warzecha Z Ceranowicz P | 2006 | Growth Horm IGF Res2006，16，56： | 1 |
| 15 | Influence of leptin administration on the course of acute ischemic pancreatitis显示文摘 | Warzecha Z Dembinski A Ceranowicz P | 2002 | J Physiol Pharmacol2002，53，42： | 1 |
| 16 | Ghrelin attenuates the development of acute pancreatitis in rat显示文摘 | Dembinski A Warzecha Z Ceranowicz P | 2003 | J Physiol Pharmacol2003，54，4： | 1 |
| 17 | Ghrelin attenuates the development of acute pancreatitis in rat显示文摘 | Dembinski A Warzecha Z Ceranowicz P | 2003 | J Physiol Pharmacol2003，54，4： | 1 |
| 18 | Protective and therapeutic effect of leptin in acute pancreatitis evoked by ischemia/reperfusion显示文摘 | Ceranowicz P Warzecha Z Dembiński A | 2003 | Folia Med Cracov2003，44，12： | 1 |
| 19 | Protective andtherapeutic effect of leptin in acute pancreatitis evoked by ischemi-a/reperfusion显示文摘 | Ceranowicz P Warzecha Z Dembinski A et a1 | 2003 | Folia Med Cracov2003，44，12： | 1 |
| 20 | lschemic preconditioning reduces the severity of ischemia reperfusion - induced pancreatitis 显示文摘 | Artur Dembin'ski Zygmunt Warzecha Piotr Ceranowicz | 2003 | Eur J Pharmacol2003，473，23： | 1 |
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